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2024-03-28 23:20:50, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_004819               4188 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens symplekin (SYMPK), mRNA.
ACCESSION   NM_004819
VERSION     NM_004819.2  GI:124028528
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4188)
  AUTHORS   Chang,H., Zhang,C. and Cao,Y.
  TITLE     Expression and distribution of symplekin regulates the assembly and
            function of the epithelial tight junction
  JOURNAL   Histochem. Cell Biol. 137 (3), 319-327 (2012)
   PUBMED   22218735
  REMARK    GeneRIF: Symplekin expression regulates the assembly of tight
            junctions, thus helps to maintain the integrity of the epithelial
            monolayer and cellular polarity.
REFERENCE   2  (bases 1 to 4188)
  AUTHORS   Cappell,K.M., Larson,B., Sciaky,N. and Whitehurst,A.W.
  TITLE     Symplekin specifies mitotic fidelity by supporting microtubule
            dynamics
  JOURNAL   Mol. Cell. Biol. 30 (21), 5135-5144 (2010)
   PUBMED   20823274
  REMARK    GeneRIF: Symplekin supports faithful mitosis by contributing to the
            formation of a bipolar spindle apparatus. Depletion of symplekin
            attenuates microtubule polymerization as well as expression of the
            critical microtubule polymerization protein CKAP5 (TOGp).
REFERENCE   3  (bases 1 to 4188)
  AUTHORS   Xiang,K., Nagaike,T., Xiang,S., Kilic,T., Beh,M.M., Manley,J.L. and
            Tong,L.
  TITLE     Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide
            complex
  JOURNAL   Nature 467 (7316), 729-733 (2010)
   PUBMED   20861839
  REMARK    GeneRIF: crystal structure at 2.4 A resolution of the
            amino-terminal domain (residues 30-340) of human symplekin in a
            ternary complex with the Pol II carboxy-terminal domain (CTD) Ser 5
            phosphatase Ssu72 and a CTD Ser 5 phosphopeptide
REFERENCE   4  (bases 1 to 4188)
  AUTHORS   Fransen,K., Visschedijk,M.C., van Sommeren,S., Fu,J.Y., Franke,L.,
            Festen,E.A., Stokkers,P.C., van Bodegraven,A.A., Crusius,J.B.,
            Hommes,D.W., Zanen,P., de Jong,D.J., Wijmenga,C., van Diemen,C.C.
            and Weersma,R.K.
  TITLE     Analysis of SNPs with an effect on gene expression identifies
            UBE2L3 and BCL3 as potential new risk genes for Crohn's disease
  JOURNAL   Hum. Mol. Genet. 19 (17), 3482-3488 (2010)
   PUBMED   20601676
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   5  (bases 1 to 4188)
  AUTHORS   Buchert,M., Papin,M., Bonnans,C., Darido,C., Raye,W.S.,
            Garambois,V., Pelegrin,A., Bourgaux,J.F., Pannequin,J., Joubert,D.
            and Hollande,F.
  TITLE     Symplekin promotes tumorigenicity by up-regulating claudin-2
            expression
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 107 (6), 2628-2633 (2010)
   PUBMED   20133805
  REMARK    GeneRIF: Data show that claudin-2 expression was reduced following
            symplekin down-regulation, and siRNA-mediated claudin-2
            down-regulation increased the transepithelial resistance and
            decreased cyclin D1 expression and ZONAB nuclear localization.
REFERENCE   6  (bases 1 to 4188)
  AUTHORS   Takagaki,Y. and Manley,J.L.
  TITLE     Complex protein interactions within the human polyadenylation
            machinery identify a novel component
  JOURNAL   Mol. Cell. Biol. 20 (5), 1515-1525 (2000)
   PUBMED   10669729
REFERENCE   7  (bases 1 to 4188)
  AUTHORS   Faber,P.W., Barnes,G.T., Srinidhi,J., Chen,J., Gusella,J.F. and
            MacDonald,M.E.
  TITLE     Huntingtin interacts with a family of WW domain proteins
  JOURNAL   Hum. Mol. Genet. 7 (9), 1463-1474 (1998)
   PUBMED   9700202
REFERENCE   8  (bases 1 to 4188)
  AUTHORS   Alwazzan,M., Hamshere,M.G., Lennon,G.G. and Brook,J.D.
