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2024-04-19 20:16:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001142286 5275 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens structural maintenance of chromosomes 6 (SMC6),
transcript variant 1, mRNA.
ACCESSION NM_001142286
VERSION NM_001142286.1 GI:214010215
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5275)
AUTHORS Stephan,A.K., Kliszczak,M. and Morrison,C.G.
TITLE The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance
of genome stability
JOURNAL FEBS Lett. 585 (18), 2907-2913 (2011)
PUBMED 21550342
REMARK GeneRIF: Studies indicate that Nse1 may function as a ubiquitin
ligase, and is targeted to chromatin through its interaction with
the Smc5/6 complex.
Review article
REFERENCE 2 (bases 1 to 5275)
AUTHORS Couch,F.J., Wang,X., Bamlet,W.R., de Andrade,M., Petersen,G.M. and
McWilliams,R.R.
TITLE Association of mitotic regulation pathway polymorphisms with
pancreatic cancer risk and outcome
JOURNAL Cancer Epidemiol. Biomarkers Prev. 19 (1), 251-257 (2010)
PUBMED 20056645
REMARK GeneRIF: Observational study of gene-disease association and
gene-environment interaction. (HuGE Navigator)
REFERENCE 3 (bases 1 to 5275)
AUTHORS Pebernard,S., Perry,J.J., Tainer,J.A. and Boddy,M.N.
TITLE Nse1 RING-like domain supports functions of the Smc5-Smc6
holocomplex in genome stability
JOURNAL Mol. Biol. Cell 19 (10), 4099-4109 (2008)
PUBMED 18667531
REMARK GeneRIF: Nse1 RING-like motif is a protein-protein interaction
domain required for Smc5-Smc6 holocomplex integrity and recruitment
to, or retention at, DNA lesions
REFERENCE 4 (bases 1 to 5275)
AUTHORS Taylor,E.M., Copsey,A.C., Hudson,J.J., Vidot,S. and Lehmann,A.R.
TITLE Identification of the proteins, including MAGEG1, that make up the
human SMC5-6 protein complex
JOURNAL Mol. Cell. Biol. 28 (4), 1197-1206 (2008)
PUBMED 18086888
REMARK GeneRIF: The four non-SMC components of the human complex were
identified and characterized and it was demonstrated that the
MAGEG1 protein is part of this complex.
REFERENCE 5 (bases 1 to 5275)
AUTHORS Potts,P.R. and Yu,H.
TITLE The SMC5/6 complex maintains telomere length in ALT cancer cells
through SUMOylation of telomere-binding proteins
JOURNAL Nat. Struct. Mol. Biol. 14 (7), 581-590 (2007)
PUBMED 17589526
REMARK GeneRIF: SMC5/6 complex facilitates telomere homologous
recombination and elongation in alternative lengthening of
telomeres cells through SUMOylation of telomere-binding proteins.
REFERENCE 6 (bases 1 to 5275)
AUTHORS Potts,P.R., Porteus,M.H. and Yu,H.
TITLE Human SMC5/6 complex promotes sister chromatid homologous
recombination by recruiting the SMC1/3 cohesin complex to
double-strand breaks
JOURNAL EMBO J. 25 (14), 3377-3388 (2006)
PUBMED 16810316
REMARK GeneRIF: SMC5/6 complex is recruited to nuclease-induced
double-strand breaks (DSBs) and is required for the recruitment of
cohesin to DSBs.
REFERENCE 7 (bases 1 to 5275)
AUTHORS Potts,P.R. and Yu,H.
TITLE Human MMS21/NSE2 is a SUMO ligase required for DNA repair
JOURNAL Mol. Cell. Biol. 25 (16), 7021-7032 (2005)
PUBMED 16055714
REMARK GeneRIF: the human SMC5/6 complex and the SUMO ligase activity of
hMMS21 are required for the prevention of DNA damage-induced
apoptosis by facilitating DNA repair in human cells
REFERENCE 8 (bases 1 to 5275)
AUTHORS Harvey,S.H., Sheedy,D.M., Cuddihy,A.R. and O'Connell,M.J.
TITLE Coordination of DNA damage responses via the Smc5/Smc6 complex
JOURNAL Mol. Cell. Biol. 24 (2), 662-674 (2004)
PUBMED 14701739
REFERENCE 9 (bases 1 to 5275)
AUTHORS Taylor,E.M., Moghraby,J.S., Lees,J.H., Smit,B., Moens,P.B. and
Lehmann,A.R.
TITLE Characterization of a novel human SMC heterodimer homologous to the
Schizosaccharomyces pombe Rad18/Spr18 complex
JOURNAL Mol. Biol. Cell 12 (6), 1583-1594 (2001)
PUBMED 11408570
REFERENCE 10 (bases 1 to 5275)
AUTHORS Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
Wiemann,S.
TITLE Systematic subcellular localization of novel proteins identified by
large-scale cDNA sequencing
JOURNAL EMBO Rep. 1 (3), 287-292 (2000)
PUBMED 11256614
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DB451629.1, AL136544.1, BC039828.1, AL832979.1 and CD369665.1.
Transcript Variant: This variant (1) represents the longer
transcript. Both variants 1 and 2 encode the same protein.
##Evidence-Data-START##
Transcript exon combination :: AL136544.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-26 DB451629.1 1-26
27-3675 AL136544.1 1-3649
3676-3946 BC039828.1 3573-3843
3947-5041 AL832979.1 3823-4917
5042-5275 CD369665.1 2-235 c
FEATURES Location/Qualifiers
source 1..5275
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p24.2"
gene 1..5275
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="structural maintenance of chromosomes 6"
/db_xref="GeneID:79677"
/db_xref="HGNC:20466"
/db_xref="MIM:609387"
exon 1..204
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
variation 59
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3747514"
exon 205..291
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
misc_feature 288..290
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="upstream in-frame stop codon"
exon 292..416
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
CDS 297..3572
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="SMC protein 6; SMC6 structural maintenance of
chromosomes 6-like 1"
/codon_start=1
/product="structural maintenance of chromosomes protein 6"
/protein_id="NP_001135758.1"
/db_xref="GI:214010216"
/db_xref="CCDS:CCDS1690.1"
/db_xref="GeneID:79677"
/db_xref="HGNC:20466"
/db_xref="MIM:609387"
/translation="
MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPVTQEEDDDQR
"
misc_feature 438..>908
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="P-loop containing Nucleoside Triphosphate
Hydrolases; Region: P-loop_NTPase; cl09099"
/db_xref="CDD:213113"
misc_feature 522..545
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="Walker A/P-loop; other site"
/db_xref="CDD:72971"
misc_feature order(531..536,540..548,867..869)
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:72971"
misc_feature 786..3503
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="Chromosome segregation ATPases [Cell division and
chromosome partitioning]; Region: Smc; COG1196"
/db_xref="CDD:31389"
misc_feature 858..869
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="Q-loop/lid; other site"
/db_xref="CDD:72971"
misc_feature 1650..2273
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96SB8.2);
Region: Flexible hinge"
misc_feature 2301..2303
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96SB8.2); phosphorylation site"
misc_feature <3066..>3371
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="P-loop containing Nucleoside Triphosphate
Hydrolases; Region: P-loop_NTPase; cl09099"
/db_xref="CDD:213113"
misc_feature 3174..3179
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="Q-loop/lid; other site"
/db_xref="CDD:72971"
misc_feature <3225..3521
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="Eukaryotic SMC6 proteins; SMC proteins are large
(approximately 110 to 170 kDa), and each is arranged into
five recognizable domains. Amino-acid sequence homology
of SMC proteins between species is largely confined to the
amino- and carboxy-terminal...; Region: ABC_SMC6_euk;
cd03276"
/db_xref="CDD:73035"
misc_feature 3255..3284
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="ABC transporter signature motif; other site"
/db_xref="CDD:73035"
misc_feature 3255..3284
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="ABC transporter signature motif; other site"
/db_xref="CDD:72971"
misc_feature 3327..3344
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="Walker B; other site"
/db_xref="CDD:73035"
misc_feature 3327..3344
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="Walker B; other site"
/db_xref="CDD:72971"
misc_feature 3351..3362
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="D-loop; other site"
/db_xref="CDD:73035"
misc_feature 3351..3362
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="D-loop; other site"
/db_xref="CDD:72971"
misc_feature 3432..3452
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/note="H-loop/switch region; other site"
/db_xref="CDD:73035"
exon 417..534
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 535..640
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 641..777
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 778..839
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 840..920
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 921..1022
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 1023..1142
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 1143..1241
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 1242..1388
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 1389..1477
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 1478..1642
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 1643..1821
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
variation 1686
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35195207"
exon 1822..2026
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 2027..2141
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 2142..2302
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 2303..2438
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
variation 2367
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1065381"
exon 2439..2519
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 2520..2690
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 2691..2828
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 2829..2974
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
variation 2973
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/replace="a"
/replace="c"
/db_xref="dbSNP:35604590"
exon 2975..3100
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
variation 3078
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/replace="a"
/replace="c"
/db_xref="dbSNP:35257753"
exon 3101..3206
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 3207..3359
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 3360..3457
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
exon 3458..5259
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/inference="alignment:Splign:1.39.8"
STS 3724..3907
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/standard_name="RH67770"
/db_xref="UniSTS:41697"
STS 4916..5073
/gene="SMC6"
/gene_synonym="hSMC6; SMC-6; SMC6L1"
/standard_name="RH94239"
/db_xref="UniSTS:88716"
ORIGIN
gagggcggggcgcaggcgcggttagtaccgcggtgggcgccggggctcccgggaatctaccttctcctgcggccggcacgcggttcccagggggccagcggcggtcagccgaggtcgagacgcccgcagggtggccttagcggccggtcgtaccacggcagccccgccgatcaggttcctttgggagacttcgacttgttggcgaaatgaaccggagaagaatcccaattgggaattgcggaaaacaggactctagggtagagaaaggttgtagaaccaatagggtttgagacctgatggccaaaagaaaggaagaaaatttttcctctcctaaaaatgccaaaaggccaagacaagaagaattggaggattttgataaagatggtgacgaagacgaatgtaaaggtactactttgactgcagcagaagttggaataattgagagtattcacctaaaaaacttcatgtgtcattcaatgcttggaccttttaagtttggttctaatgtcaactttgttgttggcaacaatggaagtgggaagagtgcagtactcacagctctcatagtcggtcttggtggaagagcagttgctactaatagaggatcctctttaaaaggttttgtgaaagatggacagaactctgcagatatctcaataacattgaggaacagaggagatgatgcctttaaagccagtgtgtatggtaactctatacttatacagcaacacatcagcatagatggaagtcgatcttataaacttaaaagtgcaacaggctccgtggtttccacgaggaaagaagagctgattgcaattcttgatcattttaacatccaggtggataatccagtttctgttttaacacaagaaatgagcaagcagttcttacagtctaaaaatgaaggagacaaatacaaattcttcatgaaagcaacgcaacttgaacagatgaaggaagattattcatacattatggaaacgaaagaaagaacaaaggagcagatacatcaaggagaagagcggcttactgaactaaagcgccagtgtgtagagaaagaggaacgttttcaaagtattgctggtttaagtacaatgaagactaatttagagtccttgaaacatgaaatggcttgggcagtggtcaatgaaattgaaaaacaattgaatgccatcagagataatatcaaaattggagaagatcgtgctgctagacttgacaggaaaatggaagaacagcaggtcagacttaatgaggcagaacaaaagtacaaggatattcaagacaaactagaaaagattagtgaagagacaaatgcacgagcaccagaatgtatggcattgaaagcagatgttgttgctaagaaaagggcctataatgaagctgaggttttatataaccgatccttaaacgaatataaagcattaaagaaagatgatgagcagctttgtaaacgaattgaagagctgaaaaaaagtactgaccaatctttggaacctgaacggttggaaagacaaaaaaaaatatcttggttaaaagagagagtaaaggcctttcaaaatcaagaaaattcagtcaatcaagagatcgaacagtttcagcaagccatagaaaaggacaaagaagaacatggcaaaattaagagagaagaattagatgtgaagcatgcactgagctacaatcagaggcaactgaaagaattgaaagatagtaaaactgatcgactcaaaagatttggccctaatgttccagctcttcttgaagccatagatgatgcttatagacaaggacattttacctataaacctgtaggccctttaggagcttgcattcatcttcgggacccagaacttgctttggctattgaatcttgcttaaaagggcttctgcaggcctattgttgccataatcatgctgatgaaagggtccttcaggcactcatgaaaaggttttatttaccagggacctcacggccaccgataatagtttctgagtttcggaatgagatatatgatgtaagacacagagctgcttatcatccagactttccaacagttctgacagctttagaaatagataatgcggttgtggcaaatagcctaattgacatgagaggcatagagacagtgctactaatcaaaaataattctgtagctcgtgcagtaatgcagtcccaaaagccacccaaaaattgtagagaagcttttactgctgatggtgatcaagtttttgcaggacgttattattcatctgaaaatacaagacctaagttcctaagcagagatgtggattctgaaataagtgacttggagaatgaggttgaaaataagacggcccagatattaaatcttcagcaacatttatctgcccttgaaaaagatattaaacacaatgaggaacttcttaaaaggtgccaactacattataaagaactaaagatgaaaataagaaaaaatatttctgaaattcgggaacttgagaacatagaagaacaccagtctgtagatattgcaactttggaagatgaagctcaggaaaataaaagcaaaatgaaaatggttgaggaacatatggagcaacaaaaagaaaatatggagcatcttaaaagtctgaaaatagaagcagaaaataagtatgatgcaattaaattcaaaattaatcaactatcggagctagcagacccacttaaggatgaattaaaccttgctgattctgaagtggataaccaaaaacgagggaaacgacattatgaagaaaaacaaaaagaacacttggataccttaaataaaaagaaacgagaactggatatgaaagagaaagaactagaggagaaaatgtcacaagcaagacaaatctgcccagagcgtatagaagtagaaaaatctgcatcaattctggacaaagaaattaatcgattaaggcagaagatacaggcagaacatgctagtcatggagatcgagaggaaataatgaggcagtaccaagaagcaagagagacctatcttgatctggatagtaaagtgaggactttaaaaaagtttattaaattactgggagaaatcatggagcacagattcaagacatatcaacaatttagaaggtgtttgactttacgatgcaaattatactttgacaacttactatctcagcgggcctattgtggaaaaatgaattttgaccacaagaatgaaactctaagtatatcagttcagcctggagaaggaaataaagctgctttcaatgacatgagagccttgtctggaggtgaacgttctttctccacagtgtgttttattctttccctgtggtccatcgcagaatctcctttcagatgcctggatgaatttgatgtctacatggatatggttaataggagaattgccatggacttgatactgaagatggcagattcccagcgttttagacagtttatcttgctcacacctcaaagcatgagttcacttccatccagtaaactgataagaattctccgaatgtctgatcctgaaagaggacaaactacattgcctttcagacctgtgactcaagaagaagatgatgaccaaaggtgatttgtaacttaacatgccttgtcctgatgttgaaggatttgtgaagggaaaaaaaattctggactctttgatataataaaatgagactggaggcattctgaaatgaaagaaactcctttatatatccaaccacaatcaaacatataaataagcctggaaaaccaactacaacctgcaatttaagattactattactttaagaaaatcaatttcatagtattggttttaaatctttttaagtttttttaatacgatctatttttataggttctttttcagaagtaaaattttgtacatatatacatgtacatatctgtttagtttgggttcatttctataacattttgtaagaaaataaaagtttgagcacctgattatatttagttttgcttttccagatattacattctatagttaccaaaaatggttgaagggagggatttctcattgcagagggtggggtgcaagggaataagacacttgtacggaacactgaagctttgccaacttctacacatgccttttttgcagtcctttaactgtccaccctaccaagagcttataaccagtatcagaactggataatgacgcagtttttcactctgacctccatcatgcttgcctgatttaaaagccctcagtttgcagtccagggactgttcaggcttgtcctcagctgagaggacacaggctagagggactgtgcagaaccaggctgggagaagggctgggaaaactgggagtggagggtggatcctcatggagcaggagagtagctcatggctccaggagcctgaggccatgcagttgatggtgagctgacatcaattctaagactcatcctaattgaggggtgttaaaaagtgtgctgcttagaatgaccaaatatagttattgtaaaaaatgatatttatgaactttttattttagaaaacatgaattttattgctccctgtattatttgtttgatactaggattcatgctaaactttttaagaatgtattggatatcaagaagcattccttacattagtagcaataaatattagaataaatatgaaattgaactattttcagaaaaagggcagtatattaagagcagggactgttctctagttattgaggaaaactggactttgtttgtgtttttggtggaggaagaagtttaagatactttagtcttaaattgaggtttgccaaatgagaagttcaaaaacttgggctttctaatcagaatttccaggaggaggaaagtgtgtgctgaatattttaaacatttcccactgatcatacaaagtctgatttttaaatttacacttataatgcctttgtattaaaattatttttaacatgtgcttttccaaattaaaaatgaagtagagtataccaaatgcataaactttcattagctaaggaactcatgtctgaattttgttgtagttttgaatgttgtgctctttcatacagaatgggaaacataatcctcaggtatcccagcatctcttgttgaattgaagattattcattgctttggcctcacaaagttttgatttcaactatcataagtgaaaatatcttcctttaatgttctaagtagtgataatattactagaatgaaagaataaaaagaaattgttcttttaaaatatgtgtaacttctaaaaataaaacttaaaatttatatgtaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:79677 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:79677 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:79677 -> Biological process: GO:0000722 [telomere maintenance via recombination] evidence: IMP
GeneID:79677 -> Biological process: GO:0000724 [double-strand break repair via homologous recombination] evidence: IEA
GeneID:79677 -> Biological process: GO:0090398 [cellular senescence] evidence: IMP
GeneID:79677 -> Cellular component: GO:0000781 [chromosome, telomeric region] evidence: IDA
GeneID:79677 -> Cellular component: GO:0005622 [intracellular] evidence: IDA
GeneID:79677 -> Cellular component: GO:0016605 [PML body] evidence: IDA
GeneID:79677 -> Cellular component: GO:0030915 [Smc5-Smc6 complex] evidence: IDA
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