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2024-04-17 05:44:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001244682 2903 bp mRNA linear PRI 15-APR-2013 DEFINITION Homo sapiens POU class 2 homeobox 3 (POU2F3), transcript variant 2, mRNA. ACCESSION NM_001244682 VERSION NM_001244682.1 GI:347658963 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2903) AUTHORS Takemoto,H., Tamai,K., Akasaka,E., Rokunohe,D., Takiyoshi,N., Umegaki,N., Nakajima,K., Aizu,T., Kaneko,T., Nakano,H. and Sawamura,D. TITLE Relation between the expression levels of the POU transcription factors Skn-1a and Skn-1n and keratinocyte differentiation JOURNAL J. Dermatol. Sci. 60 (3), 203-205 (2010) PUBMED 21074976 REMARK GeneRIF: It is possible that Skn-1a and the related isoforms have different functions in keratinocyte differentiation and proliferation. REFERENCE 2 (bases 1 to 2903) AUTHORS Lena,A.M., Cipollone,R., Amelio,I., Catani,M.V., Ramadan,S., Browne,G., Melino,G. and Candi,E. TITLE Skn-1a/Oct-11 and DeltaNp63alpha exert antagonizing effects on human keratin expression JOURNAL Biochem. Biophys. Res. Commun. 401 (4), 568-573 (2010) PUBMED 20888799 REMARK GeneRIF: the antagonistic effects of Skn-1a and p63 on keratin promoter transactivation is probably through competition for overlapping binding sites on target gene promoter or through an indirect interaction. REFERENCE 3 (bases 1 to 2903) AUTHORS Kukimoto,I., Mori,S., Sato,H., Takeuchi,T. and Kanda,T. TITLE Transcription factor human Skn-1a enhances replication of human papillomavirus DNA through the direct binding to two sites near the viral replication origin JOURNAL FEBS J. 275 (12), 3123-3135 (2008) PUBMED 18479461 REMARK GeneRIF: Skn-1a enhanced the transient replication of a plasmid containing the HPV16 replication origin in HEK293 cells when co-transfected with a plasmid expressing E1 and E2. REFERENCE 4 (bases 1 to 2903) AUTHORS Nakajima,K., Tamai,K., Yamazaki,T., Toyomaki,Y., Nakano,H., Uitto,J. and Sawamura,D. TITLE Identification of Skn-1n, a splice variant induced by high calcium concentration and specifically expressed in normal human keratinocytes JOURNAL J. Invest. Dermatol. 128 (5), 1336-1339 (2008) PUBMED 17989732 REMARK GeneRIF: splice variant induced in keratinocytes by high calcium REFERENCE 5 (bases 1 to 2903) AUTHORS Zhang,Z., Huettner,P.C., Nguyen,L., Bidder,M., Funk,M.C., Li,J. and Rader,J.S. TITLE Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer JOURNAL Oncogene 25 (39), 5436-5445 (2006) PUBMED 16607278 REMARK GeneRIF: POU2F3 in cervical cancer cells may be CC-related tumor suppressor genes, which are disrupted by both epigenetic and genetic mechanisms. REFERENCE 6 (bases 1 to 2903) AUTHORS Cabral,A., Fischer,D.F., Vermeij,W.P. and Backendorf,C. TITLE Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation JOURNAL J. Biol. Chem. 278 (20), 17792-17799 (2003) PUBMED 12624109 REMARK GeneRIF: the human Skn-1 locus encodes multifunctional protein isotypes, subjected to biochemical cross-talk, which are likely to play a major role in the fine-tuning of keratinocyte terminal differentiation REFERENCE 7 (bases 1 to 2903) AUTHORS Sugihara,T.M., Kudryavtseva,E.I., Kumar,V., Horridge,J.J. and Andersen,B. TITLE The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300 JOURNAL J. Biol. Chem. 276 (35), 33036-33044 (2001) PUBMED 11429405 REFERENCE 8 (bases 1 to 2903) AUTHORS Hildesheim,J., Foster,R.A., Chamberlin,M.E. and Vogel,J.C. TITLE Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor JOURNAL J. Biol. Chem. 274 (37), 26399-26406 (1999) PUBMED 10473598 REFERENCE 9 (bases 1 to 2903) AUTHORS Andersen,B., Weinberg,W.C., Rennekampff,O., McEvilly,R.J., Bermingham,J.R. Jr., Hooshmand,F., Vasilyev,V., Hansbrough,J.F., Pittelkow,M.R., Yuspa,S.H. and Rosenfeld,M.G. TITLE Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation JOURNAL Genes Dev. 11 (14), 1873-1884 (1997) PUBMED 9242494 REFERENCE 10 (bases 1 to 2903) AUTHORS Goldsborough,A.S., Healy,L.E., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Willison,K.R. and Ashworth,A. TITLE Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11 JOURNAL Nucleic Acids Res. 21 (1), 127-134 (1993) PUBMED 8441607 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000679.7, AK302212.1, AP001150.5 and CU451853.1. This sequence is a reference standard in the RefSeqGene project. Summary: This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302212.1 [ECO:0000332] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-63 AP000679.7 124232-124294 64-109 AK302212.1 64-109 110-110 AP001150.5 16139-16139 111-1208 AK302212.1 111-1208 1209-1362 CU451853.1 305-458 1363-2903 AP001150.5 88053-89593 FEATURES Location/Qualifiers source 1..2903 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11q23.3" gene 1..2903 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /note="POU class 2 homeobox 3" /db_xref="GeneID:25833" /db_xref="HGNC:19864" /db_xref="MIM:607394" exon 1..68 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /inference="alignment:Splign:1.39.8" variation 5 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /replace="c" /replace="t" /db_xref="dbSNP:115204245" variation 