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2025-05-09 18:43:55, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004755 3883 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 5
(RPS6KA5), transcript variant 1, mRNA.
ACCESSION NM_004755
VERSION NM_004755.2 GI:32528294
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3883)
AUTHORS Terazawa,S., Nakajima,H., Shingo,M., Niwano,T. and Imokawa,G.
TITLE Astaxanthin attenuates the UVB-induced secretion of prostaglandin
E2 and interleukin-8 in human keratinocytes by interrupting MSK1
phosphorylation in a ROS depletion-independent manner
JOURNAL Exp. Dermatol. 21 (SUPPL 1), 11-17 (2012)
PUBMED 22626465
REMARK GeneRIF: Astaxanthin attenuates the UVB-induced secretion of
prostaglandin E2 and interleukin-8 in human keratinocytes by
interrupting MSK1 phosphorylation in a ROS depletion-independent
manner
REFERENCE 2 (bases 1 to 3883)
AUTHORS Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
TITLE Genome-wide meta-analysis identifies 56 bone mineral density loci
and reveals 14 loci associated with risk of fracture
JOURNAL Nat. Genet. 44 (5), 491-501 (2012)
PUBMED 22504420
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 3883)
AUTHORS Sundar,I.K., Chung,S., Hwang,J.W., Lapek,J.D. Jr., Bulger,M.,
Friedman,A.E., Yao,H., Davie,J.R. and Rahman,I.
TITLE Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette
smoke-induced histone modifications on NF-kappaB-dependent genes
JOURNAL PLoS ONE 7 (2), E31378 (2012)
PUBMED 22312446
REMARK GeneRIF: MSK1 is an important downstream kinase involved in
CS-induced NF-kappaB activation
REFERENCE 4 (bases 1 to 3883)
AUTHORS Lau,P.N. and Cheung,P.
TITLE Histone code pathway involving H3 S28 phosphorylation and K27
acetylation activates transcription and antagonizes polycomb
silencing
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (7), 2801-2806 (2011)
PUBMED 21282660
REMARK GeneRIF: MSK1 is a direct and potent transcriptional activator when
targeted to c-fos promotor, and when targeted to alpha-globin
promoter induces H3 S28 phosphorylation reactivating expression of
this polycomb-silenced gene.
REFERENCE 5 (bases 1 to 3883)
AUTHORS Gehani,S.S., Agrawal-Singh,S., Dietrich,N., Christophersen,N.S.,
Helin,K. and Hansen,K.
TITLE Polycomb group protein displacement and gene activation through
MSK-dependent H3K27me3S28 phosphorylation
JOURNAL Mol. Cell 39 (6), 886-900 (2010)
PUBMED 20864036
REMARK GeneRIF: MSK1- and MSK2-mediated H3K27me3S28 phosphorylation serves
as a mechanism to activate a subset of PcG target genes determined
by the biological stimuli and thereby modulate the gene expression
program determining cell fate.
REFERENCE 6 (bases 1 to 3883)
AUTHORS Thomson,S., Clayton,A.L., Hazzalin,C.A., Rose,S., Barratt,M.J. and
Mahadevan,L.C.
TITLE The nucleosomal response associated with immediate-early gene
induction is mediated via alternative MAP kinase cascades: MSK1 as
a potential histone H3/HMG-14 kinase
JOURNAL EMBO J. 18 (17), 4779-4793 (1999)
PUBMED 10469656
REFERENCE 7 (bases 1 to 3883)
AUTHORS New,L., Zhao,M., Li,Y., Bassett,W.W., Feng,Y., Ludwig,S.,
Padova,F.D., Gram,H. and Han,J.
TITLE Cloning and characterization of RLPK, a novel RSK-related protein
kinase
JOURNAL J. Biol. Chem. 274 (2), 1026-1032 (1999)
PUBMED 9873047
REFERENCE 8 (bases 1 to 3883)
AUTHORS Jain,N., Zhang,T., Fong,S.L., Lim,C.P. and Cao,X.
TITLE Repression of Stat3 activity by activation of mitogen-activated
protein kinase (MAPK)
JOURNAL Oncogene 17 (24), 3157-3167 (1998)
PUBMED 9872331
REFERENCE 9 (bases 1 to 3883)
AUTHORS Deak,M., Clifton,A.D., Lucocq,L.M. and Alessi,D.R.
TITLE Mitogen- and stress-activated protein kinase-1 (MSK1) is directly
activated by MAPK and SAPK2/p38, and may mediate activation of CREB
JOURNAL EMBO J. 17 (15), 4426-4441 (1998)
PUBMED 9687510
REFERENCE 10 (bases 1 to 3883)
AUTHORS Chung,J., Uchida,E., Grammer,T.C. and Blenis,J.
