GGRNA | NM_001174069.1

LOCUS       NM_001174069            3366 bp    mRNA    linear   PRI 21-APR-2013
DEFINITION  Homo sapiens LIM homeobox transcription factor 1, alpha (LMX1A),
            transcript variant 4, mRNA.
ACCESSION   NM_001174069
VERSION     NM_001174069.1  GI:291327512
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3366)
  AUTHORS   Tsai,W.C., Lee,H.S., Lin,C.K., Chen,A., Nieh,S. and Ma,H.I.
  TITLE     The association of osteopontin and LMX1A expression with World
            Health Organization grade in meningiomas and gliomas
  JOURNAL   Histopathology 61 (5), 844-856 (2012)
   PUBMED   22882568
  REMARK    GeneRIF: Higher immunostaining intensity for OPN and LMX1A
            correlated with WHO grades for meningiomas and some gliomas.
            Contrary to our expectations, LMX1A staining in WHO grade IV
            gliomas was shown to be weaker than in WHO grade III tumours.
REFERENCE   2  (bases 1 to 3366)
  AUTHORS   Panman,L., Andersson,E., Alekseenko,Z., Hedlund,E., Kee,N.,
            Mong,J., Uhde,C.W., Deng,Q., Sandberg,R., Stanton,L.W., Ericson,J.
            and Perlmann,T.
  TITLE     Transcription factor-induced lineage selection of stem-cell-derived
            neural progenitor cells
  JOURNAL   Cell Stem Cell 8 (6), 663-675 (2011)
   PUBMED   21624811
  REMARK    GeneRIF: The Lmx1a can induce desired neuronal lineages from most
            expressing neural progenitor cells by a mechanism resembling
            developmental binary cell-fate switching.
REFERENCE   3  (bases 1 to 3366)
  AUTHORS   Bellander,M., Brehmer,Y., Westerberg,H., Karlsson,S., Furth,D.,
            Bergman,O., Eriksson,E. and Backman,L.
  TITLE     Preliminary evidence that allelic variation in the LMX1A gene
            influences training-related working memory improvement
  JOURNAL   Neuropsychologia 49 (7), 1938-1942 (2011)
   PUBMED   21435346
  REMARK    GeneRIF: One single nucleotide polymorphisms of lmx1a was strongly
            associated with the magnitude of training-related gains in verbal
            working memory
REFERENCE   4  (bases 1 to 3366)
  AUTHORS   Moyer,A.M., Fridley,B.L., Jenkins,G.D., Batzler,A.J.,
            Pelleymounter,L.L., Kalari,K.R., Ji,Y., Chai,Y., Nordgren,K.K. and
            Weinshilboum,R.M.
  TITLE     Acetaminophen-NAPQI hepatotoxicity: a cell line model system
            genome-wide association study
  JOURNAL   Toxicol. Sci. 120 (1), 33-41 (2011)
   PUBMED   21177773
REFERENCE   5  (bases 1 to 3366)
  AUTHORS   Thameem,F., Wolford,J.K., Wang,J., German,M.S., Bogardus,C. and
            Prochazka,M.
  TITLE     Cloning, expression and genomic structure of human LMX1A, and
            variant screening in Pima Indians
  JOURNAL   Gene 290 (1-2), 217-225 (2002)
   PUBMED   12062816
  REMARK    GeneRIF: Did not find evidence for association of any LMX1A SNPs
            with type 2 diabetes mellitus (T2DM) and conclude that LMX1A does
            not contribute significantly to T2DM etiology in Pima Indians.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3366)
  AUTHORS   Jurata,L.W., Pfaff,S.L. and Gill,G.N.
  TITLE     The nuclear LIM domain interactor NLI mediates homo- and
            heterodimerization of LIM domain transcription factors
  JOURNAL   J. Biol. Chem. 273 (6), 3152-3157 (1998)
   PUBMED   9452425
REFERENCE   7  (bases 1 to 3366)
  AUTHORS   Iannotti,C.A., Inoue,H., Bernal,E., Aoki,M., Liu,L.,
            Donis-Keller,H., German,M.S. and Permutt,M.A.
  TITLE     Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2:
            tissue-specific expression and linkage mapping on chromosome 9
  JOURNAL   Genomics 46 (3), 520-524 (1997)
   PUBMED   9441763
REFERENCE   8  (bases 1 to 3366)
  AUTHORS   Jurata,L.W. and Gill,G.N.
  TITLE     Functional analysis of the nuclear LIM domain interactor NLI
  JOURNAL   Mol. Cell. Biol. 17 (10), 5688-5698 (1997)
   PUBMED   9315627
REFERENCE   9  (bases 1 to 3366)
  AUTHORS   German,M.S., Wang,J., Fernald,A.A., Espinosa,R. III, Le Beau,M.M.
            and Bell,G.I.
