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2024-03-29 16:02:25, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_004178               1448 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens TAR (HIV-1) RNA binding protein 2 (TARBP2), transcript
            variant 3, mRNA.
ACCESSION   NM_004178
VERSION     NM_004178.4  GI:85068544
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Redfern,A.D., Colley,S.M., Beveridge,D.J., Ikeda,N., Epis,M.R.,
            Li,X., Foulds,C.E., Stuart,L.M., Barker,A., Russell,V.J.,
            Ramsay,K., Kobelke,S.J., Li,X., Hatchell,E.C., Payne,C.,
            Giles,K.M., Messineo,A., Gatignol,A., Lanz,R.B., O'Malley,B.W. and
            Leedman,P.J.
  TITLE     RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer
            are SRA binding nuclear receptor coregulators
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 110 (16), 6536-6541 (2013)
   PUBMED   23550157
  REMARK    GeneRIF: RISC proteins PACT, TRBP, and Dicer, together with PKR,
            are steroid receptor RNA activator-binding nuclear receptor
            coregulators that are recruited to the promoters of
            hormone-regulated genes and regulate the expression of downstream
            target genes.
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Benoit,M.P., Imbert,L., Palencia,A., Perard,J., Ebel,C.,
            Boisbouvier,J. and Plevin,M.J.
  TITLE     The RNA-binding region of human TRBP interacts with microRNA
            precursors through two independent domains
  JOURNAL   Nucleic Acids Res. 41 (7), 4241-4252 (2013)
   PUBMED   23435228
  REMARK    GeneRIF: Results show that the region of TRBP that binds immature
            miRNAs comprises two independent double-stranded RNA-binding
            domains connected by a 60-residue flexible linker.
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Koh,H.R., Kidwell,M.A., Ragunathan,K., Doudna,J.A. and Myong,S.
  TITLE     ATP-independent diffusion of double-stranded RNA binding proteins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 110 (1), 151-156 (2013)
   PUBMED   23251028
  REMARK    GeneRIF: We report an unanticipated dsRNA diffusion behavior of
            TRBP, which requires two double-stranded RNA binding domains, and
            its correlation with the role of TRBP in promoting Dicer-induced
            RNA cleavage.
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Zhang,C., Huys,A., Thibault,P.A. and Wilson,J.A.
  TITLE     Requirements for human Dicer and TRBP in microRNA-122 regulation of
            HCV translation and RNA abundance
  JOURNAL   Virology 433 (2), 479-488 (2012)
   PUBMED   22999255
  REMARK    GeneRIF: Depletion of Dicer and TRBP, proteins involved in miRNA
            biogenesis, reduced HCV RNA accumulation, mature duplex miR-122
            abundance, and miR-122 directed mRNA translation suppression,
            suggesting roles in miR-122 processing.
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Lee,H.Y. and Doudna,J.A.
  TITLE     TRBP alters human precursor microRNA processing in vitro
  JOURNAL   RNA 18 (11), 2012-2019 (2012)
   PUBMED   23006623
  REMARK    GeneRIF: TRBP is a key regulator of miRNA processing and targeting
            in humans.
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Gatignol,A., Duarte,M., Daviet,L., Chang,Y.N. and Jeang,K.T.
  TITLE     Sequential steps in Tat trans-activation of HIV-1 mediated through
            cellular DNA, RNA, and protein binding factors
  JOURNAL   Gene Expr. 5 (4-5), 217-228 (1996)
   PUBMED   8723388
REFERENCE   7  (bases 1 to 1448)
  AUTHORS   Cosentino,G.P., Venkatesan,S., Serluca,F.C., Green,S.R.,
            Mathews,M.B. and Sonenberg,N.
  TITLE     Double-stranded-RNA-dependent protein kinase and TAR RNA-binding
            protein form homo- and heterodimers in vivo
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (21), 9445-9449 (1995)
   PUBMED   7568151
REFERENCE   8  (bases 1 to 1448)
  AUTHORS   Kozak,C.A., Gatignol,A., Graham,K., Jeang,K.T. and McBride,O.W.
  TITLE     Genetic mapping in human and mouse of the locus encoding TRBP, a
            protein that binds the TAR region of the human immunodeficiency
            virus (HIV-1)
  JOURNAL   Genomics 25 (1), 66-72 (1995)
   PUBMED   7774957
REFERENCE   9  (bases 1 to 1448)
  AUTHORS   Gatignol,A., Buckler,C. and Jeang,K.T.
  TITLE     Relatedness of an RNA-binding motif in human immunodeficiency virus
            type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and
            Drosophila staufen
  JOURNAL   Mol. Cell. Biol. 13 (4), 2193-2202 (1993)
   PUBMED   8455607
REFERENCE   10 (bases 1 to 1448)
  AUTHORS   Gatignol,A., Buckler-White,A., Berkhout,B. and Jeang,K.T.
  TITLE     Characterization of a human TAR RNA-binding protein that activates
            the HIV-1 LTR
  JOURNAL   Science 251 (5001), 1597-1600 (1991)
   PUBMED   2011739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC002419.2 and M60801.1.
