LOCUS       NM_002202               2729 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens ISL LIM homeobox 1 (ISL1), mRNA.
ACCESSION   NM_002202
VERSION     NM_002202.2  GI:115387113
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2729)
  AUTHORS   Graham,R.P., Shrestha,B., Caron,B.L., Smyrk,T.C., Grogg,K.L.,
            Lloyd,R.V. and Zhang,L.
  TITLE     Islet-1 is a sensitive but not entirely specific marker for
            pancreatic neuroendocrine neoplasms and their metastases
  JOURNAL   Am. J. Surg. Pathol. 37 (3), 399-405 (2013)
   PUBMED   23348208
  REMARK    GeneRIF: Our findings confirm that Isl1 is a sensitive marker of
            pancreatic origin in cases of metastatic neuroendocrine neoplasms .
REFERENCE   2  (bases 1 to 2729)
  AUTHORS   Xue,L., Wang,X., Xu,J., Xu,X., Liu,X., Hu,Z., Shen,H. and Chen,Y.
  TITLE     ISL1 common variant rs1017 is not associated with susceptibility to
            congenital heart disease in a Chinese population
  JOURNAL   Genet Test Mol Biomarkers 16 (7), 679-683 (2012)
   PUBMED   22480195
  REMARK    GeneRIF: This is the first study which indicates that ISL1 common
            variant rs1017 may not play a role in sporadic CHD susceptibility
            in the Chinese population.
REFERENCE   3  (bases 1 to 2729)
  AUTHORS   Koo,J., Mertens,R.B., Mirocha,J.M., Wang,H.L. and Dhall,D.
  TITLE     Value of Islet 1 and PAX8 in identifying metastatic neuroendocrine
            tumors of pancreatic origin
  JOURNAL   Mod. Pathol. 25 (6), 893-901 (2012)
   PUBMED   22388755
  REMARK    GeneRIF: Both Islet 1 and PAX8 are reliable immunohistochemical
            markers for identifying metastatic neuroendocrine tumors of
            pancreatic origin.
REFERENCE   4  (bases 1 to 2729)
  AUTHORS   Wang,X., Shaffer,J.R., Zeng,Z., Begum,F., Vieira,A.R., Noel,J.,
            Anjomshoaa,I., Cuenco,K.T., Lee,M.K., Beck,J., Boerwinkle,E.,
            Cornelis,M.C., Hu,F.B., Crosslin,D.R., Laurie,C.C., Nelson,S.C.,
            Doheny,K.F., Pugh,E.W., Polk,D.E., Weyant,R.J., Crout,R.,
            McNeil,D.W., Weeks,D.E., Feingold,E. and Marazita,M.L.
  TITLE     Genome-wide association scan of dental caries in the permanent
            dentition
  JOURNAL   BMC Oral Health 12, 57 (2012)
   PUBMED   23259602
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2729)
  AUTHORS   Golzio,C., Havis,E., Daubas,P., Nuel,G., Babarit,C., Munnich,A.,
            Vekemans,M., Zaffran,S., Lyonnet,S. and Etchevers,H.C.
  TITLE     ISL1 directly regulates FGF10 transcription during human cardiac
            outflow formation
  JOURNAL   PLoS ONE 7 (1), E30677 (2012)
   PUBMED   22303449
  REMARK    GeneRIF: The relationship between human ISL1 and FGF10 within the
            embryonic time window during which the linear heart tube remodels
            into four chambers, was examined.
REFERENCE   6  (bases 1 to 2729)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   7  (bases 1 to 2729)
  AUTHORS   Riggs,A.C., Tanizawa,Y., Aoki,M., Wasson,J., Ferrer,J., Rabin,D.U.,
            Vaxillaire,M., Froguel,P. and Permutt,M.A.
  TITLE     Characterization of the LIM/homeodomain gene islet-1 and single
            nucleotide screening in NIDDM
  JOURNAL   Diabetes 44 (6), 689-694 (1995)
   PUBMED   7789634
REFERENCE   8  (bases 1 to 2729)
  AUTHORS   Tanizawa,Y., Riggs,A.C., Dagogo-Jack,S., Vaxillaire,M., Froguel,P.,
            Liu,L., Donis-Keller,H. and Permutt,M.A.
