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2024-04-20 05:06:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001618 4001 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens poly (ADP-ribose) polymerase 1 (PARP1), mRNA.
ACCESSION NM_001618
VERSION NM_001618.3 GI:156523967
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4001)
AUTHORS Zhao,W., Hu,L., Xu,J., Shen,H., Hu,Z., Ma,H., Shu,Y., Shao,Y. and
Yin,Y.
TITLE Polymorphisms in the base excision repair pathway modulate
prognosis of platinum-based chemotherapy in advanced non-small cell
lung cancer
JOURNAL Cancer Chemother. Pharmacol. 71 (5), 1287-1295 (2013)
PUBMED 23479135
REMARK GeneRIF: XRCC1 Arg399Gln, PARP1 Va1762Ala and APE1 Asp148Glu SNPs
in the base excision repair pathway may influence the prognosis of
advanced non-small cell lung cancer patients following
platinum-based chemotherapy
REFERENCE 2 (bases 1 to 4001)
AUTHORS Michels,J., Vitale,I., Galluzzi,L., Adam,J., Olaussen,K.A.,
Kepp,O., Senovilla,L., Talhaoui,I., Guegan,J., Enot,D.P.,
Talbot,M., Robin,A., Girard,P., Orear,C., Lissa,D.,
Sukkurwala,A.Q., Garcia,P., Behnam-Motlagh,P., Kohno,K., Wu,G.S.,
Brenner,C., Dessen,P., Saparbaev,M., Soria,J.C., Castedo,M. and
Kroemer,G.
TITLE Cisplatin resistance associated with PARP hyperactivation
JOURNAL Cancer Res. 73 (7), 2271-2280 (2013)
PUBMED 23554447
REMARK GeneRIF: PARP hyperactivation is associated with cisplatin
resistance in non-small cell lung carcinoma.
REFERENCE 3 (bases 1 to 4001)
AUTHORS Tchurikov,N.A., Kretova,O.V., Fedoseeva,D.M., Sosin,D.V.,
Grachev,S.A., Serebraykova,M.V., Romanenko,S.A., Vorobieva,N.V. and
Kravatsky,Y.V.
TITLE DNA double-strand breaks coupled with PARP1 and HNRNPA2B1 binding
sites flank coordinately expressed domains in human chromosomes
JOURNAL PLoS Genet. 9 (4), E1003429 (2013)
PUBMED 23593027
REMARK GeneRIF: our data suggest a novel type of gene regulation: a
coordinated transcription or silencing of gene clusters delimited
by DSB hot spots as well as PARP1 and HNRNPa2B1 binding sites.
REFERENCE 4 (bases 1 to 4001)
AUTHORS Loganathan,R., Selvaduray,K.R., Nesaretnam,K. and
Radhakrishnan,A.K.
TITLE Tocotrienols promote apoptosis in human breast cancer cells by
inducing poly(ADP-ribose) polymerase cleavage and inhibiting
nuclear factor kappa-B activity
JOURNAL Cell Prolif. 46 (2), 203-213 (2013)
PUBMED 23510475
REMARK GeneRIF: Apoptosis in breast cancer cells is induced by PARP
cleavage following vitamin E treatment.
REFERENCE 5 (bases 1 to 4001)
AUTHORS Leak,R.K., Zhang,L., Luo,Y., Li,P., Zhao,H., Liu,X., Ling,F.,
Jia,J., Chen,J. and Ji,X.
TITLE Peroxiredoxin 2 battles poly(ADP-ribose) polymerase 1- and
p53-dependent prodeath pathways after ischemic injury
JOURNAL Stroke 44 (4), 1124-1134 (2013)
PUBMED 23429506
REMARK GeneRIF: PRX2 battles poly(ADP-ribose) polymerase 1- and
p53-dependent prodeath pathways after ischemic injury
REFERENCE 6 (bases 1 to 4001)
AUTHORS Schreiber,V., Molinete,M., Boeuf,H., de Murcia,G. and Menissier-de
Murcia,J.
TITLE The human poly(ADP-ribose) polymerase nuclear localization signal
is a bipartite element functionally separate from DNA binding and
catalytic activity
JOURNAL EMBO J. 11 (9), 3263-3269 (1992)
PUBMED 1505517
REFERENCE 7 (bases 1 to 4001)
AUTHORS Baumgartner,M., Schneider,R., Auer,B., Herzog,H., Schweiger,M. and
Hirsch-Kauffmann,M.
TITLE Fluorescence in situ mapping of the human nuclear NAD+
ADP-ribosyltransferase gene (ADPRT) and two secondary sites to
human chromosomal bands 1q42, 13q34, and 14q24
JOURNAL Cytogenet. Cell Genet. 61 (3), 172-174 (1992)
PUBMED 1424803
REFERENCE 8 (bases 1 to 4001)
AUTHORS Simonin,F., Menissier-de Murcia,J., Poch,O., Muller,S.,
Gradwohl,G., Molinete,M., Penning,C., Keith,G. and de Murcia,G.
TITLE Expression and site-directed mutagenesis of the catalytic domain of
human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is
critical for activity
JOURNAL J. Biol. Chem. 265 (31), 19249-19256 (1990)
PUBMED 2121735
REFERENCE 9 (bases 1 to 4001)
AUTHORS Gradwohl,G., Menissier de Murcia,J.M., Molinete,M., Simonin,F.,
Koken,M., Hoeijmakers,J.H. and de Murcia,G.
TITLE The second zinc-finger domain of poly(ADP-ribose) polymerase
determines specificity for single-stranded breaks in DNA
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (8), 2990-2994 (1990)
PUBMED 2109322
REFERENCE 10 (bases 1 to 4001)
AUTHORS Ogura,T., Nyunoya,H., Takahashi-Masutani,M., Miwa,M., Sugimura,T.
and Esumi,H.
TITLE Characterization of a putative promoter region of the human
poly(ADP-ribose) polymerase gene: structural similarity to that of
the DNA polymerase beta gene
JOURNAL Biochem. Biophys. Res. Commun. 167 (2), 701-710 (1990)
PUBMED 2108670
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB097441.1, BC037545.1,
J03473.1 and AK225654.1.
On Aug 28, 2007 this sequence version replaced gi:11496989.
Summary: This gene encodes a chromatin-associated enzyme,
poly(ADP-ribosyl)transferase, which modifies various nuclear
proteins by poly(ADP-ribosyl)ation. The modification is dependent
on DNA and is involved in the regulation of various important
cellular processes such as differentiation, proliferation, and
tumor transformation and also in the regulation of the molecular
events involved in the recovery of cell from DNA damage. In
addition, this enzyme may be the site of mutation in Fanconi
anemia, and may participate in the pathophysiology of type I
diabetes. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK225654.1, J03473.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-574 DB097441.1 1-574
575-1022 BC037545.1 548-995
1023-1226 J03473.1 947-1150
1227-2455 BC037545.1 1200-2428
2456-3871 J03473.1 2380-3795
3872-4001 AK225654.1 3837-3966
FEATURES Location/Qualifiers
source 1..4001
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q41-q42"
gene 1..4001
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="poly (ADP-ribose) polymerase 1"
/db_xref="GeneID:142"
/db_xref="HGNC:270"
/db_xref="MIM:173870"
exon 1..291
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 155
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="g"
/db_xref="dbSNP:907187"
misc_feature 163..165
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="upstream in-frame stop codon"
variation 166
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="g"
/db_xref="dbSNP:11541662"
CDS 172..3216
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/EC_number="2.4.2.30"
/note="poly(ADP-ribose) synthetase; ADP-ribosyltransferase
NAD(+); poly (ADP-ribose) polymerase family, member 1;
ADP-ribosyltransferase (NAD+; poly (ADP-ribose)
polymerase); poly(ADP-ribosyl)transferase;
poly(ADP-ribose) polymerase; poly[ADP-ribose] synthase 1;
NAD(+) ADP-ribosyltransferase 1; ADP-ribosyltransferase
diphtheria toxin-like 1"
/codon_start=1
/product="poly [ADP-ribose] polymerase 1"
/protein_id="NP_001609.2"
/db_xref="GI:156523968"
/db_xref="CCDS:CCDS1554.1"
/db_xref="GeneID:142"
/db_xref="HGNC:270"
/db_xref="MIM:173870"
/translation="
MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
"
misc_feature 175..177
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylalanine; propagated from
UniProtKB/Swiss-Prot (P09874.4); acetylation site"
misc_feature 187..3162
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="poly [ADP-ribose] polymerase; Provisional; Region:
PLN03123"
/db_xref="CDD:178670"
misc_feature 205..441
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="Poly(ADP-ribose) polymerase and DNA-Ligase
Zn-finger region; Region: zf-PARP; pfam00645"
/db_xref="CDD:189650"
misc_feature 292..294
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P09874.4); phosphorylation site"
misc_feature 460..462
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P09874.4); acetylation site"
misc_feature 484..486
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P09874.4); acetylation site"
misc_feature 517..771
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="Poly(ADP-ribose) polymerase and DNA-Ligase
Zn-finger region; Region: zf-PARP; pfam00645"
/db_xref="CDD:189650"
misc_feature 562..564
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P09874.4); acetylation site"
misc_feature 706..708
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P09874.4); phosphorylation site"
misc_feature 790..798
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P09874.4);
Region: Nuclear localization signal"
misc_feature 832..849
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P09874.4);
Region: Nuclear localization signal"
misc_feature 1006..1167
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="PADR1 (NUC008) domain; Region: PADR1; pfam08063"
/db_xref="CDD:191934"
misc_feature 1273..1275
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P09874.4); phosphorylation site"
misc_feature 1288..1743
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P09874.4);
Region: Automodification domain"
misc_feature 1333..1554
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="BRCA1 C Terminus (BRCT) domain; Region: BRCT;
pfam00533"
/db_xref="CDD:201286"
misc_feature 1798..2106
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="WGR domain of poly(ADP-ribose) polymerase 1 and
similar proteins; Region: WGR_PARP1_like; cd08001"
/db_xref="CDD:153428"
misc_feature 1969..1971
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P09874.4); acetylation site"
misc_feature 2032..2034
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P09874.4); acetylation site"
misc_feature 2155..3162
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="Poly(ADP-ribose) polymerase (parp) catalytic domain
catalyses the covalent attachment of ADP-ribose units from
NAD+ to itself and to a limited number of other DNA
binding proteins, which decreases their affinity for DNA.
Poly(ADP-ribose) polymerase is a...; Region: parp_like;
cd01437"
/db_xref="CDD:30068"
misc_feature order(2155..2343,2350..2427,2440..2508,2530..2553)
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="parp regulatory domain; other site"
/db_xref="CDD:30068"
misc_feature order(2467..2469,2476..2481,2755..2760,2773..2775,
2803..2811,2857..2865,2881..2883,2890..2892,3133..3135)
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="Inhibitor contact residues; inhibition site"
/db_xref="CDD:30068"
misc_feature order(2467..2469,2479..2481,2755..2763,2785..2787,
2797..2805,2857..2859,2881..2883,2890..2892,3133..3135)
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/note="nad+ contact residues [chemical binding]; other
site"
/db_xref="CDD:30068"
misc_feature 2515..2517
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P09874.4); phosphorylation site"
exon 292..457
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 333
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="g"
/db_xref="dbSNP:3738708"
variation 414
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="t"
/db_xref="dbSNP:1805404"
exon 458..573
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
exon 574..788
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 693
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="g"
/db_xref="dbSNP:13306125"
variation 733
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="a"
/replace="g"
/db_xref="dbSNP:1805409"
exon 789..888
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
exon 889..1005
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
exon 1006..1182
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 1023
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="t"
/db_xref="dbSNP:1805414"
variation 1171
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="a"
/replace="g"
/db_xref="dbSNP:3219057"
exon 1183..1330
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 1227
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:1805415"
variation 1300
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230484"
variation 1319
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="a"
/replace="c"
/db_xref="dbSNP:3219062"
exon 1331..1471
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
STS 1454..1592
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/standard_name="RH70493"
/db_xref="UniSTS:3628"
exon 1472..1714
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
exon 1715..1783
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
exon 1784..1916
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
exon 1917..2112
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 2010
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="g"
/db_xref="dbSNP:1059011"
variation 2085
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="t"
/db_xref="dbSNP:13306137"
exon 2113..2241
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
exon 2242..2325
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 2253
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="a"
/replace="g"
/db_xref="dbSNP:13306138"
exon 2326..2448
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 2346
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="t"
/db_xref="dbSNP:13306119"
STS 2408..2525
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/standard_name="D1S2048E"
/db_xref="UniSTS:151523"
exon 2449..2577
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 2456
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="t"
/db_xref="dbSNP:1136410"
exon 2578..2676
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 2651
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="a"
/replace="g"
/db_xref="dbSNP:1136420"
exon 2677..2829
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 2816
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="t"
/db_xref="dbSNP:11541664"
exon 2830..2957
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 2894
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="a"
/replace="g"
/db_xref="dbSNP:1059040"
exon 2958..3019
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
variation 2990
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="a"
/replace="g"
/db_xref="dbSNP:3219145"
exon 3020..3134
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
exon 3135..3985
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/inference="alignment:Splign:1.39.8"
STS 3159..3809
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/standard_name="ADPRT_3241"
/db_xref="UniSTS:462018"
STS 3192..3436
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/standard_name="SHGC-76015"
/db_xref="UniSTS:23752"
variation 3231
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="t"
/db_xref="dbSNP:3219147"
variation 3250
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="g"
/db_xref="dbSNP:1064578"
STS 3306..3464
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/standard_name="RH11161"
/db_xref="UniSTS:91506"
variation 3311
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="a"
/replace="g"
/db_xref="dbSNP:13306133"
variation 3487
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="a"
/replace="c"
/db_xref="dbSNP:1804317"
variation 3586
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="t"
/db_xref="dbSNP:3219148"
STS 3727..3840
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/standard_name="G07110"
/db_xref="UniSTS:82324"
variation 3781
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="a"
/replace="t"
/db_xref="dbSNP:34588544"
variation 3823
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="c"
/replace="t"
/db_xref="dbSNP:8679"
STS 3828..3960
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/standard_name="SHGC-30345"
/db_xref="UniSTS:34448"
variation 3960
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
/replace="g"
/replace="t"
/db_xref="dbSNP:3219149"
polyA_signal 3961..3966
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
polyA_site 3985
/gene="PARP1"
/gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
PARP; PARP-1; PPOL"
ORIGIN
aggcatcagcaatctatcagggaacggcggtggccggtgcggcgtgttcggtggcggctctggccgctcaggcgcctgcggctgggtgagcgcacgcgaggcggcgaggcggcagcgtgtttctaggtcgtggcgtcgggcttccggagctttggcggcagctaggggaggatggcggagtcttcggataagctctatcgagtcgagtacgccaagagcgggcgcgcctcttgcaagaaatgcagcgagagcatccccaaggactcgctccggatggccatcatggtgcagtcgcccatgtttgatggaaaagtcccacactggtaccacttctcctgcttctggaaggtgggccactccatccggcaccctgacgttgaggtggatgggttctctgagcttcggtgggatgaccagcagaaagtcaagaagacagcggaagctggaggagtgacaggcaaaggccaggatggaattggtagcaaggcagagaagactctgggtgactttgcagcagagtatgccaagtccaacagaagtacgtgcaaggggtgtatggagaagatagaaaagggccaggtgcgcctgtccaagaagatggtggacccggagaagccacagctaggcatgattgaccgctggtaccatccaggctgctttgtcaagaacagggaggagctgggtttccggcccgagtacagtgcgagtcagctcaagggcttcagcctccttgctacagaggataaagaagccctgaagaagcagctcccaggagtcaagagtgaaggaaagagaaaaggcgatgaggtggatggagtggatgaagtggcgaagaagaaatctaaaaaagaaaaagacaaggatagtaagcttgaaaaagccctaaaggctcagaacgacctgatctggaacatcaaggacgagctaaagaaagtgtgttcaactaatgacctgaaggagctactcatcttcaacaagcagcaagtgccttctggggagtcggcgatcttggaccgagtagctgatggcatggtgttcggtgccctccttccctgcgaggaatgctcgggtcagctggtcttcaagagcgatgcctattactgcactggggacgtcactgcctggaccaagtgtatggtcaagacacagacacccaaccggaaggagtgggtaaccccaaaggaattccgagaaatctcttacctcaagaaattgaaggttaaaaaacaggaccgtatattccccccagaaaccagcgcctccgtggcggccacgcctccgccctccacagcctcggctcctgctgctgtgaactcctctgcttcagcagataagccattatccaacatgaagatcctgactctcgggaagctgtcccggaacaaggatgaagtgaaggccatgattgagaaactcggggggaagttgacggggacggccaacaaggcttccctgtgcatcagcaccaaaaaggaggtggaaaagatgaataagaagatggaggaagtaaaggaagccaacatccgagttgtgtctgaggacttcctccaggacgtctccgcctccaccaagagccttcaggagttgttcttagcgcacatcttgtccccttggggggcagaggtgaaggcagagcctgttgaagttgtggccccaagagggaagtcaggggctgcgctctccaaaaaaagcaagggccaggtcaaggaggaaggtatcaacaaatctgaaaagagaatgaaattaactcttaaaggaggagcagctgtggatcctgattctggactggaacactctgcgcatgtcctggagaaaggtgggaaggtcttcagtgccacccttggcctggtggacatcgttaaaggaaccaactcctactacaagctgcagcttctggaggacgacaaggaaaacaggtattggatattcaggtcctggggccgtgtgggtacggtgatcggtagcaacaaactggaacagatgccgtccaaggaggatgccattgagcacttcatgaaattatatgaagaaaaaaccgggaacgcttggcactccaaaaatttcacgaagtatcccaaaaagttctaccccctggagattgactatggccaggatgaagaggcagtgaagaagctgacagtaaatcctggcaccaagtccaagctccccaagccagttcaggacctcatcaagatgatctttgatgtggaaagtatgaagaaagccatggtggagtatgagatcgaccttcagaagatgcccttggggaagctgagcaaaaggcagatccaggccgcatactccatcctcagtgaggtccagcaggcggtgtctcagggcagcagcgactctcagatcctggatctctcaaatcgcttttacaccctgatcccccacgactttgggatgaagaagcctccgctcctgaacaatgcagacagtgtgcaggccaaggtggaaatgcttgacaacctgctggacatcgaggtggcctacagtctgctcaggggagggtctgatgatagcagcaaggatcccatcgatgtcaactatgagaagctcaaaactgacattaaggtggttgacagagattctgaagaagccgagatcatcaggaagtatgttaagaacactcatgcaaccacacacaatgcgtatgacttggaagtcatcgatatctttaagatagagcgtgaaggcgaatgccagcgttacaagccctttaagcagcttcataaccgaagattgctgtggcacgggtccaggaccaccaactttgctgggatcctgtcccagggtcttcggatagccccgcctgaagcgcccgtgacaggctacatgtttggtaaagggatctatttcgctgacatggtctccaagagtgccaactactgccatacgtctcagggagacccaataggcttaatcctgttgggagaagttgcccttggaaacatgtatgaactgaagcacgcttcacatatcagcaagttacccaagggcaagcacagtgtcaaaggtttgggcaaaactacccctgatccttcagctaacattagtctggatggtgtagacgttcctcttgggaccgggatttcatctggtgtgaatgacacctctctactatataacgagtacattgtctatgatattgctcaggtaaatctgaagtatctgctgaaactgaaattcaattttaagacctccctgtggtaattgggagaggtagccgagtcacacccggtggctctggtatgaattcacccgaagcgcttctgcaccaactcacctggccgctaagttgctgatgggtagtacctgtactaaaccacctcagaaaggattttacagaaacgtgttaaaggttttctctaacttctcaagtcccttgttttgtgttgtgtctgtggggaggggttgttttggggttgtttttgttttttcttgccaggtagataaaactgacatagagaaaaggctggagagagattctgttgcatagactagtcctatggaaaaaaccaagcttcgttagaatgtctgccttactggtttccccagggaaggaaaaatacacttccacccttttttctaagtgttcgtctttagttttgattttggaaagatgttaagcatttatttttagttaaaaataaaaactaatttcatactatttagattttcttttttatcttgcacttattgtcccctttttagttttttttgtttgcctcttgtggtgaggggtgtgggaagaccaaaggaaggaacgctaacaatttctcatacttagaaacaaaaagagctttccttctccaggaatactgaacatgggagctcttgaaatatgtagtattaaaagttgcatttgaaattcttgactttcttatgggcacttttgtcttccaaattaaaactctaccacaaatatacttacccaagggctaatagtaatactcgattaaaaatgcagatgccttctctaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:142 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:142 -> Molecular function: GO:0003950 [NAD+ ADP-ribosyltransferase activity] evidence: IDA
GeneID:142 -> Molecular function: GO:0003950 [NAD+ ADP-ribosyltransferase activity] evidence: TAS
GeneID:142 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:142 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
GeneID:142 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:142 -> Molecular function: GO:0047485 [protein N-terminus binding] evidence: IPI
GeneID:142 -> Molecular function: GO:0051287 [NAD binding] evidence: IEA
GeneID:142 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:142 -> Biological process: GO:0000723 [telomere maintenance] evidence: IEA
GeneID:142 -> Biological process: GO:0006281 [DNA repair] evidence: TAS
GeneID:142 -> Biological process: GO:0006284 [base-excision repair] evidence: IEA
GeneID:142 -> Biological process: GO:0006302 [double-strand break repair] evidence: IMP
GeneID:142 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: TAS
GeneID:142 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
GeneID:142 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
GeneID:142 -> Biological process: GO:0006471 [protein ADP-ribosylation] evidence: IDA
GeneID:142 -> Biological process: GO:0007179 [transforming growth factor beta receptor signaling pathway] evidence: TAS
GeneID:142 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:142 -> Biological process: GO:0016540 [protein autoprocessing] evidence: IEA
GeneID:142 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IDA
GeneID:142 -> Biological process: GO:0040009 [regulation of growth rate] evidence: IEA
GeneID:142 -> Biological process: GO:0042769 [DNA damage response, detection of DNA damage] evidence: IEA
GeneID:142 -> Biological process: GO:0070212 [protein poly-ADP-ribosylation] evidence: IDA
GeneID:142 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:142 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA
GeneID:142 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:142 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IDA
GeneID:142 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001609 -> EC 2.4.2.30
by
@meso_cacase at
DBCLS
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