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2025-05-09 18:24:20, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_012154 3520 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens argonaute RISC catalytic component 2 (AGO2),
transcript variant 1, mRNA.
ACCESSION NM_012154
VERSION NM_012154.3 GI:257467480
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3520)
AUTHORS Shen,J., Xia,W., Khotskaya,Y.B., Huo,L., Nakanishi,K., Lim,S.O.,
Du,Y., Wang,Y., Chang,W.C., Chen,C.H., Hsu,J.L., Wu,Y., Lam,Y.C.,
James,B.P., Liu,X., Liu,C.G., Patel,D.J. and Hung,M.C.
TITLE EGFR modulates microRNA maturation in response to hypoxia through
phosphorylation of AGO2
JOURNAL Nature 497 (7449), 383-387 (2013)
PUBMED 23636329
REMARK GeneRIF: EGFR, which is the product of a well-characterized
oncogene in human cancers, suppresses the maturation of specific
tumour-suppressor-like miRNAs in response to hypoxic stress through
phosphorylation of argonaute 2 (AGO2) at Tyr 393
REFERENCE 2 (bases 1 to 3520)
AUTHORS Cheng,N., Li,Y. and Han,Z.G.
TITLE Argonaute2 promotes tumor metastasis by way of up-regulating focal
adhesion kinase expression in hepatocellular carcinoma
JOURNAL Hepatology 57 (5), 1906-1918 (2013)
PUBMED 23258480
REMARK GeneRIF: Argonaute2 promotes tumor metastasis by way of
up-regulating focal adhesion kinase expression in hepatocellular
carcinoma.
REFERENCE 3 (bases 1 to 3520)
AUTHORS Zhang,X., Graves,P. and Zeng,Y.
TITLE Overexpression of human Argonaute2 inhibits cell and tumor growth
JOURNAL Biochim. Biophys. Acta 1830 (3), 2553-2561 (2013)
PUBMED 23201202
REMARK GeneRIF: Overexpression of human Argonaute2 inhibits cell and tumor
growth.
REFERENCE 4 (bases 1 to 3520)
AUTHORS Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
Johnson,J.A. and Boerwinkle,E.
TITLE Genome-wide association analyses suggest NELL1 influences adverse
metabolic response to HCTZ in African Americans
JOURNAL Pharmacogenomics J. (2013) In press
PUBMED 23400010
REMARK Publication Status: Available-Online prior to print
REFERENCE 5 (bases 1 to 3520)
AUTHORS Thibault,P.A., Huys,A., Dhillon,P. and Wilson,J.A.
TITLE MicroRNA-122-dependent and -independent replication of Hepatitis C
Virus in Hep3B human hepatoma cells
JOURNAL Virology 436 (1), 179-190 (2013)
PUBMED 23245472
REMARK GeneRIF: findings show that Argonaute-2 (Ago2) is required for
miR-122-dependent replication of Hepatitis C Virus, but dispensable
for miR-122-independent replication, confirming Ago2's role in
mediating the activity of miR-122
REFERENCE 6 (bases 1 to 3520)
AUTHORS Doi,N., Zenno,S., Ueda,R., Ohki-Hamazaki,H., Ui-Tei,K. and Saigo,K.
TITLE Short-interfering-RNA-mediated gene silencing in mammalian cells
requires Dicer and eIF2C translation initiation factors
JOURNAL Curr. Biol. 13 (1), 41-46 (2003)
PUBMED 12526743
REFERENCE 7 (bases 1 to 3520)
AUTHORS Carmell,M.A., Xuan,Z., Zhang,M.Q. and Hannon,G.J.
TITLE The Argonaute family: tentacles that reach into RNAi, developmental
control, stem cell maintenance, and tumorigenesis
JOURNAL Genes Dev. 16 (21), 2733-2742 (2002)
PUBMED 12414724
REMARK Review article
REFERENCE 8 (bases 1 to 3520)
AUTHORS Martinez,J., Patkaniowska,A., Urlaub,H., Luhrmann,R. and Tuschl,T.
TITLE Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
JOURNAL Cell 110 (5), 563-574 (2002)
PUBMED 12230974
REFERENCE 9 (bases 1 to 3520)
AUTHORS Mourelatos,Z., Dostie,J., Paushkin,S., Sharma,A., Charroux,B.,
Abel,L., Rappsilber,J., Mann,M. and Dreyfuss,G.
TITLE miRNPs: a novel class of ribonucleoproteins containing numerous
microRNAs
JOURNAL Genes Dev. 16 (6), 720-728 (2002)
PUBMED 11914277
REFERENCE 10 (bases 1 to 3520)
AUTHORS Koesters,R., Adams,V., Betts,D., Moos,R., Schmid,M., Siermann,A.,
Hassam,S., Weitz,S., Lichter,P., Heitz,P.U., von Knebel
Doeberitz,M. and Briner,J.
