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2024-04-20 08:01:55, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001402 3528 bp mRNA linear PRI 12-MAY-2013
DEFINITION Homo sapiens eukaryotic translation elongation factor 1 alpha 1
(EEF1A1), mRNA.
ACCESSION NM_001402
VERSION NM_001402.5 GI:83367078
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3528)
AUTHORS Yu,X., Liu,X., Liu,T., Hong,K., Lei,J., Yuan,R. and Shao,J.
TITLE Identification of a novel binding protein of FAT10: eukaryotic
translation elongation factor 1A1
JOURNAL Dig. Dis. Sci. 57 (9), 2347-2354 (2012)
PUBMED 22569823
REMARK GeneRIF: This study identified eEF1A1 as a FAT10-specific binding
protein, and when the expression of FAT10 was reduced by siRNA
knockdown, this resulted in downregulation of eEF1A1 expression in
hepatoma cells.
REFERENCE 2 (bases 1 to 3528)
AUTHORS Huang,Y., Hu,J.D., Qi,Y.L., Wu,Y.A., Zheng,J., Chen,Y.Y. and
Huang,X.L.
TITLE [Effect of knocking down eEF1A1 gene on proliferation and apoptosis
in Jurkat cells and its mechanisms]
JOURNAL Zhongguo Shi Yan Xue Ye Xue Za Zhi 20 (4), 835-841 (2012)
PUBMED 22931638
REMARK GeneRIF: Knocking down eEF1A1 gene has noticeable effects on the
proliferation inhibition and apoptosis induction of Jurkat cells.
REFERENCE 3 (bases 1 to 3528)
AUTHORS Lin,W.S., Jiao,B.Y., Wu,Y.L., Chen,W.N. and Lin,X.
TITLE Hepatitis B virus X protein blocks filamentous actin bundles by
interaction with eukaryotic translation elongat ion factor 1 alpha
1
JOURNAL J. Med. Virol. 84 (6), 871-877 (2012)
PUBMED 22499008
REMARK GeneRIF: In Huh-7 hepatoma cells, the hepatitis B virus X protein
inhibits dimer formation of eEF1A1, hence blocks filamentous actin
bundling.
REFERENCE 4 (bases 1 to 3528)
AUTHORS Itagaki,K., Naito,T., Iwakiri,R., Haga,M., Miura,S., Saito,Y.,
Owaki,T., Kamiya,S., Iyoda,T., Yajima,H., Iwashita,S., Ejiri,S. and
Fukai,F.
TITLE Eukaryotic translation elongation factor 1A induces anoikis by
triggering cell detachment
JOURNAL J. Biol. Chem. 287 (19), 16037-16046 (2012)
PUBMED 22399298
REMARK GeneRIF: Results show a new function of eEF1A that contributes to
cell regulation, including anoikis.
REFERENCE 5 (bases 1 to 3528)
AUTHORS Vui-Kee,K., Mohd Dali,A.Z., Mohamed Rose,I., Ghazali,R., Jamal,R.
and Mokhtar,N.M.
TITLE Molecular markers associated with nonepithelial ovarian cancer in
formalin-fixed, paraffin-embedded specimens by genome wide
expression profiling
JOURNAL Kaohsiung J. Med. Sci. 28 (5), 243-250 (2012)
PUBMED 22531302
REMARK GeneRIF: Overexpression of eukaryotic translation elongation factor
1 alpha 1 is associated with nonepithelial ovarian cancer.
REFERENCE 6 (bases 1 to 3528)
AUTHORS Madsen,H.O., Poulsen,K., Dahl,O., Clark,B.F. and Hjorth,J.P.
TITLE Retropseudogenes constitute the major part of the human elongation
factor 1 alpha gene family
JOURNAL Nucleic Acids Res. 18 (6), 1513-1516 (1990)
PUBMED 2183196
REFERENCE 7 (bases 1 to 3528)
AUTHORS Bec,G., Kerjan,P., Zha,X.D. and Waller,J.P.
TITLE Valyl-tRNA synthetase from rabbit liver. I. Purification as a
heterotypic complex in association with elongation factor 1
JOURNAL J. Biol. Chem. 264 (35), 21131-21137 (1989)
PUBMED 2556394
REFERENCE 8 (bases 1 to 3528)
AUTHORS Whiteheart,S.W., Shenbagamurthi,P., Chen,L., Cotter,R.J. and
Hart,G.W.
