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2024-04-19 11:55:42, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000689 2378 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens aldehyde dehydrogenase 1 family, member A1 (ALDH1A1),
mRNA.
ACCESSION NM_000689
VERSION NM_000689.4 GI:327365354
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2378)
AUTHORS Wu,A., Luo,W., Zhang,Q., Yang,Z., Zhang,G., Li,S. and Yao,K.
TITLE Aldehyde dehydrogenase 1, a functional marker for identifying
cancer stem cells in human nasopharyngeal carcinoma
JOURNAL Cancer Lett. 330 (2), 181-189 (2013)
PUBMED 23220285
REMARK GeneRIF: Aldehyde dehydrogenase 1, a functional marker for
identifying cancer stem cells in human nasopharyngeal carcinoma.
REFERENCE 2 (bases 1 to 2378)
AUTHORS de Beca,F.F., Caetano,P., Gerhard,R., Alvarenga,C.A., Gomes,M.,
Paredes,J. and Schmitt,F.
TITLE Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer
special histological types
JOURNAL J. Clin. Pathol. 66 (3), 187-191 (2013)
PUBMED 23112116
REMARK GeneRIF: Medullary and metaplastic carcinomas are the two types
highly associated with high-grade breast carcinomas, basal-like and
claudin-low molecular subtypes, and to the breast cancer stem cell
phenotype CD44(+)/CD24(-/low)/ALDH1(+).
REFERENCE 3 (bases 1 to 2378)
AUTHORS Fitzmaurice,A.G., Rhodes,S.L., Lulla,A., Murphy,N.P., Lam,H.A.,
O'Donnell,K.C., Barnhill,L., Casida,J.E., Cockburn,M., Sagasti,A.,
Stahl,M.C., Maidment,N.T., Ritz,B. and Bronstein,J.M.
TITLE Aldehyde dehydrogenase inhibition as a pathogenic mechanism in
Parkinson disease
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (2), 636-641 (2013)
PUBMED 23267077
REMARK GeneRIF: Benomyl inhibition of aldehyde dehydrogenase leads to the
accumulation of 3,4-dihydroxyphenylacetaldehyde, preferential
degeneration of dopaminergic neurons, and development of Parkinson
disease.
REFERENCE 4 (bases 1 to 2378)
AUTHORS Okudela,K., Woo,T., Mitsui,H., Tajiri,M., Masuda,M. and Ohashi,K.
TITLE Expression of the potential cancer stem cell markers, CD133, CD44,
ALDH1, and beta-catenin, in primary lung adenocarcinoma--their
prognostic significance
JOURNAL Pathol. Int. 62 (12), 792-801 (2012)
PUBMED 23252868
REMARK GeneRIF: levels of CD133, CD44, and ALDH1 had independent
prognostic value to predict the recurrence of lung adenocarcinoma
REFERENCE 5 (bases 1 to 2378)
AUTHORS Schafer,A., Teufel,J., Ringel,F., Bettstetter,M., Hoepner,I.,
Rasper,M., Gempt,J., Koeritzer,J., Schmidt-Graf,F., Meyer,B.,
Beier,C.P. and Schlegel,J.
TITLE Aldehyde dehydrogenase 1A1--a new mediator of resistance to
temozolomide in glioblastoma
JOURNAL Neuro-oncology 14 (12), 1452-1464 (2012)
PUBMED 23132408
REMARK GeneRIF: ALDH1A1 is a new mediator for resistance of glioblastoma
multiforme to temozolomide and a reliable predictor of clinical
outcome
REFERENCE 6 (bases 1 to 2378)
AUTHORS Pereira,F., Rosenmann,E., Nylen,E., Kaufman,M., Pinsky,L. and
Wrogemann,K.
TITLE The 56 kDa androgen binding protein is an aldehyde dehydrogenase
JOURNAL Biochem. Biophys. Res. Commun. 175 (3), 831-838 (1991)
PUBMED 1709013
REFERENCE 7 (bases 1 to 2378)
AUTHORS Hsu,L.C., Chang,W.C. and Yoshida,A.