15 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /replace="a" /replace="g" /db_xref="dbSNP:183641202" variation 23 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /replace="a" /replace="g" /db_xref="dbSNP:144396126" CDS 35..1351 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /note="isoform 2 is encoded by transcript variant 2; POU domain, class 2, transcription factor 3; octamer-binding protein 11; transcription factor PLA-1; transcription factor Skn-1; octamer-binding transcription factor 11; POU domain transcription factor OCT11a" /codon_start=1 /product="POU domain, class 2, transcription factor 3 isoform 2" /protein_id="NP_001231611.1" /db_xref="GI:347658964" /db_xref="CCDS:CCDS58190.1" /db_xref="GeneID:25833" /db_xref="HGNC:19864" /db_xref="MIM:607394" /translation="
MESPRTAKGGRDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLSDSLQQTLSHRPCHLSQGPAMMSGNQMSGLNASPCQDMASLHPLQQLVLVPGHLQSVSQFLLSQTQPGQQGLQPNLLPFPQQQSGLLLPQTGPGLASQAFGHPGLPGSSLEPHLEASQHLPVPKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPIKPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQNNSKAAVNSASSFNSSGSWYRWNHSTYLH
"
misc_feature 587..811
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/note="Found in Pit-Oct-Unc transcription factors; Region:
POU; smart00352"
/db_xref="CDD:197673"
misc_feature 884..1054
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(884..898,902..904,953..955,971..973,1010..1012,
1016..1021,1028..1033,1037..1045,1049..1054)
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(890..892,899..901,1019..1021,1028..1033,1040..1042)
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
variation 48
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:147851945"
variation 52
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:189258763"
variation 63
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:882856"
exon 69..137
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 77
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:201301538"
variation 95
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:201020292"
variation 102
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:372245806"
variation 103
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:150562013"
variation 110
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:150644971"
exon 138..172
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 147
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:200756719"
variation 169
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:374278692"
exon 173..298
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 181
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:139585451"
variation 197
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="g"
/replace="t"
/db_xref="dbSNP:149689245"
variation 221
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:372543314"
variation 251
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:145496153"
variation 259
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:113447905"
variation 283
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:370189714"
exon 299..401
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 318
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:199908870"
variation 391
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:369163466"
variation 399
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:139221088"
variation 400
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:143953974"
exon 402..484
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 416
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:146425412"
variation 442
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:367755083"
variation 443
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:200455762"
variation 475
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:140710784"
variation 479
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:143843036"
variation 483
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:376782432"
exon 485..667
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 486
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:201145362"
variation 489
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:151083714"
variation 494
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:202027996"
variation 495
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:7110845"
variation 544
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:150249219"
variation 555
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:139093583"
variation 586
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:201298803"
variation 604
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:370431541"
exon 668..809
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 687
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:371408943"
variation 775
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:374712708"
exon 810..946
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 818
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:201865274"
variation 820
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:377762447"
