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2024-04-19 10:53:20, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004557 6762 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens notch 4 (NOTCH4), mRNA.
ACCESSION NM_004557
VERSION NM_004557.3 GI:55770875
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6762)
AUTHORS Yamazaki,K., Umeno,J., Takahashi,A., Hirano,A., Johnson,T.A.,
Kumasaka,N., Morizono,T., Hosono,N., Kawaguchi,T., Takazoe,M.,
Yamada,T., Suzuki,Y., Tanaka,H., Motoya,S., Hosokawa,M.,
Arimura,Y., Shinomura,Y., Matsui,T., Matsumoto,T., Iida,M.,
Tsunoda,T., Nakamura,Y., Kamatani,N. and Kubo,M.
TITLE A genome-wide association study identifies 2 susceptibility Loci
for Crohn's disease in a Japanese population
JOURNAL Gastroenterology 144 (4), 781-788 (2013)
PUBMED 23266558
REFERENCE 2 (bases 1 to 6762)
AUTHORS Aberg,K.A., Liu,Y., Bukszar,J., McClay,J.L., Khachane,A.N.,
Andreassen,O.A., Blackwood,D., Corvin,A., Djurovic,S., Gurling,H.,
Ophoff,R., Pato,C.N., Pato,M.T., Riley,B., Webb,T., Kendler,K.,
O'Donovan,M., Craddock,N., Kirov,G., Owen,M., Rujescu,D., St
Clair,D., Werge,T., Hultman,C.M., Delisi,L.E., Sullivan,P. and van
den Oord,E.J.
TITLE A comprehensive family-based replication study of schizophrenia
genes
JOURNAL JAMA Psychiatry 70 (2), 1-9 (2013)
PUBMED 23571483
REFERENCE 3 (bases 1 to 6762)
AUTHORS Rubicz,R., Yolken,R., Drigalenko,E., Carless,M.A., Dyer,T.D.,
Bauman,L., Melton,P.E., Kent,J.W. Jr., Harley,J.B., Curran,J.E.,
Johnson,M.P., Cole,S.A., Almasy,L., Moses,E.K., Dhurandhar,N.V.,
Kraig,E., Blangero,J., Leach,C.T. and Goring,H.H.
TITLE A genome-wide integrative genomic study localizes genetic factors
influencing antibodies against Epstein-Barr virus nuclear antigen 1
(EBNA-1)
JOURNAL PLoS Genet. 9 (1), E1003147 (2013)
PUBMED 23326239
REFERENCE 4 (bases 1 to 6762)
AUTHORS Dieset,I., Djurovic,S., Tesli,M., Hope,S., Mattingsdal,M.,
Michelsen,A., Joa,I., Larsen,T.K., Agartz,I., Melle,I.,
Rossberg,J.I., Aukrust,P., Andreassen,O.A. and Ueland,T.
TITLE Up-regulation of NOTCH4 gene expression in bipolar disorder
JOURNAL Am J Psychiatry 169 (12), 1292-1300 (2012)
PUBMED 23212060
REMARK GeneRIF: strong association between expression and bipolar disorder
REFERENCE 5 (bases 1 to 6762)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 6 (bases 1 to 6762)
AUTHORS Uyttendaele,H., Soriano,J.V., Montesano,R. and Kitajewski,J.
TITLE Notch4 and Wnt-1 proteins function to regulate branching
morphogenesis of mammary epithelial cells in an opposing fashion
JOURNAL Dev. Biol. 196 (2), 204-217 (1998)
PUBMED 9576833
REFERENCE 7 (bases 1 to 6762)
AUTHORS Sugaya,K., Sasanuma,S., Nohata,J., Kimura,T., Fukagawa,T.,
Nakamura,Y., Ando,A., Inoko,H., Ikemura,T. and Mita,K.
TITLE Gene organization of human NOTCH4 and (CTG)n polymorphism in this
human counterpart gene of mouse proto-oncogene Int3
JOURNAL Gene 189 (2), 235-244 (1997)
PUBMED 9168133
REFERENCE 8 (bases 1 to 6762)
AUTHORS Uyttendaele,H., Marazzi,G., Wu,G., Yan,Q., Sassoon,D. and
Kitajewski,J.
TITLE Notch4/int-3, a mammary proto-oncogene, is an endothelial
cell-specific mammalian Notch gene
JOURNAL Development 122 (7), 2251-2259 (1996)
PUBMED 8681805
REFERENCE 9 (bases 1 to 6762)
AUTHORS Matsuno,K., Diederich,R.J., Go,M.J., Blaumueller,C.M. and
Artavanis-Tsakonas,S.
