2024-03-29 07:15:51, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003299 2879 bp mRNA linear PRI 02-JUN-2013 DEFINITION Homo sapiens heat shock protein 90kDa beta (Grp94), member 1 (HSP90B1), mRNA. ACCESSION NM_003299 VERSION NM_003299.2 GI:399567818 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2879) AUTHORS Martins,M., Custodio,R., Camejo,A., Almeida,M.T., Cabanes,D. and Sousa,S. TITLE Listeria monocytogenes triggers the cell surface expression of Gp96 protein and interacts with its N terminus to support cellular infection JOURNAL J. Biol. Chem. 287 (51), 43083-43093 (2012) PUBMED 23109341 REMARK GeneRIF: The Listeria-induced surface expression of Gp96 and the topology of its insertion on the plasma membrane, is reported. REFERENCE 2 (bases 1 to 2879) AUTHORS Li,G., Cai,M., Fu,D., Chen,K., Sun,M., Cai,Z. and Cheng,B. TITLE Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma JOURNAL Cell. Physiol. Biochem. 30 (6), 1481-1490 (2012) PUBMED 23208072 REMARK GeneRIF: Hsp90B1 is a direct target of miR-223 and miR- 223 may have a tumor suppressor function in osteosarcoma through the PI3K/Akt/mTOR pathway. REFERENCE 3 (bases 1 to 2879) AUTHORS Zuehlke,A. and Johnson,J.L. TITLE Hsp90 and co-chaperones twist the functions of diverse client proteins JOURNAL Biopolymers 93 (3), 211-217 (2010) PUBMED 19697319 REMARK Review article REFERENCE 4 (bases 1 to 2879) AUTHORS Chen,B., Piel,W.H., Gui,L., Bruford,E. and Monteiro,A. TITLE The HSP90 family of genes in the human genome: insights into their divergence and evolution JOURNAL Genomics 86 (6), 627-637 (2005) PUBMED 16269234 REFERENCE 5 (bases 1 to 2879) AUTHORS Prasadarao,N.V., Srivastava,P.K., Rudrabhatla,R.S., Kim,K.S., Huang,S.H. and Sukumaran,S.K. TITLE Cloning and expression of the Escherichia coli K1 outer membrane protein A receptor, a gp96 homologue JOURNAL Infect. Immun. 71 (4), 1680-1688 (2003) PUBMED 12654781 REMARK GeneRIF: OmpA of E. coli K1 interacts with a gp96-like molecule on HBMECs for invasion (Ecgp: 96-kDa human brain microvascular endothelial cell (HBMEC) glycoprotein) REFERENCE 6 (bases 1 to 2879) AUTHORS Maki,R.G., Eddy,R.L. Jr., Byers,M., Shows,T.B. and Srivastava,P.K. TITLE Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94 JOURNAL Somat. Cell Mol. Genet. 19 (1), 73-81 (1993) PUBMED 8460400 REFERENCE 7 (bases 1 to 2879) AUTHORS Schaiff,W.T., Hruska,K.A. Jr., McCourt,D.W., Green,M. and Schwartz,B.D. TITLE HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells JOURNAL J. Exp. Med. 176 (3), 657-666 (1992) PUBMED 1512535 REFERENCE 8 (bases 1 to 2879) AUTHORS Liu,E.S. and Lee,A.S. TITLE Common sets of nuclear factors binding to the conserved promoter sequence motif of two coordinately regulated ER protein genes, GRP78 and GRP94 JOURNAL Nucleic Acids Res. 19 (19), 5425-5431 (1991) PUBMED 1923827 REFERENCE 9 (bases 1 to 2879) AUTHORS Maki,R.G., Old,L.J. and Srivastava,P.K. TITLE Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding regions and relationship to stress-induced proteins JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (15), 5658-5662 (1990) PUBMED 2377606 REMARK GeneRIF: a paper describing a pathway in which this gene product functions REFERENCE 10 (bases 1 to 2879) AUTHORS Srivastava,P.K. and Old,L.J. TITLE Identification of a human homologue of the murine tumor rejection antigen GP96 JOURNAL Cancer Res. 49 (6), 1341-1343 (1989) PUBMED 2924290 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC078819.24, X15187.1 and CA419931.1. On Aug 7, 2012 this sequence version replaced gi:4507676. Summary: This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ890084.1, AK025459.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-77 AC078819.24 6906-6982 78-2857 X15187.1 1-2780 2858-2879 CA419931.1 1-22 c FEATURES Location/Qualifiers source 1..2879 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12q24.2-q24.3" gene 1..2879 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /note="heat shock protein 90kDa beta (Grp94), member 1" /db_xref="GeneID:7184" /db_xref="HGNC:12028" /db_xref="HPRD:01860" /db_xref="MIM:191175" exon 1..231 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 37 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:2722187" misc_feature 48..50 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /note="upstream in-frame stop codon" variation 71 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:2070908" variation 86 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:74866968" variation 120..126 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="" /replace="ggggtgg" /db_xref="dbSNP:62747560" variation 120 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:372933336" variation 135 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:374876307" variation 140 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:369259960" variation 155 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:17797090" variation 168 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:201473633" CDS 183..2594 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /note="tumor rejection antigen (gp96) 1; endothelial cell (HBMEC) glycoprotein; endoplasmin; 94 kDa glucose-regulated protein; heat shock protein 90 kDa beta member 1; tumor rejection antigen 1; stress-inducible tumor rejection antigen gp96" /codon_start=1 /product="endoplasmin precursor" /protein_id="NP_003290.1" /db_xref="GI:4507677" /db_xref="CCDS:CCDS9094.1" /db_xref="GeneID:7184" /db_xref="HGNC:12028" /db_xref="HPRD:01860" /db_xref="MIM:191175" /translation="
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL
" sig_peptide 183..245 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P14625.1)" mat_peptide 246..2591 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /product="Endoplasmin" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P14625.1)" misc_feature 402..2420 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /note="heat shock protein 90; Provisional; Region: PRK05218" /db_xref="CDD:179965" misc_feature 474..839 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /note="Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075" /db_xref="CDD:28956" misc_feature order(489..491,501..503,510..512,621..623,627..629, 633..635,639..644,768..779,813..815,819..821,834..839) /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:28956" misc_feature 501..503 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /note="Mg2+ binding site [ion binding]; other site" /db_xref="CDD:28956" misc_feature order(633..635,639..641,768..770,774..776) /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /note="G-X-G motif; other site" /db_xref="CDD:28956" misc_feature 1098..1100 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P14625.1); phosphorylation site" misc_feature 2211..2213 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2580..2591 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P14625.1); Region: Prevents secretion from ER" variation 187 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:200731731" variation 188 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:367697851" variation 198 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="g" /replace="t" /db_xref="dbSNP:149528402" variation 215 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:371874127" variation 218 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:375806115" variation 226 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="" /replace="c" /db_xref="dbSNP:34701102" exon 232..334 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 282 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="g" /replace="t" /db_xref="dbSNP:201068970" variation 324 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="g" /replace="t" /db_xref="dbSNP:148706377" exon 335..476 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 369 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:377222712" variation 390 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="c" /db_xref="dbSNP:370161871" variation 400 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:372981677" variation 401 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:11547724" STS 408..567 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /standard_name="MARC_26038-26039:1032450563:1" /db_xref="UniSTS:268921" variation 429 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="c" /db_xref="dbSNP:201119782" exon 477..593 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 533 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:146331537" variation 558 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:368880453" exon 594..925 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 622 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:202077306" variation 677 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:144387251" variation 753 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:376154262" variation 779 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="c" /db_xref="dbSNP:201423886" variation 786 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:368251601" STS 790..917 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /standard_name="RH67937" /db_xref="UniSTS:87570" variation 793 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:200565749" variation 832 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:371098260" variation 833 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:373905083" variation 839 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:6615" variation 880 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:199621152" variation 890 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:144333332" variation 903 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:372511163" exon 926..1037 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 926 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="c" /db_xref="dbSNP:149843361" variation 949 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:201596968" variation 974 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="g" /replace="t" /db_xref="dbSNP:145871780" variation 984 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:375719261" exon 1038..1157 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 1059 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:144242572" variation 1064 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:375011875" variation 1081 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="c" /db_xref="dbSNP:368915159" variation 1119 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:200904772" variation 1144 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:116891695" exon 1158..1274 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 1240 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="c" /db_xref="dbSNP:375594636" exon 1275..1412 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 1361 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:370436489" variation 1366 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:141254870" variation 1380 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:374437641" variation 1407 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:377747819" exon 1413..1490 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 1422 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:368374645" STS 1469..1703 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /standard_name="STS-H99801" /db_xref="UniSTS:12740" exon 1491..1556 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" exon 1557..1826 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 1586 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:200554688" variation 