LOCUS       NM_001204963            4162 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens pre-B-cell leukemia homeobox 1 (PBX1), transcript
            variant 3, mRNA.
ACCESSION   NM_001204963
VERSION     NM_001204963.1  GI:326320051
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4162)
  AUTHORS   Martinez-Mancilla,M., Rodriguez-Aguirre,I., Tejocote-Romero,I.,
            Medina-Sanson,A., Ocadiz-Delgado,R. and Gariglio,P.
  TITLE     Clinical relevance of the fusion transcripts distribution pattern
            in mexican children with acute lymphoblastic leukemia
  JOURNAL   J. Pediatr. Hematol. Oncol. 35 (3), 170-173 (2013)
   PUBMED   23511488
  REMARK    GeneRIF: E2a-pbx1-positive patients are associated with more
            aggressive acute lymphoblastic leukemia.
REFERENCE   2  (bases 1 to 4162)
  AUTHORS   Rafiq,S., Tapper,W., Collins,A., Khan,S., Politopoulos,I.,
            Gerty,S., Blomqvist,C., Couch,F.J., Nevanlinna,H., Liu,J. and
            Eccles,D.
  TITLE     Identification of inherited genetic variations influencing
            prognosis in early-onset breast cancer
  JOURNAL   Cancer Res. 73 (6), 1883-1891 (2013)
   PUBMED   23319801
REFERENCE   3  (bases 1 to 4162)
  AUTHORS   Cuda,C.M., Li,S., Liang,S., Yin,Y., Potula,H.H., Xu,Z.,
            Sengupta,M., Chen,Y., Butfiloski,E., Baker,H., Chang,L.J.,
            Dozmorov,I., Sobel,E.S. and Morel,L.
  TITLE     Pre-B cell leukemia homeobox 1 is associated with lupus
            susceptibility in mice and humans
  JOURNAL   J. Immunol. 188 (2), 604-614 (2012)
   PUBMED   22180614
  REMARK    GeneRIF: Splice isoform PBX1-d is expressed more frequently in CD4+
            T cells from lupus patients than from healthy controls. Its
            presence correlates with an increased central memory T cell
            population.
REFERENCE   4  (bases 1 to 4162)
  AUTHORS   Thiaville,M.M., Stoeck,A., Chen,L., Wu,R.C., Magnani,L.,
            Oidtman,J., Shih,Ie.M., Lupien,M. and Wang,T.L.
  TITLE     Identification of PBX1 target genes in cancer cells by global
            mapping of PBX1 binding sites
  JOURNAL   PLoS ONE 7 (5), E36054 (2012)
   PUBMED   22567123
  REMARK    GeneRIF: The results demonstrate that MEOX1 is a critical target
            gene and cofactor of PBX1 in ovarian cancers.
REFERENCE   5  (bases 1 to 4162)
  AUTHORS   Magnani,L., Ballantyne,E.B., Zhang,X. and Lupien,M.
  TITLE     PBX1 genomic pioneer function drives ERalpha signaling underlying
            progression in breast cancer
  JOURNAL   PLoS Genet. 7 (11), E1002368 (2011)
   PUBMED   22125492
  REMARK    GeneRIF: PBX1 is a novel pioneer factor defining aggressive
            ERalpha-positive breast tumors, as it guides ERalpha genomic
            activity to unique genomic regions promoting a transcriptional
            program favorable to breast cancer progression.
REFERENCE   6  (bases 1 to 4162)
  AUTHORS   Lu,Q., Wright,D.D. and Kamps,M.P.
  TITLE     Fusion with E2A converts the Pbx1 homeodomain protein into a
            constitutive transcriptional activator in human leukemias carrying
            the t(1;19) translocation
  JOURNAL   Mol. Cell. Biol. 14 (6), 3938-3948 (1994)
   PUBMED   7910944
REFERENCE   7  (bases 1 to 4162)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol. Cell. Biol. 11 (12), 6149-6157 (1991)
   PUBMED   1682799
REFERENCE   8  (bases 1 to 4162)
  AUTHORS   Hunger,S.P., Galili,N., Carroll,A.J., Crist,W.M., Link,M.P. and
            Cleary,M.L.
