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2024-04-25 08:56:01, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001813 8630 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens centromere protein E, 312kDa (CENPE), mRNA.
ACCESSION NM_001813
VERSION NM_001813.2 GI:71061467
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8630)
AUTHORS Weng,M.T., Lee,J.H., Wei,S.C., Li,Q., Shahamatdar,S., Hsu,D.,
Schetter,A.J., Swatkoski,S., Mannan,P., Garfield,S., Gucek,M.,
Kim,M.K., Annunziata,C.M., Creighton,C.J., Emanuele,M.J.,
Harris,C.C., Sheu,J.C., Giaccone,G. and Luo,J.
TITLE Evolutionarily conserved protein ERH controls CENP-E mRNA splicing
and is required for the survival of KRAS mutant cancer cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (52), E3659-E3667 (2012)
PUBMED 23236152
REMARK GeneRIF: Evolutionarily conserved protein ERH controls CENP-E mRNA
splicing and is required for the survival of KRAS mutant cancer
cells.
REFERENCE 2 (bases 1 to 8630)
AUTHORS Kumar,A. and Purohit,R.
TITLE Computational screening and molecular dynamics simulation of
disease associated nsSNPs in CENP-E
JOURNAL Mutat. Res. 738-739, 28-37 (2012)
PUBMED 22974711
REMARK GeneRIF: In this study we investigated the pathogenic effect of 132
nsSNPs reported in CENP-E using computational platform.
REFERENCE 3 (bases 1 to 8630)
AUTHORS Guo,Y., Kim,C., Ahmad,S., Zhang,J. and Mao,Y.
TITLE CENP-E--dependent BubR1 autophosphorylation enhances chromosome
alignment and the mitotic checkpoint
JOURNAL J. Cell Biol. 198 (2), 205-217 (2012)
PUBMED 22801780
REMARK GeneRIF: It was shown that the state of CENP-E-dependent BubR1
autophosphorylation in response to spindle microtubule capture by
CENP-E is important for kinetochore function in achieving accurate
chromosome segregation.
REFERENCE 4 (bases 1 to 8630)
AUTHORS Sardar,H.S. and Gilbert,S.P.
TITLE Microtubule capture by mitotic kinesin centromere protein E
(CENP-E)
JOURNAL J. Biol. Chem. 287 (30), 24894-24904 (2012)
PUBMED 22637578
REMARK GeneRIF: the unusually slow CENP-E microtubule association step
favors CENP-E binding of stable microtubules over dynamic ones, a
mechanism that would bias CENP-E binding to kinetochore fibers.
REFERENCE 5 (bases 1 to 8630)
AUTHORS Logarinho,E., Maffini,S., Barisic,M., Marques,A., Toso,A.,
Meraldi,P. and Maiato,H.
TITLE CLASPs prevent irreversible multipolarity by ensuring spindle-pole
resistance to traction forces during chromosome alignment
JOURNAL Nat. Cell Biol. 14 (3), 295-303 (2012)
PUBMED 22307330
REMARK GeneRIF: Data show that CENP-E-mediated traction forces on
misaligned chromosomes are responsible for the irreversible loss of
spindle-pole integrity in CLASP1/2-depleted cells.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 8630)
AUTHORS Wood,K.W., Sakowicz,R., Goldstein,L.S. and Cleveland,D.W.
TITLE CENP-E is a plus end-directed kinetochore motor required for
metaphase chromosome alignment
JOURNAL Cell 91 (3), 357-366 (1997)
PUBMED 9363944
REFERENCE 7 (bases 1 to 8630)
AUTHORS Thrower,D.A., Jordan,M.A., Schaar,B.T., Yen,T.J. and Wilson,L.
TITLE Mitotic HeLa cells contain a CENP-E-associated minus end-directed
microtubule motor
JOURNAL EMBO J. 14 (5), 918-926 (1995)
PUBMED 7889940
REFERENCE 8 (bases 1 to 8630)
AUTHORS Testa,J.R., Zhou,J.Y., Bell,D.W. and Yen,T.J.
TITLE Chromosomal localization of the genes encoding the kinetochore
proteins CENPE and CENPF to human chromosomes 4q24-->q25 and
1q32-->q41, respectively, by fluorescence in situ hybridization
JOURNAL Genomics 23 (3), 691-693 (1994)
PUBMED 7851898
REFERENCE 9 (bases 1 to 8630)
AUTHORS Yen,T.J., Li,G., Schaar,B.T., Szilak,I. and Cleveland,D.W.
TITLE CENP-E is a putative kinetochore motor that accumulates just before
mitosis
JOURNAL Nature 359 (6395), 536-539 (1992)
PUBMED 1406971
REFERENCE 10 (bases 1 to 8630)
AUTHORS Yen,T.J., Compton,D.A., Wise,D., Zinkowski,R.P., Brinkley,B.R.,
Earnshaw,W.C. and Cleveland,D.W.
TITLE CENP-E, a novel human centromere-associated protein required for
progression from metaphase to anaphase
JOURNAL EMBO J. 10 (5), 1245-1254 (1991)
PUBMED 2022189
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
Z15005.1, AU100312.1, BQ434767.1, BQ231878.1, CD644410.1,
AC079919.5, AL596934.1, AW499901.1, CN418651.1, AA210858.1,
AA210728.1 and BQ447425.1.
On Jul 22, 2005 this sequence version replaced gi:4502780.
Summary: Centrosome-associated protein E is a kinesin-like motor
protein that accumulates in the G2 phase of the cell cycle. Unlike
other centrosome-associated proteins, it is not present during
interphase and first appears at the centromere region of
chromosomes during prometaphase. CENPE is proposed to be one of the
motors responsible for mammalian chromosome movement and/or spindle
elongation. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support ERS025081, ERS025082
[ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-65 Z15005.1 1-65
66-332 AU100312.1 7-273
333-965 Z15005.1 333-965
966-1252 BQ434767.1 382-668
1253-1785 Z15005.1 1253-1785
1786-2116 BQ231878.1 22-352 c
2117-2793 Z15005.1 2117-2793
2794-3189 CD644410.1 306-701
3190-3978 Z15005.1 3190-3978
3979-4224 AC079919.5 47376-47621 c
4225-4692 Z15005.1 4225-4692
4693-5168 AL596934.1 102-577
5169-5714 Z15005.1 5169-5714
5715-5930 AW499901.1 371-586
5931-6111 Z15005.1 5931-6111
6112-6358 CN418651.1 155-401
6359-6608 AA210858.1 110-359
6609-6658 Z15005.1 6495-6544
6659-7101 AA210728.1 1-443 c
7102-8371 Z15005.1 6988-8257
8372-8630 BQ447425.1 1-259 c
FEATURES Location/Qualifiers
source 1..8630
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q24-q25"
gene 1..8630
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/note="centromere protein E, 312kDa"
/db_xref="GeneID:1062"
/db_xref="HGNC:1856"
/db_xref="MIM:117143"
exon 1..146
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
misc_feature 25..27
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/note="upstream in-frame stop codon"
CDS 91..8196
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/note="Centromere autoantigen E (312kD); kinesin family
member 10; kinesin-related protein CENPE; protein
phosphatase 1, regulatory subunit 61"
/codon_start=1
/product="centromere-associated protein E"
/protein_id="NP_001804.2"
/db_xref="GI:71061468"
/db_xref="CCDS:CCDS34042.1"
/db_xref="GeneID:1062"
/db_xref="HGNC:1856"
/db_xref="MIM:117143"
/translation="
MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKTQ
"
mat_peptide 91..8184
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/product="Centromere-associated protein E"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q02224.2)"
misc_feature 106..1098
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/note="Kinesin motor, catalytic domain. ATPase; Region:
KISc; smart00129"
/db_xref="CDD:197527"
misc_feature 106..1077
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/note="Kinesin motor domain, CENP-E/KIP2-like subgroup,
involved in chromosome movement and/or spindle elongation
during mitosis. This catalytic (head) domain has ATPase
activity and belongs to the larger group of P-loop
NTPases. Kinesins are...; Region: KISc_CENP_E; cd01374"
/db_xref="CDD:30096"
misc_feature order(130..132,346..348,355..357,361..372,793..795)
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:30096"
misc_feature order(940..942,949..951,958..960)
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/note="microtubule interaction site [polypeptide binding];
other site"
/db_xref="CDD:30096"
misc_feature 1354..1356
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1450..1452
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1921..1923
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3721..3723