TITLE Genomic structure of the human cytosolic aldehyde dehydrogenase
gene
JOURNAL Genomics 5 (4), 857-865 (1989)
PUBMED 2591967
REFERENCE 8 (bases 1 to 2378)
AUTHORS Agarwal,D.P., Cohn,P., Goedde,H.W. and Hempel,J.
TITLE Aldehyde dehydrogenase from human erythrocytes: structural
relationship to the liver cytosolic isozyme
JOURNAL Enzyme 42 (1), 47-52 (1989)
PUBMED 2776714
REFERENCE 9 (bases 1 to 2378)
AUTHORS Inoue,K., Nishimukai,H. and Yamasawa,K.
TITLE Purification and partial characterization of aldehyde dehydrogenase
from human erythrocytes
JOURNAL Biochim. Biophys. Acta 569 (2), 117-123 (1979)
PUBMED 224930
REFERENCE 10 (bases 1 to 2378)
AUTHORS Harada,S., Agarwal,D.P. and Goedde,H.W.
TITLE Isozyme variations in acetaldehyde dehydrogenase (e.c.1.2.1.3) in
human tissues
JOURNAL Hum. Genet. 44 (2), 181-185 (1978)
PUBMED 730161
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC398835.1, BC001505.2 and
AI074764.1.
This sequence is a reference standard in the RefSeqGene project.
On Apr 1, 2011 this sequence version replaced gi:25777722.
Summary: The protein encoded by this gene belongs to the aldehyde
dehydrogenase family. Aldehyde dehydrogenase is the next enzyme
after alcohol dehydrogenase in the major pathway of alcohol
metabolism. There are two major aldehyde dehydrogenase isozymes in
the liver, cytosolic and mitochondrial, which are encoded by
distinct genes, and can be distinguished by their electrophoretic
mobility, kinetic properties, and subcellular localization. This
gene encodes the cytosolic isozyme. Studies in mice show that
through its role in retinol metabolism, this gene may also be
involved in the regulation of the metabolic responses to high-fat
diet. [provided by RefSeq, Mar 2011].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK026641.1, AK000118.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-539 DC398835.1 20-558
540-2207 BC001505.2 248-1915
2208-2378 AI074764.1 1-171 c
FEATURES Location/Qualifiers
source 1..2378
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q21.13"
gene 1..2378
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/note="aldehyde dehydrogenase 1 family, member A1"
/db_xref="GeneID:216"
/db_xref="HGNC:402"
/db_xref="HPRD:00001"
/db_xref="MIM:100640"
exon 1..383
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
misc_feature 249..251
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/note="upstream in-frame stop codon"
variation 302
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace=""
/replace="a"
/db_xref="dbSNP:8187867"
CDS 318..1823
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/EC_number="1.2.1.36"
/note="retinaldehyde dehydrogenase 1; aldehyde
dehydrogenase 1, soluble; aldehyde dehydrogenase, liver
cytosolic; ALDH class 1; acetaldehyde dehydrogenase 1;
ALHDII; RALDH 1"
/codon_start=1
/product="retinal dehydrogenase 1"
/protein_id="NP_000680.2"
/db_xref="GI:21361176"
/db_xref="CCDS:CCDS6644.1"
/db_xref="GeneID:216"
/db_xref="HGNC:402"
/db_xref="HPRD:00001"
/db_xref="MIM:100640"
/translation="
MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS
"
misc_feature 321..323
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylserine; propagated from
UniProtKB/Swiss-Prot (P00352.2); acetylation site"
misc_feature 321..323
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/experiment="experimental evidence, no additional details
recorded"
/note="acetylation site"
misc_feature 360..1802
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/note="NAD+-dependent retinal dehydrogenase 1, ALDH
families 1A, 1B, and 2-like; Region: ALDH_F1AB_F2_RALDH1;
cd07141"
/db_xref="CDD:143459"
misc_feature 402..1793
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/note="Aldehyde dehydrogenase family; Region: Aldedh;
pfam00171"
/db_xref="CDD:201055"
misc_feature order(534..539,549..551,558..560,564..566,576..578,
699..701,708..713,723..725,729..734,741..755,759..764,
771..794,1071..1073,1080..1082,1089..1094,1101..1106,
1110..1112,1125..1127,1620..1622,1626..1628,1647..1649,
1656..1658,1662..1685,1704..1712,1719..1730,1734..1736,