  TITLE     Isolation of the human LIM/homeodomain gene islet-1 and
            identification of a simple sequence repeat polymorphism [corrected]
  JOURNAL   Diabetes 43 (7), 935-941 (1994)
   PUBMED   7912209
  REMARK    Erratum:[Diabetes 1994 Sep;43(9):1171]
REFERENCE   9  (bases 1 to 2729)
  AUTHORS   Wang,M. and Drucker,D.J.
  TITLE     The LIM domain homeobox gene isl-1: conservation of human, hamster,
            and rat complementary deoxyribonucleic acid sequences and
            expression in cell types of nonneuroendocrine lineage
  JOURNAL   Endocrinology 134 (3), 1416-1422 (1994)
   PUBMED   7907017
REFERENCE   10 (bases 1 to 2729)
  AUTHORS   Dong,J., Asa,S.L. and Drucker,D.J.
  TITLE     Islet cell and extrapancreatic expression of the LIM domain
            homeobox gene isl-1
  JOURNAL   Mol. Endocrinol. 5 (11), 1633-1641 (1991)
   PUBMED   1685766
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010478.5, BC031213.1,
            BC017027.1 and BM680522.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Sep 28, 2006 this sequence version replaced gi:4504736.
            
            Summary: This gene encodes a member of the LIM/homeodomain family
            of transcription factors. The encoded protein binds to the enhancer
            region of the insulin gene, among others, and may play an important
            role in regulating insulin gene expression. The encoded protein is
            central to the development of pancreatic cell lineages and may also
            be required for motor neuron generation. Mutations in this gene
            have been associated with maturity-onset diabetes of the young.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031213.1, U07559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025090 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               AC010478.5         100186-100761
            577-1026            BC031213.1         578-1027
            1027-2448           BC017027.1         733-2154
            2449-2729           BM680522.1         1-281               c
FEATURES             Location/Qualifiers
     source          1..2729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.1"
     gene            1..2729
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="ISL LIM homeobox 1"
                     /db_xref="GeneID:3670"
                     /db_xref="HGNC:6132"
                     /db_xref="MIM:600366"
     exon            1..576
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /inference="alignment:Splign:1.39.8"
     variation       57
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3762977"
     variation       67
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:71618117"
     variation       114
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374921619"
     variation       124
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377679399"
     variation       247
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:36216897"
     variation       309
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116222082"
     variation       336
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370591252"
     variation       340
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375825065"
     variation       401
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:121913539"
     misc_feature    462..464
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="upstream in-frame stop codon"
     variation       502
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3917084"
     variation       514
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375345896"
     variation       528
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372022305"
     variation       543
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200164834"
     CDS             549..1598
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="ISL1 transcription factor, LIM/homeodomain;
                     islet-1"
                     /codon_start=1
                     /product="insulin gene enhancer protein ISL-1"
                     /protein_id="NP_002193.2"
                     /db_xref="GI:115387114"
                     /db_xref="CCDS:CCDS43314.1"
                     /db_xref="GeneID:3670"
                     /db_xref="HGNC:6132"
                     /db_xref="MIM:600366"
                     /translation="

MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA

"
     misc_feature    597..761
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="The first LIM domain of Isl, a member of LHX
                     protein family; Region: LIM1_Isl; cd09366"
                     /db_xref="CDD:188752"
     misc_feature    order(597..599,606..608,663..665,672..674,681..683,
                     690..692,747..749,756..758)
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188752"
     misc_feature    606..767
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="Region: LIM domain"
     misc_feature    783..947
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="The second LIM domain of Isl, a member of LHX
                     protein family; Region: LIM2_Isl; cd09374"
                     /db_xref="CDD:188760"
     misc_feature    order(783..785,792..794,849..851,858..860,867..869,
                     876..878,933..935,942..944)
