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2024-04-20 03:08:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001037340 4273 bp mRNA linear PRI 14-JUL-2013
DEFINITION Homo sapiens phosphodiesterase 4B, cAMP-specific (PDE4B),
transcript variant c, mRNA.
ACCESSION NM_001037340
VERSION NM_001037340.1 GI:82799483
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4273)
AUTHORS Yang,J.J., Cheng,C., Devidas,M., Cao,X., Campana,D., Yang,W.,
Fan,Y., Neale,G., Cox,N., Scheet,P., Borowitz,M.J., Winick,N.J.,
Martin,P.L., Bowman,W.P., Camitta,B., Reaman,G.H., Carroll,W.L.,
Willman,C.L., Hunger,S.P., Evans,W.E., Pui,C.H., Loh,M. and
Relling,M.V.
TITLE Genome-wide association study identifies germline polymorphisms
associated with relapse of childhood acute lymphoblastic leukemia
JOURNAL Blood 120 (20), 4197-4204 (2012)
PUBMED 23007406
REFERENCE 2 (bases 1 to 4273)
AUTHORS Lee,J., Komatsu,K., Lee,B.C., Lim,J.H., Jono,H., Xu,H., Kai,H.,
Zhang,Z.J., Yan,C. and Li,J.D.
TITLE Phosphodiesterase 4B mediates extracellular signal-regulated
kinase-dependent up-regulation of mucin MUC5AC protein by
Streptococcus pneumoniae by inhibiting cAMP-protein kinase
A-dependent MKP-1 phosphatase pathway
JOURNAL J. Biol. Chem. 287 (27), 22799-22811 (2012)
PUBMED 22610099
REMARK GeneRIF: PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC
by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.
REFERENCE 3 (bases 1 to 4273)
AUTHORS Benjamin,D.J., Cesarini,D., van der Loos,M.J., Dawes,C.T.,
Koellinger,P.D., Magnusson,P.K., Chabris,C.F., Conley,D.,
Laibson,D., Johannesson,M. and Visscher,P.M.
TITLE The genetic architecture of economic and political preferences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (21), 8026-8031 (2012)
PUBMED 22566634
REFERENCE 4 (bases 1 to 4273)
AUTHORS Kashiwagi,E., Shiota,M., Yokomizo,A., Itsumi,M., Inokuchi,J.,
Uchiumi,T. and Naito,S.
TITLE Downregulation of phosphodiesterase 4B (PDE4B) activates protein
kinase A and contributes to the progression of prostate cancer
JOURNAL Prostate 72 (7), 741-751 (2012)
PUBMED 22529021
REMARK GeneRIF: PDE4B was downregulated and the protein kinase A pathway
was activated in castration-resistant LNCaP prostate cancer cells.
PDE4B expression was reduced in advanced prostate cancer and PDE4B
knockdown promoted castration-resistant growth of LNCaP cells.
REFERENCE 5 (bases 1 to 4273)
AUTHORS Newburn,E.N., Hyde,T.M., Ye,T., Morita,Y., Weinberger,D.R.,
Kleinman,J.E. and Lipska,B.K.
TITLE Interactions of human truncated DISC1 proteins: implications for
schizophrenia
JOURNAL Transl Psychiatry 1, E30 (2011)
PUBMED 22832604
REMARK GeneRIF: Short Disrupted-in-Schizophrenia (DISC)1 splice variants
show reduced or no binding to nudE nuclear distribution E homolog
(NDEL)1 and PDE4B proteins but fully interact with
fasciculation/elongation zeta (FEZ)1 and glycogen synthase kinase 3
GSK3beta.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4273)
AUTHORS Szpirer,C., Szpirer,J., Riviere,M., Swinnen,J., Vicini,E. and
Conti,M.
