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2025-05-09 18:33:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001870 1699 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens carboxypeptidase A3 (mast cell) (CPA3), mRNA.
ACCESSION NM_001870
VERSION NM_001870.2 GI:221316748
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1699)
AUTHORS Pejler,G., Knight,S.D., Henningsson,F. and Wernersson,S.
TITLE Novel insights into the biological function of mast cell
carboxypeptidase A
JOURNAL Trends Immunol. 30 (8), 401-408 (2009)
PUBMED 19643669
REMARK GeneRIF: Role in regulating innate immunity responses and
regulating secretory granule homeostasis
Review article
REFERENCE 2 (bases 1 to 1699)
AUTHORS Chen,Z.Q. and He,S.H.
TITLE Cloning and expression of human colon mast cell carboxypeptidase
JOURNAL World J. Gastroenterol. 10 (3), 342-347 (2004)
PUBMED 14760754
REMARK GeneRIF: The cDNA encoding human colon mast cell carboxypeptidase
can be successfully cloned and expressed in E. coli and P.
pastoris.
REFERENCE 3 (bases 1 to 1699)
AUTHORS Huang,H., Reed,C.P., Zhang,J.S., Shridhar,V., Wang,L. and
Smith,D.I.
TITLE Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone
deacetylase inhibitors during differentiation of prostate
epithelial cancer cells
JOURNAL Cancer Res. 59 (12), 2981-2988 (1999)
PUBMED 10383164
REFERENCE 4 (bases 1 to 1699)
AUTHORS Dikov,M.M., Springman,E.B., Yeola,S. and Serafin,W.E.
TITLE Processing of procarboxypeptidase A and other zymogens in murine
mast cells
JOURNAL J. Biol. Chem. 269 (41), 25897-25904 (1994)
PUBMED 7929294
REFERENCE 5 (bases 1 to 1699)
AUTHORS Natsuaki,M., Stewart,C.B., Vanderslice,P., Schwartz,L.B.,
Natsuaki,M., Wintroub,B.U., Rutter,W.J. and Goldstein,S.M.
TITLE Human skin mast cell carboxypeptidase: functional characterization,
cDNA cloning, and genealogy
JOURNAL J. Invest. Dermatol. 99 (2), 138-145 (1992)
PUBMED 1629626
REFERENCE 6 (bases 1 to 1699)
AUTHORS Reynolds,D.S., Gurley,D.S. and Austen,K.F.
TITLE Cloning and characterization of the novel gene for mast cell
carboxypeptidase A
JOURNAL J. Clin. Invest. 89 (1), 273-282 (1992)
PUBMED 1729276
REFERENCE 7 (bases 1 to 1699)
AUTHORS Reynolds,D.S., Gurley,D.S., Stevens,R.L., Sugarbaker,D.J.,
Austen,K.F. and Serafin,W.E.
TITLE Cloning of cDNAs that encode human mast cell carboxypeptidase A,
and comparison of the protein with mouse mast cell carboxypeptidase
A and rat pancreatic carboxypeptidases
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (23), 9480-9484 (1989)
PUBMED 2594780
REFERENCE 8 (bases 1 to 1699)
AUTHORS Goldstein,S.M., Kaempfer,C.E., Kealey,J.T. and Wintroub,B.U.
TITLE Human mast cell carboxypeptidase. Purification and characterization
JOURNAL J. Clin. Invest. 83 (5), 1630-1636 (1989)
PUBMED 2708524
REFERENCE 9 (bases 1 to 1699)
AUTHORS Pascual,R., Burgos,F.J., Salva,M., Soriano,F., Mendez,E. and
Aviles,F.X.
TITLE Purification and properties of five different forms of human
procarboxypeptidases
JOURNAL Eur. J. Biochem. 179 (3), 609-616 (1989)
PUBMED 2920728
REFERENCE 10 (bases 1 to 1699)
AUTHORS Goldstein,S.M., Kaempfer,C.E., Proud,D., Schwartz,L.B., Irani,A.M.
and Wintroub,B.U.
TITLE Detection and partial characterization of a human mast cell
carboxypeptidase
JOURNAL J. Immunol. 139 (8), 2724-2729 (1987)
PUBMED 2443571
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BG501260.1, M27717.1,
DR005288.1, BC012613.1 and BF508919.1.
On Jan 24, 2009 this sequence version replaced gi:4503000.
Summary: Three different forms of human pancreatic
procarboxypeptidase A have been isolated. This gene encodes a form
which is obtained as a binary complex of a procarboxypeptidase A
with proproteinase E and functions as a secretory granule
metalloexopeptidase. [provided by RefSeq, Jan 2009].
##Evidence-Data-START##
Transcript exon combination :: BC012613.1, M27717.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-52 BG501260.1 2-53
53-563 M27717.1 1-511
564-628 DR005288.1 514-578
629-1680 BC012613.1 592-1643
1681-1699 BF508919.1 1-19 c
FEATURES Location/Qualifiers
source 1..1699
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q24"
gene 1..1699
/gene="CPA3"
/gene_synonym="MC-CPA"
/note="carboxypeptidase A3 (mast cell)"
/db_xref="GeneID:1359"
/db_xref="HGNC:2298"
/db_xref="MIM:114851"
exon 1..120
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="alignment:Splign:1.39.8"
variation 6
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:373285078"
CDS 53..1306
/gene="CPA3"
/gene_synonym="MC-CPA"
/EC_number="3.4.17.1"
/note="mast cell carboxypeptidase A; tissue
carboxypeptidase A"
/codon_start=1
/product="mast cell carboxypeptidase A precursor"
/protein_id="NP_001861.2"
/db_xref="GI:221316749"
/db_xref="CCDS:CCDS3138.1"
/db_xref="GeneID:1359"
/db_xref="HGNC:2298"
/db_xref="MIM:114851"
/translation="
MRLILPVGLIATTLAIAPVRFDREKVFRVKPQDEKQADIIKDLAKTNELDFWYPGATHHVAANMMVDFRVSEKESQAIQSALDQNKMHYEILIHDLQEEIEKQFDVKEDIPGRHSYAKYNNWEKIVAWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKIGEKNERRKAIFTDCGIHAREWVSPAFCQWFVYQATKTYGRNKIMTKLLDRMNFYILPVFNVDGYIWSWTKNRMWRKNRSKNQNSKCIGTDLNRNFNASWNSIPNTNDPCADNYRGSAPESEKETKAVTNFIRSHLNEIKVYITFHSYSQMLLFPYGYTSKLPPNHEDLAKVAKIGTDVLSTRYETRYIYGPIESTIYPISGSSLDWAYDLGIKHTFAFELRDKGKFGFLLPESRIKPTCRETMLAVKFIAKYILKHTS
"
sig_peptide 53..97
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 98..1303
/gene="CPA3"
/gene_synonym="MC-CPA"
/product="mast cell carboxypeptidase A"
misc_feature 131..364
/gene="CPA3"
/gene_synonym="MC-CPA"
/note="Carboxypeptidase activation peptide; Region:
Propep_M14; pfam02244"
/db_xref="CDD:190256"
misc_feature 392..1291
/gene="CPA3"
/gene_synonym="MC-CPA"
/note="Peptidase M14 carboxypeptidase subfamily A/B-like;
Carboxypeptidase B subgroup; Region: M14_CPB; cd03871"
/db_xref="CDD:199852"
misc_feature order(578..580,587..589,803..805,962..964,1124..1126,
1133..1135,1139..1141)
/gene="CPA3"
/gene_synonym="MC-CPA"
/note="putative active site [active]"
/db_xref="CDD:199852"
misc_feature order(578..580,587..589,962..964)
/gene="CPA3"
/gene_synonym="MC-CPA"
/note="Zn binding site [ion binding]; other site"
/db_xref="CDD:199852"
variation 56
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:111593746"
variation 71
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:143377024"
variation 95
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:199499869"
variation 109
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="c"
/db_xref="dbSNP:370509092"
variation 110
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:111765977"
variation 111
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:148382472"
exon 121..196
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="alignment:Splign:1.39.8"
variation 136
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:140527015"
variation 140
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="c"
/db_xref="dbSNP:200479513"
variation 152
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:145828911"
variation 156
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:145785078"
variation 170
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:375410605"
variation 196
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:199942135"
exon 197..321
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="alignment:Splign:1.39.8"
variation 214
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="t"
/db_xref="dbSNP:376722929"
variation 221
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:142834901"
variation 229
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:146101762"
variation 230
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:138685459"
variation 237
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:75478109"
variation 241
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="t"
/db_xref="dbSNP:17850953"
variation 293
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="c"
/db_xref="dbSNP:2270523"
variation 298
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:114531478"
exon 322..424
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="alignment:Splign:1.39.8"
variation 386
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:376999632"
variation 400