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3784..6303
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/note="Chromosome segregation ATPases [Cell division and
chromosome partitioning]; Region: Smc; COG1196"
/db_xref="CDD:31389"
misc_feature 3892..3894
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 5113..7812
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
pfam02463"
/db_xref="CDD:202246"
misc_feature 6466..7518
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q02224.2);
Region: Kinetochore-binding domain"
misc_feature 7618..8184
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q02224.2);
Region: Globular autoinhibitory domain (By similarity)"
misc_feature 7912..7914
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 8005..8007
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 8029..8031
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q02224.2); phosphorylation site"
misc_feature 8041..8043
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 8050..8052
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 147..238
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
variation 155
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/replace="c"
/replace="t"
/db_xref="dbSNP:11552738"
exon 239..328
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 329..447
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
variation 333
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/replace="c"
/replace="t"
/db_xref="dbSNP:2290943"
exon 448..567
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 568..649
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 650..717
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 718..783
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 784..835
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 836..923
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 924..1053
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 1054..1173
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 1174..1332
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 1333..1480
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 1481..1569
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 1570..1737
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 1738..1812
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 1813..1932
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 1933..2055
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 2056..2221
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
variation 2115
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/replace="a"
/replace="g"
/db_xref="dbSNP:2251634"
exon 2222..2376
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 2377..2691
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 2692..2964
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 2965..3123
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 3124..3327
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 3328..3486
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 3487..3777
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 3778..3933
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 3934..4224
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 4225..4503
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 4504..4662
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 4663..4947
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 4948..5235
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 5236..5394
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 5395..5553
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 5554..5844
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 5845..6003
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 6004..6294
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 6295..6393
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 6394..6612
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 6613..6810