1743..1745,1758..1760,1779..1796,1800..1802)
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/note="homotetrameric interface [polypeptide binding];
other site"
/db_xref="CDD:143459"
misc_feature 588..590
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P00352.2); acetylation site"
misc_feature 699..701
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P00352.2); acetylation site"
misc_feature order(813..824,894..896,903..905,993..995,1005..1010,
1047..1049,1056..1058,1065..1067,1125..1130,1224..1226,
1365..1367,1374..1376,1515..1517)
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/note="NAD binding site [chemical binding]; other site"
/db_xref="CDD:143459"
misc_feature order(825..827,1122..1124,1215..1217,1224..1226)
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/note="catalytic residues [active]"
/db_xref="CDD:143459"
misc_feature 825..827
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="non-experimental evidence, no additional
details recorded"
/note="Transition state stabilizer (By similarity);
propagated from UniProtKB/Swiss-Prot (P00352.2); other
site"
misc_feature 1071..1073
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P00352.2); acetylation site"
misc_feature 1374..1376
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P00352.2); acetylation site"
misc_feature 1416..1418
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P00352.2); acetylation site"
misc_feature 1545..1547
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P00352.2); acetylation site"
misc_feature 1572..1574
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P00352.2); acetylation site"
misc_feature 1620..1622
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P00352.2); acetylation site"
misc_feature 1800..1802
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P00352.2); acetylation site"
variation 360
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11554424"
exon 384..488
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
variation 434
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554422"
variation 436
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554426"
exon 489..629
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
variation 542
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:13959"
exon 630..759
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
variation 679
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1049981"
variation 690
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11554423"
exon 760..821
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
exon 822..950
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
variation 846
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="a"
/replace="t"
/db_xref="dbSNP:8187929"
exon 951..1064
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
variation 1061
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="a"
/replace="t"
/db_xref="dbSNP:11554425"
exon 1065..1167
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
exon 1168..1352
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
exon 1353..1517
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
exon 1518..1675
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
variation 1654
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="a"
/replace="c"
/db_xref="dbSNP:1803054"
exon 1676..1750
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
variation 1714
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="a"
/replace="t"
/db_xref="dbSNP:1063447"
exon 1751..2369
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/inference="alignment:Splign:1.39.8"
variation 1885
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:8187998"
polyA_signal 2041..2046
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
variation 2063
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="a"
/replace="t"
/db_xref="dbSNP:77252691"
polyA_site 2066
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
STS 2100..2288
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/standard_name="RH12740"