1600 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="c" /db_xref="dbSNP:146962447" variation 1630 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:148024900" variation 1704 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:374505761" variation 1712 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="t" /db_xref="dbSNP:368541065" variation 1736 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:200418863" variation 1760 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:372371380" variation 1778 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:55793710" variation 1784 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="c" /db_xref="dbSNP:34482425" variation 1799 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:202050731" variation 1825 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:113326059" exon 1827..2072 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" STS 1842..2037 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /standard_name="TRA1" /db_xref="UniSTS:254008" variation 1852 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:373394058" variation 1984 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:143727498" variation 1998 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:141744749" variation 2068 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="c" /db_xref="dbSNP:114330942" exon 2073..2209 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 2088 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:377323380" variation 2108 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="t" /db_xref="dbSNP:141949667" variation 2114 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:146313005" variation 2127 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:200619766" variation 2151 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="c" /db_xref="dbSNP:3209749" variation 2180 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:138296639" variation 2189 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:142832694" exon 2210..2288 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 2218 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:373656293" variation 2221 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:367709041" variation 2233 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:144295543" variation 2257 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:372636341" variation 2284 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:374724193" exon 2289..2444 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 2295 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:200307600" variation 2348 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:148760324" variation 2378 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="g" /replace="t" /db_xref="dbSNP:199559319" variation 2386 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:369072974" variation 2423 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:188648559" variation 2426 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:142406645" exon 2445..2564 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 2459 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:7645" variation 2464 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:140225827" STS 2466..2685 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /standard_name="STS-X15187" /db_xref="UniSTS:41934" variation 2470 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:376271632" variation 2481 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:370313687" variation 2482 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="g" /replace="t" /db_xref="dbSNP:200650067" variation 2500 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:17034989" variation 2513 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:374034403" variation 2526 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:144178041" variation 2544..2546 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="" /replace="gaa" /db_xref="dbSNP:5800607" variation 2551 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="" /replace="aag" /db_xref="dbSNP:3037197" variation 2553..2555 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="" /replace="gaa" /db_xref="dbSNP:201427769" variation 2553 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:199613394" variation 2555 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="" /replace="gaa" /db_xref="dbSNP:60927295" exon 2565..2862 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /inference="alignment:Splign:1.39.8" variation 2566 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="c" /db_xref="dbSNP:372146745" STS 2605..2832 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /standard_name="SHGC-12717" /db_xref="UniSTS:24559" variation 2605 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:200512715" variation 2617 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:373539366" variation 2625 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="g" /db_xref="dbSNP:375456268" variation 2647 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="g" /replace="t" /db_xref="dbSNP:202143765" variation 2695 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="c" /replace="t" /db_xref="dbSNP:1051185" variation 2740 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:11547719" variation 2798 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="" /replace="actg" /db_xref="dbSNP:35780385" variation 2799..2801 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="" /replace="gact" /db_xref="dbSNP:2307842" variation 2834 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" /replace="a" /replace="g" /db_xref="dbSNP:111996964" polyA_signal 2839..2844 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" polyA_site 2862 /gene="HSP90B1" /gene_synonym="ECGP; GP96; GRP94; TRA1" ORIGIN