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
variation 6659
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/replace="c"
/replace="g"
/db_xref="dbSNP:1049660"
exon 6811..7014
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 7015..7233
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 7234..7419
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 7420..7532
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 7533..7630
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 7631..7814
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 7815..8101
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
exon 8102..8612
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/inference="alignment:Splign:1.39.8"
STS 8123..8283
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/standard_name="STS-Z15005"
/db_xref="UniSTS:12315"
STS 8197..8371
/gene="CENPE"
/gene_synonym="CENP-E; KIF10; PPP1R61"
/standard_name="D4S2810"
/db_xref="UniSTS:10197"
ORIGIN
taaatttaaaggcggggcggcctgtgagccctgaagtgccggccgcggagggtcctggccattttcctgggaccagttcagcctgataggatggcggaggaaggagccgtggccgtctgcgtgcgagtgcggccgctgaacagcagagaagaatcacttggagaaactgcccaagtttactggaaaactgacaataatgtcatttatcaagttgatggaagtaaatccttcaattttgatcgtgtctttcatggtaatgaaactaccaaaaatgtgtatgaagaaatagcagcaccaatcatcgattctgccatacaaggctacaatggtactatatttgcctatggacagactgcttcaggaaaaacatataccatgatgggttcagaagatcatttgggagttatacccagggcaattcatgacattttccaaaaaattaagaagtttcctgatagggaatttctcttacgtgtatcttacatggaaatatacaatgaaaccattacagatttactctgtggcactcaaaaaatgaaacctttaattattcgagaagatgtcaataggaatgtgtatgttgctgatctcacagaagaagttgtatatacatcagaaatggctttgaaatggattacaaagggagaaaagagcaggcattatggagaaacaaaaatgaatcaaagaagcagtcgttctcataccatctttaggatgattttggaaagcagagagaagggtgaaccttctaattgtgaaggatctgttaaggtatcccatttgaatttggttgatcttgcaggcagtgaaagagctgctcaaacaggcgctgcaggtgtgcggctcaaggaaggctgtaatataaatcgaagcttatttattttgggacaagtgatcaagaaacttagtgatggacaagttggtggtttcataaattatcgagatagcaagttaacacgaattctccagaattccttgggaggaaatgcaaagacacgtattatctgcacaattactccagtatcttttgatgaaacacttactgctctccagtttgccagtactgctaaatatatgaagaatactccttatgttaatgaggtatcaactgatgaagctctcctgaaaaggtatagaaaagaaataatggatcttaaaaaacaattagaggaggtttctttagagacgcgggctcaggcaatggaaaaagaccaattggcccaacttttggaagaaaaagatttgcttcagaaagtacagaatgagaaaattgaaaacttaacacggatgctggtgacctcttcttccctcacgttgcaacaggaattaaaggctaaaagaaaacgaagagttacttggtgccttggcaaaattaacaaaatgaagaactcaaactatgcagatcaatttaatataccaacaaatataacaacaaaaacacataagctttctataaatttattacgagaaattgatgaatctgtctgttcagagtctgatgttttcagtaacactcttgatacattaagtgagatagaatggaatccagcaacaaagctactaaatcaggagaatatagaaagtgagttgaactcacttcgtgctgactatgataatctggtattagactatgaacaactacgaacagaaaaagaagaaatggaattgaaattaaaagaaaagaatgatttggatgaatttgaggctctagaaagaaaaactaaaaaagatcaagagatgcaactaattcatgaaatttcgaacttaaagaatttagttaagcatgcagaagtatataatcaagatcttgagaatgaactcagttcaaaagtagagctgcttagagaaaaggaagaccagattaagaagctacaggaatacatagactctcaaaagctagaaaatataaaaatggacttgtcatactcattggaaagcattgaagacccaaaacaaatgaagcagactctgtttgatgctgaaactgtagcccttgatgccaagagagaatcagcctttcttagaagtgaaaatctggagctgaaggagaaaatgaaagaacttgcaactacatacaagcaaatggaaaatgatattcagttatatcaaagccagttggaggcaaaaaagaaaatgcaagttgatctggagaaagaattacaatctgcttttaatgagataacaaaactcacctcccttatagatggcaaagttccaaaagatttgctctgtaatttggaattggaaggaaagattactgatcttcagaaagaactaaataaagaagttgaagaaaatgaagctttgcgggaagaagtcattttgctttcagaattgaaatctttaccttctgaagtagaaaggctgaggaaagagatacaagacaaatctgaagagctccatataataacatcagaaaaagataaattgttttctgaagtagttcataaggagagtagagttcaaggtttacttgaagaaattgggaaaacaaaagatgacctagcaactacacagtcgaattataaaagcactgatcaagaattccaaaatttcaaaacccttcatatggactttgagcaaaagtataagatggtccttgaggagaatgagagaatgaatcaggaaatagttaatctctctaaagaagcccaaaaatttgattcgagtttgggtgctttgaagaccgagctttcttacaagacccaagaacttcaggagaaaacacgtgaggttcaagaaagactaaatgagatggaacagctgaaggaacaattagaaaatagagattctacgctgcaaactgtagaaagggagaaaacactgattactgagaaactgcagcaaactttagaagaagtaaaaactttaactcaagaaaaagatgatctaaaacaactccaagaaagcttgcaaattgagagggaccaactcaaaagtgatattcacgatactgttaacatgaatatagatactcaagaacaattacgaaatgctcttgagtctctgaaacaacatcaagaaacaattaatacactaaaatcgaaaatttctgaggaagtttccaggaatttgcatatggaggaaaatacaggagaaactaaagatgaatttcagcaaaagatggttggcatagataaaaaacaggatttggaagctaaaaatacccaaacactaactgcagatgttaaggataatgagataattgagcaacaaaggaagatattttctttaatacaggagaaaaatgaactccaacaaatgttagagagtgttatagcagaaaaggaacaattgaagactgacctaaaggaaaatattgaaatgaccattgaaaaccaggaagaattaagacttcttggggatgaacttaaaaagcaacaagagatagttgcacaagaaaagaaccatgccataaagaaagaaggagagctttctaggacctgtgacagactggcagaagttgaagaaaaactaaaggaaaagagccagcaactccaagaaaaacagcaacaacttcttaatgtacaagaagagatgagtgagatgcagaaaaagattaatgaaatagagaatttaaagaatgaattaaagaacaaagaattgacattggaacatatggaaacagagaggcttgagttggctcagaaacttaatgaaaattatgaggaagtgaaatctataaccaaagaaagaaaagttctaaaggaattacagaagtcatttgaaacagagagagaccaccttagaggatatataagagaaattgaagctacaggcctacaaaccaaagaagaactaaaaattgctcatattcacctaaaagaacaccaagaaactattgatgaactaagaagaagcgtatctgagaagacagctcaaataataaatactcaggacttagaaaaatcccataccaaattacaagaagagatcccagtgcttcatgaggaacaagagttactgcctaatgtgaaagaagtcagtgagactcaggaaacaatgaatgaactggagttattaacagaacagtccacaaccaaggactcaacaacactggcaagaatagaaatggaaaggctcaggttgaatgaaaaatttcaagaaagtcaggaagagataaaatctctaaccaaggaaagagacaaccttaaaacgataaaagaagcccttgaagttaaacatgaccagctgaaagaacatattagagaaactttggctaaaatccaggagtctcaaagcaaacaagaacagtccttaaatatgaaagaaaaagacaatgaaactaccaaaatcgtgagtgagatggagcaattcaaacccaaagattcagcactactaaggatagaaatagaaatgctcggattgtccaaaagacttcaagaaagtcatgatgaaatgaaatctgtagctaaggagaaagatgacctacagaggctgcaagaagttcttcaatctgaaagtgaccagctcaaagaaaacataaaagaaattgtagctaaacacctggaaactgaagaggaacttaaagttgctcattgttgcctgaaagaacaagaggaaactattaatgagttaagagtgaatctttcagagaaggaaactgaaatatcaaccattcaaaagcagttagaagcaatcaatgataaattacagaacaagatccaagagatttatgagaaagaggaacaatttaatataaaacaaattagtgaggttcaggaaaaagtgaatgaactgaaacaattcaaggagcatcgcaaagccaaggattcagcactacaaagtatagaaagtaagatgctcgagttgaccaacagacttcaagaaagtcaagaagaaatacaaattatgattaaggaaaaagaggaaatgaaaagagtacaggaggcccttcagatagagagagaccaactgaaagaaaacactaaagaaattgtagctaaaatgaaagaatctcaagaaaaagaatatcagtttcttaagatgacagctgtcaatgagactcaggagaaaatgtgtgaaatagaacacttgaaggagcaatttgagacccagaagttaaacctggaaaacatagaaacggagaatataaggttgactcagatactacatgaaaaccttgaagaaatgagatctgtaacaaaagaaagagatgaccttaggagtgtggaggagactctcaaagtagagagagaccagctcaaggaaaaccttagagaaactataactagagacctagaaaaacaagaggagctaaaaattgttcacatgcatctgaaggagcaccaagaaactattgataaactaagagggattgtttcagagaaaacaaatgaaatatcaaatatgcaaaaggacttagaacactcaaatgatgccttaaaagcacaggatctgaaaatacaagaggaactaagaattgctcacatgcatctgaaagagcagcaggaaactattgacaaactcagaggaattgtttctgagaagacagataaactatcaaatatgcaaaaagatttagaaaattcaaatgctaaattacaagaaaagattcaagaacttaaggcaaatgaacatcaacttattacgttaaaaaaagatgtcaatgagacacagaaaaaagtgtctgaaatggagcaactaaagaaacaaataaaagaccaaagcttaactctgagtaaattagaaatagagaatttaaatttggctcagaaacttcatgaaaaccttgaagaaatgaaatctgtaatgaaagaaagagataatctaagaagagtagaggagacactcaaactggagagagaccaactcaaggaaagcctgcaagaaaccaaagctagagatctggaaatacaacaggaactaaaaactgctcgtatgctatcaaaagaacacaaagaaactgttgataaacttagagaaaaaatttcagaaaagacaattcaaatttcagacattcaaaaggatttagataaatcaaaagatgaattacagaaaaagatccaagaacttcagaaaaaagaacttcaactgcttagagtgaaagaagatgtcaatatgagtcataaaaaaattaatgaaatggaacagttgaagaagcaatttgaggcccaaaacttatctatgcaaagtgtgagaatggataacttccagttgactaagaaacttcatgaaagccttgaagaaataagaattgtagctaaagaaagagatgagctaaggaggataaaagaatctctcaaaatggaaagggaccaattcatagcaaccttaagggaaatgatagctagagaccgacagaaccaccaagtaaaacctgaaaaaaggttactaagtgatggacaacagcaccttacggaaagcctgagagaaaagtgctctagaataaaagagcttttgaagagatactcagagatggatgatcattatgagtgcttgaatagattgtctcttgacttggagaaggaaattgaattccaaaaagagctttcaatgagagttaaagcaaacctctcacttccctatttacaaaccaaacacattgaaaaactttttactgcaaaccagagatgctccatggaattccacagaatcatgaagaaactgaagtatgtgttaagctatgttacaaaaataaaagaagaacaacatgaatccatcaataaatttgaaatggattttattgatgaagtggaaaagcaaaaggaattgctaattaaaatacagcaccttcaacaagattgtgatgtaccatccagagaattaagggatctcaaattgaaccagaatatggatctacatattgaggaaattctcaaagatttctcagaaagtgagttccctagcataaagactgaatttcaacaagtactaagtaataggaaagaaatgacacagtttttggaagagtggttaaatactcgttttgatatagaaaagcttaaaaatggcatccagaaagaaaatgataggatttgtcaagtgaataacttctttaataacagaataattgccataatgaatgaatcaacagagtttgaggaaagaagtgctaccatatccaaagagtgggaacaggacctgaaatcactgaaagagaaaaatgaaaaactatttaaaaactaccaaacattgaagacttccttggcatctggtgcccaggttaatcctaccacacaagacaataagaatcctcatgttacatcaagagctacacagttaaccacagagaaaattcgagagctggaaaattcactgcatgaagctaaagaaagtgctatgcataaggaaagcaagattataaagatgcagaaagaacttgaggtgactaatgacataatagcaaaacttcaagccaaagttcatgaatcaaataaatgccttgaaaaaacaaaagagacaattcaagtacttcaggacaaagttgctttaggagctaagccatataaagaagaaattgaagatctcaaaatgaagcttgtgaaaatagacctagagaaaatgaaaaatgccaaagaatttgaaaaggaaatcagtgctacaaaagccactgtagaatatcaaaaggaagttataaggctattgagagaaaatctcagaagaagtcaacaggcccaagatacctcagtgatatcagaacatactgatcctcagccttcaaataaacccttaacttgtggaggtggcagcggcattgtacaaaacacaaaagctcttattttgaaaagtgaacatataaggctagaaaaagaaatttctaagttaaagcagcaaaatgaacagctaataaaacaaaagaatgaattgttaagcaataatcagcatctttccaatgaggtcaaaacttggaaggaaagaacccttaaaagagaggctcacaaacaagtaacttgtgagaattctccaaagtctcctaaagtgactggaacagcttctaaaaagaaacaaattacaccctctcaatgcaaggaacggaatttacaagatcctgtgccaaaggaatcaccaaaatcttgtttttttgatagccgatcaaagtctttaccatcacctcatccagttcgctattttgataactcaagtttaggcctttgtccagaggtgcaaaatgcaggagcagagagtgtggattctcagccaggtccttggcacgcctcctcaggcaaggatgtgcctgagtgcaaaactcagtagactcctctttgtcacttctctggagatccagcattccttatttggaaatgactttgtttatgtgtctatccctggtaatgatgttgtagtgcagcttaatttcaattcagtctttactttgccactagagttgaaagataagggaacaggaaatgaatgcattgtggtaatttagaatggtgatagcaataccttcttcttgcatatggtaatacttttaaaagttgaattgttttatttatttgtatattttgtaaagaataaagttattgaaagaaatgtaaagttatctacatgacttagcatattccaaagcataatacatacattaatataaaacatcattttattaacaaaattgtaaatgtttttaataccttacacattcaataaatgtttagtagttctgaatcaccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1062 -> Molecular function: GO:0003777 [microtubule motor activity] evidence: IMP
GeneID:1062 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1062 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:1062 -> Molecular function: GO:0008017 [microtubule binding] evidence: IEA
GeneID:1062 -> Molecular function: GO:0043515 [kinetochore binding] evidence: IDA
GeneID:1062 -> Biological process: GO:0000089 [mitotic metaphase] evidence: TAS
GeneID:1062 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:1062 -> Biological process: GO:0007018 [microtubule-based movement] evidence: TAS
GeneID:1062 -> Biological process: GO:0007079 [mitotic chromosome movement towards spindle pole] evidence: TAS
GeneID:1062 -> Biological process: GO:0007080 [mitotic metaphase plate congression] evidence: TAS
GeneID:1062 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
GeneID:1062 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:1062 -> Biological process: GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] evidence: TAS
GeneID:1062 -> Biological process: GO:0045860 [positive regulation of protein kinase activity] evidence: IMP
GeneID:1062 -> Biological process: GO:0051301 [cell division] evidence: IEA
GeneID:1062 -> Biological process: GO:0051382 [kinetochore assembly] evidence: NAS
GeneID:1062 -> Cellular component: GO:0000775 [chromosome, centromeric region] evidence: IDA
GeneID:1062 -> Cellular component: GO:0000776 [kinetochore] evidence: IDA
GeneID:1062 -> Cellular component: GO:0000778 [condensed nuclear chromosome kinetochore] evidence: IEA
GeneID:1062 -> Cellular component: GO:0000779 [condensed chromosome, centromeric region] evidence: IDA
GeneID:1062 -> Cellular component: GO:0000940 [condensed chromosome outer kinetochore] evidence: TAS
GeneID:1062 -> Cellular component: GO:0005634 [nucleus] evidence: IMP
GeneID:1062 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:1062 -> Cellular component: GO:0005819 [spindle] evidence: IEA
GeneID:1062 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:1062 -> Cellular component: GO:0005871 [kinesin complex] evidence: IEA
GeneID:1062 -> Cellular component: GO:0005874 [microtubule] evidence: IDA
GeneID:1062 -> Cellular component: GO:0015630 [microtubule cytoskeleton] evidence: IDA
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DBCLS
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