Home |
Help |
Advanced search
2024-04-20 00:45:50, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000459 4817 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens TEK tyrosine kinase, endothelial (TEK), mRNA.
ACCESSION NM_000459
VERSION NM_000459.3 GI:183396798
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4817)
AUTHORS Yamakawa,D., Kidoya,H., Sakimoto,S., Jia,W., Naito,H. and
Takakura,N.
TITLE Ligand-independent Tie2 dimers mediate kinase activity stimulated
by high dose angiopoietin-1
JOURNAL J. Biol. Chem. 288 (18), 12469-12477 (2013)
PUBMED 23504320
REMARK GeneRIF: ligand-independent dimerization of Tie2 is essential for a
strong response upon stimulation with high dose Ang1.
REFERENCE 2 (bases 1 to 4817)
AUTHORS Scotti,L., Abramovich,D., Pascuali,N., de Zuniga,I., Oubina,A.,
Kopcow,L., Lange,S., Owen,G., Tesone,M. and Parborell,F.
TITLE Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation
syndrome (OHSS)
JOURNAL Mol. Cell. Endocrinol. 365 (2), 223-230 (2013)
PUBMED 23123737
REMARK GeneRIF: The ANGPTs/Tie-2 system shows greater biological activity
in both human and a rat model of ovarian hyperstimulation syndrome.
REFERENCE 3 (bases 1 to 4817)
AUTHORS Daly,C., Eichten,A., Castanaro,C., Pasnikowski,E., Adler,A.,
Lalani,A.S., Papadopoulos,N., Kyle,A.H., Minchinton,A.I.,
Yancopoulos,G.D. and Thurston,G.
TITLE Angiopoietin-2 functions as a Tie2 agonist in tumor models, where
it limits the effects of VEGF inhibition
JOURNAL Cancer Res. 73 (1), 108-118 (2013)
PUBMED 23149917
REMARK GeneRIF: our findings indicate that Ang2 plays a protective role in
tumor endothelial cells by activating Tie2
REFERENCE 4 (bases 1 to 4817)
AUTHORS Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
TITLE Loci associated with N-glycosylation of human immunoglobulin G show
pleiotropy with autoimmune diseases and haematological cancers
JOURNAL PLoS Genet. 9 (1), E1003225 (2013)
PUBMED 23382691
REFERENCE 5 (bases 1 to 4817)
AUTHORS Cai,J., Ruan,Q., Chen,Z.J. and Han,S.
TITLE Connection of pericyte-angiopoietin-Tie-2 system in diabetic
retinopathy: friend or foe?
JOURNAL Future Med Chem 4 (17), 2163-2176 (2012)
PUBMED 23190105
REMARK GeneRIF: This article summarizes recent advances in pericyte study
in conjunction with ANG1/ANG2-Tie-2 signaling and also discuss
possible therapeutic strategies for diabetic retinopathy by
targeting pericytes through manipulating ANG1/ANG2-Tie-2 signaling.
REFERENCE 6 (bases 1 to 4817)
AUTHORS Huang,L., Turck,C.W., Rao,P. and Peters,K.G.
TITLE GRB2 and SH-PTP2: potentially important endothelial signaling
molecules downstream of the TEK/TIE2 receptor tyrosine kinase
JOURNAL Oncogene 11 (10), 2097-2103 (1995)
PUBMED 7478529
REFERENCE 7 (bases 1 to 4817)
AUTHORS Deans,J.P., Kalt,L., Ledbetter,J.A., Schieven,G.L., Bolen,J.B. and
Johnson,P.
TITLE Association of 75/80-kDa phosphoproteins and the tyrosine kinases
Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against
involvement of the cytoplasmic regions of CD20
JOURNAL J. Biol. Chem. 270 (38), 22632-22638 (1995)
PUBMED 7545683
REFERENCE 8 (bases 1 to 4817)
AUTHORS Gallione,C.J., Pasyk,K.A., Boon,L.M., Lennon,F., Johnson,D.W.,
Helmbold,E.A., Markel,D.S., Vikkula,M., Mulliken,J.B., Warman,M.L.
et al.
TITLE A gene for familial venous malformations maps to chromosome 9p in a
second large kindred
JOURNAL J. Med. Genet. 32 (3), 197-199 (1995)
PUBMED 7783168
REFERENCE 9 (bases 1 to 4817)
AUTHORS Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
and Morton,C.C.