/db_xref="UniSTS:23088"
variation 2138
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:8187999"
STS 2144..2294
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/standard_name="HUM00D1B06"
/db_xref="UniSTS:41862"
variation 2164
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:15500"
variation 2278
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:8188000"
polyA_signal 2340..2345
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
polyA_site 2369
/gene="ALDH1A1"
/gene_synonym="ALDC; ALDH-E1; ALDH1; ALDH11; PUMB1;
RALDH1"
ORIGIN
gctgcatacacttatcacaggtttcggctttgtaaattaattcatctgcaaatagtgcactgtctccaggtacaaattcgatgctggagcactggtttcttaaggatttaagtttaaagtcaaaggcttcctgccctaggtgttacaaataagtagtgtcgttttctttttttgctctgagtttgttcatccaatcgtatccgagtatgcaaataaactttagcccgtgcagataaaaaaggaacaaataaagccaagtgctctatcagaaccaaattgctgagccagtcacctgtgttccaggagccgaatcagaaatgtcatcctcaggcacgccagacttacctgtcctactcaccgatttgaagattcaatatactaagatcttcataaacaatgaatggcatgattcagtgagtggcaagaaatttcctgtctttaatcctgcaactgaggaggagctctgccaggtagaagaaggagataaggaggatgttgacaaggcagtgaaggccgcaagacaggcttttcagattggatccccgtggcgtactatggatgcttccgagagggggcgactattatacaagttggctgatttaatcgaaagagatcgtctgctgctggcgacaatggagtcaatgaatggtggaaaactctattccaatgcatatctgaatgatttagcaggctgcatcaaaacattgcgctactgtgcaggttgggctgacaagatccagggccgtacaataccaattgatggaaatttttttacatatacaagacatgaacctattggtgtatgtggccaaatcattccttggaatttcccgttggttatgctcatttggaagatagggcctgcactgagctgtggaaacacagtggttgtcaaaccagcagagcaaactcctctcactgctctccacgtggcatctttaataaaagaggcagggtttcctcctggagtagtgaatattgttcctggttatgggcctacagcaggggcagccatttcttctcacatggatatagacaaagtagccttcacaggatcaacagaggttggcaagttgatcaaagaagctgccgggaaaagcaatctgaagagggtgaccctggagcttggaggaaagagcccttgcattgtgttagctgatgccgacttggacaatgctgttgaatttgcacaccatggggtattctaccaccagggccagtgttgtatagccgcatccaggatttttgtggaagaatcaatttatgatgagtttgttcgaaggagtgttgagcgggctaagaagtatatccttggaaatcctctgaccccaggagtcactcaaggccctcagattgacaaggaacaatatgataaaatacttgacctcattgagagtgggaagaaagaaggggccaaactggaatgtggaggaggcccgtgggggaataaaggctactttgtccagcccacagtgttctctaatgttacagatgagatgcgcattgccaaagaggagatttttggaccagtgcagcaaatcatgaagtttaaatctttagatgacgtgatcaaaagagcaaacaatactttctatggcttatcagcaggagtgtttaccaaagacattgataaagccataacaatctcctctgctctgcaggcaggaacagtgtgggtgaattgctatggcgtggtaagtgcccagtgcccctttggtggattcaagatgtctggaaatggaagagaactgggagagtacggtttccatgaatatacagaggtcaaaacagtcacagtgaaaatctctcagaagaactcataaagaaaatacaagagtggagagaagctcttcaatagctaagcatctccttacagtcactaatatagtagattttaaagacaaaatttttcttttcttgatttttttaaacataagctaaatcatattagtattaatactacccatagaaaacttgacatgtagcttcttctgaaagaattatttgccttctgaaatgtgacccccaagtcctatcctaaataaaaaaagacaaattcggatgtatgatctctctagctttgtcatagttatgtgattttcctttgtagctacttttgcaggataataattttatagaaaaggaacagttgcatttagcttctttcccttagtgactcttgaagtacttaacatacacgttaactgcagagtaaattgctctgttcccagtagttataaagtccttggactgttttgaaaagtttcctaggatgtcatgtctgcttgtcaaaagaaataatccctgtaatatttagctgtaaactgaatataaagcttaataaaaacaaccttgcatgattcttgttaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:216 -> Molecular function: GO:0001758 [retinal dehydrogenase activity] evidence: IEA
GeneID:216 -> Molecular function: GO:0004029 [aldehyde dehydrogenase (NAD) activity] evidence: EXP
GeneID:216 -> Molecular function: GO:0005099 [Ras GTPase activator activity] evidence: TAS
GeneID:216 -> Molecular function: GO:0005497 [androgen binding] evidence: TAS
GeneID:216 -> Biological process: GO:0006069 [ethanol oxidation] evidence: TAS
GeneID:216 -> Biological process: GO:0006081 [cellular aldehyde metabolic process] evidence: TAS
GeneID:216 -> Biological process: GO:0006805 [xenobiotic metabolic process] evidence: TAS
GeneID:216 -> Biological process: GO:0032320 [positive regulation of Ras GTPase activity] evidence: TAS
GeneID:216 -> Biological process: GO:0042572 [retinol metabolic process] evidence: IEA
GeneID:216 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:216 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
GeneID:216 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_000680 -> EC 1.2.1.36
by
@meso_cacase at
DBCLS
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