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:138751736"
variation 411
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:61733455"
variation 415
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:370991073"
exon 425..526
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="alignment:Splign:1.39.8"
variation 428
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:192753847"
variation 435
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:75229139"
variation 444
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:368209657"
variation 453
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="c"
/db_xref="dbSNP:146235151"
variation 477
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:374800491"
variation 496
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:200383775"
variation 497
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="g"
/db_xref="dbSNP:111881854"
variation 499
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:367753806"
variation 509
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="c"
/db_xref="dbSNP:372213795"
variation 511
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:377284175"
variation 517
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="t"
/db_xref="dbSNP:61733456"
exon 527..628
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="alignment:Splign:1.39.8"
variation 554
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:144291888"
variation 564
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:12489516"
variation 566
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:149768841"
variation 580
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:149879184"
variation 581
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:192487183"
variation 584
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:145845146"
variation 615
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:149006068"
exon 629..739
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="alignment:Splign:1.39.8"
variation 646
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:200899484"
variation 664
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="g"
/db_xref="dbSNP:78356818"
variation 672
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:138401564"
variation 677
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:141357361"
variation 708
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:145039073"
exon 740..830
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="alignment:Splign:1.39.8"
variation 743
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:370747287"
variation 746
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="t"
/db_xref="dbSNP:116686228"
variation 760
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:199944830"
variation 761
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:199600994"
variation 762
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:374150898"
variation 799
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="g"
/db_xref="dbSNP:141391874"
variation 815
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:370838199"
variation 824
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:150822877"
variation 826..827
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace=""
/replace="g"
/db_xref="dbSNP:35324938"
exon 831..1033
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="alignment:Splign:1.39.8"
variation 851
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="g"
/db_xref="dbSNP:138181056"
variation 870
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:143184657"
variation 881
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="c"
/db_xref="dbSNP:147228563"
variation 900
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:140470073"
variation 901
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:200538548"
variation 912
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:200639407"
variation 917
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:144437234"
variation 946
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:368374752"
variation 947
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:144470644"
variation 964
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:369290033"
variation 967
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:201909511"
variation 970
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:374063108"
variation 991
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:146653585"
variation 1002
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:142588358"
variation 1027
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:140411214"
variation 1031
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:367976187"
exon 1034..1118
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="alignment:Splign:1.39.8"
variation 1053
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:139830547"
variation 1066
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:139521475"
variation 1074