TITLE Isolation of novel and known genes from a human fetal cochlear cDNA
library using subtractive hybridization and differential screening
JOURNAL Genomics 23 (1), 42-50 (1994)
PUBMED 7829101
REFERENCE 10 (bases 1 to 4817)
AUTHORS Partanen,J., Armstrong,E., Makela,T.P., Korhonen,J., Sandberg,M.,
Renkonen,R., Knuutila,S., Huebner,K. and Alitalo,K.
TITLE A novel endothelial cell surface receptor tyrosine kinase with
extracellular epidermal growth factor homology domains
JOURNAL Mol. Cell. Biol. 12 (4), 1698-1707 (1992)
PUBMED 1312667
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC322431.1, DC324016.1,
BC035514.1 and AB208796.1.
This sequence is a reference standard in the RefSeqGene project.
On Apr 17, 2008 this sequence version replaced gi:88758595.
Summary: The TEK receptor tyrosine kinase is expressed almost
exclusively in endothelial cells in mice, rats, and humans. This
receptor possesses a unique extracellular domain containing 2
immunoglobulin-like loops separated by 3 epidermal growth
factor-like repeats that are connected to 3 fibronectin type
III-like repeats. The ligand for the receptor is angiopoietin-1.
Defects in TEK are associated with inherited venous malformations;
the TEK signaling pathway appears to be critical for endothelial
cell-smooth muscle cell communication in venous morphogenesis. TEK
is closely related to the TIE receptor tyrosine kinase. [provided
by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC035514.1, AB208796.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-139 DC322431.1 10-148
140-648 DC324016.1 75-583
649-2403 BC035514.1 332-2086
2404-4758 AB208796.1 2090-4444
4759-4817 BC035514.1 4442-4500
FEATURES Location/Qualifiers
source 1..4817
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p21"
gene 1..4817
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="TEK tyrosine kinase, endothelial"
/db_xref="GeneID:7010"
/db_xref="HGNC:11724"
/db_xref="MIM:600221"
exon 1..494
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 18
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149944814"
variation 27
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375999077"
variation 117
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147620532"
variation 166..167
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace=""
/replace="t"
/db_xref="dbSNP:371499623"
variation 167..168
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace=""
/replace="g"
/db_xref="dbSNP:72535318"
variation 168..169
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace=""
/replace="c"
/replace="g"
/db_xref="dbSNP:3837240"
variation 169
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:199995407"
variation 290
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188791221"
variation 303
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142131414"
variation 315
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145925243"
misc_feature 341..343
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="upstream in-frame stop codon"
variation 433
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370191539"
CDS 443..3817
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/EC_number="2.7.10.1"
/note="angiopoietin-1 receptor; soluble TIE2 variant 1;
soluble TIE2 variant 2; hTIE2; p140 TEK; tyrosine-protein
kinase receptor TEK; tunica interna endothelial cell
kinase; tyrosine-protein kinase receptor TIE-2;
endothelial tyrosine kinase; tyrosine kinase with Ig and
EGF homology domains-2"
/codon_start=1
/product="angiopoietin-1 receptor precursor"
/protein_id="NP_000450.2"
/db_xref="GI:88758596"
/db_xref="CCDS:CCDS6519.1"
/db_xref="GeneID:7010"
/db_xref="HGNC:11724"
/db_xref="MIM:600221"
/translation="
MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
"
sig_peptide 443..496
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
mat_peptide 497..3814
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/product="angiopoietin-1 receptor"
misc_feature 509..796
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Tie-2 Ig-like domain 1; Region: Ig_Tie2_1;
pfam10430"
/db_xref="CDD:118951"
misc_feature 1097..1225
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Laminin-type epidermal growth factor-like domai;
Region: EGF_Lam; smart00180"
/db_xref="CDD:197558"
misc_feature <1121..1198
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cd00054"
/db_xref="CDD:28936"
misc_feature 1373..1462
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cl09941"
/db_xref="CDD:209104"
misc_feature 1550..1765
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Immunoglobulin like; Region: IG_like; smart00410"
/db_xref="CDD:197708"
misc_feature 1775..1996
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Fibronectin type III domain; Region: fn3;
pfam00041"
/db_xref="CDD:200951"
misc_feature 2105..2341
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(2261..2263,2303..2305)
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(2306..2311,2315..2320)
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 2357..2635
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(2357..2359,2552..2554,2597..2599)
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(2600..2605,2609..2614)
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 2687..2749
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q02763.2);
transmembrane region"
misc_feature 2888..3796
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Catalytic domain of the Protein Tyrosine Kinase,
Tie2; Region: PTKc_Tie2; cd05088"
/db_xref="CDD:133219"
misc_feature 2912..3718
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="Protein kinase; unclassified specificity; Region:
