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2024-04-20 06:06:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001278736 1319 bp mRNA linear PRI 17-JUL-2013
DEFINITION Homo sapiens chemokine (C-C motif) ligand 5 (CCL5), transcript
variant 2, mRNA.
ACCESSION NM_001278736
VERSION NM_001278736.1 GI:524563422
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1319)
AUTHORS Schnur E, Kessler N, Zherdev Y, Noah E, Scherf T, Ding FX,
Rabinovich S, Arshava B, Kurbatska V, Leonciks A, Tsimanis A, Rosen
O, Naider F and Anglister J.
TITLE NMR mapping of RANTES surfaces interacting with CCR5 using linked
extracellular domains
JOURNAL FEBS J. 280 (9), 2068-2084 (2013)
PUBMED 23480650
REMARK GeneRIF: N-terminal-CCR5 and extracellular loop 2 are the major
contributors to CCR5 binding to RANTES.
REFERENCE 2 (bases 1 to 1319)
AUTHORS Kaneko Y, Masuko H, Sakamoto T, Iijima H, Naito T, Yatagai Y,
Yamada H, Konno S, Nishimura M, Noguchi E and Hizawa N.
TITLE Asthma phenotypes in Japanese adults - their associations with the
CCL5 and ADRB2 genotypes
JOURNAL Allergol Int 62 (1), 113-121 (2013)
PUBMED 23267209
REMARK GeneRIF: The current cluster analysis identified meaningful adult
asthma phenotypes linked to the functional CCL5 and ADRB2
genotypes.
REFERENCE 3 (bases 1 to 1319)
AUTHORS Shin DY, Kim I, Kim JH, Lee YG, Kang EJ, Cho HJ, Lee KH, Kim HJ,
Park EH, Lee JE, Bae JY, See CJ, Yoon SS, Park SS, Han KS, Park MH,
Hong YC, Park S and Kim BK.
TITLE RANTES polymorphisms and the risk of graft-versus-host disease in
human leukocyte antigen-matched sibling allogeneic hematopoietic
stem cell transplantation
JOURNAL Acta Haematol. 129 (3), 137-145 (2013)
PUBMED 23207898
REMARK GeneRIF: This study suggests that RANTES polymorphisms might be
associated with the occurrence of acute GVHD rather than of chronic
GVHD and also of relapse-free survival in the patients treated with
allo-HSCT.
REFERENCE 4 (bases 1 to 1319)
AUTHORS Schlecker E, Stojanovic A, Eisen C, Quack C, Falk CS, Umansky V and
Cerwenka A.
TITLE Tumor-infiltrating monocytic myeloid-derived suppressor cells
mediate CCR5-dependent recruitment of regulatory T cells favoring
tumor growth
JOURNAL J. Immunol. 189 (12), 5602-5611 (2012)
PUBMED 23152559
REMARK GeneRIF: Tumor-infiltrating monocytic myeloid-derived suppressor
cells produce high levels of transgenic CCR5 ligands CCL3, CCL4,
and CCL5 and directly attract regulatory T cells (Tregs) in a
CCR5-dependent manner.
REFERENCE 5 (bases 1 to 1319)
AUTHORS Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC and Lusso P.
TITLE Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major
HIV-suppressive factors produced by CD8+ T cells
JOURNAL Science 270 (5243), 1811-1815 (1995)
PUBMED 8525373
REFERENCE 6 (bases 1 to 1319)
AUTHORS Nelson PJ, Kim HT, Manning WC, Goralski TJ and Krensky AM.
TITLE Genomic organization and transcriptional regulation of the RANTES
chemokine gene
JOURNAL J. Immunol. 151 (5), 2601-2612 (1993)
PUBMED 7689610
REFERENCE 7 (bases 1 to 1319)
AUTHORS Kameyoshi Y, Dorschner A, Mallet AI, Christophers E and Schroder
JM.
TITLE Cytokine RANTES released by thrombin-stimulated platelets is a
potent attractant for human eosinophils
JOURNAL J. Exp. Med. 176 (2), 587-592 (1992)
PUBMED 1380064
REFERENCE 8 (bases 1 to 1319)
AUTHORS Schall TJ, Bacon K, Toy KJ and Goeddel DV.
TITLE Selective attraction of monocytes and T lymphocytes of the memory
phenotype by cytokine RANTES
JOURNAL Nature 347 (6294), 669-671 (1990)
PUBMED 1699135
REFERENCE 9 (bases 1 to 1319)
AUTHORS Donlon TA, Krensky AM, Wallace MR, Collins FS, Lovett M and
Clayberger C.