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188760"
     misc_feature    792..956
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="Region: LIM domain"
     misc_feature    1095..1268
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(1095..1106,1110..1112,1161..1163,1179..1181,
                     1218..1220,1224..1229,1236..1241,1245..1253,1257..1262)
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    1098..1277
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="Region: Homeodomain"
     misc_feature    order(1098..1100,1107..1109,1227..1229,1236..1241,
                     1248..1250)
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1332..1421
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P61371.1);
                     Region: LIM-binding domain (LID) (By similarity)"
     variation       550
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374259070"
     variation       570
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368787467"
     exon            577..766
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /inference="alignment:Splign:1.39.8"
     variation       586
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372177290"
     variation       587
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189115217"
     variation       596
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369145747"
     exon            767..1026
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /inference="alignment:Splign:1.39.8"
     STS             782..1235
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /standard_name="D10Bir8"
                     /db_xref="UniSTS:141487"
     variation       798
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373022588"
     variation       815
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201853354"
     variation       824
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376610562"
     variation       892
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201797783"
     variation       977
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374296284"
     variation       984
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200172777"
     variation       985
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371070257"
     variation       1006
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374493957"
     variation       1007
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368770808"
     exon            1027..1313
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /inference="alignment:Splign:1.39.8"
     variation       1052
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2303751"
     variation       1053
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375950160"
     variation       1061
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:121913540"
     variation       1089
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200209474"
     variation       1115
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:121913541"
     variation       1154
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200829118"
     variation       1170
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376320342"
     variation       1263
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199639357"
     variation       1303
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:121912286"
     exon            1314..1481
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /inference="alignment:Splign:1.39.8"
     variation       1326
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371499581"
     variation       1367
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373703337"
     variation       1371
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371918442"
     variation       1433
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41268419"
     variation       1434
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372119962"
     exon            1482..2718
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /inference="alignment:Splign:1.39.8"
     variation       1533
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199961324"
     variation       1586
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201718508"
     variation       1602
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369904787"
     variation       1628
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:183431669"
     variation       1638
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374773039"
     variation       1681
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139406174"
     STS             1810..2019
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /standard_name="D5S2482"
                     /db_xref="UniSTS:181718"
     variation       1860..1861
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:200597453"
     STS             1960..2710
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /standard_name="ISL1__6479"
                     /db_xref="UniSTS:464505"
     variation       2033
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201793590"
     variation       2113
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1802593"
     variation       2135
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370818896"
     variation       2137