STYKc; smart00221"
/db_xref="CDD:197583"
misc_feature order(2930..2944,2954..2956,2999..3001,3005..3007,
3056..3058,3068..3070,3077..3079,3098..3100,3146..3157,
3164..3169,3320..3322,3326..3328,3332..3334,3344..3349,
3353..3355,3380..3391,3431..3445,3470..3472,3572..3574)
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="active site"
/db_xref="CDD:133219"
misc_feature order(2930..2935,2939..2944,2954..2956,2999..3001,
3005..3007,3056..3058,3068..3070,3098..3100,3146..3157,
3164..3169,3344..3349,3353..3355,3386..3388)
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:133219"
misc_feature 3020..3022
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q02763.2); phosphorylation site"
misc_feature 3131..3133
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02571"
misc_feature order(3332..3334,3344..3346,3431..3445,3470..3472,
3572..3574)
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:133219"
misc_feature 3383..3451
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:133219"
misc_feature 3416..3418
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q02763.2); phosphorylation site"
misc_feature 3416..3418
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3584..3586
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3746..3748
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q02763.2); phosphorylation site"
misc_feature 3746..3748
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02571"
misc_feature 3764..3766
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:01470"
misc_feature 3764..3766
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q02763.2); phosphorylation site"
misc_feature 3764..3766
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3797..3799
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 454
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="c"
/db_xref="dbSNP:146485295"
variation 480
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:201171013"
variation 492
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:149096702"
exon 495..806
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 500
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202051322"
variation 501
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143178677"
variation 526
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138550182"
variation 579
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200755526"
variation 580
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:76223779"
variation 593
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140406342"
variation 630
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369048700"
variation 635
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373772509"
variation 654
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144348052"
variation 675
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146302981"
variation 676
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:55892210"
variation 762
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370256501"
variation 788
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201999962"
exon 807..917
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
STS 810..1251
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/standard_name="Tek"
/db_xref="UniSTS:144602"
variation 831
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201071647"
variation 856
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143058954"
variation 885
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35969327"
exon 918..1070
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 952
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138265705"
variation 1012
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149623302"
variation 1060
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369561720"
variation 1063
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:369286334"
exon 1071..1202
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 1107
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:144378392"
variation 1119
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35814893"
variation 1120
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149063993"
variation 1125
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374382893"
STS 1167..1244
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/standard_name="TEK"
/db_xref="UniSTS:513742"
variation 1192
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:76324455"
variation 1196
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367963556"
exon 1203..1343
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 1218
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138708761"
variation 1251
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372307879"
variation 1324
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:146169480"
exon 1344..1472
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 1357
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:371104063"
variation 1372
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139143068"
variation 1423
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:180827182"
variation 1441
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:111637971"
variation 1467
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373027386"
exon 1473..1624
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 1479
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:682632"
variation 1482
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:200235356"
variation 1518
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372811397"
variation 1546
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376994054"