TITLE STAT3 serine phosphorylation by ERK-dependent and -independent
pathways negatively modulates its tyrosine phosphorylation
JOURNAL Mol. Cell. Biol. 17 (11), 6508-6516 (1997)
PUBMED 9343414
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BG699153.1, AF074393.1, AL050099.1, AF090421.1 and BF593074.1.
On Jul 11, 2003 this sequence version replaced gi:4759051.
Transcript Variant: This variant (1) encodes the longer isoform
(a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF090421.1, AF074393.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-205 BG699153.1 34-238
206-2752 AF074393.1 156-2702
2753-3209 AL050099.1 547-1003
3210-3488 AF090421.1 3157-3435
3489-3883 BF593074.1 1-395 c
FEATURES Location/Qualifiers
source 1..3883
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q31-q32.1"
gene 1..3883
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="ribosomal protein S6 kinase, 90kDa, polypeptide 5"
/db_xref="GeneID:9252"
/db_xref="HGNC:10434"
/db_xref="HPRD:06789"
/db_xref="MIM:603607"
exon 1..318
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
misc_feature 183..185
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="upstream in-frame stop codon"
CDS 216..2624
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/EC_number="2.7.11.1"
/note="isoform a is encoded by transcript variant 1;
RSK-like protein kinase; nuclear mitogen- and
stress-activated protein kinase 1; ribosomal protein S6
kinase alpha-5; RSKL; S6K-alpha-5; 90 kDa ribosomal
protein S6 kinase 5"
/codon_start=1
/product="ribosomal protein S6 kinase alpha-5 isoform a"
/protein_id="NP_004746.2"
/db_xref="GI:32528295"
/db_xref="CCDS:CCDS9893.1"
/db_xref="GeneID:9252"
/db_xref="HGNC:10434"
/db_xref="HPRD:06789"
/db_xref="MIM:603607"
/translation="
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNPETLFQFSDSVA
"
misc_feature 357..1226
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="N-terminal catalytic domain of the Protein
Serine/Threonine Kinase, Mitogen and stress-activated
kinase 1; Region: STKc_MSK1_N; cd05613"
/db_xref="CDD:173704"
misc_feature 360..1169
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(378..392,402..404,450..452,456..458,558..560,
606..611,615..617,627..629,633..635,744..746,750..752,
756..761,765..767,795..800,807..809,852..869,954..956,
972..974,981..983)
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="active site"
/db_xref="CDD:173704"
misc_feature order(378..392,402..404,450..452,456..458,558..560,
609..617,627..629,744..746,750..752,756..761,765..767,
795..800)
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173704"
misc_feature order(390..392,627..629,633..635,744..746,750..752,
756..758,807..809,852..869,954..956,972..974,981..983)
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173704"
misc_feature order(795..827,834..869)
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173704"
misc_feature 849..851
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (O75582.1); phosphorylation site"
misc_feature 1173..1352
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="Extension to Ser/Thr-type protein kinases; Region:
S_TK_X; smart00133"
/db_xref="CDD:197531"
misc_feature 1293..1295
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAPK1, MAPK3 and MAPK14;
propagated from UniProtKB/Swiss-Prot (O75582.1);
phosphorylation site"
misc_feature 1341..1343
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (O75582.1); phosphorylation site"
misc_feature 1341..1343
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01496"
misc_feature 1341..1343
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02619"
misc_feature 1341..1343
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03479"
misc_feature 1356..1358
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (O75582.1); phosphorylation site"
misc_feature 1503..2276
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 1509..2246
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="Catalytic domain of AGC family Protein
Serine/Threonine Kinases; Region: STKc_AGC; cd05123"
/db_xref="CDD:173660"
misc_feature order(1509..1523,1533..1535,1572..1574,1578..1580,
1659..1661,1707..1712,1716..1718,1728..1730,1734..1736,
1845..1847,1851..1853,1857..1862,1866..1868,1905..1910,
1917..1919,1959..1976,2055..2057,2073..2075,2082..2084)
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="active site"
/db_xref="CDD:173660"
misc_feature order(1509..1523,1533..1535,1572..1574,1578..1580,
1659..1661,1710..1718,1728..1730,1845..1847,1851..1853,
1857..1862,1866..1868,1905..1910)
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173660"
misc_feature order(1521..1523,1728..1730,1734..1736,1845..1847,
1851..1853,1857..1859,1917..1919,1959..1976,2055..2057,
2073..2075,2082..2084)
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173660"
misc_feature order(1905..1928,1956..1976)
