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2024-04-20 08:48:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000661 766 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens ribosomal protein L9 (RPL9), transcript variant 1,
mRNA.
ACCESSION NM_000661
VERSION NM_000661.4 GI:72377390
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 766)
AUTHORS Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
Kim,N.S.
TITLE Transcriptome analysis of human gastric cancer
JOURNAL Mamm. Genome 16 (12), 942-954 (2005)
PUBMED 16341674
REFERENCE 2 (bases 1 to 766)
AUTHORS Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
Lamond,A.I. and Mann,M.
TITLE Nucleolar proteome dynamics
JOURNAL Nature 433 (7021), 77-83 (2005)
PUBMED 15635413
REFERENCE 3 (bases 1 to 766)
AUTHORS Kapp,L.D. and Lorsch,J.R.
TITLE The molecular mechanics of eukaryotic translation
JOURNAL Annu. Rev. Biochem. 73, 657-704 (2004)
PUBMED 15189156
REMARK Review article
REFERENCE 4 (bases 1 to 766)
AUTHORS Mazumder,B., Sampath,P., Seshadri,V., Maitra,R.K., DiCorleto,P.E.
and Fox,P.L.
TITLE Regulated release of L13a from the 60S ribosomal subunit as a
mechanism of transcript-specific translational control
JOURNAL Cell 115 (2), 187-198 (2003)
PUBMED 14567916
REFERENCE 5 (bases 1 to 766)
AUTHORS Odintsova,T.I., Muller,E.C., Ivanov,A.V., Egorov,T.A., Bienert,R.,
Vladimirov,S.N., Kostka,S., Otto,A., Wittmann-Liebold,B. and
Karpova,G.G.
TITLE Characterization and analysis of posttranslational modifications of
the human large cytoplasmic ribosomal subunit proteins by mass
spectrometry and Edman sequencing
JOURNAL J. Protein Chem. 22 (3), 249-258 (2003)
PUBMED 12962325
REFERENCE 6 (bases 1 to 766)
AUTHORS Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
Mann,M. and Lamond,A.I.
TITLE Directed proteomic analysis of the human nucleolus
JOURNAL Curr. Biol. 12 (1), 1-11 (2002)
PUBMED 11790298
REFERENCE 7 (bases 1 to 766)
AUTHORS Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
Hudson,T.J., Tanaka,T. and Page,D.C.
TITLE A map of 75 human ribosomal protein genes
JOURNAL Genome Res. 8 (5), 509-523 (1998)
PUBMED 9582194
REFERENCE 8 (bases 1 to 766)
AUTHORS Mazuruk,K., Schoen,T.J., Chader,G.J., Iwata,T. and Rodriguez,I.R.
TITLE Structural organization and chromosomal localization of the human
ribosomal protein L9 gene
JOURNAL Biochim. Biophys. Acta 1305 (3), 151-162 (1996)
PUBMED 8597601
REFERENCE 9 (bases 1 to 766)
AUTHORS Wool,I.G., Chan,Y.L. and Gluck,A.
TITLE Structure and evolution of mammalian ribosomal proteins
JOURNAL Biochem. Cell Biol. 73 (11-12), 933-947 (1995)
PUBMED 8722009
REMARK Review article
REFERENCE 10 (bases 1 to 766)
AUTHORS Hori,N., Murakawa,K., Matoba,R., Fukushima,A., Okubo,K. and
Matsubara,K.
TITLE A new human ribosomal protein sequence, homologue of rat L9
JOURNAL Nucleic Acids Res. 21 (18), 4395 (1993)
PUBMED 8415001
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff in
collaboration with Francesco Amaldi. The reference sequence was
derived from BM841336.1, BC066318.1 and BC031906.1.
On Aug 11, 2005 this sequence version replaced gi:67944628.
Summary: Ribosomes, the organelles that catalyze protein synthesis,
consist of a small 40S subunit and a large 60S subunit. Together
these subunits are composed of 4 RNA species and approximately 80
structurally distinct proteins. This gene encodes a ribosomal
protein that is a component of the 60S subunit. The protein belongs
to the L6P family of ribosomal proteins. It is located in the
cytoplasm. As is typical for genes encoding ribosomal proteins,
there are multiple processed pseudogenes of this gene dispersed
through the genome. Two alternatively spliced transcript variants
encoding the same protein have been found for this gene. [provided
by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the shorter
transcript and the predominant variant. Variants 1 and 2 encode the
same protein.