            On Jan 18, 2006 this sequence version replaced gi:19743837.
            
            Summary: HIV-1, the causative agent of acquired immunodeficiency
            syndrome (AIDS), contains an RNA genome that produces a
            chromosomally integrated DNA during the replicative cycle.
            Activation of HIV-1 gene expression by the transactivator Tat is
            dependent on an RNA regulatory element (TAR) located downstream of
            the transcription initiation site. The protein encoded by this gene
            binds between the bulge and the loop of the HIV-1 TAR RNA
            regulatory element and activates HIV-1 gene expression in synergy
            with the viral Tat protein. Alternative splicing results in
            multiple transcript variants encoding different isoforms. This gene
            also has a pseudogene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) lacks an internal segment in
            the 5' region, and uses a downstream AUG codon for translation, as
            compared to variant 1. The encoded isoform (b) thus has a shorter
            N-terminus, as compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M60801.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BC002419.2         1-32
            33-452              M60801.1           1-420
            453-1448            BC002419.2         901-1896
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12-q13"
     gene            1..1448
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /note="TAR (HIV-1) RNA binding protein 2"
                     /db_xref="GeneID:6895"
                     /db_xref="HGNC:11569"
                     /db_xref="MIM:605053"
     exon            1..81
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:1.39.8"
     exon            82..246
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:1.39.8"
     CDS             87..1124
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /note="isoform b is encoded by transcript variant 3; TAR
                     (HIV) RNA-binding protein 2; TAR (HIV) RNA binding protein
                     2; TAR RNA-binding protein 2; trans-activation responsive
                     RNA-binding protein; TAR RNA binding protein 2;
                     RISC-loading complex subunit TARBP2; TAR (HIV) RNA-binding
                     protein TRBP1; trans-activation-responsive RNA-binding
                     protein"
                     /codon_start=1
                     /product="RISC-loading complex subunit TARBP2 isoform b"
                     /protein_id="NP_004169.3"
                     /db_xref="GI:19743838"
                     /db_xref="CCDS:CCDS41791.1"
                     /db_xref="GeneID:6895"
                     /db_xref="HGNC:11569"
                     /db_xref="MIM:605053"
                     /translation="
MLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLEPALEDSSSFSPLDSSLPEDIPVFTAAAAATPVPSVVLTRSPPMELQPPVSPQQSECNPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEVEPDDDHFSIGVGSRLDGLRNRGPGCTWDSLRNSVGEKILSLRSCSLGSLGALGPACCRVLSELSEEQAFHVSYLDIEELSLSGLCQCLVELSTQPATVCHGSATTREAARGEAARRALQYLKIMAGSK
"
     misc_feature    111..>260
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /note="Double-stranded RNA binding motif. Binding is not
                     sequence specific but is highly specific for double
                     stranded RNA. Found in a variety of proteins including
                     dsRNA dependent protein kinase PKR, RNA helicases,
                     Drosophila staufen protein, E. coli RNase III; Region:
                     DSRM; cd00048"
                     /db_xref="CDD:28930"
     misc_feature    order(111..113,129..134,255..260)
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /note="dsRNA binding site [nucleotide binding]; other
                     site"
                     /db_xref="CDD:28930"
     misc_feature    498..689
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /note="Double-stranded RNA binding motif. Binding is not
                     sequence specific but is highly specific for double
                     stranded RNA. Found in a variety of proteins including
                     dsRNA dependent protein kinase PKR, RNA helicases,
                     Drosophila staufen protein, E. coli RNase III; Region:
                     DSRM; cd00048"
                     /db_xref="CDD:28930"
     misc_feature    order(498..500,516..521,645..656,663..665)
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /note="dsRNA binding site [nucleotide binding]; other
                     site"
                     /db_xref="CDD:28930"
     variation       97
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143690659"
     variation       102
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201806294"
     variation       107
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138314225"
     variation       115
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372439760"
     variation       147
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200955588"
     variation       182
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143814054"
     variation       208
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:374404200"
     variation       223
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368515319"
     exon            247..349
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:1.39.8"
     variation       313
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146234229"
     variation       314
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138922911"
     exon            350..445
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:1.39.8"
     variation       368
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375489701"
     variation       374
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141294828"
     variation       409
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:183009410"
     variation       431
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371431074"
     exon            446..518
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:1.39.8"
     variation       451
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150772647"
     variation       452
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374358069"
     variation       453
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139126157"
     variation       454
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374557769"
     variation       475
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149488319"
     variation       498..499
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:71687518"
     variation       503
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145961214"
     exon            519..636
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:1.39.8"
     variation       521
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139830544"
     variation       551
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200766710"
     variation       558
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199668545"