  TITLE     The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1
            coding sequences in acute lymphoblastic leukemias
  JOURNAL   Blood 77 (4), 687-693 (1991)
   PUBMED   1671560
REFERENCE   9  (bases 1 to 4162)
  AUTHORS   Kamps,M.P., Murre,C., Sun,X.H. and Baltimore,D.
  TITLE     A new homeobox gene contributes the DNA binding domain of the
            t(1;19) translocation protein in pre-B ALL
  JOURNAL   Cell 60 (4), 547-555 (1990)
   PUBMED   1967983
REFERENCE   10 (bases 1 to 4162)
  AUTHORS   Nourse,J., Mellentin,J.D., Galili,N., Wilkinson,J., Stanbridge,E.,
            Smith,S.D. and Cleary,M.L.
  TITLE     Chromosomal translocation t(1;19) results in synthesis of a
            homeobox fusion mRNA that codes for a potential chimeric
            transcription factor
  JOURNAL   Cell 60 (4), 535-545 (1990)
   PUBMED   1967982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB270853.1, AL359255.12,
            DA760179.1, BC101578.1, AK299673.1, AL390119.25 and AL049381.1.
            
            Summary: This gene encodes a nuclear protein that belongs to the
            PBX homeobox family of transcriptional factors. Studies in mice
            suggest that this gene may be involved in the regulation of
            osteogenesis, and required for skeletal patterning and programming.
            A chromosomal translocation, t(1;19) involving this gene and
            TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic
            leukemia. The resulting fusion protein, in which the DNA binding
            domain of E2A is replaced by the DNA binding domain of this
            protein, transforms cells by constitutively activating
            transcription of genes regulated by the PBX protein family.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2011].
            
            Transcript Variant: This variant (3) contains an alternate 3'
            terminal exon compared to variant 1. This results in a frame-shift
            and a shorter isoform (3) with a distinct C-terminus compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299673.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               DB270853.1         2-274
            274-274             AL359255.12        7609-7609
            275-591             DA760179.1         235-551
            592-1663            BC101578.1         181-1252
            1664-1881           AK299673.1         1280-1497
            1882-4109           AL390119.25        14600-16827
            4110-4162           AL049381.1         2226-2278
FEATURES             Location/Qualifiers
     source          1..4162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23"
     gene            1..4162
                     /gene="PBX1"
                     /note="pre-B-cell leukemia homeobox 1"
                     /db_xref="GeneID:5087"
                     /db_xref="HGNC:8632"
                     /db_xref="MIM:176310"
     exon            1..654
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       274
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12033962"
     variation       293
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377078800"
     misc_feature    452..454
                     /gene="PBX1"
                     /note="upstream in-frame stop codon"
     variation       455
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:187406949"
     CDS             464..1726
                     /gene="PBX1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     pre-B-cell leukemia transcription factor 1; homeobox
                     protein PRL; homeobox protein PBX1"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 1
                     isoform 3"
                     /protein_id="NP_001191892.1"
                     /db_xref="GI:326320052"
                     /db_xref="CCDS:CCDS55653.1"
                     /db_xref="GeneID:5087"
                     /db_xref="HGNC:8632"
                     /db_xref="MIM:176310"
                     /translation="

MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISHLPRHPRQAHYHFRLPTWHP

"
     misc_feature    578..1159
                     /gene="PBX1"
                     /note="PBC domain; Region: PBC; pfam03792"
                     /db_xref="CDD:146435"
     misc_feature    725..730
                     /gene="PBX1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Breakpoint for translocation to form TCF3-PBX1
                     oncogene; propagated from UniProtKB/Swiss-Prot (P40424.1);
                     other site"
     misc_feature    1163..1345
                     /gene="PBX1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1163..1177,1181..1183,1241..1243,1259..1261,
                     1298..1300,1304..1309,1316..1321,1325..1333,1337..1342)
                     /gene="PBX1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1169..1171,1178..1180,1307..1309,1316..1321,
