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2024-03-29 00:10:24, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001267611            7815 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens G protein-coupled receptor 161 (GPR161), transcript
            variant 4, mRNA.
ACCESSION   NM_001267611
VERSION     NM_001267611.1  GI:390190206
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7815)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur. J. Hum. Genet. 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 7815)
  AUTHORS   Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
            Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
  TITLE     Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
            genetic association with bone mineral density variation
  JOURNAL   Hum. Mol. Genet. 18 (4), 679-687 (2009)
   PUBMED   19064610
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 7815)
  AUTHORS   Matteson,P.G., Desai,J., Korstanje,R., Lazar,G., Borsuk,T.E.,
            Rollins,J., Kadambi,S., Joseph,J., Rahman,T., Wink,J., Benayed,R.,
            Paigen,B. and Millonig,J.H.
  TITLE     The orphan G protein-coupled receptor, Gpr161, encodes the
            vacuolated lens locus and controls neurulation and lens development
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 105 (6), 2088-2093 (2008)
   PUBMED   18250320
REFERENCE   4  (bases 1 to 7815)
  AUTHORS   Small,K.M., Seman,C.A., Castator,A., Brown,K.M. and Liggett,S.B.
  TITLE     False positive non-synonymous polymorphisms of G-protein coupled
            receptor genes
  JOURNAL   FEBS Lett. 516 (1-3), 253-256 (2002)
   PUBMED   11959142
  REMARK    GeneRIF: False positive non-synonymous polymorphisms of G-protein
            coupled receptor genes.
REFERENCE   5  (bases 1 to 7815)
  AUTHORS   Schoneberg,T., Schulz,A. and Gudermann,T.
  TITLE     The structural basis of G-protein-coupled receptor function and
            dysfunction in human diseases
  JOURNAL   Rev. Physiol. Biochem. Pharmacol. 144, 143-227 (2002)
   PUBMED   11987825
  REMARK    Review article
REFERENCE   6  (bases 1 to 7815)
  AUTHORS   Raming,K., Konzelmann,S. and Breer,H.
  TITLE     Identification of a novel G-protein coupled receptor expressed in
            distinct brain regions and a defined olfactory zone
  JOURNAL   Recept. Channels 6 (2), 141-151 (1998)
   PUBMED   9932290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL033532.36, AK310019.1 and AA662800.1.
            
            Summary: Upon ligand binding, G protein-coupled receptors, such as
            GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320),
            allowing the receptors to transduce extracellular signals across
            the plasma membrane into the cell. Phosphorylation of the receptor
            attenuates signaling (Matteson et al., 2008 [PubMed
            18250320]).[supplied by OMIM, Aug 2008].
            
            Transcript Variant: This variant (4) lacks a portion of the 5'
            coding region, and initiates translation at an upstream start
            codon, compared to variant 1. The resulting protein (isoform 3) is
            shorter and has a distinct N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK310019.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL033532.36        66328-66410         c
            84-1367             AK310019.1         1-1284
            1368-1368           AL033532.36        19465-19465         c
            1369-2030           AK310019.1         1286-1947
            2031-7638           AL033532.36        8548-14155          c
            7639-7815           AA662800.1         1-177               c
FEATURES             Location/Qualifiers
     source          1..7815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..7815
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /note="G protein-coupled receptor 161"
                     /db_xref="GeneID:23432"