  TITLE     Six transcripts map within 200 kilobases of the myotonic dystrophy
            expanded repeat
  JOURNAL   Mamm. Genome 9 (6), 485-487 (1998)
   PUBMED   9585442
REFERENCE   9  (bases 1 to 4188)
  AUTHORS   Ueki,K., Ramaswamy,S., Billings,S.J., Mohrenweiser,H.W. and
            Louis,D.N.
  TITLE     Chromosomal localization to 19q13.3, partial genomic structure and
            5' cDNA sequence of the human symplekin gene
  JOURNAL   Somat. Cell Mol. Genet. 23 (3), 229-231 (1997)
   PUBMED   9330635
REFERENCE   10 (bases 1 to 4188)
  AUTHORS   Keon,B.H., Schafer,S., Kuhn,C., Grund,C. and Franke,W.W.
  TITLE     Symplekin, a novel type of tight junction plaque protein
  JOURNAL   J. Cell Biol. 134 (4), 1003-1018 (1996)
   PUBMED   8769423
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB461873.1, DB044963.1,
            BC006536.2, Y10931.1 and BU752018.1.
            On Jan 23, 2007 this sequence version replaced gi:4759195.
            
            Summary: This gene encodes a nuclear protein that functions in the
            regulation of polyadenylation and promotes gene expression. The
            protein forms a high-molecular weight complex with components of
            the polyadenylation machinery. It is thought to serve as a scaffold
            for recruiting regulatory factors to the polyadenylation complex.
            It also participates in 3'-end maturation of histone mRNAs, which
            do not undergo polyadenylation. The protein also localizes to the
            cytoplasmic plaques of tight junctions in some cell types.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK300252.1, Y10931.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                DB461873.1         1-72
            73-586              DB044963.1         49-562
            587-1381            BC006536.2         294-1088
            1382-4166           Y10931.1           1200-3984
            4167-4188           BU752018.1         21-42               c
FEATURES             Location/Qualifiers
     source          1..4188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.3"
     gene            1..4188
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /note="symplekin"
                     /db_xref="GeneID:8189"
                     /db_xref="HGNC:22935"
                     /db_xref="MIM:602388"
     exon            1..233
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     variation       169..171
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /replace=""
                     /replace="cgg"
                     /db_xref="dbSNP:3840932"
     misc_feature    198..200
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /note="upstream in-frame stop codon"
     exon            234..350
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     CDS             246..4070
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /codon_start=1
                     /product="symplekin"
                     /protein_id="NP_004810.2"
                     /db_xref="GI:124028529"
                     /db_xref="CCDS:CCDS12676.2"
                     /db_xref="GeneID:8189"
                     /db_xref="HGNC:22935"
                     /db_xref="MIM:602388"
                     /translation="
MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQELIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRDENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIRTHAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLLKFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKMKLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMVYLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEKVVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGRKKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGLKAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQKDGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDLSSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAAPWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPELLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMKSIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNILSRLIMKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVRSFTPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREPEAKGNS
"
     misc_feature    246..617
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92797.2);
                     Region: Interaction with HSF1"
     misc_feature    555..683
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92797.2);
                     Region: HEAT 3"
     misc_feature    600..1301
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /note="Domain of unknown function (DUF3453); Region:
                     DUF3453; pfam11935"
