LOCUS       NM_002586               3231 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens pre-B-cell leukemia homeobox 2 (PBX2), mRNA.
ACCESSION   NM_002586
VERSION     NM_002586.4  GI:124494249
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3231)
  AUTHORS   Yamazaki,K., Umeno,J., Takahashi,A., Hirano,A., Johnson,T.A.,
            Kumasaka,N., Morizono,T., Hosono,N., Kawaguchi,T., Takazoe,M.,
            Yamada,T., Suzuki,Y., Tanaka,H., Motoya,S., Hosokawa,M.,
            Arimura,Y., Shinomura,Y., Matsui,T., Matsumoto,T., Iida,M.,
            Tsunoda,T., Nakamura,Y., Kamatani,N. and Kubo,M.
  TITLE     A genome-wide association study identifies 2 susceptibility Loci
            for Crohn's disease in a Japanese population
  JOURNAL   Gastroenterology 144 (4), 781-788 (2013)
   PUBMED   23266558
REFERENCE   2  (bases 1 to 3231)
  AUTHORS   Hirota,T., Takahashi,A., Kubo,M., Tsunoda,T., Tomita,K.,
            Sakashita,M., Yamada,T., Fujieda,S., Tanaka,S., Doi,S.,
            Miyatake,A., Enomoto,T., Nishiyama,C., Nakano,N., Maeda,K.,
            Okumura,K., Ogawa,H., Ikeda,S., Noguchi,E., Sakamoto,T., Hizawa,N.,
            Ebe,K., Saeki,H., Sasaki,T., Ebihara,T., Amagai,M., Takeuchi,S.,
            Furue,M., Nakamura,Y. and Tamari,M.
  TITLE     Genome-wide association study identifies eight new susceptibility
            loci for atopic dermatitis in the Japanese population
  JOURNAL   Nat. Genet. 44 (11), 1222-1226 (2012)
   PUBMED   23042114
REFERENCE   3  (bases 1 to 3231)
  AUTHORS   Qiu,Y., Wang,Z.L., Jin,S.Q., Pu,Y.F., Toyosawa,S., Aozasa,K. and
            Morii,E.
  TITLE     Expression level of pre-B-cell leukemia transcription factor 2
            (PBX2) as a prognostic marker for gingival squamous cell carcinoma
  JOURNAL   J Zhejiang Univ Sci B 13 (3), 168-175 (2012)
   PUBMED   22374608
  REMARK    GeneRIF: a high level of PBX2 is a poor prognosticator for
            disease-free survival and overall survival in gingival squamous
            cell carcinoma
REFERENCE   4  (bases 1 to 3231)
  AUTHORS   Hirota,T., Takahashi,A., Kubo,M., Tsunoda,T., Tomita,K., Doi,S.,
            Fujita,K., Miyatake,A., Enomoto,T., Miyagawa,T., Adachi,M.,
            Tanaka,H., Niimi,A., Matsumoto,H., Ito,I., Masuko,H., Sakamoto,T.,
            Hizawa,N., Taniguchi,M., Lima,J.J., Irvin,C.G., Peters,S.P.,
            Himes,B.E., Litonjua,A.A., Tantisira,K.G., Weiss,S.T., Kamatani,N.,
            Nakamura,Y. and Tamari,M.
  TITLE     Genome-wide association study identifies three new susceptibility
            loci for adult asthma in the Japanese population
  JOURNAL   Nat. Genet. 43 (9), 893-896 (2011)
   PUBMED   21804548
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3231)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 3231)
  AUTHORS   Katsanis,N., Fitzgibbon,J. and Fisher,E.M.
  TITLE     Paralogy mapping: identification of a region in the human MHC
            triplicated onto human chromosomes 1 and 9 allows the prediction
            and isolation of novel PBX and NOTCH loci
  JOURNAL   Genomics 35 (1), 101-108 (1996)
   PUBMED   8661110
REFERENCE   7  (bases 1 to 3231)
  AUTHORS   Aguado,B. and Campbell,R.D.