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:61747091"
variation 1075
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:146641016"
variation 1086
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:377005273"
variation 1089
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:200305769"
variation 1090
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:199984711"
variation 1118
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:201872849"
exon 1119..1686
/gene="CPA3"
/gene_synonym="MC-CPA"
/inference="alignment:Splign:1.39.8"
variation 1182
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:373298908"
variation 1190
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:375364662"
variation 1191
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:374679149"
variation 1203
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:148623762"
variation 1230
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:141324442"
variation 1250
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="g"
/db_xref="dbSNP:369125831"
variation 1252
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:61733453"
variation 1259
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:61733454"
variation 1284
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="c"
/db_xref="dbSNP:145833901"
variation 1298
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:112825175"
STS 1305..1554
/gene="CPA3"
/gene_synonym="MC-CPA"
/standard_name="SHGC-77447"
/db_xref="UniSTS:1208"
variation 1349
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="g"
/db_xref="dbSNP:375706071"
STS 1378..1598
/gene="CPA3"
/gene_synonym="MC-CPA"
/standard_name="G28614"
/db_xref="UniSTS:77210"
variation 1407
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:191632954"
variation 1447
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:183788880"
variation 1452
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace=""
/replace="c"
/db_xref="dbSNP:143922613"
variation 1513
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:188163066"
variation 1532
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:142056121"
variation 1569
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:150807042"
variation 1602
/gene="CPA3"
/gene_synonym="MC-CPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:12962"
polyA_signal 1661..1666
/gene="CPA3"
/gene_synonym="MC-CPA"
polyA_site 1686
/gene="CPA3"
/gene_synonym="MC-CPA"
ORIGIN
agggctgaggcataaaactgccagagggtctcaaggcaggcaaagaagaaccatgaggctcatcctgcctgtgggtttgattgctaccactcttgcaattgctcctgtccgctttgacagggagaaggtgttccgcgtgaagccccaggatgaaaaacaagcagacatcataaaggacttggccaaaaccaatgagcttgacttctggtatccaggtgccacccaccacgtagctgctaatatgatggtggatttccgagttagtgagaaggaatcccaagccatccagtctgccttggatcaaaataaaatgcactatgaaatcttgattcatgatctacaagaagagattgagaaacagtttgatgttaaagaagatatcccaggcaggcacagctacgcaaaatacaataattgggaaaagattgtggcttggactgaaaagatgatggataagtatcctgaaatggtctctcgtattaaaattggatctactgttgaagataatccactatatgttctgaagattggggaaaagaatgaaagaagaaaggctatttttacggattgtggcattcacgcacgagaatgggtctccccagcattctgccagtggtttgtctatcaggcaaccaaaacttatgggagaaacaaaattatgaccaaactcttggaccgaatgaatttttacattcttcctgtgttcaatgttgatggatatatttggtcatggacaaagaaccgcatgtggagaaaaaatcgttccaagaaccaaaactccaaatgcatcggcactgacctcaacaggaattttaatgcttcatggaactccattcctaacaccaatgacccatgtgcagataactatcggggctctgcaccagagtccgagaaagagacgaaagctgtcactaatttcattagaagccacctgaatgaaatcaaggtttacatcaccttccattcctactcccagatgctattgtttccctatggatatacatcaaaactgccacctaaccatgaggacttggccaaagttgcaaagattggcactgatgttctatcaactcgatatgaaacccgctacatctatggcccaatagaatcaacaatttacccgatatcaggttcttctttagactgggcttatgacctgggcatcaaacacacatttgcctttgagctccgagataaaggcaaatttggttttctccttccagaatcccggataaagccaacgtgcagagagaccatgctagctgtcaaatttattgccaagtatatcctcaagcatacttcctaaagaactgccctctgtttggaataagccaattaatccttttttgtgcctttcatcagaaagtcaatcttcagttatccccaaatgcagcttctatttcacctgaatccttctcttgctcatttaagtcccatgttactgctgtttgcttttacttactttcagtagcaccataacgaagtagctttaagtgaaaccttttaactacctttctttgctccaagtgaagtttggacccagcagaaagcattattttgaaaggtgatatacagtggggcacagaaaacaaatgaaaaccttcagtttctcacagattttcaccatgtggcttcatcaatttatgtgctaatacaataaaataaaatgcacttaatgctttaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1359 -> Molecular function: GO:0004181 [metallocarboxypeptidase activity] evidence: NAS
GeneID:1359 -> Molecular function: GO:0004181 [metallocarboxypeptidase activity] evidence: TAS
GeneID:1359 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:1359 -> Biological process: GO:0002003 [angiotensin maturation] evidence: TAS
GeneID:1359 -> Biological process: GO:0006508 [proteolysis] evidence: TAS
GeneID:1359 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
GeneID:1359 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
GeneID:1359 -> Cellular component: GO:0030133 [transport vesicle] evidence: IEA
GeneID:1359 -> Cellular component: GO:0030141 [secretory granule] evidence: NAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001861 -> EC 3.4.17.1
by
@meso_cacase at
DBCLS
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