     variation       586
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3203547"
     variation       612
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140420856"
     variation       617
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377165322"
     exon            637..764
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:1.39.8"
     variation       638
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200876264"
     variation       677
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190258088"
     variation       678
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368267516"
     variation       695
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370797559"
     variation       701
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146166955"
     variation       704
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112692079"
     variation       720
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148798022"
     exon            765..966
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:1.39.8"
     variation       775
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1126500"
     variation       812
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369459694"
     variation       848
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374237346"
     variation       909
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202227515"
     variation       947
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370082621"
     variation       965
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61499963"
     exon            967..1407
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:1.39.8"
     variation       1021
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372769309"
     variation       1023
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151303646"
     STS             1026..1398
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /standard_name="TARBP2__5191"
                     /db_xref="UniSTS:466499"
     variation       1084
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140535249"
     STS             1099..1263
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /standard_name="STS-R72841"
                     /db_xref="UniSTS:67883"
     STS             1125..1399
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /standard_name="G42930"
                     /db_xref="UniSTS:13350"
     STS             1131..1326
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /standard_name="STS-M60801"
                     /db_xref="UniSTS:14039"
     variation       1150
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376072604"
     variation       1158
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201937693"
     variation       1161
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371130451"
     variation       1168
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375653873"
     variation       1182
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2531"
     STS             1251..1393
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /standard_name="RH39878"
                     /db_xref="UniSTS:88059"
     variation       1315
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138108626"
     variation       1316
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117830235"
     variation       1334
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143775286"
     variation       1362
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185547953"
     polyA_signal    1379..1384
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
     variation       1391
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73313239"
     polyA_site      1407
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
ORIGIN      
gcctctccagctgcgacacagatggcgcgcgggctcttgggttctgtagttttctcgcgatccaaaaggctccgtgcccaaagcaaatgctggccgccaacccaggcaagaccccgatcagccttctgcaggagtatgggaccagaatagggaagacgcctgtgtacgaccttctcaaagccgagggccaagcccaccagcctaatttcaccttccgggtcaccgttggcgacaccagctgcactggtcagggccccagcaagaaggcagccaagcacaaggcagctgaggtggccctcaaacacctcaaaggggggagcatgctggagccggccctggaggacagcagttctttttctcccctagactcttcactgcctgaggacattccggtttttactgctgcagcagctgctaccccagttccatctgtagtcctaaccaggagcccccccatggaactgcagccccctgtctcccctcagcagtctgagtgcaaccccgttggtgctctgcaggagctggtggtgcagaaaggctggcggttgccggagtacacagtgacccaggagtctgggccagcccaccgcaaagaattcaccatgacctgtcgagtggagcgtttcattgagattgggagtggcacttccaaaaaattggcaaagcggaatgcggcggccaaaatgctgcttcgagtgcacacggtgcctctggatgcccgggatggcaatgaggtggagcctgatgatgaccacttctccattggtgtgggctcccgcctggatggtcttcgaaaccggggcccaggttgcacctgggattctctacgaaattcagtaggagagaagatcctgtccctccgcagttgctccctgggctccctgggtgccctgggccctgcctgctgccgtgtcctcagtgagctctctgaggagcaggcctttcacgtcagctacctggatattgaggagctgagcctgagtggactctgccagtgcctggtggaactgtccacccagccggccactgtgtgtcatggctctgcaaccaccagggaggcagcccgtggtgaggctgcccgccgtgccctgcagtacctcaagatcatggcaggcagcaagtgaagccccagctggactcatggatgtgcaccctttgctccctgctctttctgcctctgggctcatgtatctgcgcagctctggtaccctctgtgggtgccatctctacctctgacacagactgcctgccttgaagctgagaaggcacagggcaaggagccaaggaccacagagcctcagccagcccaggatccgtcctcattttattggtgatgatgaatgggaatgaaatcagggggctgtctactagagcctggaataaatatgctgctttgtggatttttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:6895 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:6895 -> Molecular function: GO:0035197 [siRNA binding] evidence: IDA
            GeneID:6895 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
            GeneID:6895 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS
            GeneID:6895 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:6895 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA
            GeneID:6895 -> Biological process: GO:0006469 [negative regulation of protein kinase activity] evidence: TAS
            GeneID:6895 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:6895 -> Biological process: GO:0030422 [production of siRNA involved in RNA interference] evidence: IDA
            GeneID:6895 -> Biological process: GO:0030423 [targeting of mRNA for destruction involved in RNA interference] evidence: IMP
            GeneID:6895 -> Biological process: GO:0031054 [pre-miRNA processing] evidence: IDA
            GeneID:6895 -> Biological process: GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA] evidence: IDA
            GeneID:6895 -> Biological process: GO:0045070 [positive regulation of viral genome replication] evidence: IDA
            GeneID:6895 -> Biological process: GO:0046782 [regulation of viral transcription] evidence: IDA
            GeneID:6895 -> Biological process: GO:0050689 [negative regulation of defense response to virus by host] evidence: IDA
            GeneID:6895 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:6895 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:6895 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:6895 -> Cellular component: GO:0016442 [RNA-induced silencing complex] evidence: IDA
            GeneID:6895 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA

by @meso_cacase at DBCLS
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