TITLE Chromosomal localization of the human and rat genes (PDE4D and
PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4
JOURNAL Cytogenet. Cell Genet. 69 (1-2), 11-14 (1995)
PUBMED 7835077
REFERENCE 7 (bases 1 to 4273)
AUTHORS Bolger,G.B., Rodgers,L. and Riggs,M.
TITLE Differential CNS expression of alternative mRNA isoforms of the
mammalian genes encoding cAMP-specific phosphodiesterases
JOURNAL Gene 149 (2), 237-244 (1994)
PUBMED 7958996
REFERENCE 8 (bases 1 to 4273)
AUTHORS Bolger,G., Michaeli,T., Martins,T., St John,T., Steiner,B.,
Rodgers,L., Riggs,M., Wigler,M. and Ferguson,K.
TITLE A family of human phosphodiesterases homologous to the dunce
learning and memory gene product of Drosophila melanogaster are
potential targets for antidepressant drugs
JOURNAL Mol. Cell. Biol. 13 (10), 6558-6571 (1993)
PUBMED 8413254
REFERENCE 9 (bases 1 to 4273)
AUTHORS Obernolte,R., Bhakta,S., Alvarez,R., Bach,C., Zuppan,P.,
Mulkins,M., Jarnagin,K. and Shelton,E.R.
TITLE The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE
IV) reveals a multigene family
JOURNAL Gene 129 (2), 239-247 (1993)
PUBMED 8392015
REFERENCE 10 (bases 1 to 4273)
AUTHORS McLaughlin,M.M., Cieslinski,L.B., Burman,M., Torphy,T.J. and
Livi,G.P.
TITLE A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from
human brain. Cloning and expression of cDNA, biochemical
characterization of recombinant protein, and tissue distribution of
mRNA
JOURNAL J. Biol. Chem. 268 (9), 6470-6476 (1993)
PUBMED 8384210
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AB209081.1, BC101480.1,
BC036108.1, BC046161.1 and AW519027.1.
Summary: This gene is a member of the type IV, cyclic AMP
(cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family.
Cyclic nucleotides are important second messengers that regulate
and mediate a number of cellular responses to extracellular
signals, such as hormones, light, and neurotransmitters. The cyclic
nucleotide phosphodiesterases (PDEs) regulate the cellular
concentrations of cyclic nucleotides and thereby play a role in
signal transduction. This gene encodes a protein that specifically
hydrolyzes cAMP. Altered activity of this protein has been
associated with schizophrenia and bipolar affective disorder.
Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (c) contains a distinct 5' UTR and
lacks an in-frame portion of the 5' coding region, compared to
variant a. The resulting isoform (3, also referred to as PDE4B3)
has a shorter and distinct N-terminus when compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB209081.1, AK290006.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1459 AB209081.1 1-1459
1460-2463 BC101480.1 1391-2394
2464-2737 AB209081.1 2464-2737
2738-3536 BC036108.1 2768-3566
3537-4111 AB209081.1 3537-4111
4112-4261 BC046161.1 1196-1345
4262-4273 AW519027.1 1-12 c
FEATURES Location/Qualifiers
source 1..4273
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p31"
gene 1..4273
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="phosphodiesterase 4B, cAMP-specific"
/db_xref="GeneID:5142"
/db_xref="HGNC:8781"
/db_xref="HPRD:02528"
/db_xref="MIM:600127"
exon 1..436
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 43
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:185818584"
variation 71
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:191369542"
variation 85
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:138542591"
variation 113
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:183182898"
variation 118
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:187710915"
variation 158
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:370243912"
misc_feature 183..185
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="upstream in-frame stop codon"
CDS 201..2366
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/EC_number="3.1.4.17"
/note="isoform 3 is encoded by transcript variant c;
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4
dunce homolog, Drosophila); dunce-like phosphodiesterase
E4; cAMP-specific 3',5'-cyclic phosphodiesterase 4B;
cAMP-specific phosphodiesterase-4 B isoform; PDE32"
/codon_start=1
/product="cAMP-specific 3',5'-cyclic phosphodiesterase 4B
isoform 3"
/protein_id="NP_001032417.1"
/db_xref="GI:82799484"
/db_xref="CCDS:CCDS30742.1"
/db_xref="GeneID:5142"
/db_xref="HGNC:8781"
/db_xref="HPRD:02528"
/db_xref="MIM:600127"
/translation="
MTAKDSSKELTASEPEVCIKTFKEQMHLELELPRLPGNRPTSPKISPRSSPRNSPCFFRKLLVNKSIRQRRRFTVAHTCFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
"
misc_feature 1368..1916
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Metal dependent phosphohydrolases with conserved
'HD' motif; Region: HDc; cd00077"
/db_xref="CDD:28958"
misc_feature order(1383..1385,1491..1496,1845..1847)
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
misc_feature 1494..1496