TITLE Localization of a human T-cell-specific gene, RANTES (D17S136E), to
chromosome 17q11.2-q12
JOURNAL Genomics 6 (3), 548-553 (1990)
PUBMED 1691736
REFERENCE 10 (bases 1 to 1319)
AUTHORS Schall TJ, Jongstra J, Dyer BJ, Jorgensen J, Clayberger C, Davis MM
and Krensky AM.
TITLE A human T cell-specific molecule is a member of a new gene family
JOURNAL J. Immunol. 141 (3), 1018-1025 (1988)
PUBMED 2456327
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CD695497.1, CR980938.1,
CB111656.1, HY265548.1, AA443491.1, AW769950.1, GD136908.1 and
BG272739.1.
Summary: This gene is one of several chemokine genes clustered on
the q-arm of chromosome 17. Chemokines form a superfamily of
secreted proteins involved in immunoregulatory and inflammatory
processes. The superfamily is divided into four subfamilies based
on the arrangement of two N-terminal cysteine residues of the
mature peptide. This chemokine, a member of the CC subfamily,
functions as a chemoattractant for blood monocytes, memory T helper
cells and eosinophils. It causes the release of histamine from
basophils and activates eosinophils. This cytokine is one of the
major HIV-suppressive factors produced by CD8+ cells. It functions
as one of the natural ligands for the chemokine receptor chemokine
(C-C motif) receptor 5 (CCR5), and it suppresses in vitro
replication of the R5 strains of HIV-1, which use CCR5 as a
coreceptor. Alternative splicing results in multiple transcript
variants that encode different isoforms. [provided by RefSeq, Jul
2013].
Transcript Variant: This variant (2) uses an alternate exon in the
3' coding region, which results in a frameshift, compared to
variant 1. The encoded isoform (2) has a longer and distinct
C-terminus, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: CR980938.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-82 CD695497.1 143-224
83-650 CR980938.1 1-568
651-838 CB111656.1 316-503
839-886 HY265548.1 419-466 c
887-927 HY265548.1 377-417 c
928-1094 AA443491.1 204-370 c
1095-1273 AW769950.1 43-221 c
1274-1309 GD136908.1 7-42
1310-1319 BG272739.1 1-10 c
FEATURES Location/Qualifiers
source 1..1319
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q12"
gene 1..1319
/gene="CCL5"
/gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
SISd; TCP228"
/note="chemokine (C-C motif) ligand 5"
/db_xref="GeneID:6352"
/db_xref="HGNC:10632"
/db_xref="MIM:187011"
exon 1..144
/gene="CCL5"
/gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
SISd; TCP228"
/inference="alignment:Splign:1.39.8"
CDS 69..533
/gene="CCL5"
/gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
SISd; TCP228"
/note="isoform 2 precursor is encoded by transcript
variant 2; T-cell specific protein p288; regulated upon
activation, normally T-expressed, and presumably secreted;
beta-chemokine RANTES; small inducible cytokine subfamily
A (Cys-Cys), member 5; C-C motif chemokine 5; eosinophil
chemotactic cytokine"
/codon_start=1
/product="C-C motif chemokine 5 isoform 2 precursor"
/protein_id="NP_001265665.1"
/db_xref="GI:524563423"
/db_xref="GeneID:6352"
/db_xref="HGNC:10632"
/db_xref="MIM:187011"
/translation="
MKVSAAALAVILIATALCAPASASPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVHRSRMPKREGQQVWQDFLYDSRLNKGKLCHPKEPPSVCQPREEMGSGVHQLFGDELGWRVLEPELTQICLFLLALVLAWEASPHYPTPPAP
"
sig_peptide 69..137
/gene="CCL5"
/gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
SISd; TCP228"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
exon 145..256
/gene="CCL5"
/gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
SISd; TCP228"
/inference="alignment:Splign:1.39.8"
exon 257..338
/gene="CCL5"
/gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
SISd; TCP228"
/inference="alignment:Splign:1.39.8"
exon 339..1312
/gene="CCL5"
/gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
SISd; TCP228"
/inference="alignment:Splign:1.39.8"
polyA_signal 1287..1292
/gene="CCL5"
/gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
SISd; TCP228"
polyA_site 1312
/gene="CCL5"
/gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
SISd; TCP228"
ORIGIN
gctgcagaggattcctgcagaggatcaagacagcacgtggacctcgcacagcctctcccacaggtaccatgaaggtctccgcggcagccctcgctgtcatcctcattgctactgccctctgcgctcctgcatctgcctccccatattcctcggacaccacaccctgctgctttgcctacattgcccgcccactgccccgtgcccacatcaaggagtatttctacaccagtggcaagtgctccaacccagcagtcgtccacaggtcaaggatgccaaagagagagggacagcaagtctggcaggatttcctgtatgactcccggctgaacaagggcaagctttgtcacccgaaagaaccgccaagtgtgtgccaacccagagaagaaatgggttcgggagtacatcaactctttggagatgagctaggatggagagtccttgaacctgaacttacacaaatttgcctgtttctgcttgctcttgtcctagcttgggaggcttcccctcactatcctaccccacccgctccttgaagggcccagattctaccacacagcagcagttacaaaaaccttccccaggctggacgtggtggctcacgcctgtaatcccagcactttgggaggccaaggtgggtggatcacttgaggtcaggagttcgagaccagcctggccaacatgatgaaaccccatctctactaaaaatacaaaaaattagccgggcgtggtagcgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacccgggaggcggagcttgcagtgagccgagatcgcgccactgcactccagcctgggcgacagagcgagactccgtctcaaaaaaaaaaaaaaaaaaaaaaatacaaaaattagccgggcgtggtggcccacgcctgtaatcccagctactcgggaggctaaggcaggaaaattgtttgaacccaggaggtggaggctgcagtgagctgagattgtgccacttcactccagcctgggtgacaaagtgagactccgtcacaacaacaacaacaaaaagcttccccaactaaagcctagaagagcttctgaggcgctgctttgtcaaaaggaagtctctaggttctgagctctggctttgccttggctttgccagggctctgtgaccaggaaggaagtcagcatgcctctagaggcaaggaggggaggaacactgcactcttaagcttccgccgtctcaacccctcacaggagcttactggcaaacatgaaaaatcggcttaccattaaagttctcaatgcaaccataaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6352 -> Molecular function: GO:0004435 [phosphatidylinositol phospholipase C activity] evidence: IDA
GeneID:6352 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:6352 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6352 -> Molecular function: GO:0008009 [chemokine activity] evidence: IDA
GeneID:6352 -> Molecular function: GO:0008009 [chemokine activity] evidence: NAS
GeneID:6352 -> Molecular function: GO:0016004 [phospholipase activator activity] evidence: IDA
GeneID:6352 -> Molecular function: GO:0030298 [receptor signaling protein tyrosine kinase activator activity] evidence: IDA
GeneID:6352 -> Molecular function: GO:0031726 [CCR1 chemokine receptor binding] evidence: IDA
GeneID:6352 -> Molecular function: GO:0031726 [CCR1 chemokine receptor binding] evidence: IPI
GeneID:6352 -> Molecular function: GO:0031726 [CCR1 chemokine receptor binding] evidence: TAS
GeneID:6352 -> Molecular function: GO:0031729 [CCR4 chemokine receptor binding] evidence: TAS
GeneID:6352 -> Molecular function: GO:0031730 [CCR5 chemokine receptor binding] evidence: IPI
GeneID:6352 -> Molecular function: GO:0042056 [chemoattractant activity] evidence: IDA
GeneID:6352 -> Molecular function: GO:0042379 [chemokine receptor binding] evidence: IPI
GeneID:6352 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
GeneID:6352 -> Molecular function: GO:0043621 [protein self-association] evidence: IDA
GeneID:6352 -> Molecular function: GO:0046817 [chemokine receptor antagonist activity] evidence: IDA
GeneID:6352 -> Biological process: GO:0000165 [MAPK cascade] evidence: IMP
GeneID:6352 -> Biological process: GO:0002407 [dendritic cell chemotaxis] evidence: TAS
GeneID:6352 -> Biological process: GO:0002548 [monocyte chemotaxis] evidence: IC
GeneID:6352 -> Biological process: GO:0002676 [regulation of chronic inflammatory response] evidence: TAS
GeneID:6352 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:6352 -> Biological process: GO:0006816 [calcium ion transport] evidence: IDA
GeneID:6352 -> Biological process: GO:0006874 [cellular calcium ion homeostasis] evidence: IDA
GeneID:6352 -> Biological process: GO:0006887 [exocytosis] evidence: IDA
GeneID:6352 -> Biological process: GO:0006935 [chemotaxis] evidence: NAS
GeneID:6352 -> Biological process: GO:0006954 [inflammatory response] evidence: IDA
GeneID:6352 -> Biological process: GO:0007159 [leukocyte cell-cell adhesion] evidence: IDA
GeneID:6352 -> Biological process: GO:0007267 [cell-cell signaling] evidence: IDA
GeneID:6352 -> Biological process: GO:0009615 [response to virus] evidence: TAS
GeneID:6352 -> Biological process: GO:0009636 [response to toxic substance] evidence: IDA
GeneID:6352 -> Biological process: GO:0010535 [positive regulation of activation of JAK2 kinase activity] evidence: TAS
GeneID:6352 -> Biological process: GO:0010759 [positive regulation of macrophage chemotaxis] evidence: IDA
GeneID:6352 -> Biological process: GO:0010820 [positive regulation of T cell chemotaxis] evidence: IDA
GeneID:6352 -> Biological process: GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] evidence: IDA
GeneID:6352 -> Biological process: GO:0014911 [positive regulation of smooth muscle cell migration] evidence: IDA
