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2024-04-19 08:20:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002600 4264 bp mRNA linear PRI 14-JUL-2013
DEFINITION Homo sapiens phosphodiesterase 4B, cAMP-specific (PDE4B),
transcript variant a, mRNA.
ACCESSION NM_002600
VERSION NM_002600.3 GI:82799480
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4264)
AUTHORS Yang,J.J., Cheng,C., Devidas,M., Cao,X., Campana,D., Yang,W.,
Fan,Y., Neale,G., Cox,N., Scheet,P., Borowitz,M.J., Winick,N.J.,
Martin,P.L., Bowman,W.P., Camitta,B., Reaman,G.H., Carroll,W.L.,
Willman,C.L., Hunger,S.P., Evans,W.E., Pui,C.H., Loh,M. and
Relling,M.V.
TITLE Genome-wide association study identifies germline polymorphisms
associated with relapse of childhood acute lymphoblastic leukemia
JOURNAL Blood 120 (20), 4197-4204 (2012)
PUBMED 23007406
REFERENCE 2 (bases 1 to 4264)
AUTHORS Lee,J., Komatsu,K., Lee,B.C., Lim,J.H., Jono,H., Xu,H., Kai,H.,
Zhang,Z.J., Yan,C. and Li,J.D.
TITLE Phosphodiesterase 4B mediates extracellular signal-regulated
kinase-dependent up-regulation of mucin MUC5AC protein by
Streptococcus pneumoniae by inhibiting cAMP-protein kinase
A-dependent MKP-1 phosphatase pathway
JOURNAL J. Biol. Chem. 287 (27), 22799-22811 (2012)
PUBMED 22610099
REMARK GeneRIF: PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC
by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.
REFERENCE 3 (bases 1 to 4264)
AUTHORS Benjamin,D.J., Cesarini,D., van der Loos,M.J., Dawes,C.T.,
Koellinger,P.D., Magnusson,P.K., Chabris,C.F., Conley,D.,
Laibson,D., Johannesson,M. and Visscher,P.M.
TITLE The genetic architecture of economic and political preferences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (21), 8026-8031 (2012)
PUBMED 22566634
REFERENCE 4 (bases 1 to 4264)
AUTHORS Kashiwagi,E., Shiota,M., Yokomizo,A., Itsumi,M., Inokuchi,J.,
Uchiumi,T. and Naito,S.
TITLE Downregulation of phosphodiesterase 4B (PDE4B) activates protein
kinase A and contributes to the progression of prostate cancer
JOURNAL Prostate 72 (7), 741-751 (2012)
PUBMED 22529021
REMARK GeneRIF: PDE4B was downregulated and the protein kinase A pathway
was activated in castration-resistant LNCaP prostate cancer cells.
PDE4B expression was reduced in advanced prostate cancer and PDE4B
knockdown promoted castration-resistant growth of LNCaP cells.
REFERENCE 5 (bases 1 to 4264)
AUTHORS Newburn,E.N., Hyde,T.M., Ye,T., Morita,Y., Weinberger,D.R.,
Kleinman,J.E. and Lipska,B.K.
TITLE Interactions of human truncated DISC1 proteins: implications for
schizophrenia
JOURNAL Transl Psychiatry 1, E30 (2011)
PUBMED 22832604
REMARK GeneRIF: Short Disrupted-in-Schizophrenia (DISC)1 splice variants
show reduced or no binding to nudE nuclear distribution E homolog
(NDEL)1 and PDE4B proteins but fully interact with
fasciculation/elongation zeta (FEZ)1 and glycogen synthase kinase 3
GSK3beta.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4264)
AUTHORS Szpirer,C., Szpirer,J., Riviere,M., Swinnen,J., Vicini,E. and
Conti,M.
TITLE Chromosomal localization of the human and rat genes (PDE4D and
PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4
JOURNAL Cytogenet. Cell Genet. 69 (1-2), 11-14 (1995)
PUBMED 7835077
REFERENCE 7 (bases 1 to 4264)
AUTHORS Bolger,G.B., Rodgers,L. and Riggs,M.
TITLE Differential CNS expression of alternative mRNA isoforms of the
mammalian genes encoding cAMP-specific phosphodiesterases
JOURNAL Gene 149 (2), 237-244 (1994)
PUBMED 7958996
REFERENCE 8 (bases 1 to 4264)
AUTHORS Bolger,G., Michaeli,T., Martins,T., St John,T., Steiner,B.,
Rodgers,L., Riggs,M., Wigler,M. and Ferguson,K.
