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2025-05-09 19:44:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001143773 3566 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens family with sequence similarity 13, member C (FAM13C),
transcript variant 3, mRNA.
ACCESSION NM_001143773
VERSION NM_001143773.1 GI:219555641
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3566)
AUTHORS Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
Ferrucci,L., Fornage,M. and Mozaffarian,D.
TITLE Genome-wide association study identifies novel loci associated with
concentrations of four plasma phospholipid fatty acids in the de
novo lipogenesis pathway: results from the Cohorts for Heart and
Aging Research in Genomic Epidemiology (CHARGE) consortium
JOURNAL Circ Cardiovasc Genet 6 (2), 171-183 (2013)
PUBMED 23362303
REFERENCE 2 (bases 1 to 3566)
AUTHORS Karasik,D., Hsu,Y.H., Zhou,Y., Cupples,L.A., Kiel,D.P. and
Demissie,S.
TITLE Genome-wide pleiotropy of osteoporosis-related phenotypes: the
Framingham Study
JOURNAL J. Bone Miner. Res. 25 (7), 1555-1563 (2010)
PUBMED 20200953
REMARK GeneRIF: Observational study and genome-wide association study of
gene-disease association. (HuGE Navigator)
REFERENCE 3 (bases 1 to 3566)
AUTHORS Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
TITLE A scan of chromosome 10 identifies a novel locus showing strong
association with late-onset Alzheimer disease
JOURNAL Am. J. Hum. Genet. 78 (1), 78-88 (2006)
PUBMED 16385451
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK299924.1, AK289796.1, BC064431.1, AI453702.1 and BM677909.1.
Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
portion of the 5' coding region, and uses a downstream start codon,
compared to variant 1. The resulting isoform (3) has a shorter
N-terminus, compared to isoform 1.
##Evidence-Data-START##
Transcript exon combination :: AK299924.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-424 AK299924.1 1-424
425-2464 AK289796.1 180-2219
2465-3492 BC064431.1 1998-3025
3493-3545 AI453702.1 6-58 c
3546-3566 BM677909.1 1-21 c
FEATURES Location/Qualifiers
source 1..3566
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q21.1"
gene 1..3566
/gene="FAM13C"
/gene_synonym="FAM13C1"
/note="family with sequence similarity 13, member C"
/db_xref="GeneID:220965"
/db_xref="HGNC:19371"
exon 1..328
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
misc_feature 162..164
/gene="FAM13C"
/gene_synonym="FAM13C1"
/note="upstream in-frame stop codon"
exon 329..367
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 368..424
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 425..629
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
CDS 555..2063
/gene="FAM13C"
/gene_synonym="FAM13C1"
/note="isoform 3 is encoded by transcript variant 3;
family with sequence similarity 13, member C1; protein
FAM13C"
/codon_start=1
/product="protein FAM13C isoform 3"
/protein_id="NP_001137245.1"
/db_xref="GI:219555642"
/db_xref="CCDS:CCDS44406.1"
/db_xref="GeneID:220965"
/db_xref="HGNC:19371"
/translation="
MGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSECQVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKDPAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPRNLLCEQPTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQDVAKTI
"
exon 630..748
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 749..812
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 813..897
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 898..1108
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 1109..1247
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 1248..1329
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 1330..1541
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 1542..1637
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 1638..1837
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 1838..1939
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
exon 1940..3549
/gene="FAM13C"
/gene_synonym="FAM13C1"
/inference="alignment:Splign:1.39.8"
STS 2117..2308
/gene="FAM13C"
/gene_synonym="FAM13C1"
