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2025-05-09 18:47:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_177949 2858 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens armadillo repeat containing, X-linked 2 (ARMCX2),
mRNA.
ACCESSION NM_177949
VERSION NM_177949.2 GI:157427677
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2858)
AUTHORS Zeller,C., Dai,W., Steele,N.L., Siddiq,A., Walley,A.J.,
Wilhelm-Benartzi,C.S., Rizzo,S., van der Zee,A., Plumb,J.A. and
Brown,R.
TITLE Candidate DNA methylation drivers of acquired cisplatin resistance
in ovarian cancer identified by methylome and expression profiling
JOURNAL Oncogene 31 (42), 4567-4576 (2012)
PUBMED 22249249
REMARK GeneRIF: Data indicate that ARMCX2, COL1A1, MDK, MEST and MLH1
genes acquired methylation in drug-resistant ovarian
cancer-sustaining (side population) cells.
REFERENCE 2 (bases 1 to 2858)
AUTHORS Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
Willey,D.L., Williams,G., Williams,L., Williamson,A.,
Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
Bentley,D.R.
TITLE The DNA sequence of the human X chromosome
JOURNAL Nature 434 (7031), 325-337 (2005)
PUBMED 15772651
REFERENCE 3 (bases 1 to 2858)
AUTHORS Goehler,H., Lalowski,M., Stelzl,U., Waelter,S., Stroedicke,M.,
Worm,U., Droege,A., Lindenberg,K.S., Knoblich,M., Haenig,C.,
Herbst,M., Suopanki,J., Scherzinger,E., Abraham,C., Bauer,B.,
Hasenbank,R., Fritzsche,A., Ludewig,A.H., Bussow,K., Coleman,S.H.,
Gutekunst,C.A., Landwehrmeyer,B.G., Lehrach,H. and Wanker,E.E.
TITLE A protein interaction network links GIT1, an enhancer of huntingtin
aggregation, to Huntington's disease
JOURNAL Mol. Cell 15 (6), 853-865 (2004)
PUBMED 15383276
REMARK Erratum:[Mol Cell. 2005 Jul 22;19(2):287. Buessow, Konrad
[corrected to Bussow, Konrad]]
REFERENCE 4 (bases 1 to 2858)
AUTHORS Kurochkin,I.V., Yonemitsu,N., Funahashi,S.I. and Nomura,H.
TITLE ALEX1, a novel human armadillo repeat protein that is expressed
differentially in normal tissues and carcinomas
JOURNAL Biochem. Biophys. Res. Commun. 280 (1), 340-347 (2001)
PUBMED 11162520
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BG548388.1, AB011084.1,
BX648494.1, Z83131.1 and BM676866.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 24, 2007 this sequence version replaced gi:29540561.
Summary: This gene encodes a member of the ALEX family of proteins
and may play a role in tumor suppression. The encoded protein
contains a potential N-terminal transmembrane domain and a single
Armadillo (arm) repeat. Other proteins containing the arm repeat
are involved in development, maintenance of tissue integrity, and
tumorigenesis. This gene is closely localized with other family
members, including ALEX1 and ALEX3, on the X chromosome. Two
alternative transcripts that encode the same protein but differ in
the 5' UTR have been described. Additional alternative transcripts
may exist but their full length natures have not been determined. A
pseudogene for this locus is located on chromosome 7. [provided by
RefSeq, Jul 2008].
##Evidence-Data-START##
Transcript exon combination :: AK291342.1, AB011084.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-41 BG548388.1 15-55
42-457 AB011084.1 1-416
458-2047 BX648494.1 418-2007
2048-2049 Z83131.1 8751-8752 c
2050-2797 BX648494.1 2010-2757
2798-2858 BM676866.1 1-61 c
FEATURES Location/Qualifiers
source 1..2858
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq21.33-q22.2"
gene 1..2858
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="armadillo repeat containing, X-linked 2"
/db_xref="GeneID:9823"
/db_xref="HGNC:16869"
/db_xref="HPRD:02293"
/db_xref="MIM:300363"
exon 1..121
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="alignment:Splign:1.39.8"
exon 122..204
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="alignment:Splign:1.39.8"
exon 205..277
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="alignment:Splign:1.39.8"
exon 278..342
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="alignment:Splign:1.39.8"
misc_feature 303..305
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="upstream in-frame stop codon"
exon 343..412
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="alignment:Splign:1.39.8"
exon 413..2847
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="alignment:Splign:1.39.8"
CDS 540..2438
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="armadillo repeat protein ALEX2; arm protein lost in
epithelial cancers, X chromosome, 2; ARM protein lost in