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173660"
misc_feature 1956..1958
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by MAPK1, MAPK3 and MAPK14;
propagated from UniProtKB/Swiss-Prot (O75582.1);
phosphorylation site"
misc_feature 1956..1958
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01496"
misc_feature 1956..1958
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:02619"
misc_feature 1956..1958
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03479"
misc_feature 2154..2156
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O75582.1); phosphorylation site"
misc_feature 2184..2186
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O75582.1); phosphorylation site"
misc_feature 2298..2300
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O75582.1); phosphorylation site"
misc_feature 2313..2315
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by MAPK1, MAPK3 and MAPK14;
propagated from UniProtKB/Swiss-Prot (O75582.1);
phosphorylation site"
misc_feature 2463..2465
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (O75582.1); phosphorylation site"
misc_feature 2469..2471
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (O75582.1); phosphorylation site"
misc_feature 2487..2489
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (O75582.1); phosphorylation site"
exon 319..390
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 391..609
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 610..725
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 726..833
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 834..917
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 918..1021
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 1022..1172
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 1173..1334
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 1335..1460
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 1461..1594
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 1595..1688
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 1689..1859
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 1860..2051
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 2052..2211
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
exon 2212..2375
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
STS 2234..2355
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/standard_name="RH93294"
/db_xref="UniSTS:85397"
exon 2376..3883
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/inference="alignment:Splign:1.39.8"
STS 3415..3564
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/standard_name="RH101942"
/db_xref="UniSTS:96277"
variation 3489
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:1053460"
variation 3715
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1053461"
variation 3826
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1053462"
variation 3836
/gene="RPS6KA5"
/gene_synonym="MSK1; MSPK1; RLPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:1053463"
ORIGIN
ttggttgcgcggtactagcggtgcccgccgaagggggaggaggcgaggagcgagccgtgcggccagagcgggaaagagactcgtctttgcgtccgagttctggagccgccgcaccccgactcctggggccgcggcagcggctgcgaggggacgggcgtccgctgtctcctgggttcccctcgtagcgacccgcgggatcggaaaaaaaggagaagatggaggaggagggtggcagcagcggcggcgccgcggggaccagcgcggacggcggcgacggaggagagcagctcctcactgtcaagcacgagctgcggactgctaatttgacaggacatgctgagaaggtgggaatagaaaattttgagctcctgaaggtcctaggaactggagcttatggaaaagtatttctagttcgtaaaataagtggccatgatactggaaagctgtatgccatgaaagttttgaaaaaggcaacaatcgttcaaaaggccaaaaccacagagcatacaaggacagaacgacaagtcctggaacacattaggcagtcgccatttttggtaacattacattatgctttccagacagaaaccaaacttcatctcattttagattatataaatggtggtgaactttttactcatctttctcaaagagagcgtttcacagagcatgaggtgcagatttatgttggagagattgtgcttgccctcgaacatctccacaagttggggattatatatcgtgatattaagcttgagaatattctacttgattctaatggccatgtggtgctgacagattttggtctgagtaaggagtttgtggctgatgaaactgaaagagcatattccttttgtggaactattgaatacatggcaccagatattgtcagagggggagattcaggacatgacaaggcagttgactggtggagtttgggtgttctaatgtatgaattactaactggagcatctcctttcactgttgatggagaaaaaaattcccaagctgagatatctaggagaatattaaaaagtgagcctccatatccccaagaaatgagtgctttagcgaaagacctaattcagcgtcttttgatgaaagatcccaagaagagattgggatgtggtccacgtgatgcagatgaaatcaaagaacatctcttctttcagaaaataaattgggatgatttagccgccaaaaaagtgcctgcaccatttaagccagtcattcgagatgaattagatgtgagtaactttgcagaagagttcacagaaatggatcccacttattctcccgcagccctgccccagagttctgagaagctgtttcagggctattcctttgttgctccttccatcctattcaagcgtaatgcagctgtcatagaccctcttcagtttcacatgggagttgaacgtcctggagtgacaaatgttgccaggagtgcaatgatgaaggactctccattctatcaacactatgacctagatttgaaggacaaacccctgggagaaggtagtttttcaatttgtcgaaagtgtgtgcataaaaaaagtaaccaagcttttgcagtcaaaataatcagcaaaaggatggaagccaatactcaaaaggaaataacagctctgaaactctgtgaaggacaccccaatattgtgaagttgcatgaagtttttcatgatcagcttcacacgtttctagtgatggaacttctgaatggaggagaactgtttgagcgcattaagaaaaagaagcacttcagtgagacggaagccagctacatcatgaggaagcttgtttcagctgtaagccacatgcatgatgttggagtggtgcacagggatctgaaacctgagaatttattgttcaccgatgaaaatgacaatttggaaattaaaataattgattttggatttgcacggctaaagccaccggataatcagcccctgaagactccatgcttcacccttcattatgccgccccagagctcttgaatcagaacggctacgatgagtcctgtgacctgtggagcttgggcgtcattttgtacacaatgttgtcaggacaggttcccttccaatctcatgaccgaagtttgacgtgtaccagcgcggtggaaatcatgaagaaaattaaaaagggagatttctcctttgaaggagaagcctggaagaatgtatcccaagaggctaaagatttgatccaaggacttctcacagtagatccaaacaaaaggcttaaaatgtctggcttgaggtacaatgaatggctacaagatggaagtcagctgtcctccaatcctctgatgactccggatattctaggatcttccggagctgccgtgcatacctgtgtgaaagcaaccttccacgcctttaacaaatacaagagagaggggttttgccttcagaatgttgataaggcccctttggctaagagaagaaaaatgaaaaagactagcaccagtaccgagacgcgcagcagttccagtgagagttcccattcttcttcctctcattctcacggtaaaactacacccaccaagacactgcagcccagcaatcctgccgacagcaataacccggagaccctcttccagttctcggactcagtagcttaggcatggtaggagtgtatcagtgatccattgcacctttattccctcagcatatgcctgaggcgatcttttatgcttttaaaaatgtttcccgttggtctcattggaatctgcctcctaatgatttttttcaggaaaacctgtttggttatcctcattcaaaagcactggacagagaatgttactgtgaatagagcacatattactctttttagcaacctagcatgatgccaacaagactattcttgaaagagcaaaggttcctgtaaatttaattagggctagatttgagctgcttgtaagtcacaggttttccagatgtctgccaacaagaaatgactcatactgtgatgataccttttgctttgccttgtggacaatgtgggtttttgaaatttgcacccttcaaacaatgatttatcagagaaaggggtctgttttcaaaaaagattctgtaatgaattttatgtgtggcatatacttatttcttgagagaagattttaacttattgtttttattttatggttacatatgatgataacctgctattattaaactttttctaaaaagtgaaaaaaaaaaaaaaagatataagaactcaaggtcccatactctgtattcgggatccatctgagatgcatgctaagctatgtgtatgtttttaattttgcactgctctttcctggcaatttgttttaatggttattgcagaatattaaggtacatgtctctctgttttaagtaatattgcactttataaaaaagtatgaataaagcaaactattttataaagtgcactgtttaaagcatttgcactgtatttttgccatttattttcattttctactttaaatttgtcctcacattcctcttctactttgtatgcaacaagtagaatggggcatgttgtgtcatgtagtcagccacttatgcaccaatgtgaggaaaacctaaagggaaattaaactaaacactgtgcttcatatttgtacactgtgttgtactacagtgaggaatttcctcctgtagtcatatattatgtacataatattttagaatcatacctatgacttgtttggaaatttttctgttaaattttaaatccagaaagcatattttataaacttatgcagagcacttttattgctcaaaagttctgaattcatacagaaaacaagtactatgtgatgaaaacatttcattaaaagattgctgcatttaaaaatacaattaattcgttccctatgcaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9252 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IEA
GeneID:9252 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:9252 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:9252 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IMP
GeneID:9252 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9252 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:9252 -> Biological process: GO:0001818 [negative regulation of cytokine production] evidence: TAS
GeneID:9252 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IDA
GeneID:9252 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IMP
GeneID:9252 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:9252 -> Biological process: GO:0006950 [response to stress] evidence: IEP
GeneID:9252 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
GeneID:9252 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0007243 [intracellular protein kinase cascade] evidence: IDA
GeneID:9252 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
GeneID:9252 -> Biological process: GO:0009605 [response to external stimulus] evidence: IEP
GeneID:9252 -> Biological process: GO:0016572 [histone phosphorylation] evidence: IDA
GeneID:9252 -> Biological process: GO:0016572 [histone phosphorylation] evidence: TAS
GeneID:9252 -> Biological process: GO:0032793 [positive regulation of CREB transcription factor activity] evidence: TAS
GeneID:9252 -> Biological process: GO:0033129 [positive regulation of histone phosphorylation] evidence: IMP
GeneID:9252 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0035066 [positive regulation of histone acetylation] evidence: IMP
GeneID:9252 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0043987 [histone H3-S10 phosphorylation] evidence: IMP
GeneID:9252 -> Biological process: GO:0043988 [histone H3-S28 phosphorylation] evidence: IMP
GeneID:9252 -> Biological process: GO:0043990 [histone H2A-S1 phosphorylation] evidence: IDA
GeneID:9252 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:9252 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:9252 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:9252 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:9252 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: IMP
GeneID:9252 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
GeneID:9252 -> Biological process: GO:0070498 [interleukin-1-mediated signaling pathway] evidence: IMP
GeneID:9252 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:9252 -> Cellular component: GO:0005634 [nucleus] evidence: IMP
GeneID:9252 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:9252 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_004746 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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