  TITLE     The novel gene G17, located in the human major histocompatibility
            complex, encodes PBX2, a homeodomain-containing protein
  JOURNAL   Genomics 25 (3), 650-659 (1995)
   PUBMED   7759099
REFERENCE   8  (bases 1 to 3231)
  AUTHORS   Sugaya,K., Fukagawa,T., Matsumoto,K., Mita,K., Takahashi,E.,
            Ando,A., Inoko,H. and Ikemura,T.
  TITLE     Three genes in the human MHC class III region near the junction
            with the class II: gene for receptor of advanced glycosylation end
            products, PBX2 homeobox gene and a notch homolog, human counterpart
            of mouse mammary tumor gene int-3
  JOURNAL   Genomics 23 (2), 408-419 (1994)
   PUBMED   7835890
REFERENCE   9  (bases 1 to 3231)
  AUTHORS   Lu,Q., Wright,D.D. and Kamps,M.P.
  TITLE     Fusion with E2A converts the Pbx1 homeodomain protein into a
            constitutive transcriptional activator in human leukemias carrying
            the t(1;19) translocation
  JOURNAL   Mol. Cell. Biol. 14 (6), 3938-3948 (1994)
   PUBMED   7910944
REFERENCE   10 (bases 1 to 3231)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol. Cell. Biol. 11 (12), 6149-6157 (1991)
   PUBMED   1682799
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X59842.1, BC082261.1,
            DB162975.1 and BQ182713.1.
            On Feb 6, 2007 this sequence version replaced gi:27436886.
            
            Summary: This gene encodes a ubiquitously expressed member of the
            TALE/PBX homeobox family. It was identified by its similarity to a
            homeobox gene which is involved in t(1;19) translocation in acute
            pre-B-cell leukemias. This protein is a transcriptional activator
            which binds to the TLX1 promoter. The gene is located within the
            major histocompatibility complex (MHC) on chromosome 6. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59842.1, BC082261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088, ERS025098 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1449              X59842.1           26-1474
            1450-2313           BC082261.1         1202-2065
            2314-2414           X59842.1           2339-2439
            2415-3001           DB162975.1         15-601
            3002-3231           BQ182713.1         1-230               c
FEATURES             Location/Qualifiers
     source          1..3231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.3"
     gene            1..3231
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="pre-B-cell leukemia homeobox 2"
                     /db_xref="GeneID:5089"
                     /db_xref="HGNC:8633"
                     /db_xref="HPRD:08890"
                     /db_xref="MIM:176311"
     exon            1..492
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    215..217
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="upstream in-frame stop codon"
     variation       243
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2853808"
     variation       258
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2555458"
     CDS             272..1564
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="homeobox 12; homeobox protein PBX2"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 2"
                     /protein_id="NP_002577.2"
                     /db_xref="GI:27436887"
                     /db_xref="CCDS:CCDS4748.1"
                     /db_xref="GeneID:5089"
                     /db_xref="HGNC:8633"
                     /db_xref="HPRD:08890"
                     /db_xref="MIM:176311"
                     /translation="

MDERLLGPPPPGGGRGGLGLVSGEPGGPGEPPGGGDPGGGSGGVPGGRGKQDIGDILQQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRSSQEEEPVDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGGVSPDNSIEHSDYRSKLAQIRHIYHSELEKYEQACNEFTTHVMNLLREQSRTRPVAPKEMERMVSIIHRKFSAIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAVKTAVSVTQGGHSRTSSPTPPSSAGSGGSFNLSGSGDMFLGMPGLNGDSYSASQVESLRHSMGPGGYGDNLGGGQMYSPREMRANGSWQEAVTPSSVTSPTEGPGSVHSDTSN

"
     misc_feature    419..1000
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="PBC domain; Region: PBC; pfam03792"
                     /db_xref="CDD:146435"
     misc_feature    584..586
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    722..724
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P40425.2); phosphorylation site"
     misc_feature    1004..1186
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1004..1018,1022..1024,1082..1084,1100..1102,
                     1139..1141,1145..1150,1157..1162,1166..1174,1178..1183)
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1010..1012,1019..1021,1148..1150,1157..1162,
                     1169..1171)
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    1259..1261
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P40425.2); phosphorylation site"
     variation       325
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:169503"
     exon            493..566
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:1.39.8"
     STS             496..794
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /standard_name="GDB:607728"
                     /db_xref="UniSTS:158273"
     exon            567..814
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:1.39.8"
     STS             567..794
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /standard_name="GDB:607725"
                     /db_xref="UniSTS:158272"
     exon            815..1005
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    998..1189
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /note="homeobox"
     exon            1006..1141
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:1.39.8"
     exon            1142..1295
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:1.39.8"
     exon            1296..1384
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:1.39.8"
     exon            1385..1471
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:1.39.8"
     exon            1472..3213
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /inference="alignment:Splign:1.39.8"
     STS             1548..2440
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /standard_name="PBX2_2038"
                     /db_xref="UniSTS:462915"
     variation       1595
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2078167"
     STS             1600..1935
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /standard_name="WI-7619"
                     /db_xref="UniSTS:7171"
     variation       1690
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:996"
     variation       1699
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:998"
     STS             1700..2474
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /standard_name="GDB:607721"
                     /db_xref="UniSTS:158271"
     variation       1706
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1002"
     variation       1750
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1001"
     variation       1789
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:997"
     variation       1806
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:995"
     variation       1828
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1000"
     variation       1837
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:999"
     STS             2108..2278
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /standard_name="RH46823"
                     /db_xref="UniSTS:88721"
     STS             2135..2461
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /standard_name="D6S2895"
                     /db_xref="UniSTS:464322"
     STS             2205..2481
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /standard_name="D3S4540"
                     /db_xref="UniSTS:53681"
     variation       2289
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1051993"
     variation       2310
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2555462"
     variation       2314
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1004095"
     variation       2317
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:169504"
     variation       2499
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2555463"
     polyA_signal    3187..3192
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
     polyA_site      3213
                     /gene="PBX2"
                     /gene_synonym="G17; HOX12; PBX2MHC"
ORIGIN      

ctctctcacacacacccccgcttgggcctcctctctctctccggctccattttctccgccgccgggggccggggtctcctgtggggggcccagccggtatcccaggtctcccttcagtgccggggtgaacccccgggggagccgggagccgggggcagacgggcgggggttggggcggagggagcagcggccccagcgagtttggggggagaagtaaccaggcggggggaggggcggagcagggagggggcctcagggcccccccccagctatggacgaacggctactggggccgccccctccaggcgggggccgggggggcctgggattggtgagtggggagcctgggggccctggcgagcctcccggtggcggagaccccggtgggggtagcgggggggtcccgggaggccgagggaagcaagacatcggggacattctgcagcagataatgaccatcaccgaccagagcctggacgaggcccaggccaagaaacacgccctaaactgccaccgaatgaagcctgctctctttagcgtcctgtgtgaaatcaaggagaaaactggcctcagcattcggagctcccaggaggaggagccggtggacccacagctgatgcgcttggacaacatgcttctggcagagggtgtggctgggcccgagaaagggggcggctcagcagcagcagctgcagccgctgcagcctctggtggtggtgtgtcccctgacaactccatcgaacactcggactatcgcagcaaacttgcccagatccgtcacatataccactcggagctggagaagtatgagcaggcatgtaatgagttcacgacccatgtcatgaacctgctgagggagcagagccgcaccaggcccgtggcccccaaagagatggaacgcatggtgagcatcatccatcgaaagttcagcgccatccagatgcagctgaagcagagcacctgcgaggctgtgatgatcctgcgctcccgtttcctggatgccagacgaaagcgccgtaacttcagcaaacaggccactgaggtcctaaatgagtatttctactcccacctgagtaacccatatcctagtgaggaggccaaggaggagcttgccaagaagtgtggcatcaccgtgtctcaggtctccaactggtttggcaacaagaggattcgctataagaaaaacatcggaaagttccaagaggaggcaaacatctatgctgtcaagaccgccgtgtcagtcacccaggggggccacagccgcaccagctccccgacacccccttcctctgcaggctctggcggctctttcaatctctcaggatctggagacatgtttctggggatgcctgggctcaacggagattcctattctgcttcccaggtggaatcactccgacactcgatggggccagggggctatggggataacctcgggggaggccagatgtacagcccacgggaaatgagggcaaatggcagctggcaagaggctgtgaccccctcttcagtgacatccccaacggagggaccagggagtgttcactctgatacctccaactgatcttgcccctcagggtcacaggggtgggggctctcacaaggcgacttgaagaggacgcaggcttccagaggacaaaccccaatacaggagaagcacaagacagagaagggccaatggggtcatcccctccctaacgagactctctgtgctgggggtgctaattacatggcaggaagaatggggcctctaaggggagtgtggggtctgtctctcccttttttccatctttttcctctctcgctttctttcttacacagaaacatacacataccgagaaacctatttctcagacccctttttctcctctgtctttctctctccctctcccacacctcacacacacatactcccacttgcaactattctgtttctctcctgggctcccccactttcccttccccaccccacttgtatgctctggaatctgtggagacgccagccctgcccaatcagagatgccaaaaatggggacatgacttctggacagaggacatgggccacgcccccatgcatccccacccccgcccctccggacggcttacttacctcatacgcagctcatcttaaaccaatagaatcgctcggtggacgagagtgtctgactcagatatctacctcggagggagtttctgctactttagggaattattgactgggctttggggttgaacttttttttttttaaagaaagaaaaagaaaccctgggatccatctgttttttttgttgttgttgttgtttttgttgttgttggtggtggtggtggtggtggttcttaatttttaatttagtttggggaagtagcttgtttttttttttataaatatgttgatttcttgtctttttttttttttatttcttactttcccatattaggggtgatagccaaaggggttctggtaagagaaagggggacaaacagaactggtaaagaggcccccctggctccaggcctgtccatcaggaagtaaattttacagggcaccaagctttgccccctaaaatcccttaggtgttctttgttcatgcaggcaggtttctgccgcatttgatgtggaggcagtgaagggcttgccctgctggcctctcatcccccttcttcccacaacccttgggcagggctggactcagtaattttgaggaaattgaagatgccatcttcccctgtgagtgacatgtctttaattttttaaaaaactactatttgaaaattggagggggaagaatgggaagggagttattgccaaatatgttaaatatgggttggggtgcttgtatatgtatcttcctcaatttccccataaatgaggtatctttttgtcacaccaaaatcaaggggtagggagagggaggaggttgcaaaaagccagatgtgggggaaaagtaacatcaacactgtcccatcctcagccctgaactagctaccatctgatcccctcagacattctcaggattttacaagactgtcagagtggggaacccctcccattaaagatccgggcaggactggggacaggttggaagtgtgatgggtgggggggtgggaggcatgggccgggggcagttctctcctcacttgtaaacttgtgtagtttcacagaaaaaaaacaaaatgcagttttaaataaagaaatttcttttttccctgggaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5089 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
            GeneID:5089 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:5089 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:5089 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:5089 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:5089 -> Biological process: GO:0009954 [proximal/distal pattern formation] evidence: IEA
            GeneID:5089 -> Biological process: GO:0030326 [embryonic limb morphogenesis] evidence: IEA
            GeneID:5089 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:5089 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5089 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA