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2024-04-19 22:33:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002275 1861 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens keratin 15 (KRT15), mRNA.
ACCESSION NM_002275
VERSION NM_002275.3 GI:216548460
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1861)
AUTHORS Khanom,R., Sakamoto,K., Pal,S.K., Shimada,Y., Morita,K., Omura,K.,
Miki,Y. and Yamaguchi,A.
TITLE Expression of basal cell keratin 15 and keratin 19 in oral squamous
neoplasms represents diverse pathophysiologies
JOURNAL Histol. Histopathol. 27 (7), 949-959 (2012)
PUBMED 22648550
REMARK GeneRIF: K15 is expressed variably in both oral squamous cell
carcinoma and squamous intraepithelial neoplasm
REFERENCE 2 (bases 1 to 1861)
AUTHORS Li,G.G., Chen,S.Y., Xie,H.T., Zhu,Y.T. and Tseng,S.C.
TITLE Angiogenesis potential of human limbal stromal niche cells
JOURNAL Invest. Ophthalmol. Vis. Sci. 53 (7), 3357-3367 (2012)
PUBMED 22538425
REMARK GeneRIF: both expanded limbal NCs and HUVEC rejoined with LEPC to
form spheres to upregulate expression of DeltaNp63alpha, CK15, and
CEBPdelta, the former but not the latter abolished expression of
CK12 keratin.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 1861)
AUTHORS Chong,L.Y., Cheok,P.Y., Tan,W.J., Thike,A.A., Allen,G., Ang,M.K.,
Ooi,A.S., Tan,P., Teh,B.T. and Tan,P.H.
TITLE Keratin 15, transcobalamin I and homeobox gene Hox-B13 expression
in breast phyllodes tumors: novel markers in biological
classification
JOURNAL Breast Cancer Res. Treat. 132 (1), 143-151 (2012)
PUBMED 21574054
REMARK GeneRIF: Stromal expression of KRT15, TCN1, and HOXB13 was
significantly correlated with tumor grade, stromal
hypercellularity, mitotic activity and microscopic borders.
REFERENCE 4 (bases 1 to 1861)
AUTHORS Sperling,L.C., Hussey,S., Wang,J.A. and Darling,T.
TITLE Cytokeratin 15 expression in central, centrifugal, cicatricial
alopecia: new observations in normal and diseased hair follicles
JOURNAL J. Cutan. Pathol. 38 (5), 407-414 (2011)
PUBMED 21251039
REMARK GeneRIF: CK15 highlights BZ cells in normal human follicles
REFERENCE 5 (bases 1 to 1861)
AUTHORS Mahalingam,M., Srivastava,A. and Hoang,M.P.
TITLE Expression of stem-cell markers (cytokeratin 15 and nestin) in
primary adnexal neoplasms-clues to etiopathogenesis
JOURNAL Am J Dermatopathol 32 (8), 774-779 (2010)
PUBMED 20700038
REMARK GeneRIF: Report expression of stem-cell markers cytokeratin 15 and
nestin in primary adnexal neoplasms.
REFERENCE 6 (bases 1 to 1861)
AUTHORS Barletta,C., Batticane,N., Ragusa,R.M., Leube,R., Peschle,C. and
Romano,V.
TITLE Subchromosomal localization of two human cytokeratin genes (KRT4
and KRT15) by in situ hybridization
JOURNAL Cytogenet. Cell Genet. 54 (3-4), 148-150 (1990)
PUBMED 1702379
REFERENCE 7 (bases 1 to 1861)
AUTHORS Bader,B.L., Jahn,L. and Franke,W.W.
TITLE Low level expression of cytokeratins 8, 18 and 19 in vascular
smooth muscle cells of human umbilical cord and in cultured cells
derived therefrom, with an analysis of the chromosomal locus
containing the cytokeratin 19 gene
JOURNAL Eur. J. Cell Biol. 47 (2), 300-319 (1988)
PUBMED 2468493
REFERENCE 8 (bases 1 to 1861)
AUTHORS Leube,R.E., Bader,B.L., Bosch,F.X., Zimbelmann,R., Achtstaetter,T.
and Franke,W.W.
TITLE Molecular characterization and expression of the
stratification-related cytokeratins 4 and 15
JOURNAL J. Cell Biol. 106 (4), 1249-1261 (1988)
PUBMED 2452170
REFERENCE 9 (bases 1 to 1861)
AUTHORS Romano,V., Bosco,P., Rocchi,M., Costa,G., Leube,R.E., Franke,W.W.
and Romeo,G.
TITLE Chromosomal assignments of human type I and type II cytokeratin
genes to different chromosomes
JOURNAL Cytogenet. Cell Genet. 48 (3), 148-151 (1988)
PUBMED 2466616
REFERENCE 10 (bases 1 to 1861)
AUTHORS Blumenberg,M. and Savtchenko,E.S.
TITLE Linkage of human keratin genes
JOURNAL Cytogenet. Cell Genet. 42 (1-2), 65-71 (1986)
PUBMED 2424675
REMARK Erratum:[Cytogenet Cell Genet 1992;61(2):160]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff in
collaboration with Michael Rogers. The reference sequence was
derived from AK122864.1, BC002641.2 and BC110649.1.
This sequence is a reference standard in the RefSeqGene project.
On Dec 9, 2008 this sequence version replaced gi:24430189.
Summary: The protein encoded by this gene is a member of the
keratin gene family. The keratins are intermediate filament
proteins responsible for the structural integrity of epithelial
cells and are subdivided into cytokeratins and hair keratins. Most
of the type I cytokeratins consist of acidic proteins which are
arranged in pairs of heterotypic keratin chains and are clustered
in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC002641.2, AK122864.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025087 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-135 AK122864.1 3396-3530
136-1738 BC002641.2 1-1603
1739-1861 BC110649.1 1702-1824
FEATURES Location/Qualifiers
source 1..1861
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.2"
gene 1..1861
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/note="keratin 15"
/db_xref="GeneID:3866"
/db_xref="HGNC:6421"
/db_xref="HPRD:01009"
/db_xref="MIM:148030"
exon 1..689
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/inference="alignment:Splign:1.39.8"
misc_feature 162..164
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/note="upstream in-frame stop codon"
CDS 192..1562
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/note="keratin-15, beta; type I cytoskeletal 15;
cytokeratin 15; keratin-15, basic; CK-15; cytokeratin-15"
/codon_start=1
/product="keratin, type I cytoskeletal 15"
/protein_id="NP_002266.2"
/db_xref="GI:24430190"
/db_xref="CCDS:CCDS11398.1"
/db_xref="GeneID:3866"
/db_xref="HGNC:6421"
/db_xref="HPRD:01009"
/db_xref="MIM:148030"
/translation="
MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGYGGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPTSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIGIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI
"
misc_feature 192..503
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19012.3);
Region: Head"
misc_feature 501..1439
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/note="Intermediate filament protein; Region: Filament;
pfam00038"
/db_xref="CDD:200948"
misc_feature 504..1430
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19012.3);
Region: Rod"
misc_feature 504..611
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19012.3);
Region: Coil 1A"
misc_feature 612..668
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19012.3);
Region: Linker 1"
misc_feature 669..944
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19012.3);
Region: Coil 1B"
misc_feature 945..1004
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19012.3);
Region: Linker 12"
misc_feature 1005..1430
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19012.3);
Region: Coil 2"
misc_feature 1431..1559
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19012.3);
Region: Tail"
variation 630
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/replace="a"
/replace="g"
/db_xref="dbSNP:1050784"
exon 690..772
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/inference="alignment:Splign:1.39.8"
exon 773..929
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/inference="alignment:Splign:1.39.8"
exon 930..1091
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/inference="alignment:Splign:1.39.8"
STS 1013..1355
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/standard_name="Krt15"
/db_xref="UniSTS:474754"
exon 1092..1217
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/inference="alignment:Splign:1.39.8"
exon 1218..1438
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/inference="alignment:Splign:1.39.8"
exon 1439..1464
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/inference="alignment:Splign:1.39.8"
exon 1465..1840
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/inference="alignment:Splign:1.39.8"
STS 1565..1839
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/standard_name="SHGC-12347"
/db_xref="UniSTS:57368"
STS 1581..1706
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/standard_name="RH17477"
/db_xref="UniSTS:48796"
variation 1739
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/replace="a"
/replace="c"
/db_xref="dbSNP:2662"
polyA_signal 1811..1816
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
variation 1826
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/replace="g"
/replace="t"
/db_xref="dbSNP:1131334"
variation 1839
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
/replace="a"
/replace="t"
/db_xref="dbSNP:3177955"
polyA_site 1840
/gene="KRT15"
/gene_synonym="CK15; K15; K1CO"
ORIGIN
cactcaaggtgtgcaggcagctgtgtttgtcaggaaggcagaaggagttggctttgctttaggggaggagacgaggtcccacaacaccctctgaagggtatataaggagccccagcgtgcagcctggcctggtacctcctgccagcatctcttgggtttgctgagaactcacgggctccagctacctggccatgaccaccacatttctgcaaacttcttcctccacctttgggggtggctcaacccgagggggttccctcctggctgggggaggtggctttggtggggggagtctctctgggggaggtggaagccgaagtatctcagcttcttctgctaggtttgtctcttcagggtcaggaggaggatatgggggtggcatgagggtctgtggctttggtggaggggctggtagtgttttcggtggaggctttggagggggcgttggtgggggttttggtggtggctttggtggtggcgatggtggtctcctctctggcaatgagaaaattaccatgcagaacctcaatgaccgcctggcctcctacctggacaaggtacgtgccctggaggaggccaatgctgacctggaggtgaagatccatgactggtaccagaagcagaccccaaccagcccagaatgcgactacagccaatacttcaagaccattgaagagctccgggacaagatcatggccaccaccatcgacaactcccgggtcatcctggagatcgacaatgccaggctggctgcggacgacttcaggctcaagtatgagaatgagctggccctgcgccagggcgttgaggctgacatcaacggcttgcgccgagtcctggatgagctgaccctggccaggactgacctggagatgcagatcgagggcctgaatgaggagctagcctacctgaagaagaaccacgaagaggagatgaaggagttcagcagccagctggccggccaggtcaatgtggagatggacgcagcaccgggtgtggacctgacccgtgtgctggcagagatgagggagcagtacgaggccatggcggagaagaaccgccgggatgtcgaggcctggttcttcagcaagactgaggagctgaacaaagaggtggcctccaacacagaaatgatccagaccagcaagacggagatcacagacctgagacgcacgatgcaggagctggagatcgagctgcagtcccagctcagcatgaaagctgggctggagaactcactggccgagacagagtgccgctatgccacgcagctgcagcagatccaggggctcattggtggcctggaggcccagctgagtgagctccgatgcgagatggaggctcagaaccaggagtacaagatgctgcttgacataaagacacggctggagcaggagatcgctacttaccgcagcctgctcgagggccaggatgccaagatggctggcattggcatcagggaagcctcttcaggaggtggtggtagcagcagcaatttccacatcaatgtagaagagtcagtggatggacaggtggtttcttcccacaagagagaaatctaagtgtctattgcaggagaaacgtcccttgccactccccactctcatcaggccaagtggaggactggccagagggcctgcacatgcaaactccagtccctgccttcagagagctgaaaagggtccctcggtcttttatttcagggctttgcatgcgctctattccccctctgcctctccccaccttctttggagcaaggagatgcagctgtattgtgtaacaagctcatttgtacagtgtctgttcatgtaataaagaattacttttccttttgcaaataaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3866 -> Molecular function: GO:0005200 [structural constituent of cytoskeleton] evidence: TAS
GeneID:3866 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3866 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IPI
GeneID:3866 -> Biological process: GO:0008544 [epidermis development] evidence: TAS
GeneID:3866 -> Cellular component: GO:0005882 [intermediate filament] evidence: IEA
by
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