TITLE Deltex acts as a positive regulator of Notch signaling through
interactions with the Notch ankyrin repeats
JOURNAL Development 121 (8), 2633-2644 (1995)
PUBMED 7671825
REFERENCE 10 (bases 1 to 6762)
AUTHORS Sugaya,K., Fukagawa,T., Matsumoto,K., Mita,K., Takahashi,E.,
Ando,A., Inoko,H. and Ikemura,T.
TITLE Three genes in the human MHC class III region near the junction
with the class II: gene for receptor of advanced glycosylation end
products, PBX2 homeobox gene and a notch homolog, human counterpart
of mouse mammary tumor gene int-3
JOURNAL Genomics 23 (2), 408-419 (1994)
PUBMED 7835890
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL705928.1, U95299.1, D63395.1
and BQ023880.1.
This sequence is a reference standard in the RefSeqGene project.
On Nov 15, 2004 this sequence version replaced gi:27894369.
Summary: This gene encodes a member of the Notch family. Members of
this Type 1 transmembrane protein family share structural
characteristics including an extracellular domain consisting of
multiple epidermal growth factor-like (EGF) repeats, and an
intracellular domain consisting of multiple, different domain
types. Notch family members play a role in a variety of
developmental processes by controlling cell fate decisions. The
Notch signaling network is an evolutionarily conserved
intercellular signaling pathway which regulates interactions
between physically adjacent cells. In Drosophilia, notch
interaction with its cell-bound ligands (delta, serrate)
establishes an intercellular signaling pathway that plays a key
role in development. Homologues of the notch-ligands have also been
identified in human, but precise interactions between these ligands
and the human notch homologues remain to be determined. This
protein is cleaved in the trans-Golgi network, and presented on the
cell surface as a heterodimer. This protein functions as a receptor
for membrane bound ligands, and may play a role in vascular, renal
and hepatic development. This gene may be associated with
susceptibility to schizophrenia in a small portion of cases. An
alternative splice variant has been described but its biological
nature has not been determined. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC140782.1, U95299.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025093 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-64 AL705928.1 1-64
65-4281 U95299.1 16-4232
4282-4430 D63395.1 1419-1567
4431-5823 U95299.1 4382-5774
5824-6740 D63395.1 2961-3877
6741-6762 BQ023880.1 1-22 c
FEATURES Location/Qualifiers
source 1..6762
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p21.3"
gene 1..6762
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="notch 4"
/db_xref="GeneID:4855"
/db_xref="HGNC:7884"
/db_xref="MIM:164951"
exon 1..212
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 23
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="t"
/db_xref="dbSNP:8192564"
STS 72..208
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/standard_name="D6S1014"
/db_xref="UniSTS:54644"
misc_feature 98..100
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="upstream in-frame stop codon"
CDS 140..6151
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Notch homolog 4"
/codon_start=1
/product="neurogenic locus notch homolog protein 4
preproprotein"
/protein_id="NP_004548.3"
/db_xref="GI:55770876"
/db_xref="CCDS:CCDS34420.1"
/db_xref="GeneID:4855"
/db_xref="HGNC:7884"
/db_xref="MIM:164951"
/translation="
MQPPSLLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGPSLALLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPTYQERAAPQTQPLGKETDSLSAGFVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLPGPLLAVHPHAGTAPPANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQSAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEGEEVGQAEETGPPSTCQLWSLSGGCGALPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWLGCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGREAGPFPRARTVSVSVPPHGGGALPRCRTLSAGAGPRGGGACLQARTWSVDLAARGGGAYSHCRSLSGVGAGGGPTPRGRRFSAGMRGPRPNPAIMRGRYGVAAGRGGRVSTDDWPCDWVALGACGSASNIPIPPPCLTPSPERGSPQLDCGPPALQEMPINQGGEGKK
"
sig_peptide 140..208
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
proprotein 209..6148
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/product="neurogenic locus notch homolog protein 4
proprotein"
mat_peptide 209..4480
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/product="neurogenic locus notch homolog protein 4
N-terminal extracellular peptide"
misc_feature 719..835
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(719..721,728..730,776..778)
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 1079..1198
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1079..1081,1088..1090,1139..1141)
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature <1229..>1291
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cl09941"
/db_xref="CDD:209104"
misc_feature 1433..1558
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1433..1435,1442..1444,1499..1501)
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 1562..1672
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1562..1564,1571..1573,1613..1615)
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 1682..1786
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1685..1687,1727..1729)
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 1790..1900
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1790..1792,1799..1801,1841..1843)
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 1904..2014
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(1904..1906,1913..1915,1955..1957)
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature <2345..2434
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature 2444..2548
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(2447..2449,2489..2491)
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature <2834..2923
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature 2930..3034
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(2936..2938,2978..2980)
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 3041..3151
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature order(3041..3043,3050..3052,3092..3094)
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28936"
misc_feature 3632..3751
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="LNR domain; Region: Notch; pfam00066"
/db_xref="CDD:200970"
misc_feature 3647..3778
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q99466.2);
Region: LNR 1"
misc_feature 3764..3877
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="LNR domain; Region: Notch; pfam00066"
/db_xref="CDD:200970"
misc_feature 3779..3889
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q99466.2);
Region: LNR 2"
misc_feature 3890..4021
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q99466.2);
Region: LNR 3"
misc_feature 3899..3994
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="LNR domain; Region: Notch; pfam00066"
/db_xref="CDD:200970"
misc_feature 4271..>4384
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="NOTCH protein; Region: NODP; pfam07684"
/db_xref="CDD:191811"
misc_feature 4430..4432
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
mat_peptide 4481..6148
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/product="neurogenic locus notch homolog protein 4
C-terminal transmembrane and cytoplasmic peptide"
misc_feature 4481..4543
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q99466.2);
transmembrane region"
misc_feature 4535..4537
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
misc_feature 4880..5302
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 5036..5134
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q99466.2);
Region: ANK 1"
misc_feature 5051..5332
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 5120..5473
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 5135..5233
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q99466.2);
Region: ANK 2"
misc_feature 5237..5335
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q99466.2);
Region: ANK 3"
misc_feature 5252..>5473
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 5336..5434
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q99466.2);
Region: ANK 4"
misc_feature 5435..5533
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q99466.2);
Region: ANK 5"
exon 213..294
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 295..590
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 394
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="t"
/db_xref="dbSNP:8192569"
variation 472
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="t"
/db_xref="dbSNP:443198"
variation 488
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="c"
/db_xref="dbSNP:915894"
exon 591..938
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 661
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:415929"
variation 697
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="t"
/db_xref="dbSNP:2071281"
variation 750
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="t"
/db_xref="dbSNP:2071282"
variation 784
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:2071283"
variation 870
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="t"
/db_xref="dbSNP:8192585"
variation 878
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="g"
/db_xref="dbSNP:8192586"
exon 939..1061
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 952
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:520688"
variation 954
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:520692"
variation 991
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:520803"
exon 1062..1298
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 1097
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:422951"
variation 1183
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="g"
/db_xref="dbSNP:423023"
exon 1299..1454
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 1455..1649
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 1650..1763
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 1739
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:8192591"
exon 1764..1877
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 1878..2000
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 2001..2160
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 2005
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3213468"
variation 2147
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:8192566"
exon 2161..2306
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 2307..2459
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 2345
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="g"
/replace="t"
/db_xref="dbSNP:3131292"
variation 2379
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="g"
/replace="t"
/db_xref="dbSNP:3131293"
variation 2420
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="g"
/replace="t"
/db_xref="dbSNP:3096699"
variation 2428
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="g"
/replace="t"
/db_xref="dbSNP:3134934"
exon 2460..2577
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 2578..2665
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 2666..2819
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 2691
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:2022060"
exon 2820..3004
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 3005..3257
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 3106
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="c"
/db_xref="dbSNP:1044506"
exon 3258..3370
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 3371..3894
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 3483
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="c"
/db_xref="dbSNP:8192571"
exon 3895..4278
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 4027
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="t"
/db_xref="dbSNP:8192574"
variation 4176
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="g"
/db_xref="dbSNP:8192573"
variation 4240
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:204987"
variation 4250
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:8192572"
exon 4279..4454
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 4282
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1127884"
variation 4291
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="c"
/db_xref="dbSNP:3134942"
exon 4455..4674
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 4675..4756
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 4757..4895
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 4896..5191
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 4967
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="t"
/db_xref="dbSNP:8192576"
exon 5192..5339
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
exon 5340..5437
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
STS 5410..6097
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/standard_name="PMC140667P2"
/db_xref="UniSTS:270957"
exon 5438..6745
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/inference="alignment:Splign:1.39.8"
variation 5566
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:8192579"
variation 5587
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="g"
/replace="t"
/db_xref="dbSNP:8192580"
variation 5701
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:8192581"
variation 5753
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="a"
/replace="g"
/db_xref="dbSNP:8192582"
variation 5824
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="g"
/replace="t"
/db_xref="dbSNP:1044507"
variation 6091
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="t"
/db_xref="dbSNP:8192583"
STS 6603..6728
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/standard_name="WI-12121"
/db_xref="UniSTS:81412"
variation 6686
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