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/note="Mg2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
variation 225
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:142761289"
variation 230
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:116566645"
variation 272
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:115074556"
variation 294
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:369469512"
variation 299
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:139413416"
variation 323
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:116785815"
variation 338
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:141279762"
variation 342
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:201170908"
variation 373
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:144055593"
variation 381
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:372397597"
variation 389
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:374443084"
exon 437..631
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 444
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:374255487"
variation 468
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:367809652"
variation 472
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:145072153"
variation 490
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:75398902"
variation 500
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:143755153"
variation 519
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:375693073"
variation 557
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:201506484"
variation 569
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:141704617"
variation 575
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:139030347"
variation 604
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:370994595"
variation 605
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:143872916"
variation 626
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:115853607"
exon 632..668
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 635
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:372187760"
variation 637
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:374832183"
exon 669..739
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 701
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:369969167"
exon 740..789
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 743
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:192869700"
exon 790..902
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 813
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371423323"
variation 852
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:116739380"
variation 872
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:140500253"
exon 903..996
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 924
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:376229903"
variation 927
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:145203756"
variation 952
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:199554373"
variation 985
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371297521"
exon 997..1175
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1038
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:138828553"
variation 1119
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:369849443"
variation 1122
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:372730987"
variation 1166
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377188281"
variation 1175
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:143554413"
exon 1176..1274
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1177
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:141692815"
STS 1270..1376
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="RH64524"
/db_xref="UniSTS:59487"
exon 1275..1439
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1292
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:138407878"
variation 1341
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:4322205"
variation 1379
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:146166974"
variation 1382
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:115052833"
variation 1385
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:368002134"
variation 1399
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:371715752"
variation 1412
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:202021123"
exon 1440..1539
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1460
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:783036"
variation 1488
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:185687552"
variation 1506
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:116379917"
exon 1540..1694
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1547
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:144798451"