variation 837
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:371185538"
variation 894
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:143121284"
variation 899
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:147033976"
variation 905
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:373394231"
variation 918
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:138343985"
variation 933
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:149531239"
exon 947..1108
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 964
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:376467328"
variation 973
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:376184076"
variation 988
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:35602880"
variation 996
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:377205553"
variation 1006
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:148695404"
variation 1039
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:372281815"
variation 1052
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:202225394"
variation 1080
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:149496403"
variation 1084
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:146242937"
variation 1088
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:375346340"
variation 1101
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:201319590"
variation 1104
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:77550935"
exon 1109..1175
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
exon 1176..1311
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 1180
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:144064421"
variation 1202
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:113676807"
variation 1209
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:2282537"
variation 1210
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:139827446"
variation 1237
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:147219684"
variation 1261
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:377039236"
variation 1289
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:150057507"
exon 1312..2903
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 1323
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:370231426"
variation 1354
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:190020776"
variation 1357
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:376587998"
variation 1388
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:376715195"
variation 1430
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:375456701"
variation 1456
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:140667393"
variation 1494
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:369925673"
variation 1511
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:61898346"
variation 1609
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:144375055"
variation 1662..1663
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="tt"
/db_xref="dbSNP:3832733"
variation 1663
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:200541107"
variation 1822
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:375085577"
variation 1853
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:112050659"
variation 1952
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:75477342"
variation 1953
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:146080572"
variation 2014
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="g"
/replace="t"
/db_xref="dbSNP:112894319"
STS 2044..2227
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/standard_name="RH69888"
/db_xref="UniSTS:27428"
variation 2115
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:151121242"
variation 2133
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:73578283"
variation 2177..2178
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="g"
/db_xref="dbSNP:35061338"
variation 2206
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:373224204"
variation 2310
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:141117331"
variation 2324..2325
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="g"
/db_xref="dbSNP:201098205"
variation 2324
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:112976121"
variation 2377
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:376535498"
variation 2391
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:78221919"
variation 2397
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:4938797"
variation 2403
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="c"
/db_xref="dbSNP:368955441"
variation 2403
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:200901486"
variation 2404
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:4938798"
variation 2408
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:78177158"
variation 2409
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:185314501"
variation 2468
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:372681012"
variation 2488
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:188928459"
STS 2492..2615
