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2024-04-20 19:51:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003183 3572 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens ADAM metallopeptidase domain 17 (ADAM17), mRNA.
ACCESSION NM_003183
VERSION NM_003183.4 GI:73747888
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3572)
AUTHORS Romee,R., Foley,B., Lenvik,T., Wang,Y., Zhang,B., Ankarlo,D.,
Luo,X., Cooley,S., Verneris,M., Walcheck,B. and Miller,J.
TITLE NK cell CD16 surface expression and function is regulated by a
disintegrin and metalloprotease-17 (ADAM17)
JOURNAL Blood 121 (18), 3599-3608 (2013)
PUBMED 23487023
REMARK GeneRIF: Over-activation of ADAM17 in NK cells may be detrimental
to their effector functions by down-regulating surface expression
of CD16 and CD62L.
REFERENCE 2 (bases 1 to 3572)
AUTHORS Dobel,T., Kunze,A., Babatz,J., Trankner,K., Ludwig,A., Schmitz,M.,
Enk,A. and Schakel,K.
TITLE FcgammaRIII (CD16) equips immature 6-sulfo LacNAc-expressing
dendritic cells (slanDCs) with a unique capacity to handle
IgG-complexed antigens
JOURNAL Blood 121 (18), 3609-3618 (2013)
PUBMED 23460612
REMARK GeneRIF: CD16 is rapidly shed from the surface of maturing 6-sulfo
LacNAc-expressing dendritic cells, resulting from the combined
action of the metalloproteinases ADAM10 and ADAM17.
REFERENCE 3 (bases 1 to 3572)
AUTHORS Tsubota,Y., Frey,J.M., Tai,P.W., Welikson,R.E. and Raines,E.W.
TITLE Monocyte ADAM17 promotes diapedesis during transendothelial
migration: identification of steps and substrates targeted by
metalloproteinases
JOURNAL J. Immunol. 190 (8), 4236-4244 (2013)
PUBMED 23479224
REMARK GeneRIF: Monocyte ADAM17 facilitates the completion of
transendothelial migration by accelerating the rate of diapedesis.
REFERENCE 4 (bases 1 to 3572)
AUTHORS Chen,X., Chen,L., Zhang,R., Yi,Y., Ma,Y., Yan,K., Jiang,X. and
Wang,X.
TITLE ADAM17 regulates self-renewal and differentiation of U87
glioblastoma stem cells
JOURNAL Neurosci. Lett. 537, 44-49 (2013)
PUBMED 23356982
REMARK GeneRIF: ADAM17 may maintain the stemness of glioblastoma stem
cells by promoting their self-renewal and inhibiting their
differentiation via Notch signaling.
REFERENCE 5 (bases 1 to 3572)
AUTHORS Li,Y.Q., Yan,J.P., Xu,W.L., Wang,H., Xia,Y.J., Wang,H.J., Zhu,Y.Y.
and Huang,X.J.
TITLE ADAM17 mediates MMP9 expression in lung epithelial cells
JOURNAL PLoS ONE 8 (1), E51701 (2013)
PUBMED 23341882
REMARK GeneRIF: Lentiviral ADAM17 RNA interference inhibited MMP9
expression, IkappaBalpha phosphorylation and the expression of
phosphorylation p65 protein in response to lipopolysaccharides.
REFERENCE 6 (bases 1 to 3572)
AUTHORS Schroeter,E.H., Kisslinger,J.A. and Kopan,R.
TITLE Notch-1 signalling requires ligand-induced proteolytic release of
intracellular domain
JOURNAL Nature 393 (6683), 382-386 (1998)
PUBMED 9620803
REFERENCE 7 (bases 1 to 3572)
AUTHORS Patel,I.R., Attur,M.G., Patel,R.N., Stuchin,S.A., Abagyan,R.A.,
Abramson,S.B. and Amin,A.R.
TITLE TNF-alpha convertase enzyme from human arthritis-affected
cartilage: isolation of cDNA by differential display, expression of
the active enzyme, and regulation of TNF-alpha
JOURNAL J. Immunol. 160 (9), 4570-4579 (1998)
PUBMED 9574564
REFERENCE 8 (bases 1 to 3572)
AUTHORS Maskos,K., Fernandez-Catalan,C., Huber,R., Bourenkov,G.P.,
Bartunik,H., Ellestad,G.A., Reddy,P., Wolfson,M.F., Rauch,C.T.,
Castner,B.J., Davis,R., Clarke,H.R., Petersen,M., Fitzner,J.N.,
Cerretti,D.P., March,C.J., Paxton,R.J., Black,R.A. and Bode,W.