TITLE Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence,
genomic organization, localization to chromosomal bands 1p34-p35,
and expression
JOURNAL Genomics 61 (2), 210-218 (1999)
PUBMED 10534406
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AI468419.1, BC125214.1,
BC125213.1 and BC018727.1.
On Sep 9, 2009 this sequence version replaced gi:29171733.
Summary: This gene encodes a member of the Argonaute family of
proteins which play a role in RNA interference. The encoded protein
is highly basic, and contains a PAZ domain and a PIWI domain. It
may interact with dicer1 and play a role in
short-interfering-RNA-mediated gene silencing. Multiple transcript
variants encoding different isoforms have been found for this gene.
[provided by RefSeq, Sep 2009].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns ERS025088,
ERS025099 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1 AI468419.1 1-1
2-881 BC125214.1 1-880
882-2875 BC125213.1 688-2681
2876-3244 BC125214.1 2772-3140
3245-3520 BC018727.1 2492-2767
FEATURES Location/Qualifiers
source 1..3520
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q24"
gene 1..3520
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/note="argonaute RISC catalytic component 2"
/db_xref="GeneID:27161"
/db_xref="HGNC:3263"
/db_xref="HPRD:06943"
/db_xref="MIM:606229"
exon 1..63
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
CDS 42..2621
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/note="isoform 1 is encoded by transcript variant 1;
argonaute 2; protein argonaute-2; PPD; hAgo2; eIF2C 2;
eIF-2C 2; argonaute2; protein slicer; PAZ Piwi domain
protein; eukaryotic translation initiation factor 2C, 2"
/codon_start=1
/product="protein argonaute-2 isoform 1"
/protein_id="NP_036286.2"
/db_xref="GI:29171734"
/db_xref="CCDS:CCDS6380.1"
/db_xref="GeneID:27161"
/db_xref="HGNC:3263"
/db_xref="HPRD:06943"
/db_xref="MIM:606229"
/translation="
MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA
"
misc_feature 114..2615
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/note="protein argonaute; Provisional; Region: PLN03202"
/db_xref="CDD:178743"
misc_feature 564..722
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/note="Domain of unknown function (DUF1785); Region:
DUF1785; pfam08699"
/db_xref="CDD:204029"
misc_feature 720..1082
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/note="PAZ domain, argonaute_like subfamily. Argonaute is
part of the RNA-induced silencing complex (RISC), and is
an endonuclease that plays a key role in the RNA
interference pathway. The PAZ domain has been named after
the proteins Piwi,Argonaut, and Zwille; Region:
PAZ_argonaute_like; cd02846"
/db_xref="CDD:30331"
misc_feature order(876..878,921..923,963..965,975..977,1029..1031,
1050..1052,1056..1058)
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/note="nucleic acid-binding interface [nucleotide
binding]; other site"
/db_xref="CDD:30331"
misc_feature 1215..2492
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/note="Piwi_ago-like: PIWI domain, Argonaute-like
subfamily. Argonaute is the central component of the
RNA-induced silencing complex (RISC) and related
complexes. The PIWI domain is the C-terminal portion of
Argonaute and consists of two subdomains, one of...;
Region: Piwi_ago-like; cd04657"
/db_xref="CDD:72942"
misc_feature order(1626..1628,1638..1640,1674..1685,1692..1694,
1716..1718,1725..1727,1737..1739,1749..1751)
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/note="5' RNA guide strand anchoring site; other site"
/db_xref="CDD:72942"
misc_feature order(1830..1832,1836..1838,2046..2048,2460..2462)
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/note="active site"
/db_xref="CDD:72942"
misc_feature 2139..2141
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/experiment="experimental evidence, no additional details
recorded"
/note="4-hydroxyproline; propagated from
UniProtKB/Swiss-Prot (Q9UKV8.3); hydroxylation site"
exon 64..256
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 257..377
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 378..559
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 560..696
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 697..831
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 832..919
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
variation 881
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/replace="c"
/replace="t"
