LOCUS       NM_001099685            1309 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens Rhox homeobox family, member 2B (RHOXF2B), mRNA.
ACCESSION   NM_001099685 XM_001126279
VERSION     NM_001099685.1  GI:153791493
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC005023.1.
            On Jul 25, 2007 this sequence version replaced gi:113430056.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns ERS025084,
                              ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               AC005023.1         130106-130374       c
            270-681             AC005023.1         129509-129920       c
            682-727             AC005023.1         128532-128577       c
            728-1309            AC005023.1         124896-125477       c
FEATURES             Location/Qualifiers
     source          1..1309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..1309
                     /gene="RHOXF2B"
                     /note="Rhox homeobox family, member 2B"
                     /db_xref="GeneID:727940"
                     /db_xref="HGNC:33519"
     exon            1..269
                     /gene="RHOXF2B"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(9)
                     /gene="RHOXF2B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6646598"
     variation       complement(89)
                     /gene="RHOXF2B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3810752"
     misc_feature    113..115
                     /gene="RHOXF2B"
                     /note="upstream in-frame stop codon"
     variation       complement(146)
                     /gene="RHOXF2B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113051913"
     CDS             191..1057
                     /gene="RHOXF2B"
                     /codon_start=1
                     /product="rhox homeobox family member 2B"
                     /protein_id="NP_001093155.1"
                     /db_xref="GI:153791494"
                     /db_xref="CCDS:CCDS43985.1"
                     /db_xref="GeneID:727940"
                     /db_xref="HGNC:33519"
                     /translation="

MEPPDQCSQYMTSLLSPAVDDEKELQDMNAMVLSLTEEVKEEEEDAQPEPEQGTAAGEKLKSAGAQGGEEKDGGGEEKDGGGAGVPGHLWEGNLEGTSGSDGNVEDSDQSEKEPGQQYSRPQGAVGGLEPGNAQQPNVHAFTPLQLQELECIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRRHQRALMARNMLPFMAVGQPVMVTAAEAITAPLFISGMRDDYFWDHSHSSSLCFPMPPFPPPSLPLPLMLLPPMPPAGQAEFGPFPFVIVPSFTFPNV

"
     misc_feature    611..769
                     /gene="RHOXF2B"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(611..613,662..664,680..682,719..721,725..730,
                     737..742,746..754,758..763)
                     /gene="RHOXF2B"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(728..730,737..742,749..751)
                     /gene="RHOXF2B"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    746..775
                     /gene="RHOXF2B"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C7M4.1);
                     Region: Nuclear localization signal (By similarity)"
     exon            270..681
                     /gene="RHOXF2B"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(440)
                     /gene="RHOXF2B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199654934"
     variation       complement(467)
                     /gene="RHOXF2B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375698805"
     variation       complement(481)
                     /gene="RHOXF2B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377626082"
     variation       complement(491)
                     /gene="RHOXF2B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202022237"
     variation       complement(505)
                     /gene="RHOXF2B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373851720"
     exon            682..727
                     /gene="RHOXF2B"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(716)
                     /gene="RHOXF2B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201815129"
     exon            728..1309
                     /gene="RHOXF2B"
                     /inference="alignment:Splign:1.39.8"
ORIGIN      

aacccacagcaaatagcgggaagcagaaaagcaagagaggaggtctctaagtggatacactgttgctgagtctagacaccagaagaacgttgcaggcggcgactcacagttctagcactgcctaggagagcgtggtggccccagctcagaatctgcagaagtgcacagctccatccacaccactcagggtatggagcctccggaccagtgtagccagtatatgaccagcttgctcagccctgcagtcgacgacgagaaagaactacaggatatgaatgctatggtgctgtcgcttactgaagaggtcaaagaggaggaagaggatgcacagcctgagcctgagcaaggcacagcagcaggagaaaagttaaagtcggcaggagcccaaggcggagaagaaaaagatggcggcggagaagaaaaagatggcggcggcgccggagttcctggccacctatgggaaggaaacctcgagggcaccagcggcagcgatggcaacgttgaggacagcgaccagagcgagaaggaacctgggcagcagtattcgcgcccacagggcgccgtcggggggctggagcctggcaacgcgcagcagcccaacgtccacgccttcaccccattgcagctgcaggagctggagtgcattttccaacgcgagcagttccccagtgagttcctgcgaaggaggctggcaagaagcatgaatgtgactgaactcgcagtgcagatttggtttgagaatagaagagccaaatggaggagacatcagagggcattaatggcaagaaacatgctgcccttcatggcagtgggccagcctgtcatggtaaccgcagctgaggccataacggcacccttgttcatcagcgggatgagagatgattacttctgggaccacagccattccagcagcctgtgtttccccatgccaccctttcctcctccgtccttgccccttccactcatgcttcttccacctatgccacccgctggccaggctgaatttggcccattcccttttgttatcgtgccttctttcacattccccaatgtctaagggatagcctctgtgccactttttgccagagtgtctttgagccagattcatattttgcatagcaccccatcaaaagtagttcatcaaatgtctattaaacgttttaaagaaaagtacatcattgacccatttttagggcacttgtaaaaatgtttctataaatatgtgaagggtatgtacatttgttttgtgtgtcacatggggtcagtaagttctcaataaaaattgttaagaaatgccattcaaaccgaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:727940 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:727940 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:727940 -> Cellular component: GO:0005634 [nucleus] evidence: IEA