TITLE Crystal structure of the catalytic domain of human tumor necrosis
factor-alpha-converting enzyme
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (7), 3408-3412 (1998)
PUBMED 9520379
REFERENCE 9 (bases 1 to 3572)
AUTHORS Moss,M.L., Jin,S.L., Milla,M.E., Bickett,D.M., Burkhart,W.,
Carter,H.L., Chen,W.J., Clay,W.C., Didsbury,J.R., Hassler,D.,
Hoffman,C.R., Kost,T.A., Lambert,M.H., Leesnitzer,M.A.,
McCauley,P., McGeehan,G., Mitchell,J., Moyer,M., Pahel,G.,
Rocque,W., Overton,L.K., Schoenen,F., Seaton,T., Su,J.L.,
Becherer,J.D. et al.
TITLE Cloning of a disintegrin metalloproteinase that processes precursor
tumour-necrosis factor-alpha
JOURNAL Nature 385 (6618), 733-736 (1997)
PUBMED 9034191
REMARK Erratum:[Nature 1997 Apr 17;386(6626):738]
REFERENCE 10 (bases 1 to 3572)
AUTHORS Black,R.A., Rauch,C.T., Kozlosky,C.J., Peschon,J.J., Slack,J.L.,
Wolfson,M.F., Castner,B.J., Stocking,K.L., Reddy,P., Srinivasan,S.,
Nelson,N., Boiani,N., Schooley,K.A., Gerhart,M., Davis,R.,
Fitzner,J.N., Johnson,R.S., Paxton,R.J., March,C.J. and
Cerretti,D.P.
TITLE A metalloproteinase disintegrin that releases tumour-necrosis
factor-alpha from cells
JOURNAL Nature 385 (6618), 729-733 (1997)
PUBMED 9034190
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CN258241.1, U86755.1,
BX339672.2, U92649.1, U69611.1, BM725368.1 and BQ186514.1.
This sequence is a reference standard in the RefSeqGene project.
On Aug 24, 2005 this sequence version replaced gi:11497003.
Summary: This gene encodes a member of the ADAM (a disintegrin and
metalloprotease domain) family. Members of this family are
membrane-anchored proteins structurally related to snake venom
disintegrins, and have been implicated in a variety of biologic
processes involving cell-cell and cell-matrix interactions,
including fertilization, muscle development, and neurogenesis. The
protein encoded by this gene functions as a tumor necrosis
factor-alpha converting enzyme; binds mitotic arrest deficient 2
protein; and also plays a prominent role in the activation of the
Notch signaling pathway. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: GQ402545.1, U92649.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-20 CN258241.1 3-22
21-2716 U86755.1 1-2696
2717-2941 BX339672.2 720-944
2942-3046 U92649.1 2922-3026
3047-3083 U69611.1 2978-3014
3084-3134 U92649.1 3063-3113
3135-3374 BM725368.1 207-446 c
3375-3572 BQ186514.1 7-204 c
FEATURES Location/Qualifiers
source 1..3572
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p25"
gene 1..3572
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/note="ADAM metallopeptidase domain 17"
/db_xref="GeneID:6868"
/db_xref="HGNC:195"
/db_xref="MIM:603639"
exon 1..280
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
variation 30
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/replace="a"
/replace="c"
/db_xref="dbSNP:55790676"
misc_feature 82..84
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/note="upstream in-frame stop codon"
CDS 184..2658
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/EC_number="3.4.24.86"
/note="snake venom-like protease; tumor necrosis factor,
alpha, converting enzyme; TNF-alpha converting enzyme;
disintegrin and metalloproteinase domain-containing
protein 17; ADAM metallopeptidase domain 18; TNF-alpha
convertase"
/codon_start=1
/product="disintegrin and metalloproteinase
domain-containing protein 17 preproprotein"
/protein_id="NP_003174.3"
/db_xref="GI:73747889"
/db_xref="CCDS:CCDS1665.1"
/db_xref="GeneID:6868"
/db_xref="HGNC:195"
/db_xref="MIM:603639"
/translation="
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
"
sig_peptide 184..234
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
proprotein 235..2655
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/product="disintegrin and metalloproteinase
domain-containing protein 17 proprotein"
misc_feature 340..684
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/note="Reprolysin family propeptide; Region:
Pep_M12B_propep; pfam01562"
/db_xref="CDD:201861"
misc_feature 727..750
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78536.1);
Region: Cysteine switch (By similarity)"
mat_peptide 832..2655
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/product="disintegrin and metalloproteinase
domain-containing protein 17"
misc_feature 850..1614
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/note="Zinc-dependent metalloprotease; TACE_like
subfamily. TACE, the tumor-necrosis factor-alpha
converting enzyme, releases soluble TNF-alpha from
