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2024-04-17 01:14:51, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001267586 3293 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens F-box and WD repeat domain containing 10 (FBXW10),
transcript variant 2, mRNA.
ACCESSION NM_001267586
VERSION NM_001267586.1 GI:389885063
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3293)
AUTHORS Chaturvedi,P. and Parnaik,V.K.
TITLE Lamin A rod domain mutants target heterochromatin protein 1alpha
and beta for proteasomal degradation by activation of F-box
protein, FBXW10
JOURNAL PLoS ONE 5 (5), E10620 (2010)
PUBMED 20498703
REMARK GeneRIF: Mislocalized lamins can induce ubiquitin-mediated
proteasomal degradation of certain HP1 isoforms by activation of
FBXW10, a member of the F-box family of proteins that is involved
in E3 ubiquitin ligase activity.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3293)
AUTHORS Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
Harper,J.W.
TITLE Systematic analysis and nomenclature of mammalian F-box proteins
JOURNAL Genes Dev. 18 (21), 2573-2580 (2004)
PUBMED 15520277
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DB055860.1, AL136822.1 and AC107982.6.
Summary: Members of the F-box protein family, such as FBXW10, are
characterized by an approximately 40-amino acid F-box motif. SCF
complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
603134), and F-box proteins, act as protein-ubiquitin ligases.
F-box proteins interact with SKP1 through the F box, and they
interact with ubiquitination targets through other protein
interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
by OMIM, Mar 2008].
Transcript Variant: This variant (2) lacks an alternate in-frame
exon in the central coding region, compared to variant 1, resulting
in an isoform (2) that is shorter than isoform 1.
##Evidence-Data-START##
Transcript exon combination :: AL136822.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025084, ERS025085 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-300 DB055860.1 1-300
301-937 AL136822.1 239-875
938-938 AC107982.6 123912-123912 c
939-1469 AL136822.1 877-1407
1470-1470 AC107982.6 115359-115359 c
1471-2533 AL136822.1 1409-2471
2534-2534 AC107982.6 95069-95069 c
2535-3293 AL136822.1 2473-3231
FEATURES Location/Qualifiers
source 1..3293
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p12"
gene 1..3293
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/note="F-box and WD repeat domain containing 10"
/db_xref="GeneID:10517"
/db_xref="HGNC:1211"
/db_xref="MIM:611679"
exon 1..737
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 3
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371194302"
variation 25
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:367810251"
misc_feature 71..73
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/note="upstream in-frame stop codon"
variation 138
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150230158"
variation 183
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369742505"
variation 198
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:186119518"
variation 214
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:116483657"
CDS 233..3232
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/note="isoform 2 is encoded by transcript variant 2; F-box
and WD-40 domain protein 10; F-box/WD repeat-containing
protein 10; ubiquitin ligase specificity factor"
/codon_start=1
/product="F-box/WD repeat-containing protein 10 isoform 2"
/protein_id="NP_001254515.1"
/db_xref="GI:389885064"
/db_xref="CCDS:CCDS58524.1"
/db_xref="GeneID:10517"
/db_xref="HGNC:1211"
/db_xref="MIM:611679"
/translation="
MENLESRLKNAPYFRCEKGTDSIPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGILKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKEILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFSPEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHLLGAASNPEEPWRNSLRCISEMNRLFSGKGDITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLIEERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHPKMVVNTESNVLMFQFEHIKWQYAVEKTKQKKNKEKEEEKEENSLMEILSKCNIQVHSPRESVSSKQTVIQELLPGKPPKSRVLLKPAKFSSAVLIEELQSQGKSKSPRRDADDVEKAQKQGQLETPGKLPSHPKKKSWKIPMSPDQFLLTVSALQHAHNSGEFAYPCRPQTEITDVWGPSISYPRKVLNFKGKSIQRAVDRLRLSNPPIDVKRTSIPLEIQKLQPNLKISLHSPRVQSTIPQPMIIRSRFSGSLKGGDQVTSSIERAVCSTGPLTSMQVIKPNRMLAPQVGTATLSLKKERPRIYTALDPFRVNTEFVLLTVKEEKEHQEAKMKEYQARESTGVVDPGKVSKAAWIRKIKGLPIDNFTKQGKTAAPELGQNVFI
"
misc_feature <1463..2110
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/note="FOG: WD40 repeat [General function prediction
only]; Region: COG2319"
/db_xref="CDD:32473"
misc_feature 1484..>2035
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; Region:
WD40; cd00200"
/db_xref="CDD:29257"
misc_feature order(1511..1513,1523..1525,1541..1546,1583..1588,
1640..1642,1652..1654,1670..1675,1709..1714,1757..1759,
1772..1774,1790..1795,1829..1831,1874..1876,1889..1891,
1907..1912,1946..1951,1997..1999,2009..2011,2027..2032)
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/note="structural tetrad; other site"
/db_xref="CDD:29257"
variation 300
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="t"
/db_xref="dbSNP:74502778"
variation 312
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200553727"
variation 326
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:143662391"
variation 338
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138647311"
variation 397
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:200806553"
variation 441
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149323817"
variation 464
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143573197"
variation 477
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201935353"
variation 500
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:148027955"
variation 536
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377476079"
variation 575
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142528410"
variation 640
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:145973790"
exon 738..902
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 742
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376114266"
variation 753
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="t"
/db_xref="dbSNP:370476175"
variation 854
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376241364"
variation 880
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:370045217"
variation 891