variation 1577
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368494167"
variation 1588
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="c"
/db_xref="dbSNP:146464819"
variation 1606
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371664404"
variation 1614
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34032300"
exon 1625..1769
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 1682
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="c"
/db_xref="dbSNP:369394656"
variation 1691
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:149712446"
variation 1700
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149842646"
variation 1735
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145574565"
variation 1736
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:75365911"
variation 1745
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="c"
/db_xref="dbSNP:372461928"
variation 1748
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:148891712"
variation 1755
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189543659"
variation 1765
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:199580378"
exon 1770..1931
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 1788
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149684174"
variation 1796
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:45607336"
variation 1799
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373235916"
variation 1829
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200857533"
variation 1878
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141586254"
variation 1883
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147057883"
variation 1885
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148120858"
variation 1888
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370562453"
variation 1898
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1334811"
exon 1932..2066
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 1949
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200574110"
variation 1989
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:150236410"
variation 2007
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:138894008"
variation 2008
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372395194"
variation 2024
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:367917552"
variation 2026
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371652913"
variation 2038
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199871826"
variation 2063
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201629688"
exon 2067..2351
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 2074
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368357438"
variation 2105
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace=""
/replace="a"
/db_xref="dbSNP:67954416"
variation 2122
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35357088"
variation 2148
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:190513747"
variation 2176
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146405482"
variation 2202
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373551083"
variation 2240
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:35030851"
variation 2259
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:376770384"
variation 2284
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142382870"
variation 2311
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:55979986"
variation 2342
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35378598"
variation 2344
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:148629677"
exon 2352..2651
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 2404
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:639225"
variation 2468
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:56367117"
variation 2488
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="c"
/db_xref="dbSNP:112475919"
variation 2494
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35818764"
variation 2520
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141769154"
variation 2536
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:45563539"
variation 2612
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4631561"
variation 2621
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373793318"
exon 2652..2806
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 2665
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147649992"
variation 2666
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141520692"
variation 2667
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:181093425"
variation 2670
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:202131936"
variation 2696
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:45510599"
variation 2746
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370492416"
variation 2747
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145334606"
variation 2764
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:542913"
variation 2777
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149152469"
variation 2804
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:374265341"
exon 2807..3017
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 2807
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:201024056"
variation 2832
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143314314"
variation 2896
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:55789591"
variation 2965
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149452320"
variation 2966
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147231791"