TITLE A family of human phosphodiesterases homologous to the dunce
learning and memory gene product of Drosophila melanogaster are
potential targets for antidepressant drugs
JOURNAL Mol. Cell. Biol. 13 (10), 6558-6571 (1993)
PUBMED 8413254
REFERENCE 9 (bases 1 to 4264)
AUTHORS Obernolte,R., Bhakta,S., Alvarez,R., Bach,C., Zuppan,P.,
Mulkins,M., Jarnagin,K. and Shelton,E.R.
TITLE The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE
IV) reveals a multigene family
JOURNAL Gene 129 (2), 239-247 (1993)
PUBMED 8392015
REFERENCE 10 (bases 1 to 4264)
AUTHORS McLaughlin,M.M., Cieslinski,L.B., Burman,M., Torphy,T.J. and
Livi,G.P.
TITLE A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from
human brain. Cloning and expression of cDNA, biochemical
characterization of recombinant protein, and tissue distribution of
mRNA
JOURNAL J. Biol. Chem. 268 (9), 6470-6476 (1993)
PUBMED 8384210
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA126733.1, L20966.1,
AA453531.1, AA206316.1, CN268011.1, BC046161.1 and AW519027.1.
On Nov 30, 2005 this sequence version replaced gi:32171240.
Summary: This gene is a member of the type IV, cyclic AMP
(cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family.
Cyclic nucleotides are important second messengers that regulate
and mediate a number of cellular responses to extracellular
signals, such as hormones, light, and neurotransmitters. The cyclic
nucleotide phosphodiesterases (PDEs) regulate the cellular
concentrations of cyclic nucleotides and thereby play a role in
signal transduction. This gene encodes a protein that specifically
hydrolyzes cAMP. Altered activity of this protein has been
associated with schizophrenia and bipolar affective disorder.
Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (a) encodes the longest isoform
(1, also referred to as PDE4B1 or Tm72). Both variants a and d
encode the same isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK289969.1, L20966.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-8 DA126733.1 1-8
9-3183 L20966.1 1-3175
3184-3553 AA453531.1 60-429
3554-3830 AA206316.1 89-365
3831-4102 CN268011.1 121-392
4103-4253 BC046161.1 1196-1346
4254-4264 AW519027.1 1-11 c
FEATURES Location/Qualifiers
source 1..4264
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p31"
gene 1..4264
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="phosphodiesterase 4B, cAMP-specific"
/db_xref="GeneID:5142"
/db_xref="HGNC:8781"
/db_xref="HPRD:02528"
/db_xref="MIM:600127"
exon 1..76
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
exon 77..188
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 119
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:12038009"
misc_feature 120..122
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="upstream in-frame stop codon"
variation 136
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:138598652"
variation 140
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:368045878"
CDS 147..2357
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/EC_number="3.1.4.17"
/note="isoform 1 is encoded by transcript variant a;
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4
dunce homolog, Drosophila); dunce-like phosphodiesterase
E4; cAMP-specific 3',5'-cyclic phosphodiesterase 4B;
cAMP-specific phosphodiesterase-4 B isoform; PDE32"
/codon_start=1
/product="cAMP-specific 3',5'-cyclic phosphodiesterase 4B
isoform 1"
/protein_id="NP_002591.2"
/db_xref="GI:32171241"
/db_xref="CCDS:CCDS632.1"
/db_xref="GeneID:5142"
/db_xref="HGNC:8781"
/db_xref="HPRD:02528"
/db_xref="MIM:600127"
/translation="
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
"
misc_feature 543..545
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03382"
misc_feature 1359..1907
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Metal dependent phosphohydrolases with conserved
'HD' motif; Region: HDc; cd00077"
/db_xref="CDD:28958"
misc_feature order(1374..1376,1482..1487,1836..1838)
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
misc_feature 1485..1487
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Mg2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
misc_feature 1845..1847
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="non-experimental evidence, no additional
details recorded"
/note="Binds AMP, but not cAMP (By similarity); propagated
from UniProtKB/Swiss-Prot (Q07343.1); other site"
misc_feature 2340..2342
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 173
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:200612585"
variation 181
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:12038033"
variation 185
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:144957956"
exon 189..427
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 221
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:138030327"
variation 302
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:79691733"
variation 338
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:147193846"
variation 425
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:367782903"
exon 428..622
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 435
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:374255487"
variation 459
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:367809652"
variation 463
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:145072153"
variation 481
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:75398902"
variation 491
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:143755153"
variation 510
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:375693073"
variation 548
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:201506484"
variation 560
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:141704617"
variation 566
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:139030347"