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370320215"
exon 903..1103
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 926
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375699839"
variation 936
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374206318"
variation 938
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:9895749"
variation 1003
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:139842854"
variation 1013
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200535885"
variation 1056
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:139431164"
variation 1067
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368213609"
exon 1104..1231
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 1175
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:372345142"
variation 1184
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:150057313"
variation 1199
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:145368701"
variation 1207
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200034399"
exon 1232..1354
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 1264
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:372134223"
variation 1306
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376056941"
variation 1307
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140944543"
variation 1332
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371774794"
variation 1333
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376006877"
variation 1343
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149924362"
variation 1346
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:7209610"
exon 1355..1464
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 1364
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201169182"
variation 1376
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:147905984"
variation 1387
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200851525"
variation 1392
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:144179290"
variation 1395
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373122324"
variation 1464
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:142047019"
exon 1465..1665
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 1470
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="t"
/db_xref="dbSNP:200464103"
variation 1478
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201657571"
variation 1479
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376791823"
variation 1527
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199572430"
variation 1564
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:373654877"
variation 1587
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376635428"
variation 1601
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370583951"
variation 1642
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:151034607"
variation 1643
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140412541"
variation 1649
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150381644"
variation 1651
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138093156"
exon 1666..1787
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 1720
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:376019829"
exon 1788..1936
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 1789
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:144567782"
variation 1814
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:368003711"
variation 1821
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:142568223"
variation 1828
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:182760245"
variation 1840
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144724584"
variation 1889
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138625739"
variation 1890
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:141626132"
variation 1904
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:144460161"
variation 1930
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:368262323"
variation 1931
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:372082761"
exon 1937..2079
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 1943
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:148396663"
variation 2005
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149882032"
variation 2016
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:375390149"
variation 2022
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150697158"
variation 2033
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140982768"
variation 2048
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147930073"
variation 2051
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:79757327"
variation 2051
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144931466"
exon 2080..2351
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 2098
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368827263"
variation 2128
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372149006"
variation 2131
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:138657360"
variation 2140
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369517876"
variation 2147
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:78640521"
variation 2157
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150329747"
variation 2166
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:137965030"
variation 2195
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:372209815"
variation 2206
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200658685"
variation 2218..2221
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace=""
/replace="tctc"
/db_xref="dbSNP:377314029"
variation 2293
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:139177136"
variation 2302
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:149546887"
variation 2319
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376804860"
variation 2320
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147138981"
exon 2352..2408
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 2399
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372890959"
variation 2400
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375352795"
exon 2409..3283
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/inference="alignment:Splign:1.39.8"
variation 2418
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:236812"
variation 2440
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377326035"
variation 2451
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372843756"
variation 2479
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace=""
/replace="g"
/db_xref="dbSNP:201275430"
variation 2491
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:202063654"
variation 2504
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:377068064"
variation 2533
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370119394"
variation 2534
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1026259"
variation 2534
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:77288131"
variation 2550
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1026260"
variation 2561
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:373000642"
variation 2573
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:200062063"
variation 2577
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:201057327"
variation 2678
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371149617"
variation 2687
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143308813"
variation 2689
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:375662938"
variation 2697
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:62070362"
variation 2714
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:147519900"
variation 2715
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377642870"
variation 2727
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:140063499"
variation 2728
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373925015"
variation 2784
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1026261"
variation 2784
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:199779085"
variation 2796
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:142904621"
variation 2798
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:150642944"
variation 2801
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:236813"
variation 2812
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:147350518"
variation 2816
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:139724959"
variation 2823
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:149783676"
variation 2863
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146784395"
variation 2890
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371467039"
variation 2985
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143459755"
variation 3020
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1318979"
variation 3020
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147994056"
variation 3030
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:77817142"
variation 3111
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373632534"
variation 3126
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1024657"
variation 3126
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:117160613"
variation 3253
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2014354"
variation 3253
/gene="FBXW10"
/gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:28690836"
ORIGIN
acggtaaagccatgtttccaaggaggtctgtacaaaaagccagacttctgctggcagttactgagagagataggctttccatccatggcagccatttacttttgctctgggagacgtttgtaatagaaaaggcacaactggggtatttattcattccccccgttcctctagtgtttggtggcgttgccgttgcaagtgcgcagggctaaaatggactggttatcttaggatcatggaaaacctggaatcaaggctcaagaatgccccctattttcgttgtgagaagggaaccgattccatccctctatgccggaagtgtgagacgtgtgtcttagcctggaagatcttctctaccaaagagtggttctgcaggatcaatgacatatcacagaggaggtttctagttggcattctgaagcagttaaatagcttatatttgttacactatttccaaaatatccttcagaccacacagggaaaggatttcatctataacaggtcccggatcaacctcagcaagaaagaggggaaagttgtgaagtcctccttgaaccaaatgttggataaaacagtagaacagaagatgaaagagatcttgtactggtttgcgaacagcacccagtggaccaaggcgaattatactctcttactgctgcagatgtgcaaccccaaattactgctcactgctgccaatgtgatcagagtcctgtttctgagagaggagaacaatatctcagggctcaatcaagacatcacagatgtgtgtttttcccctgagaaagaccacagctccaagtctgcgacctcacaagtctattggacagccaaaactcagcacacatcccttcctttgtccaaagccccagaaaatgaacacttgcttggggcagcatctaaccctgaggaaccatggaggaattcactccggtgtatatccgaaatgaataggctgttttctggaaaaggagacataaccaagccagggtacgatccctgcaatctattggttgacctggatgacatcagagacctgtcttctgggttcagcaaataccgagacttcatccgttacctgcccatccacctctccaagtacattctaagaatgctggatagacacaccctgaacaagtgcgcctctgtgagccagcactgggccgccatggctcaacaggtcaagatggacttgtcagcgcacggcttcattcagaaccagattaccttcttgcaggggtcctacacaagaggaattgatcctaattatgccaataaggtttctatcccagttcctaaaatggtagatgacgggaagagcatgcgtgtgaaacatccgaagtggaagctgagaacgaagaatgagtacaacctgtggactgcataccagaacgaggaaacgcagcaggtcctgatagaggagagaaatgttttctgtgggacctacaatgttcgcattctctctgacacgtgggatcaaaaccgagtcatccactattccgggggagatctgatagctgtgtcatctaatcgaaagatccatcttctggacatcatacaagtgaaagcgatacccgttgaattccgaggccatgctgggagtgtccgggccctcttcctgtgtgaggaggaaaactttctcctaagcgggagctatgacctaagtatcagatactgggatctgaaaagtggggtttgcacacgaatcttcggtggtcaccaggggactatcacttgcatggacttgtgtaagaacaggctcgtatctggaggaagagattgccaggtaaaagtatgggatgtagacacagggaagtgcctgaagacgtttagacacaaagaccccatcttggccaccaggatcaatgatacctacattgtgagcagctgtgagcgagggctggtgaaagtgtggcacattgccatggcccagttggtaaagactctcagtggccatgagggagccgtgaaatgcctgttctttgaccagtggcatctcctctcaggaagtactgatggcctggtcatggcctggagcatggtggggaagtacgagcgctgcctgatggccttcaagcatcccaagatggtggtcaacacagagagcaatgttctcatgttccagtttgagcacataaagtggcagtatgccgtggaaaaaacgaaacaaaagaagaataaggagaaagaggaggaaaaagaagaaaatagtctcatggaaattctctctaagtgtaatattcaggttcacagcccaagagagtctgtatccagtaaacaaactgtgatccaagagctcctaccaggcaaacctcccaagtcccgagtactcctgaagccggccaagttctcttcagcagtgttaatagaggaacttcaaagtcaaggaaagtcaaaatcaccccgaagagatgcagatgatgtggagaaagcacaaaaacaaggacaattggaaactcctggaaaactgcccagtcacccaaagaaaaagtcttggaaaatccctatgtcacctgaccaattcctcctgactgttagcgccctgcagcacgcccataattccggggaatttgcctatccctgtaggccccaaacagaaattactgatgtctggggaccttcaatttcatacccaaggaaggtcttgaatttcaaaggaaaatcaatccaacgtgcagttgatcggttgagattgagcaatcctcctatagatgtgaaacgaaccagtattccccttgaaatccagaaactgcagcccaacttgaagatctctttgcacagtcctagagtccagtccaccataccccagcccatgattatccgctccaggttctctggcagcttaaagggtggagaccaagtgaccagttcaattgaaagggctgtgtgcagtacgggtcccctgaccagtatgcaggtcattaaaccaaaccgcatgctagctccacaagtgggcacagccaccctgtctcttaagaaagaacggcctcgcatctatacagcccttgatccttttagagtgaacactgagttcgtgctgttgaccgtgaaggaggagaaggagcaccaggaagccaagatgaaggaatatcaggccagggagtccactggagtggttgatccaggaaaagtcagcaaagctgcatggatcaggaagatcaaaggcctgcctattgataatttcacgaagcaagggaaaacagcggcccctgaacttggacaaaatgtatttatctaaaccagccttgggaaattacaatgttttacaataaacagaaagccaagcggaaaaaaaaaaa
//
by
@meso_cacase at
DBCLS
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