transmembrane pro-TNF-alpha; Region: ZnMc_TACE_like;
cd04270"
/db_xref="CDD:58571"
misc_feature 1318..1320
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1327..1329
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature order(1396..1401,1408..1410,1426..1428)
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/note="active site"
/db_xref="CDD:58571"
misc_feature 1633..1863
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/note="Homologues of snake disintegrins; Region: DISIN;
smart00050"
/db_xref="CDD:197489"
misc_feature 1894..1989
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/note="Region: EGF-like domain"
misc_feature 1990..2196
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78536.1);
Region: Crambin-like"
misc_feature 2197..2265
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/note="Region: transmembrane domain"
misc_feature 2197..2259
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78536.1);
transmembrane region"
misc_feature 2266..2655
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/note="Region: cytoplasmic domain"
misc_feature 2386..2388
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by MAPK14; propagated from
UniProtKB/Swiss-Prot (P78536.1); phosphorylation site"
misc_feature 2554..2556
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
misc_feature 2554..2556
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P78536.1); phosphorylation site"
misc_feature 2554..2556
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2638..2640
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P78536.1); phosphorylation site"
misc_feature 2638..2640
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 281..413
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 414..544
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 545..633
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 634..802
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
variation 667
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/replace="a"
/replace="g"
/db_xref="dbSNP:34431503"
variation 787
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:2230818"
exon 803..936
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 937..1026
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 1027..1140
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 1141..1285
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 1286..1374
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 1375..1527
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 1528..1727
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
variation 1654
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/replace="c"
/replace="t"
/db_xref="dbSNP:55937573"
exon 1728..1831
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 1832..1966
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 1967..2097
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
variation 2007
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/replace="c"
/replace="t"
/db_xref="dbSNP:1048610"
exon 2098..2176
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 2177..2265
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
STS 2199..2658
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/standard_name="Adam17"
/db_xref="UniSTS:471064"
variation 2256
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/replace="c"
/replace="t"
/db_xref="dbSNP:34355677"
exon 2266..2316
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
exon 2317..3572
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/inference="alignment:Splign:1.39.8"
variation 2423
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/replace="c"
/replace="t"
/db_xref="dbSNP:55796712"
variation 2719
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/replace=""
/replace="a"
/db_xref="dbSNP:3833563"
STS 2760..2916
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/standard_name="RH70698"
/db_xref="UniSTS:62215"
variation 2948
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/replace="a"
/replace="g"
/db_xref="dbSNP:1130094"
variation 3233
/gene="ADAM17"
/gene_synonym="ADAM18; CD156B; CSVP; NISBD; TACE"
/replace="a"
/replace="g"
/db_xref="dbSNP:10063"
ORIGIN
acctgcacttctgggggcgtcgagcctggcggtagaatcttcccagtaggcggcgcgggagggaaaagaggattgaggggctaggccgggcggatcccgtcctcccccgatgtgagcagttttccgaaaccccgtcaggcgaaggctgcccagagaggtggagtcggtagcggggccgggaacatgaggcagtctctcctattcctgaccagcgtggttcctttcgtgctggcgccgcgacctccggatgacccgggcttcggcccccaccagagactcgagaagcttgattctttgctctcagactacgatattctctctttatctaatatccagcagcattcggtaagaaaaagagatctacagacttcaacacatgtagaaacactactaactttttcagctttgaaaaggcattttaaattatacctgacatcaagtactgaacgtttttcacaaaatttcaaggtcgtggtggtggatggtaaaaacgaaagcgagtacactgtaaaatggcaggacttcttcactggacacgtggttggtgagcctgactctagggttctagcccacataagagatgatgatgttataatcagaatcaacacagatggggccgaatataacatagagccactttggagatttgttaatgataccaaagacaaaagaatgttagtttataaatctgaagatatcaagaatgtttcacgtttgcagtctccaaaagtgtgtggttatttaaaagtggataatgaagagttgctcccaaaagggttagtagacagagaaccacctgaagagcttgttcatcgagtgaaaagaagagctgacccagatcccatgaagaacacgtgtaaattattggtggtagcagatcatcgcttctacagatacatgggcagaggggaagagagtacaactacaaattacttaatagagctaattgacagagttgatgacatctatcggaacacttcatgggataatgcaggttttaaaggctatggaatacagatagagcagattcgcattctcaagtctccacaagaggtaaaacctggtgaaaagcactacaacatggcaaaaagttacccaaatgaagaaaaggatgcttgggatgtgaagatgttgctagagcaatttagctttgatatagctgaggaagcatctaaagtttgcttggcacaccttttcacataccaagattttgatatgggaactcttggattagcttatgttggctctcccagagcaaacagccatggaggtgtttgtccaaaggcttattatagcccagttgggaagaaaaatatctatttgaatagtggtttgacgagcacaaagaattatggtaaaaccatccttacaaaggaagctgacctggttacaactcatgaattgggacataattttggagcagaacatgatccggatggtctagcagaatgtgccccgaatgaggaccagggagggaaatatgtcatgtatcccatagctgtgagtggcgatcacgagaacaataagatgttttcaaactgcagtaaacaatcaatctataagaccattgaaagtaaggcccaggagtgttttcaagaacgcagcaataaagtttgtgggaactcgagggtggatgaaggagaagagtgtgatcctggcatcatgtatctgaacaacgacacctgctgcaacagcgactgcacgttgaaggaaggtgtccagtgcagtgacaggaacagtccttgctgtaaaaactgtcagtttgagactgcccagaagaagtgccaggaggcgattaatgctacttgcaaaggcgtgtcctactgcacaggtaatagcagtgagtgcccgcctccaggaaatgctgaagatgacactgtttgcttggatcttggcaagtgtaaggatgggaaatgcatccctttctgcgagagggaacagcagctggagtcctgtgcatgtaatgaaactgacaactcctgcaaggtgtgctgcagggacctttctggccgctgtgtgccctatgtcgatgctgaacaaaagaacttatttttgaggaaaggaaagccctgtacagtaggattttgtgacatgaatggcaaatgtgagaaacgagtacaggatgtaattgaacgattttgggatttcattgaccagctgagcatcaatacttttggaaagtttttagcagacaacatcgttgggtctgtcctggttttctccttgatattttggattcctttcagcattcttgtccattgtgtggataagaaattggataaacagtatgaatctctgtctctgtttcaccccagtaacgtcgaaatgctgagcagcatggattctgcatcggttcgcattatcaaaccctttcctgcgccccagactccaggccgcctgcagcctgcccctgtgatcccttcggcgccagcagctccaaaactggaccaccagagaatggacaccatccaggaagaccccagcacagactcacatatggacgaggatgggtttgagaaggaccccttcccaaatagcagcacagctgccaagtcatttgaggatctcacggaccatccggtcaccagaagtgaaaaggctgcctcctttaaactgcagcgtcagaatcgtgttgacagcaaagaaacagagtgctaatttagttctcagctcttctgacttaagtgtgcaaaatatttttatagatttgacctacaaatcaatcacagcttgtattttgtgaagactgggaagtgacttagcagatgctggtcatgtgtttgaacttcctgcaggtaaacagttcttgtgtggtttggcccttctccttttgaaaaggtaaggtgaaggtgaatctagcttattttgaggctttcaggttttagtttttaaaatatcttttgacctgtggtgcaaaagcagaaaatacagctggattgggttatgaatatttacgtttttgtaaattaatcttttatattgataacagcactgactagggaaatgatcagtttttttttatacactgtaatgaaccgctgaatatgaggcatttggcatttatttgtgatgacaactggaatagttttttttttttttttttttttttgccttcaactaaaaacaaaggagataaatctagtatacattgtctctaaattgtgggtctatttctagttattacccagagtttttatgtagcagggaaaatatatatctaaatttagaaatcatttgggttaatatggctcttcataattctaagactaatgctctctagaaacctaaccacctaccttacagtgagggctatacatggtagccagttgaatttatggaatctaccaactgtttagggccctgatttgctgggcagtttttctgtattttataagtatcttcatgtatccctgttactgatagggatacatgctcttagaaaattcactattggctgggagtggtggctcatgcctgtaatcccagcacttggagaggctgaggttgcgccactacactccagcctgggtgacagagtgagactctgcctcaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6868 -> Molecular function: GO:0004222 [metalloendopeptidase activity] evidence: IDA
GeneID:6868 -> Molecular function: GO:0004222 [metalloendopeptidase activity] evidence: IMP
GeneID:6868 -> Molecular function: GO:0004222 [metalloendopeptidase activity] evidence: TAS
GeneID:6868 -> Molecular function: GO:0005138 [interleukin-6 receptor binding] evidence: IPI
GeneID:6868 -> Molecular function: GO:0005178 [integrin binding] evidence: IPI
GeneID:6868 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6868 -> Molecular function: GO:0008237 [metallopeptidase activity] evidence: IDA
GeneID:6868 -> Molecular function: GO:0008237 [metallopeptidase activity] evidence: IMP
GeneID:6868 -> Molecular function: GO:0008237 [metallopeptidase activity] evidence: TAS
GeneID:6868 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:6868 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA
GeneID:6868 -> Molecular function: GO:0030165 [PDZ domain binding] evidence: IPI
GeneID:6868 -> Biological process: GO:0001666 [response to hypoxia] evidence: IDA
GeneID:6868 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IMP
GeneID:6868 -> Biological process: GO:0002446 [neutrophil mediated immunity] evidence: IC
GeneID:6868 -> Biological process: GO:0002467 [germinal center formation] evidence: ISS
GeneID:6868 -> Biological process: GO:0002690 [positive regulation of leukocyte chemotaxis] evidence: IC
GeneID:6868 -> Biological process: GO:0006509 [membrane protein ectodomain proteolysis] evidence: IDA
GeneID:6868 -> Biological process: GO:0006509 [membrane protein ectodomain proteolysis] evidence: IMP
GeneID:6868 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:6868 -> Biological process: GO:0007155 [cell adhesion] evidence: IDA
GeneID:6868 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: IDA
GeneID:6868 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:6868 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: IEA
GeneID:6868 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IMP
GeneID:6868 -> Biological process: GO:0010820 [positive regulation of T cell chemotaxis] evidence: IMP
GeneID:6868 -> Biological process: GO:0022617 [extracellular matrix disassembly] evidence: TAS
GeneID:6868 -> Biological process: GO:0030183 [B cell differentiation] evidence: ISS
GeneID:6868 -> Biological process: GO:0030198 [extracellular matrix organization] evidence: TAS
GeneID:6868 -> Biological process: GO:0030307 [positive regulation of cell growth] evidence: IMP
GeneID:6868 -> Biological process: GO:0030335 [positive regulation of cell migration] evidence: IMP
GeneID:6868 -> Biological process: GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] evidence: ISS
GeneID:6868 -> Biological process: GO:0030574 [collagen catabolic process] evidence: TAS
GeneID:6868 -> Biological process: GO:0031293 [membrane protein intracellular domain proteolysis] evidence: TAS
GeneID:6868 -> Biological process: GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] evidence: IDA
GeneID:6868 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IDA
GeneID:6868 -> Biological process: GO:0032717 [negative regulation of interleukin-8 production] evidence: IMP
GeneID:6868 -> Biological process: GO:0032722 [positive regulation of chemokine production] evidence: IMP
GeneID:6868 -> Biological process: GO:0033025 [regulation of mast cell apoptotic process] evidence: ISS
GeneID:6868 -> Biological process: GO:0033077 [T cell differentiation in thymus] evidence: ISS
GeneID:6868 -> Biological process: GO:0033627 [cell adhesion mediated by integrin] evidence: IDA
GeneID:6868 -> Biological process: GO:0035313 [wound healing, spreading of epidermal cells] evidence: IEP
GeneID:6868 -> Biological process: GO:0035625 [epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway] evidence: IMP
GeneID:6868 -> Biological process: GO:0042493 [response to drug] evidence: ISS
GeneID:6868 -> Biological process: GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] evidence: IDA
GeneID:6868 -> Biological process: GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] evidence: IMP
GeneID:6868 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:6868 -> Biological process: GO:0048536 [spleen development] evidence: ISS
GeneID:6868 -> Biological process: GO:0048870 [cell motility] evidence: ISS
GeneID:6868 -> Biological process: GO:0051088 [PMA-inducible membrane protein ectodomain proteolysis] evidence: IDA
GeneID:6868 -> Biological process: GO:0051088 [PMA-inducible membrane protein ectodomain proteolysis] evidence: IMP
GeneID:6868 -> Biological process: GO:0051272 [positive regulation of cellular component movement] evidence: ISS
GeneID:6868 -> Biological process: GO:0055099 [response to high density lipoprotein particle stimulus] evidence: IDA
GeneID:6868 -> Biological process: GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] evidence: TAS
GeneID:6868 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:6868 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:6868 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:6868 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IDA
GeneID:6868 -> Cellular component: GO:0005911 [cell-cell junction] evidence: IDA
GeneID:6868 -> Cellular component: GO:0005925 [focal adhesion] evidence: IDA
GeneID:6868 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
GeneID:6868 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: IDA
GeneID:6868 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IDA
GeneID:6868 -> Cellular component: GO:0032587 [ruffle membrane] evidence: IDA
GeneID:6868 -> Cellular component: GO:0045121 [membrane raft] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_003174 -> EC 3.4.24.86
by
@meso_cacase at
DBCLS
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