  TITLE     Localization of the genes encoding two transcription factors, LMX1
            and CDX3, regulating insulin gene expression to human chromosomes 1
            and 13
  JOURNAL   Genomics 24 (2), 403-404 (1994)
   PUBMED   7698771
REFERENCE   10 (bases 1 to 3366)
  AUTHORS   German,M.S., Wang,J., Chadwick,R.B. and Rutter,W.J.
  TITLE     Synergistic activation of the insulin gene by a LIM-homeo domain
            protein and a basic helix-loop-helix protein: building a functional
            insulin minienhancer complex
  JOURNAL   Genes Dev. 6 (11), 2165-2176 (1992)
   PUBMED   1358758
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL160058.8, AK122800.1, AK127724.1, AL390730.12 and BM678780.1.
            
            Summary: This gene encodes a homeodomain and LIM-domain containing
            protein. The encoded protein is a transcription factor that acts as
            a positive regulator of insulin gene transcription. This gene also
            plays a role in the development of dopamine producing neurons
            during embryogenesis. Mutations in this gene are associated with an
            increased risk of developing Parkinson's disease. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2012].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122800.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025085 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL160058.8         14906-14908         c
            4-452               AK122800.1         4-452
            453-1243            AK127724.1         642-1432
            1244-1244           AL390730.12        11526-11526         c
            1245-2420           AK127724.1         1434-2609
            2421-2421           AK122800.1         2421-2421
            2422-2785           AK127724.1         2610-2973
            2786-3366           BM678780.1         8-588               c
FEATURES             Location/Qualifiers
     source          1..3366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.1"
     gene            1..3366
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /note="LIM homeobox transcription factor 1, alpha"
                     /db_xref="GeneID:4009"
                     /db_xref="HGNC:6653"
                     /db_xref="MIM:600298"
     exon            1..172
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(88)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72687734"
     exon            173..270
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(179)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368923297"
     variation       complement(190)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375965709"
     CDS             195..1343
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /note="LIM/homeobox protein 1.1"
                     /codon_start=1
                     /product="LIM homeobox transcription factor 1-alpha"
                     /protein_id="NP_001167540.1"
                     /db_xref="GI:291327513"
                     /db_xref="CCDS:CCDS1247.1"
                     /db_xref="GeneID:4009"
                     /db_xref="HGNC:6653"
                     /db_xref="MIM:600298"
                     /translation="

MLDGLKMEENFQSAIDTSASFSSLLGRAVSPKSVCEGCQRVILDRFLLRLNDSFWHEQCVQCASCKEPLETTCFYRDKKLYCKYDYEKLFAVKCGGCFEAIAPNEFVMRAQKSVYHLSCFCCCVCERQLQKGDEFVLKEGQLLCKGDYEKERELLSLVSPAASDSGKSDDEESLCKSAHGAGKGTAEEGKDHKRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQQQQDQQNTQRLSSAQTNGGGSAGMEGIMNPYTALPTPQQLLAIEQSVYSSDPFRQGLTPPQMPGDHMHPYGAEPLFHDLDSDDTSLSNLGDCFLATSEAGPLQSRVGNPIDHLYSMQNSYFTS

"
     misc_feature    297..452
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /note="The first LIM domain of Lmx1a; Region: LIM1_Lmx1a;
                     cd09370"
                     /db_xref="CDD:188756"
     misc_feature    order(297..299,306..308,360..362,369..371,378..380,
                     387..389,438..440,447..449)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188756"
     misc_feature    474..638
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /note="The second LIM domain of Lmx1a and Lmx1b; Region:
                     LIM2_Lmx1a_Lmx1b; cd09378"
                     /db_xref="CDD:188764"
     misc_feature    order(474..476,483..485,540..542,549..551,558..560,
                     567..569,624..626,633..635)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188764"
     misc_feature    780..950
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(780..794,798..800,849..851,867..869,906..908,
                     912..917,924..929,933..941,945..950)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(786..788,795..797,915..917,924..929,936..938)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       complement(200)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372269250"
     variation       complement(203)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144980188"
     variation       complement(205)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200643176"
     variation       complement(227)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377095215"
     variation       complement(239)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369951809"
     exon            271..457
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(312)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:139738225"
     variation       complement(313)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199877582"
     variation       complement(340)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376967723"
     variation       complement(365)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144186336"
     variation       complement(453)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141657804"
     exon            458..690
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(480)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375082642"
     variation       complement(489)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202040732"
     variation       complement(505)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144319410"
     variation       complement(533)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35943978"
     variation       complement(543)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10753668"
     variation       complement(545)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370894937"
     variation       complement(570)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376042184"
     variation       complement(574)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150222420"
     variation       complement(614)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369819729"
     variation       complement(638)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145214876"
     variation       complement(656)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9970062"
     exon            691..863
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(703)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201194517"
     variation       complement(719)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141454506"
     variation       complement(751..753)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace=""
                     /replace="ctg"
                     /db_xref="dbSNP:376588006"
     variation       complement(765)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144871103"
     variation       complement(774)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149908681"
     variation       complement(788)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200303223"
     variation       complement(833)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:34587265"
     variation       complement(857)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199831288"
     exon            864..941
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(935)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374849037"
     variation       complement(938)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146395249"
     exon            942..1011
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(942)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:148303583"
     variation       complement(957)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:367562812"
     variation       complement(978..979)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace=""
                     /replace="agc"
                     /db_xref="dbSNP:201457558"
     variation       complement(979..980)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace=""
                     /replace="gca"
                     /db_xref="dbSNP:144665555"
     variation       complement(985)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200350574"
     exon            1012..1182
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1041)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:146994534"
     variation       complement(1043)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373067545"
     variation       complement(1051)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202032483"
     variation       complement(1066)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370226701"
     variation       complement(1067)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200784612"
     variation       complement(1077)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:148227502"
     variation       complement(1080)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140864022"
     variation       complement(1092)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377473482"
     variation       complement(1098)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150936773"
     variation       complement(1125)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:186074862"
     variation       complement(1145)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35130714"
     variation       complement(1151)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374428255"
     variation       complement(1170)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369953981"
     variation       complement(1175)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116535186"
     variation       complement(1179)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200209751"
     exon            1183..3356
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1187)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199560186"
     variation       complement(1188)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200583099"
     variation       complement(1217)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186807467"
     variation       complement(1219)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142270152"
     STS             1230..1720
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /standard_name="LMX1A_7814"
                     /db_xref="UniSTS:468079"
     variation       complement(1244)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1354509"
     variation       complement(1246)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148126113"
     variation       complement(1254)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:5778428"
     variation       complement(1283)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138842147"
     variation       complement(1285)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376073290"
     variation       complement(1291)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145918505"
     variation       complement(1302)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:182575654"
     variation       complement(1358)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191246907"
     variation       complement(1390)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150977107"
     variation       complement(1544)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370020304"
     variation       complement(1664)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144312815"
     variation       complement(1698)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139580641"
     variation       complement(1748..1749)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace=""
                     /replace="tg"
                     /db_xref="dbSNP:150276008"
     variation       complement(1764)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41266638"
     variation       complement(1922)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:74118516"
     variation       complement(2024)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:143586869"
     variation       complement(2029..2030)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace=""
                     /replace="ct"
                     /db_xref="dbSNP:202181805"
     variation       complement(2040)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369994362"
     variation       complement(2180)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1936370"
     variation       complement(2207)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1936369"
     variation       complement(2247)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114236288"
     variation       complement(2265)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:188596495"
     variation       complement(2282)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183552842"
     variation       complement(2302)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:35479059"
     variation       complement(2320..2321)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34736945"
     variation       complement(2327)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148808219"
     variation       complement(2396)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:79244563"
     variation       complement(2455)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:16840972"
     variation       complement(2499)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11579653"
     variation       complement(2507)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:79493894"
     variation       complement(2528)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144378497"
     variation       complement(2641)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114160792"
     variation       complement(2647)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1553512"
     variation       complement(2748)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41266636"
     variation       complement(2783)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17402900"
     variation       complement(2918)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139366621"
     variation       complement(2942)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192272810"
     variation       complement(2958)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73027265"
     variation       complement(2990)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150866695"
     variation       complement(3020)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143525854"
     variation       complement(3022)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181899172"
     variation       complement(3045)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78693315"
     variation       complement(3066)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138006925"
     variation       complement(3074)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189523643"
     variation       complement(3159)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185154126"
     variation       complement(3221)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:114221335"
     variation       complement(3253)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181151782"
     variation       complement(3342)
                     /gene="LMX1A"
                     /gene_synonym="LMX1; LMX1.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146940954"
ORIGIN

ctcttttgcttctgcagacattcccggcactggccgactggcgggaggacctccccgcgcgccccgcacaccggctcctgcgcgcaccccaacagagcgcagcgccaggagtccagaagcgggcgggacgccctccgggtcccttacagtgccccttctcgacctggggcaggtcctcccggcccggcccgaacatgctggacggcctaaagatggaggagaacttccaaagcgcgatcgacacctcggcctccttctcctcgctgctgggcagagcggtgagccccaagtctgtctgcgagggctgtcagcgggtcatcttggacaggtttctgctgcggctcaacgacagcttctggcatgagcagtgcgtgcagtgcgcctcctgcaaagagcccctggagaccacctgcttctaccgggacaagaagctgtactgcaagtatgactacgagaagctgtttgctgttaaatgtgggggctgcttcgaggccatcgctcccaatgagtttgttatgcgggcccagaagagtgtataccacctgagctgcttctgctgctgtgtctgcgagcgacagcttcagaagggtgatgagtttgtcctgaaggaggggcagctgctctgcaaaggggactatgagaaggagcgggagctgctcagcctggtgagcccagcagcctcagactcaggtaaaagtgatgatgaagaaagtctctgcaagtcagcccatggggcagggaaaggaactgctgaggaaggcaaggaccataagcgccccaaacgtccgagaaccatcttgacaactcaacagaggcgagcattcaaggcctcatttgaagtatcctccaagccctgcaggaaggtgagagagactctggctgcagagacagggctgagtgtccgtgtcgtccaggtgtggttccaaaaccagagagcgaagatgaagaagctggccaggcgacagcagcagcagcagcaagatcagcagaacacccagaggctgagctctgctcagacaaacggtggtgggagtgctgggatggaaggaatcatgaacccctacacggctctgcccaccccacagcagctcctggccatcgagcagagtgtctacagctcagatcccttccgacagggtctcaccccaccccagatgcctggagaccacatgcacccttatggtgccgagccccttttccatgacctggatagcgacgacacctccctcagtaacctgggtgattgtttcctagcaacctcagaagctgggcctctgcagtccagagtgggaaaccccattgaccatctgtactccatgcagaattcttacttcacatcttgagtcttcccctagagttctgtgactaggctcccatatggaacaaccatattctttgaggggtcactggctttaggacagggaggccagggaagaggtgggttggggagggagttttgttggggatgctgttgtataatgatatggtgtagctcagcatttccaaagactgaatacattatggattgcatagtttaatgtttctaataagagtcttagcattagatatgaagacgtgtttatcattaaggacagagacttttaatatagacattctcatgcaaactagatacttagggactcctaacaacttcccaccatgtcggggaagctcttgtcaagaggtgcatatgtctatccatctacacaccaatagacagaaggacagatagatagatgtgtgtgtgtgagtgtgtaacctttcgtattttaccctcaaagtttattcctaattataacagacaccaactgtacagcaaaagtaactttattttcagtgtgaactatatttaaggaaatgcttgatgcacttaagttataaaatgagataatttacttttataaactttatttttagcttgacaagacttgtcagcagggcagagagggctgctccacctagccccatagctttgagtgctggggttcattctgttttcagagtgtctttcagatctggaaagaaattctgtgtggctgatggtgttctctcttgcattcttgctctctttggggttgaatcactgggcaggggtgggacagaataatctctgatcatgttctgagaaaatgtaaagcccagactcctgggctttcttttaaattctgacaagtggttgttgggcagtgctaggatgattggttcagctcttgagcttcagcatctgcaaatgtggatgaggctaatagtatgtacctacctcactgggaaacaccaaggcttaattcattcccaggacacatgagcagggctgagactaatatctgatatttgtttaagatacaaccaggccactcacttggcaaaggagggtacatagggttgcagagcaggagggctcctgaactccagagggcagttctgcctgctgaagtccctctgcaaagcctgtgctgaaggagacaccagctcagagcagttcagagggatcccagagtcccagagtggggaggaggtgaaggctgaggggatagaggagggcctggtggtgttctagagcagggttgggcaaactcctgcttgcgggcctgctttctatggcttgccagcaaagaatggtttttactttttttttgaggtcattaaaaaaaaggagaagaagaatatataacaggctgtctgtggcctggaaagcctgaaatatttgctatctgtattgtctggcccttacagaaaaagtttggggccccttgttttagagggtctgtttctaaagaacctcatggcgctcatagaggcagaaggttccagtggaaacccttggctcttccttccaactcactcctctgatcctcggcacagaagacccagcagccattgtacatggggacagttccacaccctggtctccagttgcggtgctaggatggtattgttctgtgctaggaagtctcctgggaacccagaatgagttggtggggaagacagcgggtcactgtggacccatccaggaggggccaggataggcttggcctcatttctggggacatcattggagacttgaacacagagacacgtccctatcactctggcaaggccagagggaacatgtccccttatggtagagtctatgttgtgtgatttttgtgctcttgtttataatttatgcaaaccaccaagaaacccaaaccagtctgatgagtgaaaattatgcagatgctgtatggccccacaggtttctgtggtaaagaccagttggagaatgtaggagatactatgtgagtgaaaatgaatagagatccttattccactccttaatggcataccaagatgaaattaaaatctcttacaaatgaaaaaaaaaaa

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