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/standard_name="D11S2560"
/db_xref="UniSTS:37928"
variation 2492
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:181535671"
STS 2496..2629
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/standard_name="D15S1477"
/db_xref="UniSTS:474482"
STS 2503..2596
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 2512
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:11217815"
variation 2531
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:145483650"
variation 2657
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:141111966"
variation 2694
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:112541714"
variation 2767
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:375262616"
variation 2812..2813
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="a"
/db_xref="dbSNP:200735927"
variation 2813
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="a"
/db_xref="dbSNP:373950522"
variation 2824
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:200773770"
ORIGIN
ctcactccagcccagagctcaaaaaaccggtttcatggagtctccaagaactgctaaaggaggaagggatatcaagatgagtggggatgtagccgattccacggatgctcgcagcactctcagccaggtggagccaggaaatgatcgaaatggcctagatttcaacaggcagattaaaaccgaagatctcagtgactccctgcagcagaccctctcccatcggccatgccacctgagtcaaggacctgccatgatgtccggaaaccaaatgtctgggctaaatgccagcccatgtcaggacatggcttccctccatccgctccagcagcttgtgctggttcccggccacttacagtctgtatcccagttcctgctatctcagacccagcctgggcagcaaggtctgcagccaaatctcctcccctttccacagcaacaaagcggtctcctcctcccacagactgggccgggactggcatcccaggcatttgggcaccctgggctgccaggatcctctttagaaccccacctggaagcatcccagcatctcccagtgcccaagcatctacccagctctggaggggccgatgagcccagtgacctcgaggagctggagaagtttgccaagaccttcaagcagaggcgcattaagctgggcttcacacagggagatgtggggctggcgatgggaaagctgtatggcaacgacttcagccagaccaccatctcacgatttgaggccctcaacctgagcttcaagaacatgtgcaagctcaagcccctgctggagaagtggctgaatgatgcagagtcctctccgtcagacccctcagtgagcacgcccagctcctaccccagcctcagtgaagtatttggtaggaagagaaagaaacggaccagcatcgagaccaacatccgcctgactctggagaagaggtttcaagataacccaaaacccagctcggaggagatctccatgattgcagagcagttgtccatggagaaggaggtggtgagggtctggttctgcaaccgacgccaaaaggagaagcgaatcaactgccctgtggccacacccatcaaaccacctgtctacaactcccggctggtatctccctcagggtctctgggccccctctctgtccctcctgtccacagtaccatgcctggaacagtaacgtcatcctgttcccctgggaacaacagcaggccttcatctcctggctcaggactccacgccagcagccccactgcatctcaaaataactccaaagcagcagtgaactccgcctccagttttaactcttcaggatcttggtaccgatggaatcattccacctacctccactgagaccaaaaagtttctcctactccagctggccctgtattccccctggaaggaagggaatcatgccttctatatacagacagattgccttcagaagagtggaagaaaatctccactatcaatgaacccagactcttgtcttcttcaagagcaagggcctccggagatccaaactgtgattgaaccaagtgcagactcctaatgctcttgaaatacacagcccctcctaggagcttaccattttcaccttccttgcctatgcccttgccttctagttccaaatattttagccagcttcactgtggcaatagtctttcagagaaaagacttcttgctgttattctccaactcatccgtgggcttctggggacagccatttggctggggtgccaaacaccagaaggggagataatagttttgactctgaacttggccacaacccctgaactgatcccaaaatctgtgaaaagatttgaatctgatatctccaccaaagccttgatgttttctctgtacagctaagttttctgatggaatcttcatctcaccccattttctttttaacctcgcccccttttctacaatcaaatccattcattattgcgccctccaggtcccctcctttttgcagaaggtgtaaaagagctgcccttggtgggtgccctgggcatgttgcaacgcctgctggtgcccttctgtctgtccacgtctgcctagggctcaggagtgcttgttctttcccttcctccctgtgtttctctttatcctgtcccctctcctttctcctggcagcagaaaaggaagaacacaagagcaaacacacaacaatgatggtggcaaagtacctgtatatagccctttcccattttttgcattatgttcttaactccttaatgtggaattttccagcaaaatgtttaactcaggtgtgatttttgaaaatgtctctgtaatattttatcttctttaaaaaaaagggggggaaataccaaagtgtgaaatactgtgctaccttccagagttcccacatgggctgggatttttttttctttttcttttttttttttttttttgagacagtcttgctccagcccaggctggagtgcagtggcatgatcttggctcactgcatgctctgccacttgggttcaagcgattctcctgcctcagcctctcaagtagcgggattacaggcgcccaccaccaaaaattagcccagctaatttttgtatttttagtagagatggggtttcaccatgttggtcaggctggtcttgaactcctgacctcctgatccacccacctcagcgtcccgaagtgctgggattacaggtgtgagccaccgcgcctggcctgggctgggaatctttgttgacttctttgggaacattatctctagagtctgcttttttgtgggccagtttgtagagatgtaacatgaagccattccagaaatggtaacttaaaaaaaaaaagactacatgtctaggaaactgttgagattcaaaggaatctcactgttcctaaataaatgtgtatagtgattatgaaaagt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:25833 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:25833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:25833 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA
GeneID:25833 -> Molecular function: GO:0046983 [protein dimerization activity] evidence: IEA
GeneID:25833 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:25833 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:25833 -> Biological process: GO:0008544 [epidermis development] evidence: TAS
GeneID:25833 -> Biological process: GO:0030216 [keratinocyte differentiation] evidence: IEA
GeneID:25833 -> Biological process: GO:0042060 [wound healing] evidence: IEA
GeneID:25833 -> Biological process: GO:0043922 [negative regulation by host of viral transcription] evidence: IDA
GeneID:25833 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:25833 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:25833 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
GeneID:25833 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:25833 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
by
@meso_cacase at
DBCLS
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