                     1328..1330)
                     /gene="PBX1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       472
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375925928"
     variation       524
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2275558"
     variation       541
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372558581"
     variation       555
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:192264696"
     variation       576
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370561885"
     variation       589
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144593424"
     variation       615
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111531180"
     variation       650
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148894677"
     exon            655..728
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       655
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148071998"
     variation       666
                     /gene="PBX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200380618"
     variation       687
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369144775"
     variation       719
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138090483"
     exon            729..973
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       744
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35543782"
     variation       811
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200580172"
     variation       826
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147201088"
     variation       865
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199855181"
     variation       878
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201279083"
     variation       967
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143132748"
     exon            974..1164
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       997
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375506788"
     variation       1117
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41266608"
     variation       1139
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376272015"
     exon            1165..1300
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1195
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190363555"
     variation       1252
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139881410"
     exon            1301..1460
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1396
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148808502"
     exon            1461..1573
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1556..1557
                     /gene="PBX1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34778614"
     variation       1561
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186124927"
     variation       1562
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142396283"
     exon            1574..1663
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1587
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201963901"
     variation       1623
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201029742"
     variation       1624
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188237782"
     variation       1627
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143289090"
     variation       1655
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146653553"
     exon            1664..4154
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1749
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:182360910"
     variation       1826
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143084650"
     variation       1882
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12137588"
     variation       1884
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116759584"
     variation       1955
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377715625"
     variation       1994
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1213289"
     variation       2020
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185807689"
     variation       2021
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146049929"
     variation       2025
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140017132"
     variation       2033
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41266622"
     variation       2141..2148
                     /gene="PBX1"
                     /replace=""
                     /replace="ttcctgct"
                     /db_xref="dbSNP:200522109"
     STS             2158..2266
                     /gene="PBX1"
                     /standard_name="D13S1219"
                     /db_xref="UniSTS:154178"
     variation       2181
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192322594"
     variation       2335