exon 1695..1817
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1759
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:151031090"
variation 1776
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="t"
/db_xref="dbSNP:34079300"
variation 1795
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:116816923"
variation 1805
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:373028719"
variation 1809
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:142379593"
exon 1818..2000
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 1824
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:370349934"
variation 1825
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:116312841"
variation 1835
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:34492439"
variation 1850
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:367550787"
variation 1895
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:141437989"
variation 1901
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200251647"
variation 1922
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:41286714"
variation 1935
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:201667673"
variation 1943
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114211692"
variation 1952
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:370428408"
variation 1958
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:373800241"
exon 2001..4267
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/inference="alignment:Splign:1.39.8"
variation 2066
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:149054617"
variation 2075
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:41286716"
variation 2081
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:79722858"
variation 2082
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114393853"
variation 2099
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:139001333"
variation 2110
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:200211480"
variation 2121
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371876952"
variation 2138
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:201727510"
variation 2150
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:139374179"
variation 2151
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:149588422"
variation 2152
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:144568843"
variation 2195
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:3181494"
variation 2196
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:1042020"
variation 2199
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:34469235"
variation 2207
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:373468487"
variation 2221
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:370754936"
variation 2249
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:372714875"
variation 2256
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:150977853"
variation 2262
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:2227297"
variation 2263
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:375941228"
variation 2275
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:185910614"
variation 2296
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:370636828"
variation 2310
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200854845"
variation 2319
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:114387631"
STS 2384..3268
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="PDE4B_372"
/db_xref="UniSTS:277574"
variation 2387
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:374227067"
variation 2406
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:115922110"
variation 2513
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:376708525"
variation 2569
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:57315098"
variation 2605
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:41286718"
variation 2690
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371856307"
variation 2738
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:783067"
variation 2818
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:138914808"
variation 2833
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:1804141"
variation 2906
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:141470428"
variation 3073
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="t"
/db_xref="dbSNP:377201462"
variation 3083
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:181156834"
variation 3096
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:200935637"
variation 3110
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:78315788"
variation 3330
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:150394636"
variation 3346
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:4655837"
variation 3389..3390