GeneID:6352 -> Biological process: GO:0030335 [positive regulation of cell migration] evidence: IDA
GeneID:6352 -> Biological process: GO:0031328 [positive regulation of cellular biosynthetic process] evidence: IDA
GeneID:6352 -> Biological process: GO:0031584 [activation of phospholipase D activity] evidence: IDA
GeneID:6352 -> Biological process: GO:0031663 [lipopolysaccharide-mediated signaling pathway] evidence: IDA
GeneID:6352 -> Biological process: GO:0033634 [positive regulation of cell-cell adhesion mediated by integrin] evidence: IDA
GeneID:6352 -> Biological process: GO:0034112 [positive regulation of homotypic cell-cell adhesion] evidence: IDA
GeneID:6352 -> Biological process: GO:0042102 [positive regulation of T cell proliferation] evidence: IDA
GeneID:6352 -> Biological process: GO:0042119 [neutrophil activation] evidence: IDA
GeneID:6352 -> Biological process: GO:0042327 [positive regulation of phosphorylation] evidence: IDA
GeneID:6352 -> Biological process: GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] evidence: IDA
GeneID:6352 -> Biological process: GO:0043491 [protein kinase B signaling cascade] evidence: IMP
GeneID:6352 -> Biological process: GO:0043623 [cellular protein complex assembly] evidence: IDA
GeneID:6352 -> Biological process: GO:0043922 [negative regulation by host of viral transcription] evidence: IDA
GeneID:6352 -> Biological process: GO:0044344 [cellular response to fibroblast growth factor stimulus] evidence: IEP
GeneID:6352 -> Biological process: GO:0045070 [positive regulation of viral genome replication] evidence: TAS
GeneID:6352 -> Biological process: GO:0045071 [negative regulation of viral genome replication] evidence: IDA
GeneID:6352 -> Biological process: GO:0045089 [positive regulation of innate immune response] evidence: TAS
GeneID:6352 -> Biological process: GO:0045744 [negative regulation of G-protein coupled receptor protein signaling pathway] evidence: IDA
GeneID:6352 -> Biological process: GO:0045785 [positive regulation of cell adhesion] evidence: IDA
GeneID:6352 -> Biological process: GO:0045948 [positive regulation of translational initiation] evidence: NAS
GeneID:6352 -> Biological process: GO:0046427 [positive regulation of JAK-STAT cascade] evidence: TAS
GeneID:6352 -> Biological process: GO:0048245 [eosinophil chemotaxis] evidence: IDA
GeneID:6352 -> Biological process: GO:0048246 [macrophage chemotaxis] evidence: TAS
GeneID:6352 -> Biological process: GO:0048661 [positive regulation of smooth muscle cell proliferation] evidence: IDA
GeneID:6352 -> Biological process: GO:0050863 [regulation of T cell activation] evidence: IDA
GeneID:6352 -> Biological process: GO:0050918 [positive chemotaxis] evidence: IDA
GeneID:6352 -> Biological process: GO:0051262 [protein tetramerization] evidence: IDA
GeneID:6352 -> Biological process: GO:0051928 [positive regulation of calcium ion transport] evidence: IDA
GeneID:6352 -> Biological process: GO:0070098 [chemokine-mediated signaling pathway] evidence: TAS
GeneID:6352 -> Biological process: GO:0070100 [negative regulation of chemokine-mediated signaling pathway] evidence: IDA
GeneID:6352 -> Biological process: GO:0070233 [negative regulation of T cell apoptotic process] evidence: IDA
GeneID:6352 -> Biological process: GO:0070234 [positive regulation of T cell apoptotic process] evidence: IDA
GeneID:6352 -> Biological process: GO:0071346 [cellular response to interferon-gamma] evidence: IEP
GeneID:6352 -> Biological process: GO:0071347 [cellular response to interleukin-1] evidence: IEP
GeneID:6352 -> Biological process: GO:0071356 [cellular response to tumor necrosis factor] evidence: IEP
GeneID:6352 -> Biological process: GO:0071407 [cellular response to organic cyclic compound] evidence: IDA
GeneID:6352 -> Biological process: GO:0090026 [positive regulation of monocyte chemotaxis] evidence: IDA
GeneID:6352 -> Biological process: GO:2000110 [negative regulation of macrophage apoptotic process] evidence: IEA
GeneID:6352 -> Biological process: GO:2000503 [positive regulation of natural killer cell chemotaxis] evidence: IDA
GeneID:6352 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
GeneID:6352 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
GeneID:6352 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
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