gattggtgggttcatgtttcccgtcccccgcccgcgggaagtgggggtgaaaagcggcccgacctgcttgcggtgtagtgggcggaccgcgcggctggaggtgtgaggatccgaacccaggggtggggggtggaggcggctcctgcgatcgaaggggacttgagactcaccggccgcacgccatgagggccctgtgggtgctgggcctctgctgcgtcctgctgaccttcgggtcggtcagagctgacgatgaagttgatgtggatggtacagtagaagaggatctgggtaaaagtagagaaggatcaaggacggatgatgaagtagtacagagagaggaagaagctattcagttggatggattaaatgcatcacaaataagagaacttagagagaagtcggaaaagtttgccttccaagccgaagttaacagaatgatgaaacttatcatcaattcattgtataaaaataaagagattttcctgagagaactgatttcaaatgcttctgatgctttagataagataaggctaatatcactgactgatgaaaatgctctttctggaaatgaggaactaacagtcaaaattaagtgtgataaggagaagaacctgctgcatgtcacagacaccggtgtaggaatgaccagagaagagttggttaaaaaccttggtaccatagccaaatctgggacaagcgagtttttaaacaaaatgactgaagcacaggaagatggccagtcaacttctgaattgattggccagtttggtgtcggtttctattccgccttccttgtagcagataaggttattgtcacttcaaaacacaacaacgatacccagcacatctgggagtctgactccaatgaattttctgtaattgctgacccaagaggaaacactctaggacggggaacgacaattacccttgtcttaaaagaagaagcatctgattaccttgaattggatacaattaaaaatctcgtcaaaaaatattcacagttcataaactttcctatttatgtatggagcagcaagactgaaactgttgaggagcccatggaggaagaagaagcagccaaagaagagaaagaagaatctgatgatgaagctgcagtagaggaagaagaagaagaaaagaaaccaaagactaaaaaagttgaaaaaactgtctgggactgggaacttatgaatgatatcaaaccaatatggcagagaccatcaaaagaagtagaagaagatgaatacaaagctttctacaaatcattttcaaaggaaagtgatgaccccatggcttatattcactttactgctgaaggggaagttaccttcaaatcaattttatttgtacccacatctgctccacgtggtctgtttgacgaatatggatctaaaaagagcgattacattaagctctatgtgcgccgtgtattcatcacagacgacttccatgatatgatgcctaaatacctcaattttgtcaagggtgtggtggactcagatgatctccccttgaatgtttcccgcgagactcttcagcaacataaactgcttaaggtgattaggaagaagcttgttcgtaaaacgctggacatgatcaagaagattgctgatgataaatacaatgatactttttggaaagaatttggtaccaacatcaagcttggtgtgattgaagaccactcgaatcgaacacgtcttgctaaacttcttaggttccagtcttctcatcatccaactgacattactagcctagaccagtatgtggaaagaatgaaggaaaaacaagacaaaatctacttcatggctgggtccagcagaaaagaggctgaatcttctccatttgttgagcgacttctgaaaaagggctatgaagttatttacctcacagaacctgtggatgaatactgtattcaggcccttcccgaatttgatgggaagaggttccagaatgttgccaaggaaggagtgaagttcgatgaaagtgagaaaactaaggagagtcgtgaagcagttgagaaagaatttgagcctctgctgaattggatgaaagataaagcccttaaggacaagattgaaaaggctgtggtgtctcagcgcctgacagaatctccgtgtgctttggtggccagccagtacggatggtctggcaacatggagagaatcatgaaagcacaagcgtaccaaacgggcaaggacatctctacaaattactatgcgagtcagaagaaaacatttgaaattaatcccagacacccgctgatcagagacatgcttcgacgaattaaggaagatgaagatgataaaacagttttggatcttgctgtggttttgtttgaaacagcaacgcttcggtcagggtatcttttaccagacactaaagcatatggagatagaatagaaagaatgcttcgcctcagtttgaacattgaccctgatgcaaaggtggaagaagagcccgaagaagaacctgaagagacagcagaagacacaacagaagacacagagcaagacgaagatgaagaaatggatgtgggaacagatgaagaagaagaaacagcaaaggaatctacagctgaaaaagatgaattgtaaattatactctcaccatttggatcctgtgtggagagggaatgtgaaatttacatcatttctttttgggagagacttgttttggatgccccctaatccccttctcccctgcactgtaaaatgtgggattatgggtcacaggaaaaagtgggttttttagttgaattttttttaacattcctcatgaatgtaaatttgtactatttaactgactattcttgatgtaaaatcttgtcatgtgtataaaaataaaaaagatcccaaatactcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:7184 -> Molecular function: GO:0003723 [RNA binding] evidence: IDA GeneID:7184 -> Molecular function: GO:0005509 [calcium ion binding] evidence: TAS GeneID:7184 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:7184 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:7184 -> Molecular function: GO:0019903 [protein phosphatase binding] evidence: IDA GeneID:7184 -> Molecular function: GO:0046790 [virion binding] evidence: IPI GeneID:7184 -> Molecular function: GO:0050750 [low-density lipoprotein particle receptor binding] evidence: IDA GeneID:7184 -> Molecular function: GO:0051082 [unfolded protein binding] evidence: IEA GeneID:7184 -> Biological process: GO:0001666 [response to hypoxia] evidence: IDA GeneID:7184 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS GeneID:7184 -> Biological process: GO:0006457 [protein folding] evidence: IEA GeneID:7184 -> Biological process: GO:0006987 [activation of signaling protein activity involved in unfolded protein response] evidence: TAS GeneID:7184 -> Biological process: GO:0015031 [protein transport] evidence: NAS GeneID:7184 -> Biological process: GO:0030433 [ER-associated protein catabolic process] evidence: IMP GeneID:7184 -> Biological process: GO:0030968 [endoplasmic reticulum unfolded protein response] evidence: TAS GeneID:7184 -> Biological process: GO:0031247 [actin rod assembly] evidence: IDA GeneID:7184 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP GeneID:7184 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS GeneID:7184 -> Biological process: GO:0043666 [regulation of phosphoprotein phosphatase activity] evidence: IDA GeneID:7184 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS GeneID:7184 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:7184 -> Biological process: GO:0051208 [sequestering of calcium ion] evidence: NAS GeneID:7184 -> Biological process: GO:0071318 [cellular response to ATP] evidence: IDA GeneID:7184 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS GeneID:7184 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA GeneID:7184 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: TAS GeneID:7184 -> Cellular component: GO:0005788 [endoplasmic reticulum lumen] evidence: IDA GeneID:7184 -> Cellular component: GO:0005788 [endoplasmic reticulum lumen] evidence: TAS GeneID:7184 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IDA GeneID:7184 -> Cellular component: GO:0005829 [cytosol] evidence: IDA GeneID:7184 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA GeneID:7184 -> Cellular component: GO:0030496 [midbody] evidence: IDA GeneID:7184 -> Cellular component: GO:0042470 [melanosome] evidence: IEA GeneID:7184 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA GeneID:7184 -> Cellular component: GO:0071682 [endocytic vesicle lumen] evidence: TAS
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