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2024-04-20 21:09:47, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001130105 5494 bp mRNA linear PRI 04-MAY-2013
DEFINITION Homo sapiens collagen, type IV, alpha 3 (Goodpasture antigen)
binding protein (COL4A3BP), transcript variant 3, mRNA.
ACCESSION NM_001130105
VERSION NM_001130105.1 GI:194294542
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5494)
AUTHORS Sugiki,T., Takeuchi,K., Yamaji,T., Takano,T., Tokunaga,Y.,
Kumagai,K., Hanada,K., Takahashi,H. and Shimada,I.
TITLE Structural basis for the Golgi association by the pleckstrin
homology domain of the ceramide trafficking protein (CERT)
JOURNAL J. Biol. Chem. 287 (40), 33706-33718 (2012)
PUBMED 22869376
REMARK GeneRIF: Structural basis for the Golgi association by the
pleckstrin homology domain of the ceramide trafficking protein
(CERT)
REFERENCE 2 (bases 1 to 5494)
AUTHORS Olayioye,M.A. and Hausser,A.
TITLE Integration of non-vesicular and vesicular transport processes at
the Golgi complex by the PKD-CERT network
JOURNAL Biochim. Biophys. Acta 1821 (8), 1096-1103 (2012)
PUBMED 22226883
REMARK GeneRIF: CERT is at a convergence point of non-vesicular and
vesicular transport processes and plays a central role within the
PKD signaling network at the Golgi complex. (Review)
Review article
REFERENCE 3 (bases 1 to 5494)
AUTHORS Heering,J., Weis,N., Holeiter,M., Neugart,F., Staebler,A.,
Fehm,T.N., Bischoff,A., Schiller,J., Duss,S., Schmid,S., Korte,T.,
Herrmann,A. and Olayioye,M.A.
TITLE Loss of the ceramide transfer protein augments EGF receptor
signaling in breast cancer
JOURNAL Cancer Res. 72 (11), 2855-2866 (2012)
PUBMED 22472120
REMARK GeneRIF: Loss of the ceramide transfer protein augments EGF
receptor signaling in breast cancer.
REFERENCE 4 (bases 1 to 5494)
AUTHORS Mencarelli,C., Bode,G.H., Losen,M., Kulharia,M., Molenaar,P.C.,
Veerhuis,R., Steinbusch,H.W., De Baets,M.H., Nicolaes,G.A. and
Martinez-Martinez,P.
TITLE Goodpasture antigen-binding protein/ceramide transporter binds to
human serum amyloid P-component and is present in brain amyloid
plaques
JOURNAL J. Biol. Chem. 287 (18), 14897-14911 (2012)
PUBMED 22396542
REMARK GeneRIF: The START domain in GPBP is important for this
interaction. SAP and GPBP form complexes in blood and partly
colocalize in amyloid plaques from Alzheimer disease patients.
REFERENCE 5 (bases 1 to 5494)
AUTHORS Chandran,S. and Machamer,C.E.
TITLE Inactivation of ceramide transfer protein during pro-apoptotic
stress by Golgi disassembly and caspase cleavage
JOURNAL Biochem. J. 442 (2), 391-401 (2012)
PUBMED 22129459
REMARK GeneRIF: during cellular stress, disassembly of Golgi structure
together with inactivation of CERT by caspases causes a reduction
in ceramide trafficking and sphingomyelin synthesis, and could
contribute to the cellular response to pro-apoptotic stress
REFERENCE 6 (bases 1 to 5494)
AUTHORS Kumagai,K., Yasuda,S., Okemoto,K., Nishijima,M., Kobayashi,S. and
Hanada,K.
TITLE CERT mediates intermembrane transfer of various molecular species
of ceramides
JOURNAL J. Biol. Chem. 280 (8), 6488-6495 (2005)
PUBMED 15596449
REMARK GeneRIF: results indicate that CERT can mediate transfer of various
types of ceramides that naturally exist and their close relatives
REFERENCE 7 (bases 1 to 5494)
AUTHORS Hanada,K., Kumagai,K., Yasuda,S., Miura,Y., Kawano,M., Fukasawa,M.
and Nishijima,M.