                     /db_xref="HGNC:23694"
                     /db_xref="MIM:612250"
     exon            1..184
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    175..177
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /note="upstream in-frame stop codon"
     CDS             178..1818
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /note="isoform 3 is encoded by transcript variant 4;
                     G-protein coupled receptor 161; G-protein coupled receptor
                     RE2"
                     /codon_start=1
                     /product="G-protein coupled receptor 161 isoform 3"
                     /protein_id="NP_001254540.1"
                     /db_xref="GI:390190207"
                     /db_xref="GeneID:23432"
                     /db_xref="HGNC:23694"
                     /db_xref="MIM:612250"
                     /translation="
MKVVQHALPTPRRGALTMSLNSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSHCTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR
"
     misc_feature    502..1200
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /note="7 transmembrane receptor (rhodopsin family);
                     Region: 7tm_1; pfam00001"
                     /db_xref="CDD:200918"
     exon            185..602
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:1.39.8"
     exon            603..1327
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:1.39.8"
     exon            1328..1432
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:1.39.8"
     exon            1433..1552
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:1.39.8"
     exon            1553..7807
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /inference="alignment:Splign:1.39.8"
     STS             1977..2728
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /standard_name="GPR161_2270"
                     /db_xref="UniSTS:280714"
     variation       2314
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1051426"
     variation       2420
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1051428"
     STS             2478..2617
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /standard_name="RH98556"
                     /db_xref="UniSTS:92344"
     STS             3718..3850
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /standard_name="pchcms1"
                     /db_xref="UniSTS:539559"
     variation       5913
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3202895"
     STS             6208..6312
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /standard_name="D11S3114"
                     /db_xref="UniSTS:152207"
     STS             6250..6420
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /standard_name="D1S1425"
                     /db_xref="UniSTS:149621"
     STS             7614..7784
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /standard_name="A004N15"
                     /db_xref="UniSTS:18315"
     STS             7681..7815
                     /gene="GPR161"
                     /gene_synonym="RE2"
                     /standard_name="WI-13488"
                     /db_xref="UniSTS:83528"
ORIGIN      
gactgctccctggccttttggttccgagggagtgcagggcagcagtgtgaagacctgtttacgtccactccccactccccggggctggcttcgggacgaattcactgtggtattaacagagcccgggacagagcctggcagaaggcagatggatgctcgtgcccgtcggctggatgaatgaaagtcgtccagcatgctctgcccaccccacgccgaggtgcactgaccatgagcctcaactcctccctcagctgcaggaaggagctgagtaatctcactgaggaggagggtggcgaagggggcgtcatcatcacccagttcatcgccatcattgtcatcaccatttttgtctgcctgggaaacctggtcatcgtggtcaccttgtacaagaagtcctacctcctcaccctcagcaacaagttcgtcttcagcctgactctgtccaacttcctgctgtccgtgttggtgctgccttttgtggtgacgagctccatccgcagggaatggatctttggtgtagtgtggtgcaacttctctgccctcctctacctgctgatcagctctgccagcatgctaaccctcggggtcattgccatcgaccgctactatgctgtcctgtaccccatggtgtaccccatgaagatcacagggaaccgggctgtgatggcacttgtctacatctggcttcactcgctcatcggctgcctgccacccctgtttggttggtcatccgtggagtttgacgagttcaaatggatgtgtgtggctgcttggcaccgggagcctggctacacggccttctggcagatctggtgtgccctcttcccctttctggtcatgctggtgtgctatggcttcatcttccgcgtggccagggtcaaggcacgcaaggtgcactgtggcacagtcgtcatcgtggaggaggatgctcagaggaccgggaggaagaactccagcacctccacctcctcttcaggcagcaggaggaatgcctttcagggtgtggtctactcggccaaccagtgcaaagccctcatcaccatcctggtggtcctcggtgccttcatggtcacctggggcccctacatggttgtcatcgcctctgaggccctctgggggaaaagctccgtctccccgagcctggagacttgggccacatggctgtcctttgccagcgctgtctgccaccccctgatctatggactctggaacaagacagttcgcaaagaactactgggcatgtgctttggggaccggtattatcgggaaccatttgtgcaacgacagaggacttccaggctcttcagcatttccaacaggatcacagacctgggcctgtccccacacctcactgcgctcatggcaggtggacagcccctggggcacagcagcagcacgggggacactggcttcagctgctcccaggactcagggacagatatgatgctgcttgaggactacacgtctgatgacaaccctccctctcactgcacttgcccacccaagagaaggagctcggtgacatttgaggatgaagtggaacaaatcaaagaagctgccaagaactcgattcttcatgtgaaagctgaagtacacaagtccttggacagttacgcagcaagcttggccaaagccattgaggccgaagccaaaatcaacttatttggggaggaggctttgccaggggtcttggttacagcacggactgtcccggggggcggcttcgggggccgccgaggcagcagaactcttgtgagccagaggctgcagttgcagagcatcgaagaaggagatgttttagctgccgagcagagatgagggcctcagggtgccgtggggctgcagcctgagaggctggcccggggaggagttcccatcaccgcctgtgccgcggccttgggagcatgtcactgtgtacagctggccacacacagggaaggagcagcatctggtatgcagccaccaggacaaggactgaaaataatgtctacagtccacagcttcagcatttccagagaccacatgtgagcttcttttaggtcccagtgatgggaccagaagcatctaaagcaaaaaaaaaaccaaaaaaaaatctagagatgtggctgtggctttttgggaggtggggcatgggaggaccagagacgaagggcttggaaggagacccccacatgcatcatttcctcctcttcacagtgtgctgggagtccagccgtgcactgtgccagatgcctcaggaggagaaccctccccagtgtactgtgaaggatgacacagcacttcttcctaatgacacgcgaccgtcctggtgcctctacatggttgatgcgggcagtgtgggaccctcagttctaggactggtccgcagagaaagcacccaggagcagagcgcttcggagcggtcctcagtggcgccacctgctggtgctaatagggacagccacaggcctcttgcagactggcccaccctgcctacttccctactgacaagttctttggtatttcaaaagggagaaaccactataaaagacaagaggaagggcaggtactaggtgtttcatttccagaattaaaaaaaaaatccatttaagacgtaccactgttttaccggactgaatgggactgtagtgccaagcacagccaggaaatagagaaactgttattatggaagggaatttgttcacatgggaaagcctcattaaatagattctatgtgtgatgtttgagtgaccaatgaaaatagctggcctcagttctgcatggcacactcccaagagcaacagttactattatcacaagcctggtataaataagatagaagcagccctggacccacagccagcaacctgggttattggcccagctctgtctttgtgtgcacatgtcatttggacatcttgtcacctttctaggtcctctgtaaagtgggaaaacagagtggagttggattgaatggtctccaagatcatttccagctctgacctttggtgttctcaggatttgtaaagcagagataggtaaaacacaaaagcagacccacggaccgacctttgtataactttggagtgtggttgctcatgcacatgtgaagtgcaggcagatcaaggttctgtggctttgtctgccctgtccattagagcacaatctggatagaatgccagccaccaagatgcatgaggggcagggtcaccatctcagaaggggaagcacaggaatgtgattgggatggttaaacctctcttctcctccctttgtgctggaacagcagttgaagtttggtcctggagtaattgctgtgatgacttgggaagccactgatctcctcttgcgtctgcccttggcctgcatcatgactaaataagttcaggacttctctgctttggttggcagaaggtagattccaaggagatcttgctggttgctgagaggcagctgttctagaaagtgaattacccttgtggttttttctttggggcccagctagctcctggtgaggttgtgtttttgtgttgtgtggcagaaaccaatggttagctggtcccctggtctgcagtttgtaaaagacctttcatgaggcctggagtcttgctacctgtggtgattgaactcaactattctgggtcacctggatgccaggcgctggcctagcttctggatgggagtgggaaggagcagagggcaggttcacctgtgcaggtcagacactctgcttccatcactggatggcattcctacgtctgcgtgtggttcacgttttctatatatattccctgtatatatttttttctagcacttgtctactttctgaagggaccatattcctgatcaactagtgtgcacagaggtggaacagggcagagagacctttatctctaggatgggttgctggttaggtgtaggcattcttgagtgcagcagcttggctttgaaacgcaagggttggagaatgttcccctgactgtactagactgggctctagggaaagaatcctgagacagccccccactcccccactgaccccacactagctgggctattatagaatttaatctaaatctagaaatactgcatttcacaaaatgattcactgtgtttccctttttttactgaggtccaattcatttagtcgtctaccagacactgcacatccagtgtatgcgaagcaccaggctaggctctgtaggcaataccactaaagtgtgcactctgatttagggagcaggacctgtggataccgattctaataactagcaaagtcaagtcgtggttatagaaagaagtgtggcttcagagggaggtgggtatttccaaatatggagttagggatggctccatgaggtaagtgacagtttgagctaagtcttgaaggatgcttggcagctagaaccatattttccatattcaggaattcaaatttgcctttattcagctagagagaaagagagaagggggtgtgggggagaaggaaaagagaattttcacacattttgaagttcctgagagcatttctgaggatatctgccgttagtgcagaaggtcgaaaccccaagtgcccccactaaacccaggctctttagctgtaaactgccatgcagtggcaggcctgcagccttcctgatgggaccacatggacagtggcacatgggacatttggctactcgttagcttaaacaactcagtcctgtgtcttctggttttgacaagaccacatttaggactgctgcccacctctgcctctttcattgagatttccgccttattgggtccctgtgctatgccacagataccaggtttggggttgttttgacccagaaggcattgggagtcccacattacagagcacacacacagctcaacacagccatttccctggccagaggcaccaagactgaagttcaggcccttagacactaggtggcagcggtgtggctgtgcagagccaaggatgaacctgagagcttgtttgcctctggctgggcactcttgttttgaattcctttgcccttatcgtgtagtccacggccttggtgaccaaggaccacctggctagcctgcttacatgcatgaccccatccaggttcacaggtattgccactgagtgatcttaggtagatcactgctcctggagaagcagagttgaggagtgtaagacaagggccatctagtgccaatgttccttgattcttatttgaggagctactatgtggtctttctgtaaacaagtgaacaaccaatgagactaaatatttgcaatagataggctaaggaatttgggttgagacaggagacggaggaaaaatgctttgatacaatgacagatggttagtctcttcagatttccctgaatattttccatcccgacaatatgcctcttagatacttgcagattagacatgtctctggatggaccacaagatacattcacaacatgtgttcagccttgagccctggctgtgtcctgtctggaaggaactgaggatgatgtggctataaagaggaggcagtgagctggcatgtgactgccttctgtgggcctgacctgtttgacatttgagggcctatgatgtgctaggtgctgtgttaggtacttccaaatgctttatctcattttaccccagtgcaagtgtgatatagtgaggatggtgaagacgtgggtatggttaagtcatgagttcagatcccgtgcttccaattacatgggtgttttcaaacaagtcactacttatgagtttcctcatctgtgaagggaagtttagtcatctgtttcaatgtggagacacacaggattgagggagtcctccgtcacagggtgactgtctggattctatgaggaaatacttggaaagcatgcagcacaatgcctggggtgcagctgaagctgagccactggtgtttcttcacagtatctctgtggggagggtgtattattcctttttatagggatctctataatgaagtgagaatcttgaaaatataagtgttatcctagatgggaggtgttaaaggtttttgccttgggaattttgtcatatttgttgcacagcaaggaaggactttcagaaaagcagggatgtggtgaggaagagcaggcaatagagagcagggaggaaaggctaagtagcatctggaacttgagaagtctaagggagccaaaatgagattttctattaaaaatgtctatcctcagccgggcgtggtagctcacgcctgtaatcccagcactttggggggtcgagatgggcagatcacctgaggtcaggagttcgagaccagcctgaccaatatggagaaaccccgtctctactaaaaatacaaaattagttgcgcgtggtggtgggcgcctgtaatcccagctactcaggagcctgaggcaggagaatcacttaaacccaggaggcggaggttgcagtgagccgagatcgcgccattgcactccagcctgggcaacaagagcgaaaccccgcctaaaaaaagaaaaaaaagaaaaagtctatcctctatgctactggcctgtttgtacaaagataaaatcattctaatttgtccggaatgactatcaaagatgatcaaatccccagggcctggtgtaacgttccaaatcatagcacaaatacagcttgaccttccttacagtccagaaaggacattctccctgagaaatgcccttggttgctgaggacagctctgtcctgtagtgacagagtgactgcctggctgtggctcttgggttcacagaatccctaatcctccaagcccctaagaggcagggcagggatgctacccacaatatatgcagaaccccagatggagcctgtgggagagagaggaaattaccgtcttcactgtaggcaaaggagaatggctgtgattagccatatatgcctataagaaggagcagagccatactgtccttgtgggttgggagaggggacacagaatccagggcaattgtctgaggtctcaaagtaagttaagccagagtcaaagccaaactccaagtcttggccaaggggatgagaaaagcaaggagctagtcttataggtcaaggaagatgaggtatagttaagagtcatcagtatcacagaacaggccagcagggctttattaggtatgtagaactattataaaccaaggatcttgggagatattaatatctgctggccagacctaaaaaaaactgaaggcccaaggaaagtgactggactcactggaaagtatctaacaaatactttggattccaaagtatttccaataccttgaagattcctttgaaaacatcaaagcacaaactcaaatctgcacaagattacaaaagcacaattttggtgttatttttagaatgcaatacacaaagctatgttcatttctctcagcaagcattttcctgggtagtagtaatagcttaggaatcaaatgccacttttgtttttccttttttcactagtttgaaataccacaaatcacaggtgagtcagtcctcccagaggaaaagacagtcctagggagaatcacaggcctggcagacaagaccacactgagagcagtagaaggaacctgcatgcttaagggacagaggactgtgttgtgttctcataatagaccgctggatgaagaagtggttaaaaaccaaccctcgaaaaacaaaaatccctggctaatcctgaaatatatttaacttgaagtctttggatgatttttttaaggttaaaaaaaagtttaggattattataaatcaatatttataaataagcaacaatgtatttggaatttttgtttacctgattaaatatgtttttggtatgtgtaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:23432 -> Molecular function: GO:0004930 [G-protein coupled receptor activity] evidence: ISS
            GeneID:23432 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: ISS
            GeneID:23432 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
            GeneID:23432 -> Biological process: GO:0030819 [positive regulation of cAMP biosynthetic process] evidence: ISS
            GeneID:23432 -> Biological process: GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning] evidence: ISS
            GeneID:23432 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:23432 -> Cellular component: GO:0055037 [recycling endosome] evidence: ISS
            GeneID:23432 -> Cellular component: GO:0060170 [cilium membrane] evidence: IEA
            GeneID:23432 -> Cellular component: GO:0072372 [primary cilium] evidence: ISS

by @meso_cacase at DBCLS
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