                     /db_xref="CDD:192887"
     misc_feature    702..821
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92797.2);
                     Region: HEAT 4"
     misc_feature    924..1043
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92797.2);
                     Region: HEAT 5"
     misc_feature    1278..1325
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92797.2);
                     Region: Nuclear localization signal (Potential)"
     misc_feature    1725..1727
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q92797.2); phosphorylation site"
     misc_feature    2904..3452
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /note="Symplekin tight junction protein C terminal;
                     Region: Symplekin_C; pfam12295"
                     /db_xref="CDD:152730"
     misc_feature    3972..3974
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q92797.2); phosphorylation site"
     misc_feature    3972..3974
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    4014..4016
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q92797.2); phosphorylation site"
     misc_feature    4020..4022
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q92797.2); phosphorylation site"
     exon            351..416
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            417..470
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            471..544
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            545..671
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     variation       557
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2303014"
     exon            672..921
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     variation       692
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3206292"
     exon            922..1092
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            1093..1332
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            1333..1487
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            1488..1638
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            1639..1843
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            1844..1994
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            1995..2230
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            2231..2312
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            2313..2426
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            2427..2574
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            2575..2735
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            2736..2844
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            2845..2945
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            2946..3036
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            3037..3138
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            3139..3326
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            3327..3503
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            3504..3599
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     exon            3600..3932
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     variation       3626
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1132645"
     exon            3933..4188
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /inference="alignment:Splign:1.39.8"
     STS             3952..4072
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /standard_name="RH11655"
                     /db_xref="UniSTS:35107"
     variation       3993
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1804616"
     variation       4089
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3810332"
     variation       4129
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
                     /replace=""
                     /replace="ggacggggcgggg"
                     /db_xref="dbSNP:3840933"
     polyA_signal    4161..4166
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
     polyA_site      4188
                     /gene="SYMPK"
                     /gene_synonym="SPK; SYM"
ORIGIN      