##Evidence-Data-START##
Transcript exon combination :: CD247802.1, CD173747.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-33 BM841336.1 1-33
34-737 BC066318.1 1-704
738-766 BC031906.1 685-713
FEATURES Location/Qualifiers
source 1..766
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p13"
gene 1..766
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/note="ribosomal protein L9"
/db_xref="GeneID:6133"
/db_xref="HGNC:10369"
/db_xref="HPRD:04732"
/db_xref="MIM:603686"
exon 1..58
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/inference="alignment:Splign:1.39.8"
misc_feature 1
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/note="5'-most of multiple alternative transcription
initiation sites"
variation 6
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/replace=""
/replace="a"
/db_xref="dbSNP:17553177"
misc_feature 34
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/note="predominant transcription initiation site"
exon 59..105
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/inference="alignment:Splign:1.39.8"
CDS 60..638
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/codon_start=1
/product="60S ribosomal protein L9"
/protein_id="NP_000652.2"
/db_xref="GI:15431303"
/db_xref="CCDS:CCDS3452.1"
/db_xref="GeneID:6133"
/db_xref="HGNC:10369"
/db_xref="HPRD:04732"
/db_xref="MIM:603686"
/translation="
MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQADE
"
misc_feature 60..632
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/note="60S ribosomal protein L6; Provisional; Region:
PTZ00027"
/db_xref="CDD:240234"
misc_feature 60..62
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/experiment="experimental evidence, no additional details
recorded"
/note="Not acetylated; propagated from
UniProtKB/Swiss-Prot (P32969.1); other site"
misc_feature 93..320
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/note="Ribosomal protein L6; Region: Ribosomal_L6;
pfam00347"
/db_xref="CDD:215872"
misc_feature 354..593
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/note="Ribosomal protein L6; Region: Ribosomal_L6;
pfam00347"
/db_xref="CDD:215872"
misc_feature 420..422
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P32969.1); acetylation site"
exon 106..221
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/inference="alignment:Splign:1.39.8"
exon 222..317
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/inference="alignment:Splign:1.39.8"
exon 318..450
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/inference="alignment:Splign:1.39.8"
variation 425
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/replace="c"
/replace="t"
/db_xref="dbSNP:2125313"
exon 451..531
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/inference="alignment:Splign:1.39.8"
STS 509..680
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/standard_name="D4S3187"
/db_xref="UniSTS:28767"
STS 526..685
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/standard_name="RH67836"
/db_xref="UniSTS:84205"
exon 532..648
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/inference="alignment:Splign:1.39.8"
exon 649..750
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/inference="alignment:Splign:1.39.8"
polyA_signal 715..720
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
variation 716
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
/replace="a"
/replace="g"
/db_xref="dbSNP:1802628"
polyA_site 737
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
polyA_site 750
/gene="RPL9"
/gene_synonym="L9; NPC-A-16"
ORIGIN
acgcgatacaagtacgtaatgacgacagacgttctttctttgctgcgtctactgcgagaatgaagactattctcagcaatcagactgtcgacattccagaaaatgtcgacattactctgaagggacgcacagttatcgtgaagggccccagaggaaccctgcggagggacttcaatcacatcaatgtagaactcagccttcttggaaagaaaaaaaagaggctccgggttgacaaatggtggggtaacagaaaggaactggctaccgttcggactatttgtagtcatgtacagaacatgatcaagggtgttacactgggcttccgttacaagatgaggtctgtgtatgctcacttccccatcaacgttgttatccaggagaatgggtctcttgttgaaatccgaaatttcttgggtgaaaaatatatccgcagggttcggatgagaccaggtgttgcttgttcagtatctcaagcccagaaagatgaattaatccttgaaggaaatgacattgagcttgtttcaaattcagcggctttgattcagcaagccacaacagttaaaaacaaggatatcaggaaatttttggatggtatctatgtctctgaaaaaggaactgttcagcaggctgatgaataagatctaagagttacctggctacagaaagaagatgccagatgacacttaagacctacttgtgatatttaaatgatgcaataaaagacctattgatttggaccttcttcttaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6133 -> Molecular function: GO:0003723 [RNA binding] evidence: TAS
GeneID:6133 -> Molecular function: GO:0003735 [structural constituent of ribosome] evidence: NAS
GeneID:6133 -> Molecular function: GO:0019843 [rRNA binding] evidence: IEA
GeneID:6133 -> Biological process: GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] evidence: TAS
GeneID:6133 -> Biological process: GO:0006412 [translation] evidence: NAS
GeneID:6133 -> Biological process: GO:0006412 [translation] evidence: TAS
GeneID:6133 -> Biological process: GO:0006413 [translational initiation] evidence: TAS
GeneID:6133 -> Biological process: GO:0006414 [translational elongation] evidence: TAS
GeneID:6133 -> Biological process: GO:0006415 [translational termination] evidence: TAS
GeneID:6133 -> Biological process: GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] evidence: TAS
GeneID:6133 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:6133 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:6133 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:6133 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:6133 -> Biological process: GO:0019058 [viral infectious cycle] evidence: TAS
GeneID:6133 -> Biological process: GO:0019083 [viral transcription] evidence: TAS
GeneID:6133 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
GeneID:6133 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:6133 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:6133 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:6133 -> Cellular component: GO:0005840 [ribosome] evidence: TAS
GeneID:6133 -> Cellular component: GO:0022625 [cytosolic large ribosomal subunit] evidence: IDA
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@meso_cacase at
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