LOCUS       NM_001204961            6805 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens pre-B-cell leukemia homeobox 1 (PBX1), transcript
            variant 2, mRNA.
ACCESSION   NM_001204961
VERSION     NM_001204961.1  GI:326320047
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6805)
  AUTHORS   Martinez-Mancilla,M., Rodriguez-Aguirre,I., Tejocote-Romero,I.,
            Medina-Sanson,A., Ocadiz-Delgado,R. and Gariglio,P.
  TITLE     Clinical relevance of the fusion transcripts distribution pattern
            in mexican children with acute lymphoblastic leukemia
  JOURNAL   J. Pediatr. Hematol. Oncol. 35 (3), 170-173 (2013)
   PUBMED   23511488
  REMARK    GeneRIF: E2a-pbx1-positive patients are associated with more
            aggressive acute lymphoblastic leukemia.
REFERENCE   2  (bases 1 to 6805)
  AUTHORS   Rafiq,S., Tapper,W., Collins,A., Khan,S., Politopoulos,I.,
            Gerty,S., Blomqvist,C., Couch,F.J., Nevanlinna,H., Liu,J. and
            Eccles,D.
  TITLE     Identification of inherited genetic variations influencing
            prognosis in early-onset breast cancer
  JOURNAL   Cancer Res. 73 (6), 1883-1891 (2013)
   PUBMED   23319801
REFERENCE   3  (bases 1 to 6805)
  AUTHORS   Cuda,C.M., Li,S., Liang,S., Yin,Y., Potula,H.H., Xu,Z.,
            Sengupta,M., Chen,Y., Butfiloski,E., Baker,H., Chang,L.J.,
            Dozmorov,I., Sobel,E.S. and Morel,L.
  TITLE     Pre-B cell leukemia homeobox 1 is associated with lupus
            susceptibility in mice and humans
  JOURNAL   J. Immunol. 188 (2), 604-614 (2012)
   PUBMED   22180614
  REMARK    GeneRIF: Splice isoform PBX1-d is expressed more frequently in CD4+
            T cells from lupus patients than from healthy controls. Its
            presence correlates with an increased central memory T cell
            population.
REFERENCE   4  (bases 1 to 6805)
  AUTHORS   Thiaville,M.M., Stoeck,A., Chen,L., Wu,R.C., Magnani,L.,
            Oidtman,J., Shih,Ie.M., Lupien,M. and Wang,T.L.
  TITLE     Identification of PBX1 target genes in cancer cells by global
            mapping of PBX1 binding sites
  JOURNAL   PLoS ONE 7 (5), E36054 (2012)
   PUBMED   22567123
  REMARK    GeneRIF: The results demonstrate that MEOX1 is a critical target
            gene and cofactor of PBX1 in ovarian cancers.
REFERENCE   5  (bases 1 to 6805)
  AUTHORS   Magnani,L., Ballantyne,E.B., Zhang,X. and Lupien,M.
  TITLE     PBX1 genomic pioneer function drives ERalpha signaling underlying
            progression in breast cancer
  JOURNAL   PLoS Genet. 7 (11), E1002368 (2011)
   PUBMED   22125492
  REMARK    GeneRIF: PBX1 is a novel pioneer factor defining aggressive
            ERalpha-positive breast tumors, as it guides ERalpha genomic
            activity to unique genomic regions promoting a transcriptional
            program favorable to breast cancer progression.
REFERENCE   6  (bases 1 to 6805)
  AUTHORS   Lu,Q., Wright,D.D. and Kamps,M.P.
  TITLE     Fusion with E2A converts the Pbx1 homeodomain protein into a
            constitutive transcriptional activator in human leukemias carrying
            the t(1;19) translocation
  JOURNAL   Mol. Cell. Biol. 14 (6), 3938-3948 (1994)
   PUBMED   7910944
REFERENCE   7  (bases 1 to 6805)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol. Cell. Biol. 11 (12), 6149-6157 (1991)
   PUBMED   1682799
REFERENCE   8  (bases 1 to 6805)
  AUTHORS   Hunger,S.P., Galili,N., Carroll,A.J., Crist,W.M., Link,M.P. and
            Cleary,M.L.
  TITLE     The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1
            coding sequences in acute lymphoblastic leukemias
  JOURNAL   Blood 77 (4), 687-693 (1991)
   PUBMED   1671560
REFERENCE   9  (bases 1 to 6805)
  AUTHORS   Kamps,M.P., Murre,C., Sun,X.H. and Baltimore,D.
  TITLE     A new homeobox gene contributes the DNA binding domain of the
            t(1;19) translocation protein in pre-B ALL
  JOURNAL   Cell 60 (4), 547-555 (1990)
   PUBMED   1967983
REFERENCE   10 (bases 1 to 6805)
  AUTHORS   Nourse,J., Mellentin,J.D., Galili,N., Wilkinson,J., Stanbridge,E.,
            Smith,S.D. and Cleary,M.L.
  TITLE     Chromosomal translocation t(1;19) results in synthesis of a
            homeobox fusion mRNA that codes for a potential chimeric
            transcription factor
  JOURNAL   Cell 60 (4), 535-545 (1990)
   PUBMED   1967982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB270853.1, AL359255.12,
            DA760179.1, BC143451.1, AK291415.1, BX647313.1, DA483403.1,
            AK022962.1, AL390119.25 and AL049381.1.
            
            Summary: This gene encodes a nuclear protein that belongs to the
            PBX homeobox family of transcriptional factors. Studies in mice
            suggest that this gene may be involved in the regulation of
            osteogenesis, and required for skeletal patterning and programming.
            A chromosomal translocation, t(1;19) involving this gene and
            TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic
            leukemia. The resulting fusion protein, in which the DNA binding
            domain of E2A is replaced by the DNA binding domain of this
            protein, transforms cells by constitutively activating
            transcription of genes regulated by the PBX protein family.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2011].
            
            Transcript Variant: This variant (2) is missing an internal coding
            exon compared to variant 1. This results in a frame-shift and a
            shorter isoform (2, also known as isoform PBX1b) with a distinct
            C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               DB270853.1         2-274
            274-274             AL359255.12        7609-7609
            275-591             DA760179.1         235-551
            592-1673            BC143451.1         181-1262
            1674-1960           AK291415.1         1469-1755
            1961-2455           BX647313.1         2670-3164
            2456-2765           DA483403.1         338-647
            2766-3210           BX647313.1         3475-3919
            3211-3302           AK022962.1         506-597
            3303-4636           BX647313.1         4012-5345
            4637-6752           AL390119.25        14712-16827
            6753-6805           AL049381.1         2226-2278
FEATURES             Location/Qualifiers
     source          1..6805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23"
     gene            1..6805
                     /gene="PBX1"
                     /note="pre-B-cell leukemia homeobox 1"
                     /db_xref="GeneID:5087"
                     /db_xref="HGNC:8632"
                     /db_xref="MIM:176310"
     exon            1..654
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       274
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12033962"
     variation       293
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377078800"
     STS             412..1686
                     /gene="PBX1"
                     /db_xref="UniSTS:484332"
     misc_feature    452..454
                     /gene="PBX1"
                     /note="upstream in-frame stop codon"
     variation       455
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:187406949"
     CDS             464..1507
                     /gene="PBX1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pre-B-cell leukemia transcription factor 1; homeobox
                     protein PRL; homeobox protein PBX1"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 1
                     isoform 2"
                     /protein_id="NP_001191890.1"
                     /db_xref="GI:326320048"
                     /db_xref="CCDS:CCDS55654.1"
                     /db_xref="GeneID:5087"
                     /db_xref="HGNC:8632"
                     /db_xref="MIM:176310"
                     /translation="

MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGGYPSPCYQPDRRIQ

"
     misc_feature    578..1159
                     /gene="PBX1"
                     /note="PBC domain; Region: PBC; pfam03792"
                     /db_xref="CDD:217730"
     misc_feature    725..730
                     /gene="PBX1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Breakpoint for translocation to form TCF3-PBX1
                     oncogene; propagated from UniProtKB/Swiss-Prot (P40424.1);
                     other site"
     misc_feature    1163..1345
                     /gene="PBX1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(1163..1177,1181..1183,1241..1243,1259..1261,
                     1298..1300,1304..1309,1316..1321,1325..1333,1337..1342)
                     /gene="PBX1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1169..1171,1178..1180,1307..1309,1316..1321,
                     1328..1330)
                     /gene="PBX1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     variation       472
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375925928"
     variation       524
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2275558"
     variation       541
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372558581"
     variation       555
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:192264696"
     variation       576
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370561885"
     variation       589
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144593424"
     variation       615
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111531180"
     variation       650
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148894677"
     exon            655..728
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       655
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148071998"
     variation       666
                     /gene="PBX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200380618"
     variation       687
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369144775"
     variation       719
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138090483"
     exon            729..973
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       744
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35543782"
     variation       811
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200580172"
     variation       826
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147201088"
     variation       865
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199855181"
     variation       878
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201279083"
     variation       967
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143132748"
     exon            974..1164
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       997
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375506788"
     variation       1117
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41266608"
     variation       1139
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376272015"
     exon            1165..1300
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1195
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190363555"
     variation       1252
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139881410"
     exon            1301..1460
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1396
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148808502"
     exon            1461..1550
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1474
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201963901"
     variation       1510
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201029742"
     variation       1511
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188237782"
     variation       1514
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143289090"
     variation       1542
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146653553"
     exon            1551..6797
                     /gene="PBX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1596..1597
                     /gene="PBX1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34262468"
     variation       1613
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369700366"
     variation       1615
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150307059"
     variation       1635
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112169952"
     variation       1654
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377526450"
     variation       1657
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377334192"
     variation       1663
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370789005"
     variation       1667
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142359401"
     variation       1674
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1057073"
     variation       1689
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374816345"
     variation       1719
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3205270"
     STS             1723..1961
                     /gene="PBX1"
                     /standard_name="RH75790"
                     /db_xref="UniSTS:90797"
     variation       1798
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12135379"
     variation       1806
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184165420"
     variation       1834
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9771"
     variation       1838
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:14832"
     variation       1894
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111327965"
     variation       1897
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188518874"
     variation       1932
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375939144"
     variation       1934
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373586993"
     polyA_signal    2017..2022
                     /gene="PBX1"
     polyA_site      2040
                     /gene="PBX1"
     variation       2145
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41266618"
     variation       2208..2209
                     /gene="PBX1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35445188"
     variation       2302
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3738195"
     variation       2336
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115818637"
     STS             2440..2578
                     /gene="PBX1"
                     /standard_name="RH64526"
                     /db_xref="UniSTS:52782"
     variation       2456
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6426881"
     variation       2489
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147638800"
     variation       2514
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142283079"
     variation       2519
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368405625"
     variation       2642
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145716228"