variation 2967
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200750146"
variation 2987
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:80338908"
variation 2988
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376225163"
variation 3015
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373458643"
exon 3018..3128
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 3083
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201842573"
variation 3091
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375837222"
exon 3129..3319
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 3132
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:80338909"
variation 3154
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148059950"
variation 3157
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372316383"
variation 3186
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:387906745"
variation 3208
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145880361"
variation 3215
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138463877"
variation 3240
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199701926"
variation 3241
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372897403"
variation 3253
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183991501"
variation 3269
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143080429"
variation 3274
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150499673"
variation 3280
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:45505400"
variation 3283
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:56154987"
variation 3291
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376285577"
variation 3310
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113493000"
exon 3320..3433
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 3409
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149269841"
variation 3418
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3737188"
variation 3431
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200011475"
variation 3433
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370591821"
exon 3434..3504
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 3463
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368457184"
exon 3505..3545
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 3532
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:56133834"
exon 3546..3642
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 3556
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:145261015"
variation 3562
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147198662"
variation 3565
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2273719"
variation 3593
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2273718"
variation 3595
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:377362798"
variation 3601
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201502264"
variation 3622
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369172187"
variation 3628
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:55702716"
exon 3643..3742
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 3661
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149296103"
variation 3715
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:144527376"
variation 3733
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:377406447"
exon 3743..4759
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/inference="alignment:Splign:1.39.8"
variation 3748
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:151035628"
variation 3751
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199954698"
variation 3757
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148842789"
variation 3790..3791
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace=""
/replace="t"
/db_xref="dbSNP:34067938"
variation 3810
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369356295"
variation 3822
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112801403"
variation 3825
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147570838"
variation 3832
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141937008"
variation 3857
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372823330"
variation 3869
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:117748450"
variation 3875
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="c"
/db_xref="dbSNP:1051728"
variation 3985
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372214778"
variation 4023
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="c"
/db_xref="dbSNP:45521836"
variation 4060
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190522156"
variation 4131
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:7037246"
variation 4134
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:183136289"
variation 4198
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:10967789"
variation 4251
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:1051729"
variation 4262
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:188713985"
variation 4284
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:41272849"
variation 4301
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="g"
/db_xref="dbSNP:192476871"
STS 4333..4657
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/standard_name="SHGC-12831"
/db_xref="UniSTS:78903"
variation 4333..4334
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace=""
/replace="tc"
/db_xref="dbSNP:139215084"
variation 4361
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1049"
variation 4372