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:41268421"
     STS             2143..2473
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /standard_name="D5S2482"
                     /db_xref="UniSTS:69430"
     variation       2213
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35133332"
     variation       2237
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1006"
     variation       2249
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1017"
     variation       2341
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:187027859"
     variation       2432..2433
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace=""
                     /replace="t"
                     /replace="tt"
                     /db_xref="dbSNP:3033046"
     variation       2601..2602
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35701884"
     polyA_signal    2688..2693
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
     polyA_site      2714
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
     polyA_site      2718
                     /gene="ISL1"
                     /gene_synonym="Isl-1; ISLET1"
ORIGIN      

gaaggaagaggaagaggaggagagggaggccagagccagaacagcccggcagcccgagcttcgggggagaacggcctgagccccgagcaagttgcctcgggagccctaatcctctcccgctggctcgccgagcggtcagtggcgctcagcggcggcgaggctgaaatatgataatcagaacagctgcgccgcgcgccctgcagccaatgggcgcggcgctcgcctgacgtccccgcgcgctgcgtcagaccaatggcgatggagctgagttggagcagagaagtttgagtaagagataaggaagagaggtgcccgagccgcgccgagtctgccgccgccgcagcgcctccgctccgccaactccgccggcttaaattggactcctagatccgcgagggcgcggcgcagccgagcagcggctctttcagcattggcaaccccaggggccaatatttcccacttagccacagctccagcatcctctctgtgggctgttcaccaactgtacaaccaccatttcactgtggacattactccctcttacagatatgggagacatgggagatccaccaaaaaaaaaacgtctgatttccctatgtgttggttgcggcaatcagattcacgatcagtatattctgagggtttctccggatttggaatggcatgcggcatgtttgaaatgtgcggagtgtaatcagtatttggacgagagctgtacatgctttgttagggatgggaaaacctactgtaaaagagattatatcaggttgtacgggatcaaatgcgccaagtgcagcatcggcttcagcaagaacgacttcgtgatgcgtgcccgctccaaggtgtatcacatcgagtgtttccgctgtgtggcctgcagccgccagctcatccctggggacgaatttgcgcttcgggaggacggtctcttctgccgagcagaccacgatgtggtggagagggccagtctaggcgctggcgacccgctcagtcccctgcatccagcgcggccactgcaaatggcagcggagcccatctccgccaggcagccagccctgcggccccacgtccacaagcagccggagaagaccacccgcgtgcggactgtgctgaacgagaagcagctgcacaccttgcggacctgctacgccgcaaacccgcggccagatgcgctcatgaaggagcaactggtagagatgacgggcctcagtccccgtgtgatccgggtctggtttcaaaacaagcggtgcaaggacaagaagcgaagcatcatgatgaagcaactccagcagcagcagcccaatgacaaaactaatatccaggggatgacaggaactcccatggtggctgccagtccagagagacacgacggtggcttacaggctaacccagtggaagtacaaagttaccagccaccttggaaagtactgagcgacttcgccttgcagagtgacatagatcagcctgcttttcagcaactggtcaatttttcagaaggaggaccgggctctaattccactggcagtgaagtagcatcaatgtcctctcaacttccagatacacctaacagcatggtagccagtcctattgaggcatgaggaacattcattctgtattttttttccctgttggagaaagtgggaaattataatgtcgaactctgaaacaaaagtatttaacgacccagtcaatgaaaactgaatcaagaaatgaatgctccatgaaatgcacgaagtctgttttaatgacaaggtgatatggtagcaacactgtgaagacaatcatgggattttactagaattaaacaacaaacaaaacgcaaaacccagtatatgctattcaatgatcttagaagtactgaaaaaaaaagacgtttttaaaacgtagaggatttatattcaaggatctcaaagaaagcattttcatttcactgcacatctagagaaaaacaaaaatagaaaattttctagtccatcctaatctgaatggtgctgtttctatattggtcattgccttgccaaacaggagctccagcaaaagcgcaggaagagagactggcctccttggctgaaagagtcctttcaggaaggtggagctgcattggtttgatatgtttaaagttgactttaacaaggggttaattgaaatcctgggtctcttggcctgtcctgtagctggtttattttttactttgccccctccccactttttttgagatccatcctttatcaagaagtctgaagcgactataaaggtttttgaattcagatttaaaaaccaacttataaagcattgcaacaaggttacctctattttgccacaagcgtctcgggattgtgtttgacttgtgtctgtccaagaacttttcccccaaagatgtgtatagttattggttaaaatgactgttttctctctctatggaaataaaaaggaaaaaaaaaaaggaaactttttttgtttgctcttgcattgcaaaaattataaagtaatttattatttattgtcggaagacttgccacttttcatgtcatttgacattttttgtttgctgaagtgaaaaaaaaagataaaggttgtacggtggtctttgaattatatgtctaattctatgtgttttgtctttttcttaaatattatgtgaaatcaaagcgccatatgtagaattatatcttcaggactatttcactaataaacatttggcatagataaataaataaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3670 -> Molecular function: GO:0001102 [RNA polymerase II activating transcription factor binding] evidence: IPI
            GeneID:3670 -> Molecular function: GO:0001105 [RNA polymerase II transcription coactivator activity] evidence: IDA
            GeneID:3670 -> Molecular function: GO:0001158 [enhancer sequence-specific DNA binding] evidence: IDA
            GeneID:3670 -> Molecular function: GO:0001158 [enhancer sequence-specific DNA binding] evidence: NAS
            GeneID:3670 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
            GeneID:3670 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:3670 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:3670 -> Molecular function: GO:0016922 [ligand-dependent nuclear receptor binding] evidence: ISS
            GeneID:3670 -> Molecular function: GO:0030331 [estrogen receptor binding] evidence: ISS
            GeneID:3670 -> Molecular function: GO:0043425 [bHLH transcription factor binding] evidence: IPI
            GeneID:3670 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: ISS
            GeneID:3670 -> Biological process: GO:0001755 [neural crest cell migration] evidence: IEA
            GeneID:3670 -> Biological process: GO:0003139 [secondary heart field specification] evidence: IMP
            GeneID:3670 -> Biological process: GO:0003148 [outflow tract septum morphogenesis] evidence: ISS