/replace="c"
/replace="g"
/db_xref="dbSNP:3180963"
polyA_signal 6723..6728
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
polyA_site 6745
/gene="NOTCH4"
/gene_synonym="INT3; NOTCH3"
ORIGIN
agacgtgaggcttgcagcaggccgaggaggaagaagaggggcagtgggagcagaggaggtggctcctgccccagtgagagctctgagggtccctgcctgaagagggacagggaccggggcttggagaaggggctgtggaatgcagcccccttcactgctgctgctgctgctgctgctgctgctgctatgtgtctcagtggtcagacccagagggctgctgtgtgggagtttcccagaaccctgtgccaatggaggcacctgcctgagcctgtctctgggacaagggacctgccagtgtgcccctggcttcctgggtgagacgtgccagtttcctgacccctgccagaacgcccagctctgccaaaatggaggcagctgccaagccctgcttcccgctcccctagggctccccagctctccctctccattgacacccagcttcttgtgcacttgcctccctggcttcactggtgagagatgccaggccaagcttgaagacccttgtcctccctccttctgttccaaaaggggccgctgccacatccaggcctcgggccgcccacagtgctcctgcatgcctggatggacaggtgagcagtgccagcttcgggacttctgttcagccaacccatgtgttaatggaggggtgtgtctggccacatacccccagatccagtgccactgcccaccgggcttcgagggccatgcctgtgaacgtgatgtcaacgagtgcttccaggacccaggaccctgccccaaaggcacctcctgccataacaccctgggctccttccagtgcctctgccctgtggggcaggagggtccacgttgtgagctgcgggcaggaccctgccctcctaggggctgttcgaatgggggcacctgccagctgatgccagagaaagactccacctttcacctctgcctctgtcccccaggtttcataggcccagactgtgaggtgaatccagacaactgtgtcagccaccagtgtcagaatgggggcacttgccaggatgggctggacacctacacctgcctctgcccagaaacctggacaggctgggactgctccgaagatgtggatgagtgtgagacccagggtccccctcactgcagaaacgggggcacctgccagaactctgctggtagctttcactgcgtgtgtgtgagtggctggggcggcacaagctgtgaggagaacctggatgactgtattgctgccacctgtgccccgggatccacctgcattgaccgggtgggctctttctcctgcctctgcccacctggacgcacaggactcctgtgccacttggaagacatgtgtctgagccagccgtgccatggggatgcccaatgcagcaccaaccccctcacaggctccacactctgcctgtgtcagcctggctattcggggcccacctgccaccaggacctggacgagtgtctgatggcccagcaaggcccaagtccctgtgaacatggcggttcctgcctcaacactcctggctccttcaactgcctctgtccacctggctacacaggctcccgttgtgaggctgatcacaatgagtgcctctcccagccctgccacccaggaagcacctgtctggacctacttgccaccttccactgcctctgcccgccaggcttagaagggcagctctgtgaggtggagaccaacgagtgtgcctcagctccctgcctgaaccacgcggattgccatgacctgctcaacggcttccagtgcatctgcctgcctggattctccggcacccgatgtgaggaggatatcgatgagtgcagaagctctccctgtgccaatggtgggcagtgccaggaccagcctggagccttccactgcaagtgtctcccaggctttgaagggccacgctgtcaaacagaggtggatgagtgcctgagtgacccatgtcccgttggagccagctgccttgatcttccaggagccttcttttgcctctgcccctctggtttcacaggccagctctgtgaggttcccctgtgtgctcccaacctgtgccagcccaagcagatatgtaaggaccagaaagacaaggccaactgcctctgtcctgatggaagccctggctgtgccccacctgaggacaactgcacctgccaccacgggcactgccagagatcctcatgtgtgtgtgacgtgggttggacggggccagagtgtgaggcagagctagggggctgcatctctgcaccctgtgcccatggggggacctgctacccccagccctctggctacaactgcacctgccctacaggctacacaggacccacctgtagtgaggagatgacagcttgtcactcagggccatgtctcaatggcggctcctgcaaccctagccctggaggctactactgcacctgccctccaagccacacagggccccagtgccaaaccagcactgactactgtgtgtctgccccgtgcttcaatgggggtacctgtgtgaacaggcctggcaccttctcctgcctctgtgccatgggcttccagggcccgcgctgtgagggaaagctccgccccagctgtgcagacagcccctgtaggaatagggcaacctgccaggacagccctcagggtccccgctgcctctgccccactggctacaccggaggcagctgccagactctgatggacttatgtgcccagaagccctgcccacgcaattcccactgcctccagactgggccctccttccactgcttgtgcctccagggatggaccgggcctctctgcaaccttccactgtcctcctgccagaaggctgcactgagccaaggcatagacgtctcttccctttgccacaatggaggcctctgtgtcgacagcggcccctcctatttctgccactgcccccctggattccaaggcagcctgtgccaggatcacgtgaacccatgtgagtccaggccttgccagaacggggccacctgcatggcccagcccagtgggtatctctgccagtgtgccccaggctacgatggacagaactgctcaaaggaactcgatgcttgtcagtcccaaccctgtcacaaccatggaacctgtactcccaaacctggaggattccactgtgcctgccctccaggctttgtggggctacgctgtgagggagacgtggacgagtgtctggaccagccctgccaccccacaggcactgcagcctgccactctctggccaatgccttctactgccagtgtctgcctggacacacaggccagtggtgtgaggtggagatagacccctgccacagccaaccctgctttcatggagggacctgtgaggccacagcaggatcacccctgggtttcatctgccactgccccaagggttttgaaggccccacctgcagccacagggccccttcctgcggcttccatcactgccaccacggaggcctgtgtctgccctcccctaagccaggcttcccaccacgctgtgcctgcctcagtggctatgggggtcctgactgcctgaccccaccagctcctaaaggctgtggccctccctccccatgcctatacaatggcagctgctcagagaccacgggcttggggggcccaggctttcgatgctcctgccctcacagctctccagggccccggtgtcagaaacccggagccaaggggtgtgagggcagaagtggagatggggcctgcgatgctggctgcagtggcccgggaggaaactgggatggaggggactgctctctgggagtcccagacccctggaagggctgcccctcccactctcggtgctggcttctcttccgggacgggcagtgccacccacagtgtgactctgaagagtgtctgtttgatggctacgactgtgagacccctccagcctgcactccagcctatgaccagtactgccatgatcacttccacaacgggcactgtgagaaaggctgcaacactgcagagtgtggctgggatggaggtgactgcaggcctgaagatggggacccagagtgggggccctccctggccctgctggtggtactgagccccccagccctagaccagcagctgtttgccctggcccgggtgctgtccctgactctgagggtaggactctgggtaaggaaggatcgtgatggcagggacatggtgtacccctatcctggggcccgggctgaagaaaagctaggaggaactcgggaccccacctatcaggagagagcagcccctcaaacgcagcccctgggcaaggagaccgactccctcagtgctgggtttgtggtggtcatgggtgtggatttgtcccgctgtggccctgaccacccggcatcccgctgtccctgggaccctgggcttctactccgcttccttgctgcgatggctgcagtgggagccctggagcccctgctgcctggaccactgctggctgtccaccctcatgcagggaccgcaccccctgccaaccagcttccctggcctgtgctgtgctccccagtggccggggtgattctcctggccctaggggctcttctcgtcctccagctcatccggcgtcgacgccgagagcatggagctctctggctgccccctggtttcactcgacggcctcggactcagtcagctccccaccgacgccggcccccactaggcgaggacagcattggtctcaaggcactgaagccaaaggcagaagttgatgaggatggagttgtgatgtgctcaggccctgaggagggagaggaggtgggccaggctgaagaaacaggcccaccctccacgtgccagctctggtctctgagtggtggctgtggggcgctccctcaggcagccatgctaactcctccccaggaatctgagatggaagcccctgacctggacacccgtggacctgatggggtgacacccctgatgtcagcagtttgctgtggggaagtacagtccgggaccttccaaggggcatggttgggatgtcctgagccctgggaacctctgctggatggaggggcctgtccccaggctcacaccgtgggcactggggagacccccctgcacctggctgcccgattctcccggccaaccgctgcccgccgcctccttgaggctggagccaaccccaaccagccagaccgggcagggcgcacaccccttcatgctgctgtggctgctgatgctcgggaggtctgccagcttctgctccgtagcagacaaactgcagtggacgctcgcacagaggacgggaccacacccttgatgctggctgccaggctggcggtggaagacctggttgaagaactgattgcagcccaagcagacgtgggggccagagataaatgggggaaaactgcgctgcactgggctgctgccgtgaacaacgcccgagccgcccgctcgcttctccaggccggagccgataaagatgcccaggacaacagggagcagacgccgctattcctggcggcgcgggaaggagcggtggaagtagcccagctactgctggggctgggggcagcccgagagctgcgggaccaggctgggctagcgccggcggacgtcgctcaccaacgtaaccactgggatctgctgacgctgctggaaggggctgggccaccagaggcccgtcacaaagccacgccgggccgcgaggctgggcccttcccgcgcgcacggacggtgtcagtaagcgtgcccccgcatgggggcggggctctgccgcgctgccggacgctgtcagccggagcaggccctcgtgggggcggagcttgtctgcaggctcggacttggtccgtagacttggctgcgcgggggggcggggcctattctcattgccggagcctctcgggagtaggagcaggaggaggcccgacccctcgcggccgtaggttttctgcaggcatgcgcgggcctcggcccaaccctgcgataatgcgaggaagatacggagtggctgccgggcgcggaggcagggtctcaacggatgactggccctgtgattgggtggccctgggagcttgcggttctgcctccaacattccgatcccgcctccttgccttactccgtccccggagcggggatcacctcaacttgactgtggtcccccagccctccaagaaatgcccataaaccaaggaggagagggtaaaaaatagaagaatacatggtagggaggaattccaaaaatgattacccattaaaaggcaggctggaaggccttcctggttttaagatggatcccccaaaatgaagggttgtgagtttagtttctctcctaaaatgaatgtatgcccaccagagcagacatcttccacgtggagaagctgcagctctggaaagagggtttaagatgctaggatgaggcaggcccagtcctcctccagaaaataagacaggccacaggagggcagagtggagtggaaatacccctaagttggaaccaagaattgcaggcatatgggatgtaagatgttctttcctatatatggtttccaaagggtgcccctatgatccattgtccccactgcccacaaatggctgacaaatatttattgggcacctactatgtgccaggcactgtgtaggtgctgaaaagtggccaagggccacccccgctgatgactccttgcattccctcccctcacaacaaagaactccactgtggggatgaagcgcttcttctagccactgctatcgctatttaagaaccctaaatctgtcacccataataaagctgatttgaagtgttaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4855 -> Molecular function: GO:0004872 [receptor activity] evidence: TAS
GeneID:4855 -> Molecular function: GO:0005509 [calcium ion binding] evidence: TAS
GeneID:4855 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4855 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: TAS
GeneID:4855 -> Biological process: GO:0001569 [patterning of blood vessels] evidence: ISS
GeneID:4855 -> Biological process: GO:0001709 [cell fate determination] evidence: TAS
GeneID:4855 -> Biological process: GO:0001763 [morphogenesis of a branching structure] evidence: ISS
GeneID:4855 -> Biological process: GO:0001886 [endothelial cell morphogenesis] evidence: IEA
GeneID:4855 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
GeneID:4855 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: TAS
GeneID:4855 -> Biological process: GO:0007220 [Notch receptor processing] evidence: TAS
GeneID:4855 -> Biological process: GO:0007221 [positive regulation of transcription of Notch receptor target] evidence: TAS
GeneID:4855 -> Biological process: GO:0009790 [embryo development] evidence: ISS
GeneID:4855 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:4855 -> Biological process: GO:0030097 [hemopoiesis] evidence: TAS
GeneID:4855 -> Biological process: GO:0030154 [cell differentiation] evidence: NAS
GeneID:4855 -> Biological process: GO:0030879 [mammary gland development] evidence: IDA
GeneID:4855 -> Biological process: GO:0045596 [negative regulation of cell differentiation] evidence: NAS
GeneID:4855 -> Biological process: GO:0045602 [negative regulation of endothelial cell differentiation] evidence: ISS
GeneID:4855 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: TAS
GeneID:4855 -> Cellular component: GO:0000139 [Golgi membrane] evidence: TAS
GeneID:4855 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
GeneID:4855 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
GeneID:4855 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:4855 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
GeneID:4855 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:4855 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:4855 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:4855 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.