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:183653789"
     variation       2441
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189051618"
     variation       2484
                     /gene="PBX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:4035254"
     variation       2486
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2347802"
     variation       2509..2510
                     /gene="PBX1"
                     /replace=""
                     /replace="aaca"
                     /db_xref="dbSNP:138419870"
     variation       2513..2514
                     /gene="PBX1"
                     /replace=""
                     /replace="aaca"
                     /db_xref="dbSNP:144153490"
     variation       2517
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4035255"
     variation       2547
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2881731"
     variation       2552
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:15171"
     variation       2671
                     /gene="PBX1"
                     /replace=""
                     /replace="aaaaaa"
                     /db_xref="dbSNP:4035256"
     variation       2708
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12119896"
     variation       2791..2792
                     /gene="PBX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:58819847"
     variation       2831
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149358308"
     variation       2868
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182844405"
     variation       3001
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114960248"
     variation       3184
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144730408"
     variation       3249
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12723035"
     variation       3254
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:187111912"
     variation       3276
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148544292"
     variation       3277
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376221491"
     variation       3324
                     /gene="PBX1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:372152597"
     variation       3388
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191566129"
     variation       3406
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377612148"
     variation       3412
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184546154"
     variation       3452
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370785680"
     variation       3497
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111404742"
     variation       3557..3558
                     /gene="PBX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:80017588"
     variation       3605
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373883472"
     STS             3650..3777
                     /gene="PBX1"
                     /standard_name="RH102792"
                     /db_xref="UniSTS:97126"
     variation       3744
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189019083"
     variation       3781..3782
                     /gene="PBX1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:200183940"
     variation       3867
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142594726"
     polyA_signal    4124..4129
                     /gene="PBX1"
     variation       4144
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192705206"
     polyA_site      4154
                     /gene="PBX1"
ORIGIN      

aaagtttgcattgcaatccccctgccttcctctcctttctcccgatcaatgcatatttgcaaaaggattaagccacagatttaagcgccgggagcccatttctgccttgcaaaggagaccggactgaaaaacctaaagccagctctgatttcttttcgccaagtgggaaggtggtttatttttcttgctttttggagtcaacacccttccccaccagcccttatccccaccctcaccccgcaaccccttcacgccccctccccctccccctcctcatcctcccaccatcctctaaagaggcaaagggattttttttttcttttggtcttcttttttcccccttccctgtttatcctgaaaaggatttgaagacaagcttgaaggataaaaagccttggtgcttcccaggagccgagccgaggagcagaagaggaagagccgggggctgccgtagcctttggagatggacgagcagcccaggctgatgcattcccatgctggggtcgggatggccggacaccccggcctgtcccagcacttgcaggatggggccggagggaccgagggggagggcgggaggaagcaggacattggagacattttacagcaaattatgaccatcacagaccagagtttggatgaggcgcaggccagaaaacatgctttaaactgccacagaatgaagcctgccttgtttaatgtgttgtgtgaaatcaaagaaaaaacagttttgagtatccgaggagcccaggaggaggaacccacagacccccagctgatgcggctggacaacatgctgttagcggaaggcgtggcggggcctgagaagggcggagggtcggcggcagcggcggcagcggcggcggcttctggaggggcaggttcagacaactcagtggagcattcagattacagagccaaactctcacagatcagacaaatctaccatacggagctggagaaatacgagcaggcctgcaacgagttcaccacccacgtgatgaatctcctgcgagagcaaagccggaccaggcccatctccccaaaggagattgagcggatggtcagcatcatccaccgcaagttcagctccatccagatgcagctcaagcagagcacgtgcgaggcggtgatgatcctgcgttcccgatttctggatgcgcggcggaagagacggaatttcaacaagcaagcgacagaaatcctgaatgaatatttctattcccatctcagcaacccttaccccagtgaggaagccaaagaggagttagccaagaagtgtggcatcacagtctcccaggtatcaaactggtttggaaataagcgaatccggtacaagaagaacataggtaaatttcaagaggaagccaatatttatgctgccaaaacagctgtcactgctaccaatgtgtcagcccatggaagccaagctaactcgccctcaactcccaactcggctggttcttccagttcttttaacatgtcaaactctggagatttgttcatgagcgtgcagtcactcaatggggattcttaccaaggggcccaggttggagccaacgtgcaatcacaggtggatacccttcgccatgttatcagccagacaggaggatacagtgatggactcgcagccagtcagatgtacagtccgcagggcatcagtcacctcccccggcacccccggcaagcccactatcacttccgacttccaacgtggcatccgtgagatctgtccacattaggcgaagcaggagaacactgagagcagcaggatgggtttggaaagagcatgcctctggaaacacagcttcctgggaattcacatgaggccagtcctacagagagcaagatgcaccccaggatttcttcattttctaatagatgtgggagtgctccattttccccgacagcgaatttcccctgagaaacgatactagaccctgggtttgcccaccttgtaactcttccttatctcctccttttcatccctaatccatcctccctctggcatggaattgacgcccgtgcagtacatttgccaagtggcaccttctttcaatttatgttttattttgctatggtggtgattctttatttgctggttgtcttttctcacacatctttctctctgtctctctctttcctgctctttgtttttctgcccagaaaaacctgacttcgataccaaaaaagatgaaactacagaaactcaaatttaaaaaaaactttaaaagaaacaaaaaaatactcaacgattctttcagctttattaacattttccattgtttcttgcgacttgtgtctcgttctttgtagtattgatgatgaacatttgataatgaatgttcttgtatattcagataaagaaaaaaaaaaccaaaaaagcggtctgaatttaatagtgtttataataaaaattttaaaaatgaccctcatagcacgcaaaacaggatggggaatttcccctcttctttctgtgacaatgcgcatcattcctgcattagtttttaacaccagactacctacattcatcatttccctcatttttcttttattttcttgcatttgtgaattagttcaagaatgctagaaaagtgtcgagttgtgcacatccatttcttgtttcacaatgtttaaaagtgacagtaattcattttgtaaactaaaaaaaaaaaaaaaaaggttggaatagtgagcataataggtacaacctaacacattattatgtttattaactttgagacccagaaataaattcttttcttttcttgattcttgctcttaaaaatacaaaaaaaaaaatgttttgttttgtgttatttttggtttgtttattggggggctttttttaattgtcaggattatgatcttgctgtttttcttcaatatgtatacaaggtgatgtgaaaagatgacttgggcagaggagtaagaacaagtaggcttgttcttctactttgcttcagaattcagttaatgccaaaagcgaagatcaagcccatgttgatgtctcgttgctcacctgcatttccagagagtgtgacactcatgcagtccctgagaaaaataaaatcagggacatacttctccttttagccttttaaaaattcaaaaacgtttagtccaagggaactttttatgctatcaggaaaggtttttgctgtttttgattctgattatcacagccaagtactttgttttatttctccctaattaataactacattccatgaggcctcttccaaccaaagaggccttttcttccaggagagtcccgcaggagatgctggtatgatgggcaccattggttaagtaaactacatgcaggaagaagtccttggggccagtctgccagctgagtcctggttttggatgaagagttaatgagatattgggccaggctcaatgctgtagttttaatgctaagaggttacgtttacttcacagagtacacctcttagtaacctctgacttaggcagctgcttaaagcaaattgcaaaactggcttgatttggaatgtttttattagaggaaaaaagaaagccatattatctggaaaaaaattcattttaaataccatcattcaacaaattatgttcagaaagtggtcagaacttaagcaagaaaagtaaagaaagaatgcagaattgtggagcaatgctttaggaaatatttctacctgaacacttgtactcttgaagtcacaacaaaataatgatgagcttttcacatcacctttatggtttcaatccctagctcaaagcttcctggaatcttttattttttgtaaacttttttttcttttgttaaaataaataaaacattcaatgtttttctccttttctctcttattacttctttcctttggcattttcaatttgaaatgctttcctttggttgttggttttattctccccctacccctccccttttcttattattcagaatataaacctgcaaagctctgctctgttttggttttgaaagtttaagcttttctgcttctgtgagagcacaggcttctgtcccttttgattccaactgaacttttgtgttctctaatgatactaacacggtgtaggttttacagtctcctaatttgtactggtaatgcatattccaaataaatagtttcttttgttgcaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5087 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IEA
            GeneID:5087 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
            GeneID:5087 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS
            GeneID:5087 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5087 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:5087 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:5087 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
            GeneID:5087 -> Biological process: GO:0001658 [branching involved in ureteric bud morphogenesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0006694 [steroid biosynthetic process] evidence: IEA
            GeneID:5087 -> Biological process: GO:0007548 [sex differentiation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0009887 [organ morphogenesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:5087 -> Biological process: GO:0009954 [proximal/distal pattern formation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] evidence: IEA
            GeneID:5087 -> Biological process: GO:0030278 [regulation of ossification] evidence: IEA
            GeneID:5087 -> Biological process: GO:0030325 [adrenal gland development] evidence: IEA
            GeneID:5087 -> Biological process: GO:0030326 [embryonic limb morphogenesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0035162 [embryonic hemopoiesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:5087 -> Biological process: GO:0045665 [negative regulation of neuron differentiation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0048536 [spleen development] evidence: IEA
            GeneID:5087 -> Biological process: GO:0048538 [thymus development] evidence: IEA
            GeneID:5087 -> Biological process: GO:0048706 [embryonic skeletal system development] evidence: IEA
            GeneID:5087 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5087 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
            GeneID:5087 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:5087 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA