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2024-03-28 18:22:09, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001203248            2681 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens enhancer of zeste homolog 2 (Drosophila) (EZH2),
            transcript variant 4, mRNA.
ACCESSION   NM_001203248
VERSION     NM_001203248.1  GI:322506098
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2681)
  AUTHORS   Luo,M., Li,Z., Wang,W., Zeng,Y., Liu,Z. and Qiu,J.
  TITLE     Long non-coding RNA H19 increases bladder cancer metastasis by
            associating with EZH2 and inhibiting E-cadherin expression
  JOURNAL   Cancer Lett. 333 (2), 213-221 (2013)
   PUBMED   23354591
  REMARK    GeneRIF: Long non-coding RNA H19 is associated with enhancer of
            zeste homolog 2 (EZH2)
REFERENCE   2  (bases 1 to 2681)
  AUTHORS   Zhang,Y., Liu,G., Lin,C., Liao,G. and Tang,B.
  TITLE     Silencing the EZH2 gene by RNA interference reverses the drug
            resistance of human hepatic multidrug-resistant cancer cells to
            5-Fu
  JOURNAL   Life Sci. 92 (17-19), 896-902 (2013)
   PUBMED   23562851
  REMARK    GeneRIF: EZH2 is highly expressed in the human hepatic
            multidrug-resistant cancer cell line Bel/Fu
REFERENCE   3  (bases 1 to 2681)
  AUTHORS   Li,C.H., To,K.F., Tong,J.H., Xiao,Z., Xia,T., Lai,P.B., Chow,S.C.,
            Zhu,Y.X., Chan,S.L., Marquez,V.E. and Chen,Y.
  TITLE     Enhancer of zeste homolog 2 silences microRNA-218 in human
            pancreatic ductal adenocarcinoma cells by inducing formation of
            heterochromatin
  JOURNAL   Gastroenterology 144 (5), 1086-1097 (2013)
   PUBMED   23395645
  REMARK    GeneRIF: EZH2 is up-regulated in PDAC samples from patients and
            silences miR-218. MicroRNA-218 prevents proliferation of PDAC cells
            in culture, and tumor growth and metastasis in nude mice.
REFERENCE   4  (bases 1 to 2681)
  AUTHORS   Wang,J., Yu,L., Cai,J., Jia,J., Gao,Y., Liang,M. and Wang,Z.
  TITLE     The role of EZH2 and DNA methylation in hMLH1 silencing in
            epithelial ovarian cancer
  JOURNAL   Biochem. Biophys. Res. Commun. 433 (4), 470-476 (2013)
   PUBMED   23523787
  REMARK    GeneRIF: EZH2 can modulate the transcription of basally expressed
            hMLH1 (human mutL homolog 1 gene) via a
            non-DNA-methylation-dependent pathway, but it has no effect on
            hMLH1 silencing that is mediated by DNA hypermethylation.
REFERENCE   5  (bases 1 to 2681)
  AUTHORS   Cao,W., Ribeiro Rde,O., Liu,D., Saintigny,P., Xia,R., Xue,Y.,
            Lin,R., Mao,L. and Ren,H.
  TITLE     EZH2 promotes malignant behaviors via cell cycle dysregulation and
            its mRNA level associates with prognosis of patient with non-small
            cell lung cancer
  JOURNAL   PLoS ONE 7 (12), E52984 (2012)
   PUBMED   23300840
  REMARK    GeneRIF: EZH2 mRNA levels may serve as a prognostic predictor for
            patients with non-small cell lung cancer.
REFERENCE   6  (bases 1 to 2681)
  AUTHORS   Cardoso,C., Timsit,S., Villard,L., Khrestchatisky,M., Fontes,M. and
            Colleaux,L.
  TITLE     Specific interaction between the XNP/ATR-X gene product and the SET
            domain of the human EZH2 protein
  JOURNAL   Hum. Mol. Genet. 7 (4), 679-684 (1998)
   PUBMED   9499421
REFERENCE   7  (bases 1 to 2681)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J. 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (bases 1 to 2681)
  AUTHORS   Chen,H., Rossier,C. and Antonarakis,S.E.
  TITLE     Cloning of a human homolog of the Drosophila enhancer of zeste gene
            (EZH2) that maps to chromosome 21q22.2
  JOURNAL   Genomics 38 (1), 30-37 (1996)
   PUBMED   8954776
REFERENCE   9  (bases 1 to 2681)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (bases 1 to 2681)
  AUTHORS   Hobert,O., Jallal,B. and Ullrich,A.
  TITLE     Interaction of Vav with ENX-1, a putative transcriptional regulator
            of homeobox gene expression
  JOURNAL   Mol. Cell. Biol. 16 (6), 3066-3073 (1996)
   PUBMED   8649418
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN283479.1, AK293239.1,
            BC010858.2 and BU953788.1.