ggaaatgaagggtctgctcgccgtagtatggaggcgggcagaatgccgctcgcacgggacgaggcatgggcggggtcgggctgtgctctggactccatttcccggcggccctgggtgtgtggcgcgtgcgcaccgttcccggcgacgaacggaagatggcggcggcggcggcggcggagtgtaggaagaggcactgctgagggggcgcgaggggaacggaggccagagctgcgctgacagcagccatggcgagcggcagtggagacagcgtcacccgtcggagcgtggcatcacagtttttcactcaagaggaggggccgggcatcgatggcatgaccacctcagagagggtggtggatcttctgaaccaggcggcgctgatcaccaatgactcaaagatcacagtgctcaaacaggtccaggagctgatcatcaacaaagaccccacactactggacaacttcctggatgagatcatcgcattccaagcagacaagtcaatcgaagtgcgaaaatttgtcatcggcttcatcgaggaggcatgcaagcgagacattgagttgctgctgaaactcattgcaaacctcaacatgctcttgagggacgagaatgtgaacgtggtgaagaaggctatcctcaccatgacccagctctacaaggtggccctgcagtggatggtaaagtcacgggtcattagcgagctacaggaggcctgctgggacatggtatctgccatggcgggggacatcatcctgctattggactctgacaatgacggcatccgcacccacgccatcaagtttgtggagggcctcattgtcaccctgtcaccccgcatggctgactcagagataccccgacgccaggagcatgatatcagcctggaccgcatccctcgtgaccacccctacatccagtacaacgtgctatgggaagagggcaaggcagccttggagcagctgcttaagttcatggtgcaccctgccatctcctccatcaacctgaccacagcgctgggctcccttgccaatatcgcccgccagagacccatgttcatgtctgaggtgatccaggcctatgaaactctgcatgccaacctgcccccgacgctggccaaatcgcaggtgagcagtgtgcgtaagaatctgaagctgcacctgttgagtgtgctgaagcacccggcttccttggagttccaggcccagatcaccaccctgctggtggacctgggcacacctcaggccgagatcgcccgcaacatgccgagcagcaaggacacccgcaagcggccccgcgatgactcggactccacactcaagaagatgaagctggagcccaacctgggggaggacgatgaggacaaagacttggagccaggcccgtcggggacctcgaaggcctcagcgcagatctccggccagtcagacacggacatcacagctgagttcctgcagcctctgctgacgcctgataatgtggctaatctggtcctcatcagcatggtgtacctacccgaggccatgccagcctccttccaggccatctacacccccgtggagtcagcaggcacggaagcccagatcaagcacctggctcggctcatggccacacagatgacagctgccggactgggaccaggtgtagagcagaccaaacagtgcaaggaggagcccaaggaggagaaggtggtgaagacagagagcgtcctgatcaagcggcgcctgtcagcccagggccaagccatctcggtggtgggttccctgagctccatgtcccccctggaggaagaggcaccgcaggccaagaggaggccagagcccattatccctgtcactcagccccggctggcaggcgctggtgggcgcaagaaaattttccgtctcagcgacgtgctgaagccccttaccgatgcccaggtggaagccatgaagctgggcgctgtgaagcggatcctgcgggctgagaaggctgtggcctgcagcggggcagcccaggtccgcataaagatcctggccagcctggtgacacagttcaactcgggcctgaaggcggaggtcctgtccttcatcctggaggatgtgcgggcccgcctggacctggccttcgcctggctctaccaggagtacaacgcctacctggccgcaggtgcctcgggctccctggacaagtatgaggactgcctcatccgcctgttgtctggcctgcaggagaaaccagaccagaaggatgggatcttcaccaaggttgtgctggaggcgccactcatcacagagagtgccctggaggtggtccgcaagtactgcgaggatgagagtcgcacctatctgggcatgtccacacttcgagacctgatcttcaagcgcccgtcccgccagttccagtacctgcatgtcctcctcgacctcagctcccatgagaaggacaaggtgcgctcccaggccctgctgttcatcaaacgcatgtatgagaaggagcagctgcgggagtatgtggagaaatttgccctcaactacctgcagctcctggtgcaccccaacccaccgtctgtgctgtttggagctgacaaggacacagaggtggcagcaccctggacggaggagacagtgaagcagtgtctgtacctctacctggccctcctgcctcagaaccacaagctgatccacgaactggcggccgtgtacactgaagccatcgccgacatcaagcggacggtgctgagggtcattgagcagccgatccgaggaatgggcatgaactccccggagctgctcctgctggtggaaaattgtcccaagggagcagagacactggtcacgagatgtctgcacagcctcacagacaaagtcccaccctccccagagctggtgaagcgggtccgggatctctaccacaagcgactgccagacgtccgcttcctcatcccggtgctcaatgggctggagaagaaagaggtgatccaggccctgcctaaactcatcaaactcaaccccatcgtggtgaaggaagtcttcaaccgcctgctgggcacccagcatggtgagggaaactcagccttgtccccgctgaaccctggagagctcctgatcgcattacacaacattgactccgtgaagtgcgacatgaaatccatcatcaaagccaccaacctgtgctttgcggagcggaacgtgtacacgtcagaggtgctggccgtggtgatgcagcagctgatggagcagagccccctgcccatgctgctcatgaggaccgtcatccagtccctgaccatgtacccccgcctggggggcttcgtcatgaacatcctgtcccgcctcatcatgaagcaggtgtggaagtaccccaaggtgtgggagggcttcatcaagtgctgccagcgcacaaagccccagagcttccaggtcatcctgcagctgccgccccagcagctgggagccgtctttgacaagtgcccagagctccgggagcccctgctggcccatgtccgctccttcaccccccaccagcaagctcacatccctaactccatcatgaccatcttggaggccagcggcaagcaggagccagaggccaaggaggcgcctgcggggcccttggaggaggatgatctggagcccctgaccttggccccggccccagcaccccggccccctcaggacctcatcggcctgcgactggcccaggagaaggccttaaagcggcagctggaggaggaacagaagctgaagccgggaggagtgggagccccctcctcttcctccccctctccctctccgtcggcccggccaggcccgcccccgtctgaggaagccatggatttccgggaggaggggcctgagtgcgagaccccgggcatcttcatcagcatggatgacgactcggggctgaccgaggccgcgctgttggactctagtctcgagggccccctacccaaggagacggcagcgggcgggctgaccttgaaggaggagcggagcccccagaccctcgcacctgttggagaagatgctatgaagactcccagcccggctgccgaggacgccagggaacccgaggccaaggggaacagctgacggggctcgagggggaaagggggtgggacagggactcggggctgggggacggggcggggcttgacctgcgggtgctttgccttaaaaagaaataaaagatgtgaacttgggcaagtta
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8189 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:8189 -> Biological process: GO:0006378 [mRNA polyadenylation] evidence: IMP
            GeneID:8189 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
            GeneID:8189 -> Biological process: GO:0035307 [positive regulation of protein dephosphorylation] evidence: IDA
            GeneID:8189 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:8189 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IDA
            GeneID:8189 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:8189 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:8189 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
            GeneID:8189 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:8189 -> Cellular component: GO:0005923 [tight junction] evidence: IEA

by @meso_cacase at DBCLS
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