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2024-04-20 14:09:19, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001276451 955 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens dorsal root ganglia homeobox (DRGX), mRNA. ACCESSION NM_001276451 VERSION NM_001276451.1 GI:449784875 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 955) AUTHORS Kim,B.Y., Jin,H.J. and Kim,J.Y. TITLE Genome-wide association analysis of Sasang constitution in the Korean population JOURNAL J Altern Complement Med 18 (3), 262-269 (2012) PUBMED 22394158 REFERENCE 2 (bases 1 to 955) AUTHORS Saito,T., Greenwood,A., Sun,Q. and Anderson,D.J. TITLE Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets JOURNAL Mol. Cell. Neurosci. 6 (3), 280-292 (1995) PUBMED 7496632 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY131276.1, AC027674.10 and DW009785.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by partial human and full-length orthologous transcript alignments. CCDS Note: The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. This updated representation lacks full-length transcript support and it therefore has an inferred exon combination; the inferred structure is supported by a combination of tiled EST alignments and RNA-Seq data, and by homologous transcript alignments. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-108 HY131276.1 1-108 109-109 AC027674.10 130014-130014 c 110-533 HY131276.1 110-533 534-657 DW009785.1 1-124 c 658-689 AC027674.10 120997-121028 c 690-955 AC027674.10 100634-100899 c FEATURES Location/Qualifiers source 1..955 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10q11.23" gene 1..955 /gene="DRGX" /gene_synonym="DRG11; PRRXL1" /note="dorsal root ganglia homeobox" /db_xref="GeneID:644168" /db_xref="HGNC:21536" /db_xref="MIM:606701" exon 1..82 /gene="DRGX" /gene_synonym="DRG11; PRRXL1" /inference="alignment:Splign:1.39.8" variation complement(24) /gene="DRGX" /gene_synonym="DRG11; PRRXL1" /replace="g" /replace="t" /db_xref="dbSNP:370258237" exon 83..197 /gene="DRGX" /gene_synonym="DRG11; PRRXL1" /inference="alignment:Splign:1.39.8" variation complement(109) /gene="DRGX" /gene_synonym="DRG11; PRRXL1" /replace="c" /replace="g" /db_xref="dbSNP:141419681" misc_feature 152..154 /gene="DRGX" /gene_synonym="DRG11; PRRXL1" /note="upstream in-frame stop codon" CDS 164..955 /gene="DRGX" /gene_synonym="DRG11; PRRXL1" /note="paired-like homeodomain trancription factor DRG11; paired related homeobox-like 1" /codon_start=1 /product="dorsal root ganglia homeobox protein" /protein_id="NP_001263380.1" /db_xref="GI:449784876" /db_xref="CCDS:CCDS44388.1" /db_xref="GeneID:644168" /db_xref="HGNC:21536" /db_xref="MIM:606701" /translation="
MFYFHCPPQLEGTATFGNHSSGDFDDGFLRRKQRRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGASDQEPGAKEPMAEVTPPPVRNINSPPPGDQARSKKEALEAQQSLGRTVGPAGPFFPSCLPGTLLNTATYAQALSHVASLKGGPLCSCCVPDPMGLSFLPTYGCQSNRTASVATLRMKAREHSEAVLQSANLLPSTSSSPGPVAKPAPPDGSQEKTSPTKEQSEAEKSV
"
misc_feature 263..439
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(263..277,281..283,332..334,350..352,389..391,
395..400,407..412,416..424,428..433)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(269..271,278..280,398..400,407..412,419..421)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
misc_feature 764..820
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/note="OAR domain; Region: OAR; pfam03826"
/db_xref="CDD:146451"
misc_feature 773..814
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (A6NNA5.1);
Region: OAR"
variation complement(192)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:182583486"
variation complement(197)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371034824"
exon 198..295
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/inference="alignment:Splign:1.39.8"
variation complement(252)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201322873"
variation complement(277)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:374888788"
variation complement(280)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371956315"
exon 296..397
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/inference="alignment:Splign:1.39.8"
variation complement(322)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:188251168"
exon 398..576
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/inference="alignment:Splign:1.39.8"
variation complement(411)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199823782"
variation complement(455)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:200413142"
variation complement(468)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:202198114"
variation complement(473)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:202188185"
variation complement(494)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376932057"
variation complement(522)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369562104"
variation complement(524)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377684318"
variation complement(527)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374285988"
variation complement(536)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:369938719"
variation complement(542)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376423419"
variation complement(543)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371463020"
variation complement(554)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369269542"
variation complement(558)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201611931"
variation complement(559)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201182244"
exon 577..689
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/inference="alignment:Splign:1.39.8"
variation complement(585)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192582282"
variation complement(588)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200296572"
variation complement(614)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368712608"
variation complement(628)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374594424"
variation complement(645)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201624460"
variation complement(647)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201954478"
variation complement(648)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373974700"
variation complement(651)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201852529"
variation complement(652)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:370753569"
variation complement(655)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377612688"
variation complement(670)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:188198595"
variation complement(673)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368235434"
exon 690..955
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/inference="alignment:Splign:1.39.8"
variation complement(712)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369280603"
variation complement(713)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143541395"
variation complement(725)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371865203"
variation complement(727)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:200974922"
variation complement(766)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201682854"
variation complement(791)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:375388153"
variation complement(802)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183224892"
variation complement(803)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370735058"
variation complement(804)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201807477"
variation complement(805)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:201659578"
variation complement(814)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:374365523"
variation complement(865)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370393487"
variation complement(885)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368054205"
variation complement(900)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:375343755"
variation complement(912)
/gene="DRGX"
/gene_synonym="DRG11; PRRXL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370954422"
ORIGIN
gagccccgcccgccgccagccgagcagggcttgcggatcggaggcggtcacgctccgacctcctcgaccgccgcccgccgagccaggcaggagcaacgcgcgcgggtccgttctgctgccaccctcccaggtctcggccgtccagccgatctgacagccggcgatgttttatttccactgcccgccacagctagagggcactgcaacctttggcaatcactcttcgggggattttgatgacgggtttctgcgtagaaaacagcgccggaaccggacgacgttcactcttcagcagctggaagctctcgaggccgtttttgcccaaacacactatccagatgtcttcaccagagaagagctcgccatgaaaataaacctcacagaagccagagtgcaggtttggttccagaacagaagggccaaatggaggaagacagagagaggggcctcagaccaggagccaggagccaaggagcccatggcagaggtgacacctcctccagtgagaaacatcaactccccgccccctggggaccaagcccggagtaagaaggaggcgctggaggcccagcagagcctggggcgaacggtaggtcctgcagggcctttcttcccctcctgcttgccggggactctcctgaacacggccacctacgcccaggccttgtcccatgtggcttccctcaaagggggcccactgtgctcttgctgcgtcccagaccccatgggactctccttccttcccacctatggctgccagagtaaccgcacggccagcgtggccaccctgcgcatgaaggcccgcgagcactcagaagctgtcctgcagtcagccaacctcctgccttccaccagcagcagccccggccctgtcgccaagccggcgcccccagatggcagccaggaaaagacctctcccaccaaggaacagagcgaggcagagaagagtgtatga
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:644168 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:644168 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:644168 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:644168 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
GeneID:644168 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
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