            
            Summary: This gene encodes a member of the Polycomb-group (PcG)
            family. PcG family members form multimeric protein complexes, which
            are involved in maintaining the transcriptional repressive state of
            genes over successive cell generations. This protein associates
            with the embryonic ectoderm development protein, the VAV1
            oncoprotein, and the X-linked nuclear protein. This protein may
            play a role in the hematopoietic and central nervous systems.
            Multiple alternatively splcied transcript variants encoding
            distinct isoforms have been identified for this gene. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (4) lacks two in-frame segments in
            the coding region, as compared to variant 1. The resulting isoform
            (d) lacks two internal segments, as compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                CN283479.1         1-62
            63-2427             AK293239.1         1-2365
            2428-2668           BC010858.2         2399-2639
            2669-2681           BU953788.1         491-503
FEATURES             Location/Qualifiers
     source          1..2681
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35-q36"
     gene            1..2681
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /note="enhancer of zeste homolog 2 (Drosophila)"
                     /db_xref="GeneID:2146"
                     /db_xref="HGNC:3527"
                     /db_xref="MIM:601573"
     exon            1..186
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    32..34
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /note="upstream in-frame stop codon"
     exon            187..310
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     CDS             194..2407
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /EC_number="2.1.1.43"
                     /note="isoform d is encoded by transcript variant 4;
                     lysine N-methyltransferase 6; histone-lysine
                     N-methyltransferase EZH2"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     d"
                     /protein_id="NP_001190177.1"
                     /db_xref="GI:322506099"
                     /db_xref="CCDS:CCDS56518.1"
                     /db_xref="GeneID:2146"
                     /db_xref="HGNC:3527"
                     /db_xref="MIM:601573"
                     /translation="
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSCSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
"
     misc_feature    254..256
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by PKB/AKT1; propagated from
                     UniProtKB/Swiss-Prot (Q15910.2); phosphorylation site"
     misc_feature    308..397
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /note="WD repeat binding protein EZH2; Region:
                     EZH2_WD-Binding; pfam11616"
                     /db_xref="CDD:204691"
     misc_feature    308..397
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15910.2);
                     Region: Interaction with EED (By similarity)"
     misc_feature    1199..1201
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by CDK1 and CDK2; propagated from
                     UniProtKB/Swiss-Prot (Q15910.2); phosphorylation site"
     misc_feature    1262..1264
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q15910.2); phosphorylation site"
     misc_feature    1265..1267
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q15910.2); phosphorylation site"
     misc_feature    1625..1627
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q15910.2); phosphorylation site"
     misc_feature    2000..2365
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax)
                     domain; Region: SET; smart00317"
                     /db_xref="CDD:197649"
     exon            311..412
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            413..529
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            530..650
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            651..791
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            792..894
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            895..1058
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     variation       919
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11541109"
     exon            1059..1150
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            1151..1391
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            1392..1561
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            1562..1656
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            1657..1697
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            1698..1823
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            1824..2002
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            2003..2098
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            2099..2180
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            2181..2261
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            2262..2346
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     exon            2347..2681
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /inference="alignment:Splign:1.39.8"
     variation       2428
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:3217095"
     variation       2428
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201597962"
     variation       2491
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11541108"
     variation       2527
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:8829"
     polyA_signal    2648..2653
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
     polyA_site      2679
                     /gene="EZH2"
                     /gene_synonym="ENX-1; ENX1; EZH1; KMT6; KMT6A; WVS; WVS2"
ORIGIN      
ggcggcgcttgattgggctgggggggccaaataaaagcgatggcgattgggctgccgcgtttggcgctcggtccggtcgcgtccgacacccggtgggactcagaaggcagtggagccccggcggcggcggcggcggcgcgcgggggcgacgcgcgggaacaacgcgagtcggcgcgcgggacgaagaataatcatgggccagactgggaagaaatctgagaagggaccagtttgttggcggaagcgtgtaaaatcagagtacatgcgactgagacagctcaagaggttcagacgagctgatgaagtaaagagtatgtttagttccaatcgtcagaaaattttggaaagaacggaaatcttaaaccaagaatggaaacagcgaaggatacagcctgtgcacatcctgacttcttgttcggtgaccagtgacttggattttccaacacaagtcatcccattaaagactctgaatgcagttgcttcagtacccataatgtattcttggtctcccctacagcagaattttatggtggaagatgaaactgttttacataacattccttatatgggagatgaagttttagatcaggatggtactttcattgaagaactaataaaaaattatgatgggaaagtacacggggatagagaatgtgggtttataaatgatgaaatttttgtggagttggtgaatgcccttggtcaatataatgatgatgacgatgatgatgatggagacgatcctgaagaaagagaagaaaagcagaaagatctggaggatcaccgagatgataaagaaagccgcccacctcggaaatttccttctgataaaatttttgaagccatttcctcaatgtttccagataagggcacagcagaagaactaaaggaaaaatataaagaactcaccgaacagcagctcccaggcgcacttcctcctgaatgtacccccaacatagatggaccaaatgctaaatctgttcagagagagcaaagcttacactcctttcatacgcttttctgtaggcgatgttttaaatatgactgcttcctacatccttttcatgcaacacccaacacttataagcggaagaacacagaaacagctctagacaacaaaccttgtggaccacagtgttaccagcatttggagggagcaaaggagtttgctgctgctctcaccgctgagcggataaagaccccaccaaaacgtccaggaggccgcagaagaggacggcttcccaataacagtagcaggcccagcacccccaccattaatgtgctggaatcaaaggatacagacagtgatagggaagcagggactgaaacggggggagagaacaatgataaagaagaagaagagaagaaagatgaaacttcgagctcctctgaagcaaattctcggtgtcaaacaccaataaagatgaagccaaatattgaacctcctgagaatgtggagtggagtggtgctgaagcctcaatgtttagagtcctcattggcacttactatgacaatttctgtgccattgctaggttaattgggaccaaaacatgtagacaggtgtatgagtttagagtcaaagaatctagcatcatagctccagctcccgctgaggatgtggatactcctccaaggaaaaagaagaggaaacaccggttgtgggctgcacactgcagaaagatacagctgaaaaaggacggctcctctaaccatgtttacaactatcaaccctgtgatcatccacggcagccttgtgacagttcgtgcccttgtgtgatagcacaaaatttttgtgaaaagttttgtcaatgtagttcagagtgtcaaaaccgctttccgggatgccgctgcaaagcacagtgcaacaccaagcagtgcccgtgctacctggctgtccgagagtgtgaccctgacctctgtcttacttgtggagccgctgaccattgggacagtaaaaatgtgtcctgcaagaactgcagtattcagcggggctccaaaaagcatctattgctggcaccatctgacgtggcaggctgggggatttttatcaaagatcctgtgcagaaaaatgaattcatctcagaatactgtggagagattatttctcaagatgaagctgacagaagagggaaagtgtatgataaatacatgtgcagctttctgttcaacttgaacaatgattttgtggtggatgcaacccgcaagggtaacaaaattcgttttgcaaatcattcggtaaatccaaactgctatgcaaaagttatgatggttaacggtgatcacaggataggtatttttgccaagagagccatccagactggcgaagagctgttttttgattacagatacagccaggctgatgccctgaagtatgtcggcatcgaaagagaaatggaaatcccttgacatctgctacctcctcccccctcctctgaaacagctgccttagcttcaggaacctcgagtactgtgggcaatttagaaaaagaacatgcagtttgaaattctgaatttgcaaagtactgtaagaataatttatagtaatgagtttaaaaatcaactttttattgccttctcaccagctgcaaagtgttttgtaccagtgaatttttgcaataatgcagtatggtacatttttcaactttgaataaagaatacttgaacttgtccttgttgaatc
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2146 -> Molecular function: GO:0001047 [core promoter binding] evidence: IEA
            GeneID:2146 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS
            GeneID:2146 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA
            GeneID:2146 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
            GeneID:2146 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:2146 -> Molecular function: GO:0018024 [histone-lysine N-methyltransferase activity] evidence: IEA
            GeneID:2146 -> Molecular function: GO:0042054 [histone methyltransferase activity] evidence: IDA
            GeneID:2146 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:2146 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:2146 -> Biological process: GO:0006325 [chromatin organization] evidence: TAS
            GeneID:2146 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:2146 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS
            GeneID:2146 -> Biological process: GO:0010718 [positive regulation of epithelial to mesenchymal transition] evidence: IDA
            GeneID:2146 -> Biological process: GO:0014013 [regulation of gliogenesis] evidence: IEA
            GeneID:2146 -> Biological process: GO:0021695 [cerebellar cortex development] evidence: IEA
            GeneID:2146 -> Biological process: GO:0032320 [positive regulation of Ras GTPase activity] evidence: IDA
            GeneID:2146 -> Biological process: GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter] evidence: IEA
            GeneID:2146 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IEA
            GeneID:2146 -> Biological process: GO:0043406 [positive regulation of MAP kinase activity] evidence: IDA
            GeneID:2146 -> Biological process: GO:0045605 [negative regulation of epidermal cell differentiation] evidence: IEA
            GeneID:2146 -> Biological process: GO:0045814 [negative regulation of gene expression, epigenetic] evidence: IDA
            GeneID:2146 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IMP
            GeneID:2146 -> Biological process: GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] evidence: IMP
            GeneID:2146 -> Biological process: GO:0051154 [negative regulation of striated muscle cell differentiation] evidence: IEA
            GeneID:2146 -> Biological process: GO:0070314 [G1 to G0 transition] evidence: IEA
            GeneID:2146 -> Biological process: GO:0070734 [histone H3-K27 methylation] evidence: IEA
            GeneID:2146 -> Biological process: GO:0071902 [positive regulation of protein serine/threonine kinase activity] evidence: IDA
            GeneID:2146 -> Biological process: GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] evidence: IEA
            GeneID:2146 -> Cellular component: GO:0035098 [ESC/E(Z) complex] evidence: IDA
            GeneID:2146 -> Cellular component: GO:0045120 [pronucleus] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001190177 -> EC 2.1.1.43

by @meso_cacase at DBCLS
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