TITLE Murine elongation factor 1 alpha (EF-1 alpha) is
posttranslationally modified by novel amide-linked
ethanolamine-phosphoglycerol moieties. Addition of
ethanolamine-phosphoglycerol to specific glutamic acid residues on
EF-1 alpha
JOURNAL J. Biol. Chem. 264 (24), 14334-14341 (1989)
PUBMED 2569467
REFERENCE 9 (bases 1 to 3528)
AUTHORS Uetsuki,T., Naito,A., Nagata,S. and Kaziro,Y.
TITLE Isolation and characterization of the human chromosomal gene for
polypeptide chain elongation factor-1 alpha
JOURNAL J. Biol. Chem. 264 (10), 5791-5798 (1989)
PUBMED 2564392
REFERENCE 10 (bases 1 to 3528)
AUTHORS Motorin,Yu.A., Wolfson,A.D., Orlovsky,A.F. and Gladilin,K.L.
TITLE Mammalian valyl-tRNA synthetase forms a complex with the first
elongation factor
JOURNAL FEBS Lett. 238 (2), 262-264 (1988)
PUBMED 3169261
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff in
collaboration with Francesco Amaldi. The reference sequence was
derived from BC066893.1, AJ420488.1 and AL603910.6.
On Dec 8, 2005 this sequence version replaced gi:25453469.
Summary: This gene encodes an isoform of the alpha subunit of the
elongation factor-1 complex, which is responsible for the enzymatic
delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1)
is expressed in brain, placenta, lung, liver, kidney, and pancreas,
and the other isoform (alpha 2) is expressed in brain, heart and
skeletal muscle. This isoform is identified as an autoantigen in
66% of patients with Felty syndrome. This gene has been found to
have multiple copies on many chromosomes, some of which, if not
all, represent different pseudogenes. [provided by RefSeq, Jul
2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC066893.1, EF219140.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1747 BC066893.1 1-1747
1748-2631 AJ420488.1 1708-2591
2632-2632 AL603910.6 110144-110144 c
2633-3528 AJ420488.1 2593-3488
FEATURES Location/Qualifiers
source 1..3528
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q14.1"
gene 1..3528
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="eukaryotic translation elongation factor 1 alpha 1"
/db_xref="GeneID:1915"
/db_xref="HGNC:3189"
/db_xref="HPRD:00559"
/db_xref="MIM:130590"
exon 1..33
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/inference="alignment:Splign:1.39.8"
misc_feature 1
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="predominant transcription initiation site"
exon 34..207
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/inference="alignment:Splign:1.39.8"
misc_feature 40..42
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="upstream in-frame stop codon"
CDS 64..1452
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="cervical cancer suppressor 3; eukaryotic
translation elongation factor 1 alpha 1-like 14; leukocyte
receptor cluster (LRC) member 7; CTCL tumor antigen;
prostate tumor-inducing protein 1; EF1a-like protein;
glucocorticoid receptor AF-1 specific elongation factor;
elongation factor 1 alpha subunit; elongation factor Tu;
EF-1-alpha-1; eukaryotic elongation factor 1 A-1;
leukocyte receptor cluster member 7"
/codon_start=1
/product="elongation factor 1-alpha 1"
/protein_id="NP_001393.1"
/db_xref="GI:4503471"
/db_xref="CCDS:CCDS4980.1"
/db_xref="GeneID:1915"
/db_xref="HGNC:3189"
/db_xref="HPRD:00559"
/db_xref="MIM:130590"
/translation="
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
"
misc_feature 64..1359
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="elongation factor 1- alpha; Provisional; Region:
PTZ00141"
/db_xref="CDD:185474"
misc_feature 88..777
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="Elongation Factor 1-alpha (EF1-alpha) protein
family; Region: EF1_alpha; cd01883"
/db_xref="CDD:206670"
misc_feature 103..126
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="G1 box; other site"
/db_xref="CDD:206670"
misc_feature order(106..108,112..114,124..129,136..138,145..150,
289..294,346..351,418..423,568..570,580..582)
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="putative GEF interaction site [polypeptide
binding]; other site"
/db_xref="CDD:206670"
misc_feature order(112..114,118..129,520..525,529..531,643..651)
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206670"
misc_feature order(124..126,253..255,262..267,271..273,277..279,
283..291,295..297,328..330,334..336,340..348,352..354,
361..363)
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="EF1Balpha binding site [polypeptide binding]; other
site"
/db_xref="CDD:206670"
misc_feature 226..228
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6,N6-dimethyllysine; propagated from
UniProtKB/Swiss-Prot (P68104.1); methylation site"
misc_feature 259..291
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="Switch I region; other site"
/db_xref="CDD:206670"
misc_feature 277..279
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="G2 box; other site"
/db_xref="CDD:206670"
misc_feature 319..321
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 334..345
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="G3 box; other site"
/db_xref="CDD:206670"
misc_feature 340..396
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="Switch II region; other site"
/db_xref="CDD:206670"
misc_feature 520..531
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="G4 box; other site"
/db_xref="CDD:206670"
misc_feature 556..558
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6,N6-dimethyllysine; propagated from
UniProtKB/Swiss-Prot (P68104.1); methylation site"
misc_feature 643..651
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="G5 box; other site"
/db_xref="CDD:206670"
misc_feature 763..765
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/experiment="experimental evidence, no additional details
recorded"
/note="S-nitrosylation site; modified site"
misc_feature 787..1059
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="EF1_alpha_II: this family represents the domain II
of elongation factor 1-alpha (EF-1a) that is found in
archaea and all eukaryotic lineages. EF-1A is very
abundant in the cytosol, where it is involved in the
GTP-dependent binding of aminoacyl-tRNAs to...; Region:
EF1_alpha_II; cd03693"
/db_xref="CDD:239664"
misc_feature 961..963
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by TGFBR1; propagated from
UniProtKB/Swiss-Prot (P68104.1); phosphorylation site"
misc_feature 964..966
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/experiment="experimental evidence, no additional details
recorded"
/note="5-glutamyl glycerylphosphorylethanolamine;
propagated from UniProtKB/Swiss-Prot (P68104.1);
phosphorylation site"
misc_feature 1066..1359
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/note="Domain III of EF-1. Eukaryotic elongation factor 1
(EF-1) is responsible for the GTP-dependent binding of
aminoacyl-tRNAs to ribosomes. EF-1 is composed of four
subunits: the alpha chain, which binds GTP and
aminoacyl-tRNAs, the gamma chain that probably...; Region:
EF1_alpha_III; cd03705"
/db_xref="CDD:239676"
misc_feature 1183..1185
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/experiment="experimental evidence, no additional details
recorded"
/note="5-glutamyl glycerylphosphorylethanolamine;
propagated from UniProtKB/Swiss-Prot (P68104.1);
phosphorylation site"
misc_feature 1294..1296
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/experiment="experimental evidence, no additional details
recorded"
/note="glutathionylation site; modified site"
misc_feature 1357..1359
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PASK; propagated from
UniProtKB/Swiss-Prot (P68104.1); phosphorylation site"
misc_feature 1357..1359
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01501"
STS 126..548
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="MARC_24185-24186:1034710364:1"
/db_xref="UniSTS:268853"
exon 208..387
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/inference="alignment:Splign:1.39.8"
variation 326
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11556658"
variation 334
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11550816"
variation 338
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11550792"
variation 355
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11550789"
variation 360
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11556654"
variation 365
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="a"
/replace="c"
/db_xref="dbSNP:11550840"
variation 366
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11550851"
variation 375
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11556662"
variation 381
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11556702"
variation 383
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11550818"
exon 388..684
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/inference="alignment:Splign:1.39.8"
STS 593..996
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="PMC26240P1"
/db_xref="UniSTS:272315"
STS 594..996
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="GDB:632624"
/db_xref="UniSTS:158480"
exon 685..835
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/inference="alignment:Splign:1.39.8"
variation 765
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11556692"
STS 820..1657
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="EEF1A1_3552"
/db_xref="UniSTS:462171"
exon 836..1092
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/inference="alignment:Splign:1.39.8"
STS 858..1532
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="ECD01636"
/db_xref="UniSTS:282737"
exon 1093..1327
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/inference="alignment:Splign:1.39.8"
variation 1135
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11550843"
STS 1139..2102
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="stSG625947"
/db_xref="UniSTS:457113"
STS 1253..1386
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="RH47178"
/db_xref="UniSTS:90057"
exon 1328..3512
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/inference="alignment:Splign:1.39.8"
STS 1344..1502
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="SHGC-178"
/db_xref="UniSTS:91474"
STS 1351..1477
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="RH65848"
/db_xref="UniSTS:84955"
STS 1375..1532
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="EEF1A1"
/db_xref="UniSTS:278329"
STS 1457..1731
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="D1S3313"
/db_xref="UniSTS:63106"
STS 1513..1717
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="GDB:555019"
/db_xref="UniSTS:157667"
STS 1603..2470
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="ECD01365"
/db_xref="UniSTS:282471"
polyA_signal 1726..1731
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
STS 1738..1963
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="REN33105"
/db_xref="UniSTS:357905"
STS 1740..1992
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="REN33104"
/db_xref="UniSTS:357904"
polyA_site 1747
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/experiment="experimental evidence, no additional details
recorded"
/note="predominant polyadenylation site"
STS 1966..2215
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="REN33103"
/db_xref="UniSTS:357903"
STS 2083..3135
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="stSG625946"
/db_xref="UniSTS:457112"
STS 2214..2461
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="REN33102"
/db_xref="UniSTS:357902"
variation 2318
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="a"
/replace="g"
/db_xref="dbSNP:41501347"
STS 2459..2724
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="REN33101"
/db_xref="UniSTS:357901"
STS 2701..2969
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="REN33100"
/db_xref="UniSTS:357900"
variation 2740
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/replace="a"
/replace="c"
/db_xref="dbSNP:1128073"
STS 2741..2845
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="D11S2560"
/db_xref="UniSTS:37928"
STS 2924..3152
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="REN33099"
/db_xref="UniSTS:357899"
STS 3041..3272
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="REN33098"
/db_xref="UniSTS:357898"
STS 3056..3274
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
/standard_name="STS-W63684"
/db_xref="UniSTS:65109"
polyA_signal 3490..3495
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
polyA_site 3512
/gene="EEF1A1"
/gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1"
ORIGIN