TITLE Molecular machinery for non-vesicular trafficking of ceramide
JOURNAL Nature 426 (6968), 803-809 (2003)
PUBMED 14685229
REMARK GeneRIF: CERT mediates the intracellular trafficking of ceramide in
a non-vesicular manner
REFERENCE 8 (bases 1 to 5494)
AUTHORS Raya,A., Revert-Ros,F., Martinez-Martinez,P., Navarro,S.,
Rosello,E., Vieites,B., Granero,F., Forteza,J. and Saus,J.
TITLE Goodpasture antigen-binding protein, the kinase that phosphorylates
the goodpasture antigen, is an alternatively spliced variant
implicated in autoimmune pathogenesis
JOURNAL J. Biol. Chem. 275 (51), 40392-40399 (2000)
PUBMED 11007769
REFERENCE 9 (bases 1 to 5494)
AUTHORS Raya,A., Revert,F., Navarro,S. and Saus,J.
TITLE Characterization of a novel type of serine/threonine kinase that
specifically phosphorylates the human goodpasture antigen
JOURNAL J. Biol. Chem. 274 (18), 12642-12649 (1999)
PUBMED 10212244
REFERENCE 10 (bases 1 to 5494)
AUTHORS Kalluri,R.
TITLE Goodpasture syndrome
JOURNAL Kidney Int. 55 (3), 1120-1122 (1999)
PUBMED 10027952
REMARK Review article
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK096854.1, AK000604.1 and
AC008897.7.
This sequence is a reference standard in the RefSeqGene project.
Summary: This gene encodes a kinase that specifically
phosphorylates the N-terminal region of the non-collagenous domain
of the alpha 3 chain of type IV collagen, known as the Goodpasture
antigen. Goodpasture disease is the result of an autoimmune
response directed at this antigen. One isoform of this protein is
also involved in ceramide intracellular transport. Three transcript
variants encoding different isoforms have been found for this gene.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (3) represents the longest
transcript and encodes the longest isoform (3).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK096854.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2442 AK096854.1 158-2599
2443-3327 AK000604.1 1286-2170
3328-5494 AC008897.7 28425-30591
FEATURES Location/Qualifiers
source 1..5494
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q13.3"
gene 1..5494
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/note="collagen, type IV, alpha 3 (Goodpasture antigen)
binding protein"
/db_xref="GeneID:10087"
/db_xref="HGNC:2205"
/db_xref="MIM:604677"
exon 1..223
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
CDS 138..2396
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/EC_number="2.7.11.1"
/note="isoform 3 is encoded by transcript variant 3;
ceramide transporter; StAR-related lipid transfer (START)
domain containing 11; lipid-transfer protein CERTL; hCERT;
ceramide transfer protein"
/codon_start=1
/product="collagen type IV alpha-3-binding protein isoform
3"
/protein_id="NP_001123577.1"
/db_xref="GI:194294543"
/db_xref="CCDS:CCDS47235.1"
/db_xref="GeneID:10087"
/db_xref="HGNC:2205"
/db_xref="MIM:604677"
/translation="
MQHSCIPTPPSPFSAPPAFLPVVTRESRRGLSSGGSAGRNAGVTATAAAADGWKGRLPSPLVLLPRSARCQARRRRGGRTSSLLLLPPTPERALFASPSPDPSPRGLGASSGAAEGAGAGLLLGCRASMSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKKKSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF
"
misc_feature 597..866
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/note="Goodpasture antigen binding protein (GPBP)
Pleckstrin homology (PH) domain; Region: PH_GPBP; cd01247"
/db_xref="CDD:176323"
misc_feature order(597..599,603..605,642..644,648..656)
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/note="putative phosphoinositide binding site [chemical
binding]; other site"
/db_xref="CDD:176323"
misc_feature 1692..2393
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/note="Ceramide-binding START domain of mammalian STARD11
and related domains; Region: START_STARD11-like; cd08872"
/db_xref="CDD:176881"
misc_feature order(1905..1907,1923..1925,1932..1937,1941..1946,
1998..2000,2004..2009,2013..2018,2022..2024,2031..2033,
2037..2039,2043..2045,2109..2111,2160..2162,2166..2168,
2172..2174,2256..2258,2268..2270,2274..2276,2301..2303,
2310..2315,2319..2327,2334..2336)
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/note="ceramide binding site [chemical binding]; other
site"
/db_xref="CDD:176881"
exon 224..617
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
variation 273
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/replace="a"
/replace="g"
/db_xref="dbSNP:11549098"
exon 618..752
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 753..869
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 870..977
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 978..1116
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 1117..1200
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 1201..1358
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 1359..1451
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 1452..1538
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 1539..1631
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 1632..1709
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 1710..1805
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 1806..1938
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 1939..2009
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 2010..2138
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 2139..2268
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 2269..2405
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
exon 2406..5494
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/inference="alignment:Splign:1.39.8"
polyA_signal 5244..5249
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
polyA_site 5264
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
STS 5346..5450
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/standard_name="SHGC-36269"
/db_xref="UniSTS:82739"
polyA_signal 5410..5415
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
polyA_site 5433
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
polyA_signal 5444..5449
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
polyA_signal 5473..5478
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
polyA_site 5492
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
variation 5493
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
/replace="a"
/replace="t"
/db_xref="dbSNP:3180743"
polyA_site 5494
/gene="COL4A3BP"
/gene_synonym="CERT; CERTL; GPBP; STARD11"
ORIGIN
aaacgaagcccacccaccgactgacaaggccccaaggggacaagcgatccccgcgcgggatactcacccgttacctcaggatcgcgactacaactcccaggaggctgcgcgagcgacggaccaacgcccttcccagaatgcagcacagctgcatccctaccccgccctctcctttctccgctcctcctgcttttctacccgtcgtcacccgggagagccggagggggctaagttcgggtggcagcgccgggcgcaacgcaggggtcacggcgacggcggcggcggctgacggctggaagggtaggcttccttcaccgctcgtcctccttcctcgctccgctcggtgtcaggcgcggcggcggcgcggcgggcggacttcgtccctcctcctgctcccccccacaccggagcgggcactcttcgcttcgccatcccccgacccttcaccccgaggactgggcgcctcctccggcgcagctgagggagcgggggccggtctcctgctcggttgtcgagcctccatgtcggataatcagagctggaactcgtcgggctcggaggaggatccagagacggagtctgggccgcctgtggagcgctgcggggtcctcagtaagtggacaaactacattcatgggtggcaggatcgttgggtagttttgaaaaataatgctctgagttactacaaatctgaagatgaaacagagtatggctgcagaggatccatctgtcttagcaaggctgtcatcacacctcacgattttgatgaatgtcgatttgatattagtgtaaatgatagtgtttggtatcttcgtgctcaggatccagatcatagacagcaatggatagatgccattgaacagcacaagactgaatctggatatggatctgaatccagcttgcgtcgacatggctcaatggtgtccctggtgtctggagcaagtggctactctgcaacatccacctcttcattcaagaaaggccacagtttacgtgagaagttggctgaaatggaaacatttagagacatcttatgtagacaagttgacacgctacagaagtactttgatgcctgtgctgatgctgtctctaaggatgaacttcaaagggataaagtggtagaagatgatgaagatgactttcctacaacgcgttctgatggtgacttcttgcatagtaccaacggcaataaagaaaagttatttccacatgtgacaccaaaaggaattaatggtatagactttaaaggggaagcgataacttttaaagcaactactgctggaatccttgcaacactttctcattgtattgaactaatggttaaacgtgaggacagctggcagaagagactggataaggaaactgagaagaaaagaagaacagaggaagcatataaaaatgcaatgacagaacttaagaaaaaatcccactttggaggaccagattatgaagaaggccctaacagtctgattaatgaagaagagttctttgatgctgttgaagctgctcttgacagacaagataaaatagaagaacagtcacagagtgaaaaggtgagattacattggcctacatccttgccctctggagatgccttttcttctgtggggacacatagatttgtccaaaagccctatagtcgctcttcctccatgtcttccattgatctagtcagtgcctctgatgatgttcacagattcagctcccaggttgaagagatggtgcagaaccacatgacttactcattacaggatgtaggcggagatgccaattggcagttggttgtagaagaaggagaaatgaaggtatacagaagagaagtagaagaaaatgggattgttctggatcctttaaaagctacccatgcagttaaaggcgtcacaggacatgaagtctgcaattatttctggaatgttgacgttcgcaatgactgggaaacaactatagaaaactttcatgtggtggaaacattagctgataatgcaatcatcatttatcaaacacacaagagggtgtggcctgcttctcagcgagacgtattatatctttctgtcattcgaaagataccagccttgactgaaaatgaccctgaaacttggatagtttgtaatttttctgtggatcatgacagtgctcctctaaacaaccgatgtgtccgtgccaaaataaatgttgctatgatttgtcaaaccttggtaagcccaccagagggaaaccaggaaattagcagggacaacattctatgcaagattacatatgtagctaatgtgaaccctggaggatgggcaccagcctcagtgttaagggcagtggcaaagcgagagtatcctaaatttctaaaacgttttacttcttacgtccaagaaaaaactgcaggaaagcctattttgttctagtattaacagtgactgaagcaaggctgtgtgacattccatgttggagaaaaaaagaaaaaaaaaagctgaatgctctaagctggaacgtaggatctatagccttgtctgtggcccaagaccttggccttgtgtacaaaaatgacaaaatattgcaatagcaaagctgaacatctaacactagctatctcttgctagatctccttgctcagcatataactataaatacatgtaaaattacatgtatatggctatatttttatttgcttgctcctagaagagaaaaaaaaatcaactttgaatcacaactaggaattgatgctttaatttttggatactttttcagaatttttaatttactatggtccggcctaagatcctctgttgtatcaggttttgtgcacaaaagaaaagcacaaaagttgaatgcacatggggcatgtgctttctgtgcaccaaatatctggatgaggttcttttttcaggcctacagtcaaatctgtgtccagaattttttgacttttttgctttgtataatcatagaattcattgctgctgatttctataatgattcatgttgtcatgtgtctcttaataactgagggctgtcagtaacctgtgattttgccttttctatagtcttactcccatgaagaaccttggttctgatggagaaagtgaaaagctttatttcttcccctagatatctttatatttctattatattttttagttgtgtactgtgtactagagatttttttcagtttgttatgaacacaatttggtaagccctaaattggttctgcctgtctccaaacagaaacatctgtacaaatcttgttggtatagactactttctggaaaatggtcaagataagttcatgttttcttgaaatttctaagatagtatatggtatcacttgtttaaagcaaatcagactgagtttgacatttaattcaatatttctggtattcagtaacgggtatatatgtttgttcttccagtttgggtcagtttaaaagatatgttgcaaagtatacatagaaaatgtgagcaatgcctctctttgccttttgatcagaaacttcagcagagcggtaaggattccacatgatttaaactgaaatgcttttctttgttgctgtaagaacttaaaatgtaaaatacctttttcagtttaagtcctgtaaacaacattgaagcatggagatgaggcaaggaatagtactcactgaagttgaaatgactgcccacttcaaaatcttcattgtgtttacacaccagtgtatttatacaaatcagaggcattttgtagatgctttgctgacttgttcagctctgtaaaaacacagaaatcagacccattttgtaaagcggaaaatcatgttacatggaacatgtcctgtatatatcacatacatggtaatggagtcttaatgataagtgcaagataataatttaatgatgggattagtctgatcgcttaatatgcacaatcctggaagtgaattacttgcatcagatatagtgatatttattattctgtacagagagaaaaatacatataaaacatatgcttacattacatgcacgcggatttcatgctccataatcttttctattttttaatttacctttctgtaaatgatgtgcatggaatatgccttatagaaaaatgctgttcataatttgactacgtggaaaagtgcctatatggtggtaatgctagtaaggcaaataagacaaattatcatgttggtttactacatcaccagttaacattttatattgtgatgtttaaaaaagaaaaatttatacctcaaatgtgtattttattttacaatcagctgtggggtatggggttgggatgggagaatgggggggttggggagggcaggtttattcaccatagccgctgataagaatcttcaaaaaaattctatatgcgcactataaatgtttctctgtttgccatttctggtaactatcatgaacacagacagttaactctttcataactgaattggatagctttattttacagaagtatggcaagtttacaaagcaatatctaaatctaattatcattagttgcatttggactaaatgtgatgatatacttttgcaattgattctgtaaataaaaggattacactaaaatatttgtattaaaagaagaaaagataacattttacctttagataactgcacttgtacctcactagagttaatcccacccaatcagattgagaaataaattggggaatgtggaaagagtccaaaagaggtcagaatttggagaggtactggccttctggacaacatttagaccctctacaattattttcattaagctgattcctacatcctgaatattcatgttttctcatctacagatatttgtcttcccccaaactaaaagaaaaaaaactaccctttactctcttttctactcagttactcttttgtgctatgttagaaacttgaaatatattggtgatgtggggattttgtccctgactgcccactgtacaggacaagagagtacagtgtttcagttggaattcaggactcctggttttgaggtagaggatgatcactgcagtacttggtttggaattgccacaggggtagctaaaccaaaggagggttatatctgcaagggaggtgtaagaaggcaaaataaggaaaaggaggaatgggttttctatttgttcagtttcatcaactaatttatacacttaatacaacttcagtgtcaattgctattaagaaatttttagttgggctgagctggttctcttgtgaaattgtgctggttatctttaagcttatcagttatttgtccaattaaacacttttcaccagtatttagtccgagttgtacagacgatgtatttggattttgtcatggttcatctacagactcaaaacataatcattttaaagtaccttgggagtgtgtagagtaacttctataatagctttatgatcctgatgatgttttttaaacacaataaagttggatcttccatgttacaatcacagaattaaaaccagtatttaaagtggaaaagtattaaaatattatggacaaata
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10087 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
GeneID:10087 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10087 -> Molecular function: GO:0035620 [ceramide transporter activity] evidence: IDA
GeneID:10087 -> Molecular function: GO:0070273 [phosphatidylinositol-4-phosphate binding] evidence: IDA
GeneID:10087 -> Molecular function: GO:0097001 [ceramide binding] evidence: IDA
GeneID:10087 -> Biological process: GO:0000902 [cell morphogenesis] evidence: IEA
GeneID:10087 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:10087 -> Biological process: GO:0003007 [heart morphogenesis] evidence: IEA
GeneID:10087 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
GeneID:10087 -> Biological process: GO:0006665 [sphingolipid metabolic process] evidence: TAS
GeneID:10087 -> Biological process: GO:0006672 [ceramide metabolic process] evidence: IEA
GeneID:10087 -> Biological process: GO:0006936 [muscle contraction] evidence: IEA
GeneID:10087 -> Biological process: GO:0006955 [immune response] evidence: NAS
GeneID:10087 -> Biological process: GO:0007029 [endoplasmic reticulum organization] evidence: IEA
GeneID:10087 -> Biological process: GO:0007165 [signal transduction] evidence: IEA
GeneID:10087 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA
GeneID:10087 -> Biological process: GO:0030148 [sphingolipid biosynthetic process] evidence: TAS
GeneID:10087 -> Biological process: GO:0034976 [response to endoplasmic reticulum stress] evidence: IEA
GeneID:10087 -> Biological process: GO:0035621 [ER to Golgi ceramide transport] evidence: IGI
GeneID:10087 -> Biological process: GO:0035621 [ER to Golgi ceramide transport] evidence: IMP
GeneID:10087 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:10087 -> Biological process: GO:0055088 [lipid homeostasis] evidence: IEA
GeneID:10087 -> Biological process: GO:0070584 [mitochondrion morphogenesis] evidence: IEA
GeneID:10087 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:10087 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:10087 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:10087 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
GeneID:10087 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:10087 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:10087 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001123577 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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