2024-04-25 05:49:26, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002399 3074 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens Meis homeobox 2 (MEIS2), transcript variant f, mRNA. ACCESSION NM_002399 VERSION NM_002399.3 GI:333805651 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3074) AUTHORS Bjerke,G.A., Hyman-Walsh,C. and Wotton,D. TITLE Cooperative transcriptional activation by Klf4, Meis2, and Pbx1 JOURNAL Mol. Cell. Biol. 31 (18), 3723-3733 (2011) PUBMED 21746878 REMARK GeneRIF: Klf4 recruits a complex of Meis and Pbx proteins to DNA, resulting in Meis2 transcriptional activation domain-dependent activation of a subset of Klf4 target genes. REFERENCE 2 (bases 1 to 3074) AUTHORS Shibata,M., Nakao,H., Kiyonari,H., Abe,T. and Aizawa,S. TITLE MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors JOURNAL J. Neurosci. 31 (9), 3407-3422 (2011) PUBMED 21368052 REMARK GeneRIF: Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression. REFERENCE 3 (bases 1 to 3074) AUTHORS Adkins,D.E., Aberg,K., McClay,J.L., Bukszar,J., Zhao,Z., Jia,P., Stroup,T.S., Perkins,D., McEvoy,J.P., Lieberman,J.A., Sullivan,P.F. and van den Oord,E.J. TITLE Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs JOURNAL Mol. Psychiatry 16 (3), 321-332 (2011) PUBMED 20195266 REMARK GeneRIF: The Single Nucleotide Polymorphism in Meis homeobox 2 (MEIS2) mediated the effects of risperidone on hip circumference (q=0.004). GeneRIF: Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) REFERENCE 4 (bases 1 to 3074) AUTHORS Larsen,K.B., Lutterodt,M.C., Laursen,H., Graem,N., Pakkenberg,B., Mollgard,K. and Moller,M. TITLE Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain JOURNAL Dev. Neurosci. 32 (2), 149-162 (2010) PUBMED 20523026 REMARK GeneRIF: Data demonstrate by in situ hybridization and immunohistochemistry that the two homeobox genes Pax6 and MEIS2 are expressed during early fetal brain development in humans. REFERENCE 5 (bases 1 to 3074) AUTHORS Hyman-Walsh,C., Bjerke,G.A. and Wotton,D. TITLE An autoinhibitory effect of the homothorax domain of Meis2 JOURNAL FEBS J. 277 (12), 2584-2597 (2010) PUBMED 20553494 REMARK GeneRIF: This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect. REFERENCE 6 (bases 1 to 3074) AUTHORS Fujino,T., Yamazaki,Y., Largaespada,D.A., Jenkins,N.A., Copeland,N.G., Hirokawa,K. and Nakamura,T. TITLE Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes JOURNAL Exp. Hematol. 29 (7), 856-863 (2001) PUBMED 11438208 REFERENCE 7 (bases 1 to 3074) AUTHORS Liu,Y., MacDonald,R.J. and Swift,G.H. TITLE DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex JOURNAL J. Biol. Chem. 276 (21), 17985-17993 (2001) PUBMED 11279116 REFERENCE 8 (bases 1 to 3074) AUTHORS Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and Mouradian,M.M. TITLE Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription JOURNAL J. Biol. Chem. 275 (27), 20734-20741 (2000) PUBMED 10764806 REFERENCE 9 (bases 1 to 3074) AUTHORS Smith,J.E., Afonja,O., Yee,H.T., Inghirami,G. and Takeshita,K. TITLE Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene JOURNAL Mamm. Genome 8 (12), 951-952 (1997) PUBMED 9383298 REFERENCE 10 (bases 1 to 3074) AUTHORS Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T., Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M. TITLE Identification of a conserved family of Meis1-related homeobox genes JOURNAL Genome Res. 7 (2), 142-156 (1997) PUBMED 9049632 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK300247.1, BC001516.2 and BM679305.1. This sequence is a reference standard in the RefSeqGene project. On May 24, 2011 this sequence version replaced gi:27502374. Summary: This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (f) differs in the 5' UTR and coding sequence compared to variant a. The resulting isoform (f) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001516.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-408 AK300247.1 23-430 409-684 AK300247.1 442-717 685-2668 BC001516.2 689-2672 2669-3074 BM679305.1 1-406 c FEATURES Location/Qualifiers source 1..3074 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="15" /map="15q14" gene 1..3074 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /note="Meis homeobox 2" /db_xref="GeneID:4212" /db_xref="HGNC:7001" /db_xref="MIM:601740" exon 1..408 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" variation complement(1) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:3110012" variation complement(149) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:143532159" variation complement(329..330) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="" /replace="c" /db_xref="dbSNP:34332784" variation