ctttttcgcaacgggtttgccgccagaacacaggtgtcgtgaaaactacccctaaaagccaaaatgggaaaggaaaagactcatatcaacattgtcgtcattggacacgtagattcgggcaagtccaccactactggccatctgatctataaatgcggtggcatcgacaaaagaaccattgaaaaatttgagaaggaggctgctgagatgggaaagggctccttcaagtatgcctgggtcttggataaactgaaagctgagcgtgaacgtggtatcaccattgatatctccttgtggaaatttgagaccagcaagtactatgtgactatcattgatgccccaggacacagagactttatcaaaaacatgattacagggacatctcaggctgactgtgctgtcctgattgttgctgctggtgttggtgaatttgaagctggtatctccaagaatgggcagacccgagagcatgcccttctggcttacacactgggtgtgaaacaactaattgtcggtgttaacaaaatggattccactgagccaccctacagccagaagagatatgaggaaattgttaaggaagtcagcacttacattaagaaaattggctacaaccccgacacagtagcatttgtgccaatttctggttggaatggtgacaacatgctggagccaagtgctaacatgccttggttcaagggatggaaagtcacccgtaaggatggcaatgccagtggaaccacgctgcttgaggctctggactgcatcctaccaccaactcgtccaactgacaagcccttgcgcctgcctctccaggatgtctacaaaattggtggtattggtactgttcctgttggccgagtggagactggtgttctcaaacccggtatggtggtcacctttgctccagtcaacgttacaacggaagtaaaatctgtcgaaatgcaccatgaagctttgagtgaagctcttcctggggacaatgtgggcttcaatgtcaagaatgtgtctgtcaaggatgttcgtcgtggcaacgttgctggtgacagcaaaaatgacccaccaatggaagcagctggcttcactgctcaggtgattatcctgaaccatccaggccaaataagcgccggctatgcccctgtattggattgccacacggctcacattgcatgcaagtttgctgagctgaaggaaaagattgatcgccgttctggtaaaaagctggaagatggccctaaattcttgaagtctggtgatgctgccattgttgatatggttcctggcaagcccatgtgtgttgagagcttctcagactatccacctttgggtcgctttgctgttcgtgatatgagacagacagttgcggtgggtgtcatcaaagcagtggacaagaaggctgctggagctggcaaggtcaccaagtctgcccagaaagctcagaaggctaaatgaatattatccctaatacctgccaccccactcttaatcagtggtggaagaacggtctcagaactgtttgtttcaattggccatttaagtttagtagtaaaagactggttaatgataacaatgcatcgtaaaaccttcagaaggaaaggagaatgttttgtggaccactttggttttcttttttgcgtgtggcagttttaagttattagtttttaaaatcagtactttttaatggaaacaacttgaccaaaaatttgtcacagaattttgagacccattaaaaaagttaaatgagaaacctgtgtgttcctttggtcaacaccgagacatttaggtgaaagacatctaattctggttttacgaatctggaaacttcttgaaaatgtaattcttgagttaacacttctgggtggagaatagggttgttttccccccacataattggaaggggaaggaatatcatttaaagctatgggagggttgctttgattacaacactggagagaaatgcagcatgttgctgattgcctgtcactaaaacaggccaaaaactgagtccttgtgttgcatagaaagcttcatgttgctaaaccaatgttaagtgaatctttggaaacaaaatgtttccaaattactgggatgtgcatgttgaaacgtgggttaaaatgactgggcagtgaaagttgactatttgccatgacataagaaataagtgtagtggctagtgtacaccctatgagtggaagggtccattttgaagtcagtggagtaagctttatgccagtttgatggtttcacaagttctattgagtgctattcagaataggaacaaggttctaatagaaaaagatggcaatttgaagtagctataaaattagactaatctacattgcttttctcctgcagagtctaataccttttatgctttgataattagcagtttgtctacttggtcactaggaatgaaactacatggtaataggcttaacaggtgtaatagcccacttactcctgaatctttaagcatttgtgcatttgaaaaatgcttttcgcgatcttcctgctgggattacaggcatgagccactgtgcctgacctcccatatgtaaaagtgtctaaaggtttttttttggttataaaaggaaaatttttgcttaagtttgaaggataggtaaaattaaaggacatgctttctgtttgtgtgatggtttttaaaaattttttttaagatggagttcttgttgcccaggctagaatgcaatggcaaaatctcactgcaatctcctcctcctgggttcaagcaattctcctacttcagcctcccaagtagctgggattacaggcatgtgctaatttggtgtttttaatagagatgaggtttttccatgttggtcaggctggtctcaaactcctgaccttaggtgatcgcctcggcctcctaaagtgctggaattacaggcatgagccaccatgcctggccaggacatgtgttcttaaggacatgctaagcaggagttaaagcagcccaagagataaggcctcttaaagtgactggcaatgtgtattgctcaagattcaaaggtacttgaattggccatagacaagtctgtaatgaagtgttatcgttttccctcatctgagtctgaattagataaaatgccttcccatcagccagtgctctgaggtatcaagtctaaattgaactagagatttttgtccttagtttctttgctatctaatgtttacacaagtaaatagtctaagatttgctggatgacagaaaaaacaggtaaggcctttaatagatggccaatagatgccctgataatgaaagttgacacctgtaagatttaccagtagagaattcttgacatgcaaggaagcaagatttaactgaaaaattgttcccactggaagcaggaatgagtcagtttacttgcatatactgagattgagattaacttcctgtgaaacccagtgtcttagacaactgtggcttgagcaccacctgctggtattcattacaaacttgctcactacaataaatgaattttaagctttaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1915 -> Molecular function: GO:0003746 [translation elongation factor activity] evidence: TAS
GeneID:1915 -> Molecular function: GO:0003924 [GTPase activity] evidence: IEA
GeneID:1915 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1915 -> Molecular function: GO:0005525 [GTP binding] evidence: TAS
GeneID:1915 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
GeneID:1915 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:1915 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:1915 -> Biological process: GO:0006412 [translation] evidence: TAS
GeneID:1915 -> Biological process: GO:0006414 [translational elongation] evidence: TAS
GeneID:1915 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:1915 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
GeneID:1915 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:1915 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:1915 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
GeneID:1915 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:1915 -> Cellular component: GO:0005853 [eukaryotic translation elongation factor 1 complex] evidence: TAS
GeneID:1915 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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