/db_xref="dbSNP:2292778"
exon 920..1067
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 1068..1187
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
variation 1142
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/replace="a"
/replace="g"
/db_xref="dbSNP:2271738"
exon 1188..1310
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 1311..1444
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 1445..1629
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
variation 1484
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/replace="c"
/replace="t"
/db_xref="dbSNP:2292781"
exon 1630..1789
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 1790..1880
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 1881..2075
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
STS 1989..2588
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/standard_name="Eif2c2"
/db_xref="UniSTS:479157"
exon 2076..2210
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
variation 2082
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/replace="c"
/replace="t"
/db_xref="dbSNP:1137903"
exon 2211..2312
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 2313..2512
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
exon 2513..3500
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/inference="alignment:Splign:1.39.8"
STS 2686..2890
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/standard_name="RH45183"
/db_xref="UniSTS:89345"
polyA_signal 2867..2872
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
variation 2876
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/replace="a"
/replace="g"
/db_xref="dbSNP:1060832"
variation 2883
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/replace="a"
/replace="g"
/db_xref="dbSNP:2944776"
polyA_site 2896
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
STS 3209..3310
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
/standard_name="WI-11623"
/db_xref="UniSTS:81391"
polyA_site 3500
/gene="AGO2"
/gene_synonym="EIF2C2; Q10"
ORIGIN
gcggccgcccctcggccccggagcccctcggcggcgccaccatgtactcgggagccggccccgcacttgcacctcctgcgccgccgccccccatccaaggatatgccttcaagcctccacctagacccgactttgggacctccgggagaacaatcaaattacaggccaatttcttcgaaatggacatccccaaaattgacatctatcattatgaattggatatcaagccagagaagtgcccgaggagagttaacagggaaatcgtggaacacatggtccagcactttaaaacacagatctttggggatcggaagcccgtgtttgacggcaggaagaatctatacacagccatgccccttccgattgggagggacaaggtggagctggaggtcacgctgccaggagaaggcaaggatcgcatcttcaaggtgtccatcaagtgggtgtcctgcgtgagcttgcaggcgttacacgatgcactttcagggcggctgcccagcgtcccttttgagacgatccaggccctggacgtggtcatgaggcacttgccatccatgaggtacacccccgtgggccgctccttcttcaccgcgtccgaaggctgctctaaccctcttggcgggggccgagaagtgtggtttggcttccatcagtccgtccggccttctctctggaaaatgatgctgaatattgatgtgtcagcaacagcgttttacaaggcacagccagtaatcgagtttgtttgtgaagttttggattttaaaagtattgaagaacaacaaaaacctctgacagattcccaaagggtaaagtttaccaaagaaattaaaggtctaaaggtggagataacgcactgtgggcagatgaagaggaagtaccgcgtctgcaatgtgacccggcggcccgccagtcaccaaacattcccgctgcagcaggagagcgggcagacggtggagtgcacggtggcccagtatttcaaggacaggcacaagttggttctgcgctacccccacctcccatgtttacaagtcggacaggagcagaaacacacctaccttcccctggaggtctgtaacattgtggcaggacaaagatgtattaaaaaattaacggacaatcagacctcaaccatgatcagagcgactgctaggtcggcgcccgatcggcaagaagagattagcaaattgatgcgaagtgcaagtttcaacacagatccatacgtccgtgaatttggaatcatggtcaaagatgagatgacagacgtgactgggcgggtgctgcagccgccctccatcctctacgggggcaggaataaagctattgcgacccctgtccagggcgtctgggacatgcggaacaagcagttccacacgggcatcgagatcaaggtgtgggccattgcgtgcttcgccccccagcgccagtgcacggaagtccatctgaagtccttcacagagcagctcagaaagatctcgagagacgccggcatgcccatccagggccagccgtgcttctgcaaatacgcgcagggggcggacagcgtggagcccatgttccggcacctgaagaacacgtatgcgggcctgcagctggtggtggtcatcctgcccggcaagacgcccgtgtacgccgaggtcaagcgcgtgggagacacggtgctggggatggccacgcagtgcgtgcagatgaagaacgtgcagaggaccacgccacagaccctgtccaacctctgcctgaagatcaacgtcaagctgggaggcgtgaacaacatcctgctgccccagggcaggccgccggtgttccagcagcccgtcatctttctgggagcagacgtcactcacccccccgccggggatgggaagaagccctccattgccgccgtggtgggcagcatggacgcccaccccaatcgctactgcgccaccgtgcgcgtgcagcagcaccggcaggagatcatacaagacctggccgccatggtccgcgagctcctcatccagttctacaagtccacgcgcttcaagcccacccgcatcatcttctaccgcgacggtgtctctgaaggccagttccagcaggttctccaccacgagttgctggccatccgtgaggcctgtatcaagctagaaaaagactaccagcccgggatcaccttcatcgtggtgcagaagaggcaccacacccggctcttctgcactgacaagaacgagcgggttgggaaaagtggaaacattccagcaggcacgactgtggacacgaaaatcacccaccccaccgagttcgacttctacctgtgtagtcacgctggcatccaggggacaagcaggccttcgcactatcacgtcctctgggacgacaatcgtttctcctctgatgagctgcagatcctaacctaccagctgtgtcacacctacgtgcgctgcacacgctccgtgtccatcccagcgccagcatactacgctcacctggtggccttccgggccaggtaccacctggtggataaggaacatgacagtgctgaaggaagccatacctctgggcagagtaacgggcgagaccaccaagcactggccaaggcggtccaggttcaccaagacactctgcgcaccatgtactttgcttgacatgttttagtgtttagcgattgtgtaccgagtgggattcacgagaccagctacactcagaccaacagatggccagcccttccgtgacagccagcatcgaacatgagacgtcattgattttattagattctccgttttccagaatgccttccgtcccagatttcaaacttggattttgaactgcagacctgtatgagaacccaatgtcataggaaatatggtttgctaaaatctataagctgcttattaaaacagagtcccgtgtgtcctaaaaatctcctaaaaccagtctatgaactcagggctttaaaacatttttaatttatttggtcattcaatttacttgtttttaatacatgattctctatgaaattgatgggctcaaactagctgtgaatcttctgagagtgaaagcaacacaaaacacaagtgtggttttaaagccttgaacattctgatgttgtcactaaagttgatttccaggcgatgctcgtgtgcccctggcgtggctcacccaagttcctcgactgagggccggtggccatgcagaggcgtccgcaggtgccgtgttctgccagcaccgcccttcacccggcctgaactaaggagcagtggcagaaggtgggccccgtgtgtttacagcatttccaggtccagagaggttggcagacaagtgccattttaataaaaaatgtatttaaaaaaagaaaaaagacaatatactgacagtctaatcatcagatttgtcctataggactgtgacatttattttccaaagtttttaaagaatacgggtctgtggtgataaatacagtacaatcctttttcactgttatgtctttaatgtaagagaagaatatatatatctggtttgcagtaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:27161 -> Molecular function: GO:0000340 [RNA 7-methylguanosine cap binding] evidence: IDA
GeneID:27161 -> Molecular function: GO:0003729 [mRNA binding] evidence: IEA
GeneID:27161 -> Molecular function: GO:0003743 [translation initiation factor activity] evidence: NAS
GeneID:27161 -> Molecular function: GO:0004521 [endoribonuclease activity] evidence: EXP
GeneID:27161 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:27161 -> Molecular function: GO:0035197 [siRNA binding] evidence: IDA
GeneID:27161 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:27161 -> Molecular function: GO:0070551 [endoribonuclease activity, cleaving siRNA-paired mRNA] evidence: IDA
GeneID:27161 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:27161 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:27161 -> Biological process: GO:0006412 [translation] evidence: NAS
GeneID:27161 -> Biological process: GO:0006413 [translational initiation] evidence: NAS
GeneID:27161 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:27161 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: TAS
GeneID:27161 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
GeneID:27161 -> Biological process: GO:0009791 [post-embryonic development] evidence: IEA
GeneID:27161 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:27161 -> Biological process: GO:0031047 [gene silencing by RNA] evidence: ISS
GeneID:27161 -> Biological process: GO:0031054 [pre-miRNA processing] evidence: IDA
GeneID:27161 -> Biological process: GO:0035278 [negative regulation of translation involved in gene silencing by miRNA] evidence: IDA
GeneID:27161 -> Biological process: GO:0035278 [negative regulation of translation involved in gene silencing by miRNA] evidence: IMP
GeneID:27161 -> Biological process: GO:0035279 [mRNA cleavage involved in gene silencing by miRNA] evidence: IDA
GeneID:27161 -> Biological process: GO:0035279 [mRNA cleavage involved in gene silencing by miRNA] evidence: IMP
GeneID:27161 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:27161 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:27161 -> Biological process: GO:0045947 [negative regulation of translational initiation] evidence: IDA
GeneID:27161 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:27161 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
GeneID:27161 -> Biological process: GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] evidence: ISS
GeneID:27161 -> Biological process: GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] evidence: ISS
GeneID:27161 -> Cellular component: GO:0000932 [cytoplasmic mRNA processing body] evidence: IDA
GeneID:27161 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:27161 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:27161 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:27161 -> Cellular component: GO:0005844 [polysome] evidence: IDA
GeneID:27161 -> Cellular component: GO:0005845 [mRNA cap binding complex] evidence: IDA
GeneID:27161 -> Cellular component: GO:0016442 [RNA-induced silencing complex] evidence: IDA
GeneID:27161 -> Cellular component: GO:0030529 [ribonucleoprotein complex] evidence: IDA
GeneID:27161 -> Cellular component: GO:0035068 [micro-ribonucleoprotein complex] evidence: IDA
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