complement(357) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="g" /db_xref="dbSNP:376028608" misc_feature 388..390 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /note="upstream in-frame stop codon" exon 409..641 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" variation complement(420) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="g" /replace="t" /db_xref="dbSNP:369672617" CDS 436..1581 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /note="isoform f is encoded by transcript variant f; Meis homolog 2; TALE homeobox protein Meis2; Meis1-related gene 1; meis1-related protein 1; Meis1, myeloid ecotropic viral integration site 1 homolog 2" /codon_start=1 /product="homeobox protein Meis2 isoform f" /protein_id="NP_002390.1" /db_xref="GI:24762225" /db_xref="CCDS:CCDS42014.1" /db_xref="GeneID:4212" /db_xref="HGNC:7001" /db_xref="MIM:601740" /translation="
MDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM
" misc_feature 1234..1395 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /note="Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; Region: homeodomain; cd00086" /db_xref="CDD:238039" misc_feature order(1234..1239,1243..1245,1303..1305,1321..1323, 1360..1362,1366..1371,1378..1383,1387..1395) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238039" misc_feature order(1240..1242,1369..1371,1378..1383,1390..1392) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /note="specific DNA base contacts [nucleotide binding]; other site" /db_xref="CDD:238039" variation complement(486) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="g" /replace="t" /db_xref="dbSNP:376901048" variation complement(498) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:200799360" variation complement(499) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:138503850" variation complement(516) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:144628203" variation complement(546) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:375301418" variation complement(549) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:140890748" variation complement(563) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="g" /db_xref="dbSNP:372646327" exon 642..783 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" STS 643..1505 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /standard_name="Mrg1" /db_xref="UniSTS:507072" variation complement(725..726) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="" /replace="ggggggggg" /db_xref="dbSNP:138513608" exon 784..834 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" variation complement(796) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:200496429" exon 835..885 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" variation complement(867) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:137952617" exon 886..1035 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" variation complement(903) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:139184400" variation complement(922) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:368930165" variation complement(936) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:149182994" variation complement(975) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:377204162" variation complement(1003) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="c" /db_xref="dbSNP:185278462" variation complement(1011) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="c" /db_xref="dbSNP:145358549" variation complement(1014) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:150470779" variation complement(1026) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:141907934" exon 1036..1150 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" variation complement(1078) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:147874392" variation complement(1128) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:61734550" variation complement(1129) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:375357305" variation complement(1138) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:376747133" variation complement(1146) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:370758497" exon 1151..1296 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" variation complement(1205) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:369609025" variation complement(1206) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:183075611" exon 1297..1373 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" variation complement(1335) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:140793410" exon 1374..1432 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" variation complement(1426) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="c" /db_xref="dbSNP:367563077" exon 1433..1522 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" exon 1523..1618 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" variation complement(1528) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:201131653" variation complement(1536) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:113622091" variation complement(1543) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:372540616" variation complement(1580) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:201431601" variation complement(1603) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:369556038" exon 1619..3057 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /inference="alignment:Splign:1.39.8" variation complement(1645) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:151055354" variation complement(1652) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:142878520" variation complement(1685) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:113747758" variation complement(1704) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:57860578" variation complement(1725) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:148444214" variation complement(1733) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:144548752" variation complement(1734) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:199728455" variation complement(1780) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:374458760" variation complement(1783) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:141054432" variation complement(1785) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="g" /replace="t" /db_xref="dbSNP:200282136" variation complement(1794) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:139991974" variation complement(1795) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:201588285" variation complement(1812) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="c" /db_xref="dbSNP:145933742" variation complement(1814) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="c" /db_xref="dbSNP:370135711" variation complement(1823) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:142325445" variation complement(1825) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:377210457" variation complement(1836) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="g" /db_xref="dbSNP:372766056" variation complement(1886) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:150313361" variation complement(1898) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:369601092" variation complement(1937) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:77635771" variation complement(1974) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="g" /replace="t" /db_xref="dbSNP:146614487" variation complement(2159) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="t" /db_xref="dbSNP:144383417" variation complement(2243) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="t" /db_xref="dbSNP:139647839" variation complement(2319..2320) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="" /replace="c" /db_xref="dbSNP:34412514" variation complement(2331) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="c" /replace="t" /db_xref="dbSNP:72708659" variation complement(2357) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:117434306" variation complement(2381..2382) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="" /replace="g" /db_xref="dbSNP:34654533" variation complement(2393..2394) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="" /replace="g" /db_xref="dbSNP:35427488" variation complement(2527) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="c" /db_xref="dbSNP:146332496" variation complement(2567) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:373295254" variation complement(2621) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="g" /db_xref="dbSNP:369432376" variation complement(2645) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="g" /replace="t" /db_xref="dbSNP:376202599" variation complement(2669) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="" /replace="a" /db_xref="dbSNP:34362471" variation complement(2832) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="" /replace="a" /db_xref="dbSNP:375754667" STS 2847..3025 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /db_xref="UniSTS:34756" variation complement(2994..2995) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="" /replace="aa" /db_xref="dbSNP:79470888" variation complement(3004) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="" /replace="a" /db_xref="dbSNP:34976538" variation complement(3004) /gene="MEIS2" /gene_synonym="HsT18361; MRG1" /replace="a" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:200863215" polyA_signal 3028..3033 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" polyA_site 3057 /gene="MEIS2" /gene_synonym="HsT18361; MRG1" ORIGIN
ttggctacatcggacccagatgactgcctcctcacttcctccctcccgattccgccgcggcccccaaagactctcggggtggccccttgtccgcaccgcttggagggagtgtgctctgagttaagctggtctcttctggtcctggaaaaaaatgagtattgacaaggttgctggatctgcgcagaaaagaaagtgccacttaataaaaaatttagcccggcagtggtaccgtctgcagagcttgctgcccttggacgttagcaggaagccttcggggtgctgtaatcggcgggcagaggagagggaggccgcggaattaaaaggaacaaaagctagagcgccatgccaaacgtccccggcaagacccagttaggcaggagccgggagtgatgggaaaatgaactagaatacgatgagctgccccattacggcgggatggacggagtaggggttcccgcttccatgtacggagaccctcacgcgccgcggccgatccccccggttcaccacctgaaccacgggccgccgctccacgccacacagcactacggcgcgcacgccccgcaccccaatgtcatgccggccagtatgggatccgctgtcaacgacgccttgaagcgggacaaggacgcgatctatgggcacccgttgtttcctctgttagctctggtctttgagaagtgcgagctggcgacctgcactccccgggaacctggagtggctggcggagacgtctgctcctccgactccttcaacgaggacatcgcggtcttcgccaagcaggttcgcgccgaaaagccacttttttcctcaaatccagagctggacaatttgatgatacaagcaatacaagtactaaggtttcatcttttggagttagaaaaggtccacgaactgtgcgataacttctgccaccgatacattagctgtttgaaggggaaaatgcccatcgacctcgtcattgatgaaagagacggcagctccaagtcagatcatgaagaactttcaggctcctccacaaatctcgctgaccataacccttcttcttggcgagaccacgatgatgcaacctcaacccactcagcaggcaccccagggccctccagtgggggccatgcttcccagagcggagacaacagcagtgagcaaggggatggtttagacaacagtgtagcttcacctggtacaggtgacgatgatgatccggataaggacaaaaaacgccagaagaaaagaggcattttccccaaagtagcaacaaatatcatgagagcatggctcttccagcatctcacacatccgtacccttccgaagagcagaagaaacagttagcgcaagacacaggacttacaattctccaagtaaacaactggtttattaatgccagaagaagaatagtacagcccatgattgaccagtcaaatcgagcagtgagccaaggagcagcatatagtccagagggtcagcccatggggagctttgtgttggatggtcagcaacacatggggatccggcctgcaggacctatgagtggaatgggcatgaatatgggcatggatgggcaatggcactacatgtaaccttcatcatgtaaagcaatcgcaaagcaagggggaagtttgcagagcatgccaggggactacgtttctcagggtggtcctatgggaatgagtatggcacagccaagttacactcctccccagatgaccccacaccctactcaattaagacatggacccccaatgcattcatatttgccaagccatccccaccacccagccatgatgatgcacggaggaccccctacccaccctggaatgactatgtcagcacagagccccacaatgttaaattctgtagatcccaatgttggcggacaggttatggacattcatgcccaatagtataagggaactcaagggaaaaggaaacacacgcaaaaactattttaagactttctgaactttgaccagatgttgacacttaatatgaaattccagacagctgtgattattttttacttttgtcatttttcatcaagcaacagaggaccaatgcaacaagaacacaaatgtgaaatcatgggctgactgagacaattctgtccatgtaaagatcctctggaaaaagactccgagagttataactactgtagtataaatataggaactaagttaaacttgtacatttctgttgatcacgccgttatgttgcctcaaatagttttagaagagaaaaaaaaatatatccttgttttccacactatgtgtgttgttcccaaaagaatgactgttttggttcatcagtgaattcaccatccaggagagactgtggtatatattttaaacctgttgggccaatgagaaaagaaccacactggagatcatgatgaacttttggctgaacctcatcactcgaactccagcttcaagaatgtgttttcatgcccggcctttgttcctccataaatgtgtcctttagtttcaaacagatctttatagttcgtgcttcataagccaattcttattattatttttgggggactcttcttcaaagagcttgccaatgaagatttaaagacagagcaggagcttcttccaggagttctgagccttggttgtggacaaaacaatcttaagttgggcagctttcctcaacacaaaaaaaagttattaatggtcattgaaccataactaggactttatcagaaactcaaagcttgggggataaaaaggagcaagagaatactgtaacaaacttcgtacagagttcggtctattaattgtttcatgttagatattctatgtgtttacctcaattgaaaaaaaaaagaatgtttttgctagtatcagatctgctgtggaattggtattgtatgtccatgaattcttcttttctcagcacgtgttcctcactagaagaaaatgctgttacctttaagctttgtcaaatttacattaaaatacttgtatgaggactgtgacgttatgttaaaaaaaaaaaggtgttaagtcacaaaaagcggtaataaatatttcatttttgattttttgttaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:4212 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA GeneID:4212 -> Molecular function: GO:0003712 [transcription cofactor activity] evidence: ISS GeneID:4212 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: TAS GeneID:4212 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:4212 -> Molecular function: GO:0008134 [transcription factor binding] evidence: ISS GeneID:4212 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA GeneID:4212 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA GeneID:4212 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: TAS GeneID:4212 -> Biological process: GO:0001654 [eye development] evidence: IEA GeneID:4212 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS GeneID:4212 -> Biological process: GO:0045638 [negative regulation of myeloid cell differentiation] evidence: ISS GeneID:4212 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA GeneID:4212 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
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