            GeneID:3670 -> Biological process: GO:0003151 [outflow tract morphogenesis] evidence: ISS
            GeneID:3670 -> Biological process: GO:0003203 [endocardial cushion morphogenesis] evidence: ISS
            GeneID:3670 -> Biological process: GO:0003215 [cardiac right ventricle morphogenesis] evidence: ISS
            GeneID:3670 -> Biological process: GO:0003266 [regulation of secondary heart field cardioblast proliferation] evidence: IEA
            GeneID:3670 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
            GeneID:3670 -> Biological process: GO:0010575 [positive regulation vascular endothelial growth factor production] evidence: ISS
            GeneID:3670 -> Biological process: GO:0021520 [spinal cord motor neuron cell fate specification] evidence: IEA
            GeneID:3670 -> Biological process: GO:0021522 [spinal cord motor neuron differentiation] evidence: ISS
            GeneID:3670 -> Biological process: GO:0021524 [visceral motor neuron differentiation] evidence: IEA
            GeneID:3670 -> Biological process: GO:0021559 [trigeminal nerve development] evidence: ISS
            GeneID:3670 -> Biological process: GO:0021983 [pituitary gland development] evidence: IEA
            GeneID:3670 -> Biological process: GO:0031016 [pancreas development] evidence: ISS
            GeneID:3670 -> Biological process: GO:0031103 [axon regeneration] evidence: IEA
            GeneID:3670 -> Biological process: GO:0031290 [retinal ganglion cell axon guidance] evidence: IEA
            GeneID:3670 -> Biological process: GO:0032024 [positive regulation of insulin secretion] evidence: IC
            GeneID:3670 -> Biological process: GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production] evidence: ISS
            GeneID:3670 -> Biological process: GO:0032729 [positive regulation of interferon-gamma production] evidence: ISS
            GeneID:3670 -> Biological process: GO:0032730 [positive regulation of interleukin-1 alpha production] evidence: ISS
            GeneID:3670 -> Biological process: GO:0032731 [positive regulation of interleukin-1 beta production] evidence: ISS
            GeneID:3670 -> Biological process: GO:0032735 [positive regulation of interleukin-12 production] evidence: ISS
            GeneID:3670 -> Biological process: GO:0032755 [positive regulation of interleukin-6 production] evidence: ISS
            GeneID:3670 -> Biological process: GO:0032760 [positive regulation of tumor necrosis factor production] evidence: ISS
            GeneID:3670 -> Biological process: GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway] evidence: ISS
            GeneID:3670 -> Biological process: GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein] evidence: IEA
            GeneID:3670 -> Biological process: GO:0043388 [positive regulation of DNA binding] evidence: IEA
            GeneID:3670 -> Biological process: GO:0043524 [negative regulation of neuron apoptotic process] evidence: ISS
            GeneID:3670 -> Biological process: GO:0045665 [negative regulation of neuron differentiation] evidence: IEA
            GeneID:3670 -> Biological process: GO:0045766 [positive regulation of angiogenesis] evidence: ISS
            GeneID:3670 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: ISS
            GeneID:3670 -> Biological process: GO:0048665 [neuron fate specification] evidence: ISS
            GeneID:3670 -> Biological process: GO:0048762 [mesenchymal cell differentiation] evidence: ISS
            GeneID:3670 -> Biological process: GO:0048880 [sensory system development] evidence: ISS
            GeneID:3670 -> Biological process: GO:0048936 [peripheral nervous system neuron axonogenesis] evidence: ISS
            GeneID:3670 -> Biological process: GO:0050728 [negative regulation of inflammatory response] evidence: ISS
            GeneID:3670 -> Biological process: GO:0055010 [ventricular cardiac muscle tissue morphogenesis] evidence: ISS
            GeneID:3670 -> Biological process: GO:0060037 [pharyngeal system development] evidence: ISS
            GeneID:3670 -> Biological process: GO:0060379 [cardiac muscle cell myoblast differentiation] evidence: IEA
            GeneID:3670 -> Biological process: GO:0060384 [innervation] evidence: ISS
            GeneID:3670 -> Biological process: GO:0060413 [atrial septum morphogenesis] evidence: ISS
            GeneID:3670 -> Biological process: GO:0060913 [cardiac cell fate determination] evidence: IDA
            GeneID:3670 -> Biological process: GO:0071385 [cellular response to glucocorticoid stimulus] evidence: ISS
            GeneID:3670 -> Biological process: GO:0071657 [positive regulation of granulocyte colony-stimulating factor production] evidence: ISS
            GeneID:3670 -> Biological process: GO:0090074 [negative regulation of protein homodimerization activity] evidence: ISS
            GeneID:3670 -> Biological process: GO:0090090 [negative regulation of canonical Wnt receptor signaling pathway] evidence: IEA
            GeneID:3670 -> Biological process: GO:1901258 [positive regulation of macrophage colony-stimulating factor production] evidence: ISS
            GeneID:3670 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
            GeneID:3670 -> Cellular component: GO:0005737 [cytoplasm] evidence: NAS