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:182565061"
variation 4373
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:857"
variation 4396
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138916876"
STS 4416..4609
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/standard_name="G10657"
/db_xref="UniSTS:38250"
STS 4419..4596
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/standard_name="RH68989"
/db_xref="UniSTS:23344"
variation 4534
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:41272851"
variation 4605..4606
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace=""
/replace="at"
/db_xref="dbSNP:140755654"
variation 4635
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141265339"
variation 4705
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150338418"
polyA_signal 4732..4737
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
variation 4739
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:9987817"
polyA_site 4759
/gene="TEK"
/gene_synonym="CD202B; TIE-2; TIE2; VMCM; VMCM1"
ORIGIN
agtttcccgcctatgagaggatacccctattgtttctgaaaatgctgaccgggacccacacttccaacaaaaattcctctgcccctacagcagcagcaaaagcagcagcagaagcaacagcaacagataagtgttttgatgaattgcgagatggatagggcttgagtgcccccagccctgctgataccaaatgcctttaagatacagcctttcccatcctaatctacaaaggaaacaggaaaaaggaacttaaaactccctgtgctcagacagaaatgagactgttacagcctgcttctgtgctgttccttcttgcctctaacttgtaaacaagacgtagtaggacgatgctaatggaaagtcacaaaccgctgggtttttgaaaggatccttgggacctcatgcacatttgtggaaactggatggagagatttggggaagcatggactctttagccagcttagttctctgtggagtcagcttgctcctttctggaactgtggaaggtgccatggacttgatcttgatcaattccctacctcttgtatctgatgctgaaacatctctcacctgcattgcctctgggtggcgcccccatgagcccatcaccataggaagggactttgaagccttaatgaaccagcaccaggatccgctggaagttactcaagatgtgaccagagaatgggctaaaaaagttgtttggaagagagaaaaggctagtaagatcaatggtgcttatttctgtgaagggcgagttcgaggagaggcaatcaggatacgaaccatgaagatgcgtcaacaagcttccttcctaccagctactttaactatgactgtggacaagggagataacgtgaacatatctttcaaaaaggtattgattaaagaagaagatgcagtgatttacaaaaatggttccttcatccattcagtgccccggcatgaagtacctgatattctagaagtacacctgcctcatgctcagccccaggatgctggagtgtactcggccaggtatataggaggaaacctcttcacctcggccttcaccaggctgatagtccggagatgtgaagcccagaagtggggacctgaatgcaaccatctctgtactgcttgtatgaacaatggtgtctgccatgaagatactggagaatgcatttgccctcctgggtttatgggaaggacgtgtgagaaggcttgtgaactgcacacgtttggcagaacttgtaaagaaaggtgcagtggacaagagggatgcaagtcttatgtgttctgtctccctgacccctatgggtgttcctgtgccacaggctggaagggtctgcagtgcaatgaagcatgccaccctggtttttacgggccagattgtaagcttaggtgcagctgcaacaatggggagatgtgtgatcgcttccaaggatgtctctgctctccaggatggcaggggctccagtgtgagagagaaggcataccgaggatgaccccaaagatagtggatttgccagatcatatagaagtaaacagtggtaaatttaatcccatttgcaaagcttctggctggccgctacctactaatgaagaaatgaccctggtgaagccggatgggacagtgctccatccaaaagactttaaccatacggatcatttctcagtagccatattcaccatccaccggatcctcccccctgactcaggagtttgggtctgcagtgtgaacacagtggctgggatggtggaaaagcccttcaacatttctgttaaagttcttccaaagcccctgaatgccccaaacgtgattgacactggacataactttgctgtcatcaacatcagctctgagccttactttggggatggaccaatcaaatccaagaagcttctatacaaacccgttaatcactatgaggcttggcaacatattcaagtgacaaatgagattgttacactcaactatttggaacctcggacagaatatgaactctgtgtgcaactggtccgtcgtggagagggtggggaagggcatcctggacctgtgagacgcttcacaacagcttctatcggactccctcctccaagaggtctaaatctcctgcctaaaagtcagaccactctaaatttgacctggcaaccaatatttccaagctcggaagatgacttttatgttgaagtggagagaaggtctgtgcaaaaaagtgatcagcagaatattaaagttccaggcaacttgacttcggtgctacttaacaacttacatcccagggagcagtacgtggtccgagctagagtcaacaccaaggcccagggggaatggagtgaagatctcactgcttggacccttagtgacattcttcctcctcaaccagaaaacatcaagatttccaacattacacactcctcagctgtgatttcttggacaatattggatggctattctatttcttctattactatccgttacaaggttcaaggcaagaatgaagaccagcacgttgatgtgaagataaagaatgccaccatcactcagtatcagctcaagggcctagagcctgaaacagcataccaggtggacatttttgcagagaacaacatagggtcaagcaacccagccttttctcatgaactggtgaccctcccagaatctcaagcaccagcggacctcggaggggggaagatgctgcttatagccatccttggctctgctggaatgacctgcctgactgtgctgttggcctttctgatcatattgcaattgaagagggcaaatgtgcaaaggagaatggcccaagccttccaaaacgtgagggaagaaccagctgtgcagttcaactcagggactctggccctaaacaggaaggtcaaaaacaacccagatcctacaatttatccagtgcttgactggaatgacatcaaatttcaagatgtgattggggagggcaattttggccaagttcttaaggcgcgcatcaagaaggatgggttacggatggatgctgccatcaaaagaatgaaagaatatgcctccaaagatgatcacagggactttgcaggagaactggaagttctttgtaaacttggacaccatccaaacatcatcaatctcttaggagcatgtgaacatcgaggctacttgtacctggccattgagtacgcgccccatggaaaccttctggacttccttcgcaagagccgtgtgctggagacggacccagcatttgccattgccaatagcaccgcgtccacactgtcctcccagcagctccttcacttcgctgccgacgtggcccggggcatggactacttgagccaaaaacagtttatccacagggatctggctgccagaaacattttagttggtgaaaactatgtggcaaaaatagcagattttggattgtcccgaggtcaagaggtgtatgtgaaaaagacaatgggaaggctcccagtgcgctggatggccatcgagtcactgaattacagtgtgtacacaaccaacagtgatgtatggtcctatggtgtgttactatgggagattgttagcttaggaggcacaccctactgcgggatgacttgtgcagaactctacgagaagctgccccagggctacagactggagaagcccctgaactgtgatgatgaggtgtatgatctaatgagacaatgctggcgggagaagccttatgagaggccatcatttgcccagatattggtgtccttaaacagaatgttagaggagcgaaagacctacgtgaataccacgctttatgagaagtttacttatgcaggaattgactgttctgctgaagaagcggcctaggacagaacatctgtataccctctgtttccctttcactggcatgggagacccttgacacctgctgagaaaacatgcctctgccaaaggatgtgatatataagtgtacatatgtgctgtacacctgggaccttcaccactgtagatcccatgcatggatctatgtagtatgctctgactctaataggactgtatatactgttttaagaatgggctgaaatcagaatgcctgtttgtggtttcatatgcaataatatatttttttaaaaatgtggacttcataggaaggcgtgagtacaattagtataatgcataactcattgttgtcctagatattttgatatttacctttatgttgaatgctattaaatgttttcctgtgtcaaagtaaaatattgttaataaacctaacaatgaccctgatagtacaggttaagtgagagaactatatgaattctaacaagtcataggttaatatttaagacactgaaaaatctaagtgatataaatcagattcttctctctcaattttatccctcacctgtagcagccagtcccgtttcatttagtcatgtgaccactctgtcttgtgtttccacagcctgcaagtcagtccaggatgctaacatctaaaaatagacttaaatctcattgcttacaagcctaagaatctttagagaagtatacataagtttaggataaaataatgggattttcttttcttttctctggtaatattgacttgtatattttaagaaataacagaaagcctgggtgacatttgggagacatgtgacatttatatattgaattaatatccctacatgtattgcacattgtaaaaagttttagttttgatgagttgtgagtttaccttgtatactgtaggcacactttgcactgatatatcatgagtgaataaatgtcttgcctactcacgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7010 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