     variation       2670
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184230234"
     variation       2686
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3185695"
     variation       2773
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147776492"
     variation       2837
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141192050"
     variation       2959
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6683162"
     variation       3001
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181970491"
     variation       3019
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143488511"
     variation       3044
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79721421"
     variation       3117
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375028098"
     variation       3216
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369440305"
     variation       3242
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1128595"
     variation       3299
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1128596"
     variation       3409
                     /gene="PBX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:41266620"
     polyA_signal    3439..3444
                     /gene="PBX1"
     variation       3466
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148020619"
     polyA_site      3472
                     /gene="PBX1"
     variation       3538
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141517830"
     STS             3623..3702
                     /gene="PBX1"
                     /standard_name="RH26827"
                     /db_xref="UniSTS:13448"
     variation       3726
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150459354"
     variation       3876
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:187013832"
     variation       4051
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190818629"
     variation       4055
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371564314"
     variation       4101
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138455027"
     variation       4109
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:181559889"
     variation       4117
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185832619"
     variation       4217
                     /gene="PBX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375873881"
     variation       4224
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111698027"
     variation       4233
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190159894"
     variation       4252
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113819464"
     variation       4280
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368896544"
     variation       4392
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:182360910"
     variation       4469
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143084650"
     variation       4525
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12137588"
     variation       4527
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116759584"
     variation       4598
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377715625"
     variation       4637
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1213289"
     variation       4663
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185807689"
     variation       4664
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146049929"
     variation       4668
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140017132"
     variation       4676
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41266622"
     variation       4784..4791
                     /gene="PBX1"
                     /replace=""
                     /replace="ttcctgct"
                     /db_xref="dbSNP:200522109"
     STS             4801..4909
                     /gene="PBX1"
                     /standard_name="D13S1219"
                     /db_xref="UniSTS:154178"
     variation       4824
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192322594"
     variation       4978
                     /gene="PBX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:183653789"
     variation       5084
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189051618"
     variation       5127
                     /gene="PBX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:4035254"
     variation       5129
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2347802"
     variation       5152..5153
                     /gene="PBX1"
                     /replace=""
                     /replace="aaca"
                     /db_xref="dbSNP:138419870"
     variation       5156..5157
                     /gene="PBX1"
                     /replace=""
                     /replace="aaca"
                     /db_xref="dbSNP:144153490"
     variation       5160
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4035255"
     variation       5190
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2881731"
     variation       5195
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:15171"
     variation       5314
                     /gene="PBX1"
                     /replace=""
                     /replace="aaaaaa"
                     /db_xref="dbSNP:4035256"
     variation       5351
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12119896"
     variation       5434..5435
                     /gene="PBX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:58819847"
     variation       5474
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149358308"
     variation       5511
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182844405"
     variation       5644
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114960248"
     variation       5827
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144730408"
     variation       5892
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12723035"
     variation       5897
                     /gene="PBX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:187111912"
     variation       5919
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148544292"
     variation       5920
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376221491"
     variation       5967
                     /gene="PBX1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:372152597"
     variation       6031
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191566129"
     variation       6049
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377612148"
     variation       6055
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184546154"
     variation       6095
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370785680"
     variation       6140
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111404742"
     variation       6200..6201
                     /gene="PBX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:80017588"
     variation       6248
                     /gene="PBX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373883472"
     STS             6293..6420
                     /gene="PBX1"
                     /standard_name="RH102792"
                     /db_xref="UniSTS:97126"
     variation       6387
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189019083"
     variation       6424..6425
                     /gene="PBX1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:200183940"
     variation       6510
                     /gene="PBX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142594726"
     polyA_signal    6767..6772
                     /gene="PBX1"
     variation       6787
                     /gene="PBX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192705206"
     polyA_site      6797
                     /gene="PBX1"
ORIGIN      

aaagtttgcattgcaatccccctgccttcctctcctttctcccgatcaatgcatatttgcaaaaggattaagccacagatttaagcgccgggagcccatttctgccttgcaaaggagaccggactgaaaaacctaaagccagctctgatttcttttcgccaagtgggaaggtggtttatttttcttgctttttggagtcaacacccttccccaccagcccttatccccaccctcaccccgcaaccccttcacgccccctccccctccccctcctcatcctcccaccatcctctaaagaggcaaagggattttttttttcttttggtcttcttttttcccccttccctgtttatcctgaaaaggatttgaagacaagcttgaaggataaaaagccttggtgcttcccaggagccgagccgaggagcagaagaggaagagccgggggctgccgtagcctttggagatggacgagcagcccaggctgatgcattcccatgctggggtcgggatggccggacaccccggcctgtcccagcacttgcaggatggggccggagggaccgagggggagggcgggaggaagcaggacattggagacattttacagcaaattatgaccatcacagaccagagtttggatgaggcgcaggccagaaaacatgctttaaactgccacagaatgaagcctgccttgtttaatgtgttgtgtgaaatcaaagaaaaaacagttttgagtatccgaggagcccaggaggaggaacccacagacccccagctgatgcggctggacaacatgctgttagcggaaggcgtggcggggcctgagaagggcggagggtcggcggcagcggcggcagcggcggcggcttctggaggggcaggttcagacaactcagtggagcattcagattacagagccaaactctcacagatcagacaaatctaccatacggagctggagaaatacgagcaggcctgcaacgagttcaccacccacgtgatgaatctcctgcgagagcaaagccggaccaggcccatctccccaaaggagattgagcggatggtcagcatcatccaccgcaagttcagctccatccagatgcagctcaagcagagcacgtgcgaggcggtgatgatcctgcgttcccgatttctggatgcgcggcggaagagacggaatttcaacaagcaagcgacagaaatcctgaatgaatatttctattcccatctcagcaacccttaccccagtgaggaagccaaagaggagttagccaagaagtgtggcatcacagtctcccaggtatcaaactggtttggaaataagcgaatccggtacaagaagaacataggtaaatttcaagaggaagccaatatttatgctgccaaaacagctgtcactgctaccaatgtgtcagcccatggaagccaagctaactcgccctcaactcccaactcggctggtggatacccttcgccatgttatcagccagacaggaggatacagtgatggactcgcagccagtcagatgtacagtccgcagggcatcagtgctaatggaggttggcaggatgctactaccccttcatcagtgacctcccctacagaaggccctggcagtgttcactctgatacctccaactgatctcccagcaatcgcatcccggctgaccctgtgccccagttggggcaggggcaggagggagggtttctctcccaacgctgaagcggtcagactggaggtcgaagcaatcagcaaacacaataagagtctccttctcttctcttctttgggatgctatttcagccaatctggacacttctttatactctcttcccttttttttctgggtagaagccacccttccctgcctccagctgtcagcctggttttcgtcatcttccctgcccctgtgcctctgtcctagactcccggggtccccgccctctctcatatcactgaaggatattttcaacaattagaggaatttaaagaggaaaaaaattacaaagaaaataataaaagtgtttgtacgttttcatgctggtggtttgaggagccaaatttacctcactcgaatccctcactccctatgttaacaggcaatccttctctgtttctcttattactctcactacctcttagcaggaatactccacattgccctattcattccaggcctccctgcttcctcttgctcttcctccctggggacagtactgattggaacactttcctcctcttccttcctagccccagctattcactggggactgtcatagctgggattctaaaggtgccacatttttcagtttcatctccactaggttggttcccgggcaggaagtcaggcagcagggaaggacacgggaacagcaggtggagaattcctacagtctttcttaccctgctagcaatagctctcagtttcagaggcacagtctttggagaccattcagcactgagaaagcaatatttagaacctattgcaaaactgggcctgagttaggcatggtgatgaatgcatcagcaaggaatagaaagttcttatcgtgaaacccttcaacctcaactatgccttcatagacacacacgttcatgcacatgtaggcacatgtaccatctcacatcttcactttcccgagatgccatatacaattacctacattaataactgtagcactatgccttttgagcccgagagagggaattagtgactctaagtgaaggtcactgacacagagaagcagtatgtgtctggggcttccaggacctgcaggcccactagcgtgcacttaccagaatggcatacacaggacctgatcatgaggaagaccaggtttccagtgtaaactactcttgttcccaccacctctggagcactcagggagccccatacagtacttacaatgtctttaatggacttgattctgtttaattttttgttttatattaggcacactgtattaattttccaaaatgttataccacactatgttcttggtcctgacctattgctctggaggaaagagttgtataagaacgtggctcatgtgaacttttgctagcttcatttgaggacctgagaatcatggggaaagggaaggtaatgttttcattgaaatcatcacagtgatttttattccctgggaacacagcgtgtactaaaaatacatgagaaaatagcatgtatatgaaagctattctcaaaagtcacctgagctcaccatcttcatagccaaccctaccagttataaagatggcagctctatcacttgattaagtgggaggtggtcaaatattttggtgcctcattttcttcatctgtgagatgggaactgttatgcctggcttactaagagtcttgtgagagactgagaagttgattttgttcatatccaatctgtaaatgcgaagtcaggggaagtaatgtccctgaaataaacgggttcatgccatctagggacaataaatggttttcttgttgtaacttctggttaatatcagtaccttgatgtcatcaccgtgatgacaaagagaagagttattgttgatcttcttggttttggtctgtctcttttcttaggataaagaaaaacttccaaactagaaaaacaggccctggttcccttagtttgcacttgaacccaatatgttgccttgtacatacttggtccctgtcacattgactgcttgggaggcttccagggagaagtatgagaccctgaggggtgagaatgggcagctagcaagaacatggaaattctgcttggcactacagtcataaatagaaaacactgtgtgtgctcaggggagcaggggatgccactgaagaaactcaagggaatgtgtatttgaaggaaatgcaaaaactaagtatttagcaaaatgaaattatgccttgatgactaaaaggcactagaaaggttgtgtctactaacttcagccctaatcagaacagatgcctagaaggagcatttttgtgacaacttcatagtgattagaatcagtggagaactccatcttagtggcaggaatataatgaaactacccacgcaagaacatggttgaatcacatttgcttgacttagggcaaagtacgaaagagagacaaaagggttctcttggaaacaagaagagtgactccagatgtggcctgaataattgccatgttaagttaatgcaaaagatcagaacagggctacatttgcacaggcagtttctctccgggccgtagttttcactgatgatcacctttcacagcattttccccaaccagcatttcacttagtcttctctatacccagcacctcccccggcacccccggcaagcccactatcacttccgacttccaacgtggcatccgtgagatctgtccacattaggcgaagcaggagaacactgagagcagcaggatgggtttggaaagagcatgcctctggaaacacagcttcctgggaattcacatgaggccagtcctacagagagcaagatgcaccccaggatttcttcattttctaatagatgtgggagtgctccattttccccgacagcgaatttcccctgagaaacgatactagaccctgggtttgcccaccttgtaactcttccttatctcctccttttcatccctaatccatcctccctctggcatggaattgacgcccgtgcagtacatttgccaagtggcaccttctttcaatttatgttttattttgctatggtggtgattctttatttgctggttgtcttttctcacacatctttctctctgtctctctctttcctgctctttgtttttctgcccagaaaaacctgacttcgataccaaaaaagatgaaactacagaaactcaaatttaaaaaaaactttaaaagaaacaaaaaaatactcaacgattctttcagctttattaacattttccattgtttcttgcgacttgtgtctcgttctttgtagtattgatgatgaacatttgataatgaatgttcttgtatattcagataaagaaaaaaaaaaccaaaaaagcggtctgaatttaatagtgtttataataaaaattttaaaaatgaccctcatagcacgcaaaacaggatggggaatttcccctcttctttctgtgacaatgcgcatcattcctgcattagtttttaacaccagactacctacattcatcatttccctcatttttcttttattttcttgcatttgtgaattagttcaagaatgctagaaaagtgtcgagttgtgcacatccatttcttgtttcacaatgtttaaaagtgacagtaattcattttgtaaactaaaaaaaaaaaaaaaaaggttggaatagtgagcataataggtacaacctaacacattattatgtttattaactttgagacccagaaataaattcttttcttttcttgattcttgctcttaaaaatacaaaaaaaaaaatgttttgttttgtgttatttttggtttgtttattggggggctttttttaattgtcaggattatgatcttgctgtttttcttcaatatgtatacaaggtgatgtgaaaagatgacttgggcagaggagtaagaacaagtaggcttgttcttctactttgcttcagaattcagttaatgccaaaagcgaagatcaagcccatgttgatgtctcgttgctcacctgcatttccagagagtgtgacactcatgcagtccctgagaaaaataaaatcagggacatacttctccttttagccttttaaaaattcaaaaacgtttagtccaagggaactttttatgctatcaggaaaggtttttgctgtttttgattctgattatcacagccaagtactttgttttatttctccctaattaataactacattccatgaggcctcttccaaccaaagaggccttttcttccaggagagtcccgcaggagatgctggtatgatgggcaccattggttaagtaaactacatgcaggaagaagtccttggggccagtctgccagctgagtcctggttttggatgaagagttaatgagatattgggccaggctcaatgctgtagttttaatgctaagaggttacgtttacttcacagagtacacctcttagtaacctctgacttaggcagctgcttaaagcaaattgcaaaactggcttgatttggaatgtttttattagaggaaaaaagaaagccatattatctggaaaaaaattcattttaaataccatcattcaacaaattatgttcagaaagtggtcagaacttaagcaagaaaagtaaagaaagaatgcagaattgtggagcaatgctttaggaaatatttctacctgaacacttgtactcttgaagtcacaacaaaataatgatgagcttttcacatcacctttatggtttcaatccctagctcaaagcttcctggaatcttttattttttgtaaacttttttttcttttgttaaaataaataaaacattcaatgtttttctccttttctctcttattacttctttcctttggcattttcaatttgaaatgctttcctttggttgttggttttattctccccctacccctccccttttcttattattcagaatataaacctgcaaagctctgctctgttttggttttgaaagtttaagcttttctgcttctgtgagagcacaggcttctgtcccttttgattccaactgaacttttgtgttctctaatgatactaacacggtgtaggttttacagtctcctaatttgtactggtaatgcatattccaaataaatagtttcttttgttgcaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5087 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IEA
            GeneID:5087 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
            GeneID:5087 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS
            GeneID:5087 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5087 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:5087 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:5087 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
            GeneID:5087 -> Biological process: GO:0001658 [branching involved in ureteric bud morphogenesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0006694 [steroid biosynthetic process] evidence: IEA
            GeneID:5087 -> Biological process: GO:0007548 [sex differentiation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0009887 [organ morphogenesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:5087 -> Biological process: GO:0009954 [proximal/distal pattern formation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] evidence: IEA
            GeneID:5087 -> Biological process: GO:0030278 [regulation of ossification] evidence: IEA
            GeneID:5087 -> Biological process: GO:0030325 [adrenal gland development] evidence: IEA
            GeneID:5087 -> Biological process: GO:0030326 [embryonic limb morphogenesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0035162 [embryonic hemopoiesis] evidence: IEA
            GeneID:5087 -> Biological process: GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:5087 -> Biological process: GO:0045665 [negative regulation of neuron differentiation] evidence: IEA
            GeneID:5087 -> Biological process: GO:0048536 [spleen development] evidence: IEA
            GeneID:5087 -> Biological process: GO:0048538 [thymus development] evidence: IEA
            GeneID:5087 -> Biological process: GO:0048706 [embryonic skeletal system development] evidence: IEA
            GeneID:5087 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5087 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
            GeneID:5087 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:5087 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA