GGRNA Home | Help | Advanced search

2024-03-29 13:43:32, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001077664            3831 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens upregulator of cell proliferation (URGCP), transcript
            variant 2, mRNA.
ACCESSION   NM_001077664
VERSION     NM_001077664.1  GI:117968344
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3831)
  AUTHORS   Dodurga,Y., Yonguc,G.N., Avci,C.B., Bagci,G., Gunduz,C. and
            Satiroglu-Tufan,N.L.
  TITLE     Investigation of microRNA expression changes in HepG2 cell line in
            presence of URG4/URGCP and in absence of URG4/URGCP suppressed by
            RNA interference
  JOURNAL   Mol. Biol. Rep. 39 (12), 11119-11124 (2012)
   PUBMED   23053999
  REMARK    GeneRIF: microRNA profiles were analyzedin HepG2 cells in presence
            or absence of URG4/URGCP gene using RNA interference.
REFERENCE   2  (bases 1 to 3831)
  AUTHORS   Dodurga,Y., Avci,C.B., Susluer,S.Y., Satiroglu Tufan,N.L. and
            Gunduz,C.
  TITLE     The expression of URGCP gene in prostate cancer cell lines:
            correlation with rapamycin
  JOURNAL   Mol. Biol. Rep. 39 (12), 10173-10177 (2012)
   PUBMED   23007575
  REMARK    GeneRIF: Rapamycin diminishes URGCP gene expression in DU145 and
            PC3 cells, but increases expression in LNCaP cells.
REFERENCE   3  (bases 1 to 3831)
  AUTHORS   Xie,C., Song,L.B., Wu,J.H., Li,J., Yun,J.P., Lai,J.M., Xie,D.Y.,
            Lin,B.L., Yuan,Y.F., Li,M. and Gao,Z.L.
  TITLE     Upregulator of cell proliferation predicts poor prognosis in
            hepatocellular carcinoma and contributes to hepatocarcinogenesis by
            downregulating FOXO3a
  JOURNAL   PLoS ONE 7 (7), E40607 (2012)
   PUBMED   22815774
  REMARK    GeneRIF: The effects of URGCP/URG4-overexpression or -knockdown on
            expression of cell cycle regulators and transcriptional activity of
            FOXO3a, were examined.
REFERENCE   4  (bases 1 to 3831)
  AUTHORS   Oymak,Y., Dodurga,Y., Turedi,A., Yaman,Y., Ozek,G., Carti,O.,
            Gunes,B.T., Erbudak,E., Berber,E., Avci,C.B. and Vergin,C.
  TITLE     Higher expression of the novel gene upregulated gene 4 in two acute
            lymphoblastic leukemia patients with poor prednisolone response
  JOURNAL   Acta Haematol. 128 (2), 73-76 (2012)
   PUBMED   22677619
  REMARK    GeneRIF: higher expression of URG4 in our 2 patients suggests that
            URG4 might be involved in leukemogenesis
REFERENCE   5  (bases 1 to 3831)
  AUTHORS   Satiroglu-Tufan,N.L., Dodurga,Y., Gok,D., Cetinkaya,A. and
            Feitelson,M.A.
  TITLE     RNA interference-mediated URG4 gene silencing diminishes cyclin D1
            mRNA expression in HepG2 cells
  JOURNAL   Genet. Mol. Res. 9 (3), 1557-1567 (2010)
   PUBMED   20714998
  REMARK    GeneRIF: The data suggest that URG4 may play an important role in
            the development of hepatocellular carcinoma by partially regulating
            the expression of cyclin D1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3831)
  AUTHORS   Huang,J., Zhu,B., Lu,L., Lian,Z., Wang,Y., Yang,X.,
            Satiroglu-Tufan,N.L., Liu,J. and Luo,Z.
  TITLE     The expression of novel gene URG4 in osteosarcoma: correlation with
            patients' prognosis
  JOURNAL   Pathology 41 (2), 149-154 (2009)
   PUBMED   18972316
  REMARK    GeneRIF: URG4 may play important roles in the development of
            osteosarcoma, and might be a useful molecular marker for predicting
            the prognosis of osteosarcoma.
REFERENCE   7  (bases 1 to 3831)
  AUTHORS   Song,J., Xie,H., Lian,Z., Yang,G., Du,R., Du,Y., Zou,X., Jin,H.,
            Gao,J., Liu,J. and Fan,D.
  TITLE     Enhanced cell survival of gastric cancer cells by a novel gene URG4
  JOURNAL   Neoplasia 8 (12), 995-1002 (2006)
   PUBMED   17217616
  REMARK    GeneRIF: URG4 plays an important role in the development of human
            gastric cancer by regulating the expression of cyclin D1.
REFERENCE   8  (bases 1 to 3831)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   9  (bases 1 to 3831)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   10 (bases 1 to 3831)
  AUTHORS   Tufan,N.L., Lian,Z., Liu,J., Pan,J., Arbuthnot,P., Kew,M.,
            Clayton,M.M., Zhu,M. and Feitelson,M.A.
  TITLE     Hepatitis Bx antigen stimulates expression of a novel cellular
            gene, URG4, that promotes hepatocellular growth and survival
  JOURNAL   Neoplasia 4 (4), 355-368 (2002)
   PUBMED   12082552
  REMARK    GeneRIF: URG4 may be a natural effector of HBxAg that contributes
            importantly to multistep hepatocarcinogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD628752.1, BG722670.1, AK026185.1, DR421788.1, AK000661.1 and
            AL833744.1.
            
            Summary: URG4 is upregulated in the presence of hepatitis B virus
            (HBV)-encoded X antigen (HBxAg) and may contribute to the
            development of hepatocellular carcinoma by promoting hepatocellular
            growth and survival (Tufan et al., 2002 [PubMed
            12082552]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) contains a different segment
            for the 5' UTR and 5' coding region, compared to variant 3. These
            differences cause translation initiation at a downstream AUG and a
            protein (isoform 2) with a shorter and distinct N-terminus compared
            to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI489953.1, DC424451.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025082, ERS025083 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CD628752.1         8-24
            18-694              BG722670.1         10-686
            695-2039            AK026185.1         114-1458
            2040-2575           DR421788.1         130-665
            2576-3802           AK000661.1         525-1751
            3803-3831           AL833744.1         2148-2176
FEATURES             Location/Qualifiers
     source          1..3831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..3831
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="upregulator of cell proliferation"
                     /db_xref="GeneID:55665"
                     /db_xref="HGNC:30890"
                     /db_xref="MIM:610337"
     exon            1..266
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    250..252
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="upstream in-frame stop codon"
     variation       250
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2528382"
     exon            267..293
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     exon            294..364
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     exon            365..415
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     CDS             382..3048
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     up-regulated gene 4; HBxAg up-regulated gene 4 protein;
                     HBV X protein up-regulated gene 4 protein; up-regulator of
                     cell proliferation"
                     /codon_start=1
                     /product="up-regulator of cell proliferation isoform 2"
                     /protein_id="NP_001071132.1"
                     /db_xref="GI:117968345"
                     /db_xref="CCDS:CCDS43572.1"
                     /db_xref="GeneID:55665"
                     /db_xref="HGNC:30890"
                     /db_xref="MIM:610337"
                     /translation="
MEGDDCEFRYGDGTNEAQDNDFPTVERSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVEISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRAIVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFISGISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGVEHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVRWVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLITVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETKDIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQMEKQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNGLSNQNKNIQQLIELVRRL
"
     misc_feature    <1495..1653
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="Protein of unknown function (DUF460); Region:
                     DUF460; pfam04312"
                     /db_xref="CDD:146773"
     misc_feature    2356..>2628
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="P-loop containing Nucleoside Triphosphate
                     Hydrolases; Region: P-loop_NTPase; cl09099"
                     /db_xref="CDD:213113"
     misc_feature    order(2356..2373,2515..2517)
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206648"
     misc_feature    2356..2370
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="G1 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    2437..2445
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206648"
     misc_feature    2506..2517
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="G3 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    order(2512..2517,2599..2604)
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206648"
     exon            416..454
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     variation       453
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:17423654"
     exon            455..3813
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     variation       1533
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17172256"
     variation       1710
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232098"
     variation       1844
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232099"
     variation       1971
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2232100"
     variation       1980
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232101"
     variation       1991
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232102"
     variation       2040
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232103"
     variation       2055
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232104"
     variation       2301
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232105"
     variation       2341
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232106"
     variation       2532
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232107"
     variation       2587
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2232108"
     variation       2823
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232109"
     variation       3176
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1468405"
     STS             3427..3558
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /standard_name="RH103374"
                     /db_xref="UniSTS:97701"
     STS             3662..3720
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /standard_name="STS-Z40982"
                     /db_xref="UniSTS:64179"
     STS             3664..3788
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /standard_name="SHGC-36996"
                     /db_xref="UniSTS:13584"
     variation       3666
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1043200"
     polyA_signal    3782..3787
                     /gene="URGCP"
                     /gene_synonym="URG4"
     polyA_site      3802
                     /gene="URGCP"
                     /gene_synonym="URG4"
     polyA_site      3813
                     /gene="URGCP"
                     /gene_synonym="URG4"
ORIGIN      
gtcgccgcgtgccgagcgtcctggcgcggccgaggggaagcagcggggctgcccgggttacgctggccacccgcacctggtcctgtggcttcgaccactagtcagcaaggccccggagaggccagcgaagaggaggggctcgttggctttacggagacgcgcggagcaccctcaaggtgccacacgctcgcctgctccctgttcctacatcctgggcgtcttcccaggctgtcatataactcctgagaatagtggttcttaactctgatagaagtggaattactgggcaaagggcattcagatttgggagaagtagccccagaaataaaagcatcagagagacgaacagctgtggccattgcagatttggaatggagagaaatggaaggagatgattgcgagttccgttatggagatggtacaaatgaggctcaggacaatgattttccaacagtggagagaagcaggcttcaagaaatgctgtcacttttgggcctagagacgtaccaggtccagaaactcagcctccaggactctctgcagatcagttttgacagtatgaagaactgggcccctcaggttcccaaagacttgccctggaatttcctcaggaagttgcaggccctcaatgctgatgccaggaataccactatggtgctggacgtgctcccagacgccaggcctgtggagaaggagagccagatggaagaggagatcatctactgggacccagctgatgaccttgctgccgacatttattccttttctgagctgcccacccctgatacgccagtgaaccccttagaccttctctgtgccctgctgctctcctcagacagtttcctgcaacaagaaatagcgttgaaaatggccctctgccagtttgcactcccactcgtgttgcctgactcggagaaccactaccatacatttctgctgtgggccatgcggggcattgtgaggacatggtggtcccagcccccaaggggcatggggagcttccgggaagacagcgtggtcttgtccagggcgcccgccttcgccttcgtgcgcatggacgtcagtagcaactccaagtcccagcttctcaacgccgtcctcagcccgggccacaggcagtgggactgcttctggcatcgggacctcaacttgggcaccaatgcccgggagatttcggatgggttggtagaaatttcctggttttttcccagcggaagggaggacttggacattttcccagaacctgtggcctttctgaacctgagaggtgacatcgggtctcactggctgcagtttaagctcttgacagaaatctcctccgctgtgtttatattgactgacaatatcagtaagaaggaatacaaattgctgtactccatgaaggagtcaaccacaaaatactacttcatcctgagtccctaccgtgggaagcgcaacacaaacctgagatttctgaataagttaattcctgtgctgaaaatagaccactcacatgtcctggtaaaggtcagcagcactgacagcgacagcttcgtgaagaggatccgggccatcgttgggaatgtgctgcgggcaccctgcaggcgggtatctgtggaggacatggcgcacgcagcccgcaaactgggcctaaaggtcgacgaggactgtgaggagtgtcagaaagcgaaagaccggatggagaggattaccaggaaaatcaaagactcggatgcctacagaagggacgagctgaggctgcagggggacccctggagaaaggcagcccaagtggagaaggagttctgccagctccagtgggccgtggacccccctgagaagcacagggctgagctgaggcggcggctgctagaacttcgaatgcagcagaacggccatgatccctcctcgggggtgcaggagttcatctcggggatcagcagcccctccttgagtgagaagcagtacttcctgaggtggatggagtggggcctggcacgggtggcccagccgcgactgagacagcctccggagacgcttctcaccctgagaccaaagcatgggggcaccacagacgtgggggagccgctctggcctgagcccctaggggtggaacacttcttgcgggagatgggacagttttatgaggctgagagctgtcttgtggaggcagggaggctgccggcaggccagaggcgttttgcccacttcccaggcttggcctcggagctgctgctgacagggctgcctctggagctaatcgatgggagcacgctgagcatgcccgtccgctgggtcacagggctcctgaaggagctgcacgtccgactggagagacggtcaaggctggtggttctgtcaaccgtcggggtgccaggcacgggcaagtccacactcctcaacaccatgtttgggctgcggtttgccacagggaagagctgcggtcctcgaggggccttcatgcagctcatcacagtggctgagggcttcagccaggacctgggctgtgaccacatcctggtgatagactccgggggcttgataggtggggccttgacgtcagctggggacagatttgagctggaggcttccttggccactctgctcatgggactgagcaatgtcaccgtgatcagtctagctgaaaccaaggacattccagcagctattctgcatgcatttctgaggttagaaaaaacggggcacatgcccaactaccagtttgtataccagaaccttcatgatgtatctgttcccggccctaggcccagagacaagagacagctcctggatccacctggtgacctgagcagggctgcagcccagatggagaaacagggcgacggcttccgggcactggcaggcctggccttctgcgaccctgagaagcagcacatctggcacatcccaggcctgtggcacggagcacctcccatggccgcagtgagcttggcctacagtgaagccatatttgaattgaagagatgcctactcgaaaacatcaggaacggcttgtcgaaccaaaacaaaaacatccagcagctcattgagctggtgagacggctgtgagtgtgcagagaaacccagttcaggtgtaggaggctgctgtgggcagccctgtctgatggggcacccgtgtggggctgtgctctggtgcctgagaatggctggtgcccaatcgacatgagaagacgaggaaaagacagggtttggagtctcctcaacagtgttaaaagaggaagtgacctcacagaccagctcagagatgttaccaagaatatcacagcccccagggtagggagacaagcagcagtttgttctgtctcagctcctgtcaaggatcctgcggggtgggccctctgtatagctgctctctgtcactggcccctggagtgggagcagcgtccttagtcactgcaggcccaggcgggcaggtggtcccaggacagaggtggggaagttgtcctgaggaagcagaagtaggccttgctcccgcccaacccaagggcctccagtggaccagcattcaagatgtgagtgcccgtggtgtgcaaggcactcccatggcaccgtatttattgactgatctgtgaaggcttccctgacccctgcccaggaagagttcactggtcgctctgttgtgccccacagcactttgttatacctctgccacacacttcacgcagcgcgttgtaactcatgtgtttacatgtctgtccccccagactgtgagctccttgagggcagggactgtacattctccagctctgtgtccccagggcctggcacattgtagacgcttaataaatgtctgttaaatgaatgagtgcacaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:55665 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
            GeneID:55665 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
            GeneID:55665 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:55665 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.