GeneID:7010 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: IDA
GeneID:7010 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: TAS
GeneID:7010 -> Molecular function: GO:0004714 [transmembrane receptor protein tyrosine kinase activity] evidence: IEA
GeneID:7010 -> Molecular function: GO:0004872 [receptor activity] evidence: TAS
GeneID:7010 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7010 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:7010 -> Biological process: GO:0001525 [angiogenesis] evidence: ISS
GeneID:7010 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IDA
GeneID:7010 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IMP
GeneID:7010 -> Biological process: GO:0001935 [endothelial cell proliferation] evidence: ISS
GeneID:7010 -> Biological process: GO:0001938 [positive regulation of endothelial cell proliferation] evidence: TAS
GeneID:7010 -> Biological process: GO:0002040 [sprouting angiogenesis] evidence: IMP
GeneID:7010 -> Biological process: GO:0007160 [cell-matrix adhesion] evidence: IEA
GeneID:7010 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:7010 -> Biological process: GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] evidence: IDA
GeneID:7010 -> Biological process: GO:0007267 [cell-cell signaling] evidence: TAS
GeneID:7010 -> Biological process: GO:0007507 [heart development] evidence: ISS
GeneID:7010 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:7010 -> Biological process: GO:0010595 [positive regulation of endothelial cell migration] evidence: IDA
GeneID:7010 -> Biological process: GO:0010595 [positive regulation of endothelial cell migration] evidence: IMP
GeneID:7010 -> Biological process: GO:0010740 [positive regulation of intracellular protein kinase cascade] evidence: IMP
GeneID:7010 -> Biological process: GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] evidence: IMP
GeneID:7010 -> Biological process: GO:0016337 [cell-cell adhesion] evidence: IEA
GeneID:7010 -> Biological process: GO:0016525 [negative regulation of angiogenesis] evidence: IMP
GeneID:7010 -> Biological process: GO:0018108 [peptidyl-tyrosine phosphorylation] evidence: IDA
GeneID:7010 -> Biological process: GO:0032878 [regulation of establishment or maintenance of cell polarity] evidence: IMP
GeneID:7010 -> Biological process: GO:0033138 [positive regulation of peptidyl-serine phosphorylation] evidence: IEA
GeneID:7010 -> Biological process: GO:0034446 [substrate adhesion-dependent cell spreading] evidence: IMP
GeneID:7010 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:7010 -> Biological process: GO:0043114 [regulation of vascular permeability] evidence: TAS
GeneID:7010 -> Biological process: GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] evidence: IMP
GeneID:7010 -> Biological process: GO:0045766 [positive regulation of angiogenesis] evidence: IDA
GeneID:7010 -> Biological process: GO:0045766 [positive regulation of angiogenesis] evidence: IMP
GeneID:7010 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:7010 -> Biological process: GO:0048014 [Tie signaling pathway] evidence: IDA
GeneID:7010 -> Biological process: GO:0050728 [negative regulation of inflammatory response] evidence: TAS
GeneID:7010 -> Biological process: GO:0050900 [leukocyte migration] evidence: TAS
GeneID:7010 -> Biological process: GO:0051259 [protein oligomerization] evidence: IDA
GeneID:7010 -> Biological process: GO:0051894 [positive regulation of focal adhesion assembly] evidence: IMP
GeneID:7010 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IDA
GeneID:7010 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IMP
GeneID:7010 -> Biological process: GO:0060216 [definitive hemopoiesis] evidence: TAS
GeneID:7010 -> Biological process: GO:0060347 [heart trabecula formation] evidence: ISS
GeneID:7010 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: IDA
GeneID:7010 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: IMP
GeneID:7010 -> Biological process: GO:2000251 [positive regulation of actin cytoskeleton reorganization] evidence: IMP
GeneID:7010 -> Biological process: GO:2000351 [regulation of endothelial cell apoptotic process] evidence: TAS
GeneID:7010 -> Biological process: GO:2000352 [negative regulation of endothelial cell apoptotic process] evidence: ISS
GeneID:7010 -> Cellular component: GO:0001725 [stress fiber] evidence: IDA
GeneID:7010 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
GeneID:7010 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:7010 -> Cellular component: GO:0005884 [actin filament] evidence: IDA
GeneID:7010 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:7010 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IDA
GeneID:7010 -> Cellular component: GO:0005902 [microvillus] evidence: IDA
GeneID:7010 -> Cellular component: GO:0005911 [cell-cell junction] evidence: IDA
GeneID:7010 -> Cellular component: GO:0005925 [focal adhesion] evidence: IEA
GeneID:7010 -> Cellular component: GO:0009925 [basal plasma membrane] evidence: IDA
GeneID:7010 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
GeneID:7010 -> Cellular component: GO:0016323 [basolateral plasma membrane] evidence: IDA
GeneID:7010 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IDA
GeneID:7010 -> Cellular component: GO:0045121 [membrane raft] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_000450 -> EC 2.7.10.1
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.