/standard_name="G65661"
/db_xref="UniSTS:225452"
STS 2224..2323
/gene="FAM13C"
/gene_synonym="FAM13C1"
/standard_name="SHGC-30631"
/db_xref="UniSTS:51822"
variation 2608
/gene="FAM13C"
/gene_synonym="FAM13C1"
/replace="a"
/replace="t"
/db_xref="dbSNP:11540126"
STS 3371..3472
/gene="FAM13C"
/gene_synonym="FAM13C1"
/standard_name="D10S1860"
/db_xref="UniSTS:65450"
ORIGIN
aaaattggtaggagacatgtggaagaaagcaagtctcccgggtatttcagcacttcggcagaaacactggggcattctcattgccagcctcggggggtggctggcacaaagagcccaagattaaacgcggcgcctgggctggcgaggtcggggtcgtgtggtaactctccaggtgctcctcgctggatcccggggtcccagccccgccgccgcgccccgcccagctctgtccccgcagcctcgcgggctgccgggctttgtggttcgcccgtgccgctgggcccctgctgggggtgtcgttacgagcatgtgcagacagcagcccaagccttcaggataattccttcagcagcaccactgtaacagagtgtgacgaagatccagtctctctacatgaagaccagactgattgctccagtctcagagatgaaaacaataaagagaactaccccgacgcaggggctctggtagaagagcacgcgccgccctcttgggagccgcagcagcagaatgtagaggcgaccgtgctggtggacagcgtattgcgacccagcatgggcaacttcaagtccaggaagcccaagtccatcttcaaagcggagagcgggaggagccacggagaaagtcaggagacagagcatgtggtatccagccagtcagagtgtcaggtgagagcaggaacaccagctcatgagagtccacaaaacaatgccttcaagtgccaagaaacagtgcgacttcaaccaagaatagaccagaggactgccatttcgccaaaggatgcttttgaaactcggcaggacttaaatgaggaagaagctgctcaggtgcatggagtcaaggacccggcgccagcatcaacccagagcgtgcttgccgatgggacagattctgcagacccctcaccagtccacaaagatgggcagaatgaggccgacagtgcaccagaagacctccactctgtggggaccagcaggctgctctatcacatcactgatggtgataacccactgctgtcgccacgatgctccatcttcagccaaagccagagattcaacttagaccccgagtcagccccatctccacccagcactcagcagtttatgatgccgcggagttcttcacgctgcagctgtggagatggcaaggagccacagaccatcacccagctcaccaagcacatccagagcctcaagcggaaaattcggaaatttgaagaaaaatttgaacaagaaaagaaataccggccttcacatggtgacaagacttctaatcctgaagtcctgaaatggatgaatgatttggctaaaggtcgtaaacagctcaaagaactaaagctaaagctgtcagaagaacaagggagtgctcccaaaggtccacctagaaacctgttgtgtgagcaacccacagtccccagagaaaatgggaaaccggaagctgcgggcccggagccaagctcctctggagaagagactccagatgctgccttgacatgcctgaaggagagaagagagcaacttcctccccaggaggattctaaggtaactaagcaagacaagaacctcataaagccgctttatgaccgatacagaattatcaagcaaatcttgtcaacaccttcccttattccaacaattcaggaggaagaggactctgatgaagaccgtccacagggaagccaacaaccttctttggcagatccagcatctcaccttcctgttggtgaccacctcacctactctaatgagactgagcctgttagggcccttttaccagatgaaaagaaagaagtaaaaccaccagctctctccatgtctaatttacatgaggctaccatgcctgtacttcttgaccatctccgagaaactagggctgacaagaagagactgcggaaagccttaagagaatttgaagaacagttttttaaacaaacaggaagaagtccacaaaaggaagataggataccaatggcagatgagtattatgaatataagcacataaaagccaaactgagactattagaggtcctcatcagcaagcaagatgtggccaaaactatttgaggttcaggaaatgttatgatcactttcacccatgatataaagtaaagtttattttcctctgccatccttgctaagtagttttgacacaatgaaaatggaagcactttagtggtagtattagctgtttttaagaaggaatagcaagtttaattatatacaaggagaagggatttaaacggggggaagaatacaacaggtagccatataattgggaaaaaattcagtgtcctccatgccaagcagaaaactcatagtcaatacaagtatttttaaaaatgtctaatattttatcaaatctaaataacatagctaggacacttgttagggaaagtttatttagtatccaaagactgtttatgttgatgtatggaaaagagcatgattttaaaaaatcaatcataggaggaaaagaaattcgcttttcaagtaggaaggaatacagctagcaagaaagcaatttatttgaaacttctaatggatttttgagtgataaaacatttactaccttgtcctttaagtctgctaggctctcagtaccctaaaataaactagattgtgttgctattttttttctttctctataaaaataacacattattttatccgttatttgaaattttacatttctggttaccaaagttcattctgatagcatgtactttgtgaattattatctttgtctataactgacagatgtttatattaaaataaaatattgtattaaaaatttaaaataggtattttggatagatatgtgtctgtagtatataatctaatgtgtccatagtattattgctaatcttttggtttactataagatgatataactattttttcattgggaatatacatttttcttaatgttccaacatctatactttgtaaagtcaaaacatttcccatgagctgtagttattcatccttctgtacaaaatgaaaagtttggaaattgtttgccctgataccttgaaaaagaagccagaatatttatttgcttcatcaacttcagtgtatatcattttgtgttattttatacgaaaacatgtttattattttcatttttgtaaaaggaagtaaaaggtcaacattttctctcatgtaccaaccttgtttgtatttctattttctgtaatgtttaagtatgatgttgaagaaattcacattctcttatagtttggatgggaagactattgactatttcagaaacagacttatttcagaggcttattgttttctctgtatttacctaatattttataacttttatgaatcagaataatgtccttcataaatttgtttaattgaagtcatctacttctaacaggacagatacacaactatttgaggtttacaaattacatctttgataagggaaatggtttcgtgacatgtacacagttgctattaaaatgtaactctatatattctatatgattgtaaatattttatacaacaatacaaataaaatatttttctattatatttaaaaaaaaaaaaaaaaaa
//
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@meso_cacase at
DBCLS
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