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="aaca"
/db_xref="dbSNP:199875231"
variation 3410
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:186227828"
variation 3510
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:190701813"
STS 3568..3900
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="D1S2393"
/db_xref="UniSTS:66663"
variation 3601
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:371829302"
variation 3646
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="t"
/db_xref="dbSNP:76335673"
variation 3648
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:112424842"
variation 3662
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:3176927"
variation 3691
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:138156061"
variation 3733
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="c"
/db_xref="dbSNP:149577217"
variation 3762
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:144286936"
variation 3786
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="g"
/db_xref="dbSNP:183451410"
STS 3814..3914
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/standard_name="SGC30670"
/db_xref="UniSTS:79282"
variation 3858
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:186230480"
variation 3874
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:190745276"
variation 3889
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377465393"
variation 3897
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:377626847"
polyA_signal 3941..3946
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
variation 3963
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="c"
/replace="t"
/db_xref="dbSNP:182887410"
polyA_site 3975
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/experiment="experimental evidence, no additional details
recorded"
variation 3992
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:374581239"
variation 4109..4110
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="tgggtt"
/db_xref="dbSNP:368800294"
variation 4109
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="aaccca"
/db_xref="dbSNP:16354"
variation 4110..4111
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="gg"
/replace="tgggtt"
/db_xref="dbSNP:71807410"
variation 4111..4112
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="ggtttg"
/db_xref="dbSNP:141736339"
variation 4112..4113
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="ggtttg"
/db_xref="dbSNP:71682925"
variation 4112
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:368211356"
variation 4113
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:371168935"
variation 4115
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:374364770"
variation 4164
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="a"
/replace="g"
/db_xref="dbSNP:376802391"
variation 4175
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace="g"
/replace="t"
/db_xref="dbSNP:138911836"
variation 4186..4187
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
/replace=""
/replace="tat"
/db_xref="dbSNP:202242622"
polyA_signal 4243..4248
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
polyA_site 4267
/gene="PDE4B"
/gene_synonym="DPDE4; PDE4B5; PDEIVB"
ORIGIN
aaagctccttgtgacagcctgacttgctattcttcgagtatgctgctcttgctctaagacgctcatacattggagtcacagcttcgtaaattaaactggaaatagtttgcagacttatcagtcttctgacctgcagcagtgtctctgctatgtttgagatttttgttttggatggtgaaagctagcactccttacaagacatgacagcaaaagattcttcaaaggaacttactgcttctgaacctgaggtttgcataaagactttcaaggagcaaatgcatttagaacttgagcttccgagattaccaggaaacagacctacatctcctaaaatttctccacgcagttcaccaaggaactcaccatgctttttcagaaagttgctggtgaataaaagcattcggcagcgtcgtcgcttcactgtggctcatacatgctttgatgtggaaaatggcccttccccaggtcggagtccactggatccccaggccagctcttccgctgggctggtacttcacgccacctttcctgggcacagccagcgcagagagtcatttctctacagatcagacagcgactatgacttgtcaccaaaggcgatgtcgagaaactcttctcttccaagcgagcaacacggcgatgacttgattgtaactccttttgcccaggtccttgccagcttgcgaagtgtgagaaacaacttcactatactgacaaaccttcatggtacatctaacaagaggtccccagctgctagtcagcctcctgtctccagagtcaacccacaagaagaatcttatcaaaaattagcaatggaaacgctggaggaattagactggtgtttagaccagctagagaccatacagacctaccggtctgtcagtgagatggcttctaacaagttcaaaagaatgctgaaccgggagctgacacacctctcagagatgagccgatcagggaaccaggtgtctgaatacatttcaaatactttcttagacaagcagaatgatgtggagatcccatctcctacccagaaagacagggagaaaaagaaaaagcagcagctcatgacccagataagtggagtgaagaaattaatgcatagttcaagcctaaacaatacaagcatctcacgctttggagtcaacactgaaaatgaagatcacctggccaaggagctggaagacctgaacaaatggggtcttaacatctttaatgtggctggatattctcacaatagacccctaacatgcatcatgtatgctatattccaggaaagagacctcctaaagacattcagaatctcatctgacacatttataacctacatgatgactttagaagaccattaccattctgacgtggcatatcacaacagcctgcacgctgctgatgtagcccagtcgacccatgttctcctttctacaccagcattagacgctgtcttcacagatttggagatcctggctgccatttttgcagctgccatccatgacgttgatcatcctggagtctccaatcagtttctcatcaacacaaattcagaacttgctttgatgtataatgatgaatctgtgttggaaaatcatcaccttgctgtgggtttcaaactgctgcaagaagaacactgtgacatcttcatgaatctcaccaagaagcagcgtcagacactcaggaagatggttattgacatggtgttagcaactgatatgtctaaacatatgagcctgctggcagacctgaagacaatggtagaaacgaagaaagttacaagttcaggcgttcttctcctagacaactataccgatcgcattcaggtccttcgcaacatggtacactgtgcagacctgagcaaccccaccaagtccttggaattgtatcggcaatggacagaccgcatcatggaggaatttttccagcagggagacaaagagcgggagaggggaatggaaattagcccaatgtgtgataaacacacagcttctgtggaaaaatcccaggttggtttcatcgactacattgtccatccattgtgggagacatgggcagatttggtacagcctgatgctcaggacattctcgataccttagaagataacaggaactggtatcagagcatgatacctcaaagtccctcaccaccactggacgagcagaacagggactgccagggtctgatggagaagtttcagtttgaactgactctcgatgaggaagattctgaaggacctgagaaggagggagagggacacagctatttcagcagcacaaagacgctttgtgtgattgatccagaaaacagagattccctgggagagactgacatagacattgcaacagaagacaagtcccccgtggatacataatccccctctccctgtggagatgaacattctatccttgatgagcatgccagctatgtggtagggccagcccaccatgggggccaagacctgcacaggacaagggccacctggcctttcagttacttgagtttggagtcagaaagcaagaccaggaagcaaatagcagctcaggaaatcccacggttgacttgccttgatggcaagcttggtggagagggctgaagctgttgctgggggccgattctgatcaagacacatggcttgaaaatggaagacacaaaactgagagatcattctgcactaagtttcgggaacttatccccgacagtgactgaactcactgactaataacttcatttatgaatcttctcacttgtccctttgtctgccaacctgtgtgccttttttgtaaaacattttcatgtctttaaaatgcctgttgaatacctggagtttagtatcaacttctacacagataagctttcaaagttgacaaacttttttgactctttctggaaaagggaaagaaaatagtcttccttctttcttgggcaatatccttcactttactacagttacttttgcaaacagacagaaaggatacacttctaaccacattttacttccttcccctgttgtccagtccaactccacagtcactcttaaaacttctctctgtttgcctgcctccaacagtacttttaactttttgctgtaaacagaataaaattgaacaaattagggggtagaaaggagcagtggtgtcgttcaccgtgagagtctgcatagaactcagcagtgtgccctgctgtgtcttggaccctgccccccacaggagttgtacagtccctggccctgttccctacctcctctcttcaccccgttaggctgttttcaatgtaatgctgccgtccttctcttgcactgccttctgcgctaacacctccattcctgtttataaccgtgtatttattacttaatgtatataatgtaatgttttgtaagttattaatttatatatctaacattgcctgccaatggtggtgttaaatttgtgtagaaaactctgcctaagagttacgactttttcttgtaatgttttgtattgtgtattatataacccaaacgtcacttagtagagacatatggcccccttggcagagaggacaggggtgggcttttgttcaaagggtctgccctttccctgcctgagttgctacttctgcacaacccctttatgaaccagttttggaaacaatattctcacattagatactaaatggtttatactgagcttttacttttgtatagcttgataggggcagggggcaatgggatgtagtttttacccaggttctatccaaatctatgtgggcatgagttgggttataactggatcctactatcattgtggctttggttcaaaaggaaacactacatttgctcacagatgattcttctgaatgctcccgaactactgactttgaagaggtagcctcctgcctgccattaagcaggaatgtcatgttccagttcattacaaaagaaaacaataaaacaatgtgaatttttataataaaatgtgaactgatgtagcaaattacgcaaatgtgaagcctcttctgataacacttgttaggcctcttactgatgtcagtttcagtttgtaaaatatgtttcatgctttcagttcagcattgtgactcagtaattacagaaaatggcacaaatgtgcatgaccaatgtatgtctatgaacactgcattgtttcaggtggacattttatcattttcaaatgtttctcacaatgtatgttatagtattattattatatattgtgttcaaatgcattctaaagagacttttatatgaggtgaataaagaaaagcatgattagattaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5142 -> Molecular function: GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] evidence: ISS
GeneID:5142 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IDA
GeneID:5142 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IGI
GeneID:5142 -> Molecular function: GO:0030552 [cAMP binding] evidence: IGI
GeneID:5142 -> Molecular function: GO:0044325 [ion channel binding] evidence: ISS
GeneID:5142 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:5142 -> Biological process: GO:0001780 [neutrophil homeostasis] evidence: ISS
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IDA
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IEA
GeneID:5142 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IGI
GeneID:5142 -> Biological process: GO:0030593 [neutrophil chemotaxis] evidence: ISS
GeneID:5142 -> Biological process: GO:0032729 [positive regulation of interferon-gamma production] evidence: IMP
GeneID:5142 -> Biological process: GO:0032743 [positive regulation of interleukin-2 production] evidence: IMP
GeneID:5142 -> Biological process: GO:0035690 [cellular response to drug] evidence: ISS
GeneID:5142 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: IMP
GeneID:5142 -> Biological process: GO:0050900 [leukocyte migration] evidence: ISS
GeneID:5142 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: ISS
GeneID:5142 -> Biological process: GO:0071872 [cellular response to epinephrine stimulus] evidence: ISS
GeneID:5142 -> Biological process: GO:0086004 [regulation of cardiac muscle cell contraction] evidence: ISS
GeneID:5142 -> Biological process: GO:1901841 [regulation of high voltage-gated calcium channel activity] evidence: ISS
GeneID:5142 -> Biological process: GO:1901898 [negative regulation of relaxation of cardiac muscle] evidence: ISS
GeneID:5142 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:5142 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5142 -> Cellular component: GO:0005891 [voltage-gated calcium channel complex] evidence: ISS
GeneID:5142 -> Cellular component: GO:0030018 [Z disc] evidence: ISS
GeneID:5142 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001032417 -> EC 3.1.4.17
by
@meso_cacase at
DBCLS
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