variation 595
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:370994595"
variation 596
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:143872916"
variation 617
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:115853607"
exon 623..659
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 626
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:372187760"
variation 628
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:374832183"
exon 660..730
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 692
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:369969167"
exon 731..780
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 734
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:192869700"
exon 781..893
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 804
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371423323"
variation 843
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:116739380"
variation 863
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:140500253"
exon 894..987
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 915
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:376229903"
variation 918
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:145203756"
variation 943
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:199554373"
variation 976
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371297521"
exon 988..1166
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1029
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:138828553"
variation 1110
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:369849443"
variation 1113
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:372730987"
variation 1157
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377188281"
variation 1166
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:143554413"
exon 1167..1265
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1168
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:141692815"
STS 1261..1367
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="RH64524"
/db_xref="UniSTS:59487"
exon 1266..1430
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1283
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:138407878"
variation 1332
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:4322205"
variation 1370
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:146166974"
variation 1373
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:115052833"
variation 1376
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:368002134"
variation 1390
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:371715752"
variation 1403
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:202021123"
exon 1431..1530
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1451
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:783036"
variation 1479
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:185687552"
variation 1497
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:116379917"
exon 1531..1685
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1538
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:144798451"
exon 1686..1808
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1750
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:151031090"
variation 1767
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="t"
/db_xref="dbSNP:34079300"
variation 1786
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:116816923"
variation 1796
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:373028719"
variation 1800
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:142379593"
exon 1809..1991
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1815
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:370349934"
variation 1816
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:116312841"
variation 1826
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:34492439"
variation 1841
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:367550787"
variation 1886
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:141437989"
variation 1892
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200251647"
variation 1913
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:41286714"
variation 1926
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:201667673"
variation 1934
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114211692"
variation 1943
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:370428408"
variation 1949
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:373800241"
exon 1992..4258
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 2057
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:149054617"
variation 2066
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:41286716"
variation 2072
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:79722858"
variation 2073
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114393853"
variation 2090
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:139001333"
variation 2101
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:200211480"
variation 2112
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371876952"
variation 2129
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:201727510"
variation 2141
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:139374179"
variation 2142
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:149588422"
variation 2143
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:144568843"
variation 2186
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:3181494"
variation 2187
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:1042020"
variation 2190
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:34469235"
variation 2198
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:373468487"
variation 2212
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:370754936"
variation 2240
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:372714875"
variation 2247
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:150977853"
variation 2253
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:2227297"
variation 2254
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:375941228"
variation 2266
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:185910614"
variation 2287
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:370636828"
variation 2301
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200854845"
variation 2310
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114387631"
STS 2375..3259
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="PDE4B_372"
/db_xref="UniSTS:277574"
variation 2378
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:374227067"
variation 2397
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:115922110"
variation 2504
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:376708525"
variation 2560
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:57315098"
variation 2596
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:41286718"
variation 2681
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371856307"
variation 2729
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:783067"
variation 2809
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:138914808"
variation 2824
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:1804141"
variation 2897
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:141470428"
variation 3064
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="t"
/db_xref="dbSNP:377201462"
variation 3074
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:181156834"
variation 3087
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200935637"
variation 3101
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:78315788"
variation 3321
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:150394636"
variation 3337
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:4655837"
variation 3380..3381
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="aaca"
/db_xref="dbSNP:199875231"
variation 3401
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:186227828"
variation 3501
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:190701813"
STS 3559..3891
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="D1S2393"
/db_xref="UniSTS:66663"
variation 3592
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:371829302"
variation 3637
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:76335673"
variation 3639
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:112424842"
variation 3653
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:3176927"
variation 3682
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:138156061"
variation 3724
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:149577217"
variation 3753
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:144286936"
variation 3777
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:183451410"
STS 3805..3905
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="SGC30670"
/db_xref="UniSTS:79282"
variation 3849
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:186230480"
variation 3865
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:190745276"
variation 3880
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377465393"
variation 3888
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377626847"
polyA_signal 3932..3937
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
variation 3954
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:182887410"
polyA_site 3966
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/experiment="experimental evidence, no additional details
recorded"
variation 3983
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:374581239"
variation 4100..4101
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="tgggtt"
/db_xref="dbSNP:368800294"
variation 4100
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="aaccca"
/db_xref="dbSNP:16354"
variation 4101..4102
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="gg"
/replace="tgggtt"
/db_xref="dbSNP:71807410"
variation 4102..4103
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="ggtttg"
/db_xref="dbSNP:141736339"
variation 4103..4104
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="ggtttg"
/db_xref="dbSNP:71682925"
variation 4103
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:368211356"
variation 4104
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371168935"
variation 4106
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:374364770"
variation 4155
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:376802391"
variation 4166
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:138911836"
variation 4177..4178
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="tat"
/db_xref="dbSNP:202242622"
polyA_signal 4234..4239
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
polyA_site 4258
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
ORIGIN
agagcgctgcggccgcggcggtgcagcagaggcgcctcgggcaggaggagggcggcttctgcgagggcagcctgaggtattaaaaagtgtcagcaaactgcattgaataacagacatcctaagaggggatattttccacctctataatgaagaaaagcaggagtgtgatgacggtgatggctgatgataatgttaaagattattttgaatgtagcttgagtaaatcctacagttcttccagtaacacacttgggatcgacctctggagagggagaaggtgttgctcaggaaacttacagttaccaccactgtctcaaagacagagtgaaagggcaaggactcctgagggagatggtatttccaggccgaccacactgcctttgacaacgcttccaagcattgctattacaactgtaagccaggagtgctttgatgtggaaaatggcccttccccaggtcggagtccactggatccccaggccagctcttccgctgggctggtacttcacgccacctttcctgggcacagccagcgcagagagtcatttctctacagatcagacagcgactatgacttgtcaccaaaggcgatgtcgagaaactcttctcttccaagcgagcaacacggcgatgacttgattgtaactccttttgcccaggtccttgccagcttgcgaagtgtgagaaacaacttcactatactgacaaaccttcatggtacatctaacaagaggtccccagctgctagtcagcctcctgtctccagagtcaacccacaagaagaatcttatcaaaaattagcaatggaaacgctggaggaattagactggtgtttagaccagctagagaccatacagacctaccggtctgtcagtgagatggcttctaacaagttcaaaagaatgctgaaccgggagctgacacacctctcagagatgagccgatcagggaaccaggtgtctgaatacatttcaaatactttcttagacaagcagaatgatgtggagatcccatctcctacccagaaagacagggagaaaaagaaaaagcagcagctcatgacccagataagtggagtgaagaaattaatgcatagttcaagcctaaacaatacaagcatctcacgctttggagtcaacactgaaaatgaagatcacctggccaaggagctggaagacctgaacaaatggggtcttaacatctttaatgtggctggatattctcacaatagacccctaacatgcatcatgtatgctatattccaggaaagagacctcctaaagacattcagaatctcatctgacacatttataacctacatgatgactttagaagaccattaccattctgacgtggcatatcacaacagcctgcacgctgctgatgtagcccagtcgacccatgttctcctttctacaccagcattagacgctgtcttcacagatttggagatcctggctgccatttttgcagctgccatccatgacgttgatcatcctggagtctccaatcagtttctcatcaacacaaattcagaacttgctttgatgtataatgatgaatctgtgttggaaaatcatcaccttgctgtgggtttcaaactgctgcaagaagaacactgtgacatcttcatgaatctcaccaagaagcagcgtcagacactcaggaagatggttattgacatggtgttagcaactgatatgtctaaacatatgagcctgctggcagacctgaagacaatggtagaaacgaagaaagttacaagttcaggcgttcttctcctagacaactataccgatcgcattcaggtccttcgcaacatggtacactgtgcagacctgagcaaccccaccaagtccttggaattgtatcggcaatggacagaccgcatcatggaggaatttttccagcagggagacaaagagcgggagaggggaatggaaattagcccaatgtgtgataaacacacagcttctgtggaaaaatcccaggttggtttcatcgactacattgtccatccattgtgggagacatgggcagatttggtacagcctgatgctcaggacattctcgataccttagaagataacaggaactggtatcagagcatgatacctcaaagtccctcaccaccactggacgagcagaacagggactgccagggtctgatggagaagtttcagtttgaactgactctcgatgaggaagattctgaaggacctgagaaggagggagagggacacagctatttcagcagcacaaagacgctttgtgtgattgatccagaaaacagagattccctgggagagactgacatagacattgcaacagaagacaagtcccccgtggatacataatccccctctccctgtggagatgaacattctatccttgatgagcatgccagctatgtggtagggccagcccaccatgggggccaagacctgcacaggacaagggccacctggcctttcagttacttgagtttggagtcagaaagcaagaccaggaagcaaatagcagctcaggaaatcccacggttgacttgccttgatggcaagcttggtggagagggctgaagctgttgctgggggccgattctgatcaagacacatggcttgaaaatggaagacacaaaactgagagatcattctgcactaagtttcgggaacttatccccgacagtgactgaactcactgactaataacttcatttatgaatcttctcacttgtccctttgtctgccaacctgtgtgccttttttgtaaaacattttcatgtctttaaaatgcctgttgaatacctggagtttagtatcaacttctacacagataagctttcaaagttgacaaacttttttgactctttctggaaaagggaaagaaaatagtcttccttctttcttgggcaatatccttcactttactacagttacttttgcaaacagacagaaaggatacacttctaaccacattttacttccttcccctgttgtccagtccaactccacagtcactcttaaaacttctctctgtttgcctgcctccaacagtacttttaactttttgctgtaaacagaataaaattgaacaaattagggggtagaaaggagcagtggtgtcgttcaccgtgagagtctgcatagaactcagcagtgtgccctgctgtgtcttggaccctgccccccacaggagttgtacagtccctggccctgttccctacctcctctcttcaccccgttaggctgttttcaatgtaatgctgccgtccttctcttgcactgccttctgcgctaacacctccattcctgtttataaccgtgtatttattacttaatgtatataatgtaatgttttgtaagttattaatttatatatctaacattgcctgccaatggtggtgttaaatttgtgtagaaaactctgcctaagagttacgactttttcttgtaatgttttgtattgtgtattatataacccaaacgtcacttagtagagacatatggcccccttggcagagaggacaggggtgggcttttgttcaaagggtctgccctttccctgcctgagttgctacttctgcacaacccctttatgaaccagttttggaaacaatattctcacattagatactaaatggtttatactgagcttttacttttgtatagcttgataggggcagggggcaatgggatgtagtttttacccaggttctatccaaatctatgtgggcatgagttgggttataactggatcctactatcattgtggctttggttcaaaaggaaacactacatttgctcacagatgattcttctgaatgctcccgaactactgactttgaagaggtagcctcctgcctgccattaagcaggaatgtcatgttccagttcattacaaaagaaaacaataaaacaatgtgaatttttataataaaatgtgaactgatgtagcaaattacgcaaatgtgaagcctcttctgataacacttgttaggcctcttactgatgtcagtttcagtttgtaaaatatgtttcatgctttcagttcagcattgtgactcagtaattacagaaaatggcacaaatgtgcatgaccaatgtatgtctatgaacactgcattgtttcaggtggacattttatcattttcaaatgtttctcacaatgtatgttatagtattattattatatattgtgttcaaatgcattctaaagagacttttatatgaggtgaataaagaaaagcatgattagattaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5142 -> Molecular function: GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] evidence: ISS
GeneID:5142 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IDA
GeneID:5142 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IGI
GeneID:5142 -> Molecular function: GO:0030552 [cAMP binding] evidence: IGI
GeneID:5142 -> Molecular function: GO:0044325 [ion channel binding] evidence: ISS
GeneID:5142 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:5142 -> Biological process: GO:0001780 [neutrophil homeostasis] evidence: ISS
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IDA
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IEA
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IGI
GeneID:5142 -> Biological process: GO:0030593 [neutrophil chemotaxis] evidence: ISS
GeneID:5142 -> Biological process: GO:0032729 [positive regulation of interferon-gamma production] evidence: IMP
GeneID:5142 -> Biological process: GO:0032743 [positive regulation of interleukin-2 production] evidence: IMP
GeneID:5142 -> Biological process: GO:0035690 [cellular response to drug] evidence: ISS
GeneID:5142 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: IMP
GeneID:5142 -> Biological process: GO:0050900 [leukocyte migration] evidence: ISS
GeneID:5142 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: ISS
GeneID:5142 -> Biological process: GO:0071872 [cellular response to epinephrine stimulus] evidence: ISS
GeneID:5142 -> Biological process: GO:0086004 [regulation of cardiac muscle cell contraction] evidence: ISS
GeneID:5142 -> Biological process: GO:1901841 [regulation of high voltage-gated calcium channel activity] evidence: ISS
GeneID:5142 -> Biological process: GO:1901898 [negative regulation of relaxation of cardiac muscle] evidence: ISS
GeneID:5142 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:5142 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5142 -> Cellular component: GO:0005891 [voltage-gated calcium channel complex] evidence: ISS
GeneID:5142 -> Cellular component: GO:0030018 [Z disc] evidence: ISS
GeneID:5142 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002591 -> EC 3.1.4.17
by
@meso_cacase at
DBCLS
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