epithelial cancers on chromosome X 2"
/codon_start=1
/product="armadillo repeat-containing X-linked protein 2"
/protein_id="NP_808818.1"
/db_xref="GI:29540562"
/db_xref="CCDS:CCDS14490.1"
/db_xref="GeneID:9823"
/db_xref="HGNC:16869"
/db_xref="HPRD:02293"
/db_xref="MIM:300363"
/translation="
MSRVRDAGCVAAGIVIGAGAWYCVYKYTRGRDQTKKRMAKPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVAPAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAGAPKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSATGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAEVPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRPFPYEIDEILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDPHIKEKALMAMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNSYVESEILINALTLFEIIYDNLRAEVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLLVKVKVIKLVNKF
"
misc_feature 558..614
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
transmembrane region"
misc_feature 1662..2393
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="Armadillo-like; Region: Arm_2; pfam04826"
/db_xref="CDD:191105"
misc_feature 1665..1787
/gene="ARMCX2"
/gene_synonym="ALEX2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
Region: ARM 1"
misc_feature 1677..2030
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="Armadillo/beta-catenin-like repeats. An
approximately 40 amino acid long tandemly repeated
sequence motif first identified in the Drosophila segment
polarity gene armadillo; these repeats were also found in
the mammalian armadillo homolog beta-catenin; Region: ARM;
cd00020"
/db_xref="CDD:28904"
misc_feature order(1752..1754,1764..1766,1776..1778,1866..1868,
1878..1880,1887..1889,1899..1901,1998..2000,2010..2012,
2019..2024)
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="protein binding surface [polypeptide binding];
other site"
/db_xref="CDD:28904"
misc_feature 1791..1910
/gene="ARMCX2"
/gene_synonym="ALEX2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
Region: ARM 2"
misc_feature 2031..2150
/gene="ARMCX2"
/gene_synonym="ALEX2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
Region: ARM 3"
STS 1933..2657
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="ARMCX2_8998"
/db_xref="UniSTS:468291"
STS 2603..2755
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="RH46199"
/db_xref="UniSTS:52966"
STS 2656..2775
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="A001V26"
/db_xref="UniSTS:784"
STS 2656..2775
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="G19687"
/db_xref="UniSTS:783"
STS 2661..2814
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="DXS7453"
/db_xref="UniSTS:99408"
STS 2708..2813
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="SGC30561"
/db_xref="UniSTS:17375"
polyA_signal 2818..2823
/gene="ARMCX2"
/gene_synonym="ALEX2"
variation 2842
/gene="ARMCX2"
/gene_synonym="ALEX2"
/replace="a"
/replace="c"
/db_xref="dbSNP:3177613"
polyA_site 2847
/gene="ARMCX2"
/gene_synonym="ALEX2"
ORIGIN
cttaaagccctgaccgtcgttctccgtcctcctctgggtaccaactctattgcgcagctcgctgccgtgcgtttaacccaggcgaggaggaggaggagaaaattcccccagattcgggcaggcccgcaccccacattccgtcctgttttgagaggaggagggaagagaaataaacgtggcagcgcatagaaggccagcagggagactgctttccagacacctccggcccacacagccgttcaccccccgtcttttcagtcctggaaaaggaattcggtctgtccttaggatgaagctctaactgaactgaagtaaggagaaacagccttgaatctttggagggtctgtcttccttttgggctctgtgcaactgcagctacagtggaaaaaagcaaactgctcttgatcccaggccctgcctaagcctcagcagaacttgtaagcctaaactgaagagcctcacccggacgagcaggcatcccttaaccttaagcaatccagttccacgccctggatcagtgaataaccccagctgcaccatgagccgcgttcgggatgctggctgtgtagcggcggggatagtgataggggctggtgcctggtactgtgtctacaaatacaccagggggagagaccagaccaagaagagaatggccaagcccaaaaaccgggctgtggctgggactggagccagggctagagctgggctaagagccggattcacaatcgaccttgggtcaggattcagtcccccaaccccagtccgtgctgaagcagaggacagggcccaggatgaagcctctgctctggacacagttggagctgaggcagtggccccagctgcatccagcgctgaggctcagagtggggcaggcagtcaggcccaagaggcagatggagccggggttgggcctaaggccgaatcagtagttggggctgcaatggcttctgcaatagcaccacctcccggggtgacagaggcccttggggctgcagaagcccctgcaatggcaggggctcccaaagtggcagaagctcccagagaagcggagacttccagggcagcggtgcctcctgggacagtggtgcctaccgaagcggcagcacccactgaggtgaccgagggtcctggggtagcagcacctaccaaggtagctgaagctcccggggtggcatcgcctaccgaggcagctgaggctcctgtgcccgcaacgcctactggggctgcagcacctactggggctgcagagtctcctggaacttctggttcccctagaacagcggtggttcctggaacatcagctgccaagaaagcaacccctggggctcacactggggctataccgaaagccacatcagcgactggagcggtacccaaaggtggaggcaagggtgtaaccaggtcccggaatgggggcaagggcaagggcaagaaaagcaaagttgaagtagacgaactggggatgggcttccgtcctggagatggggctgcagcagctgctgcagcctctgctaatggcggacaggctttcctggcagaggtccctgattctgaggaaggggagtccgggtggactgacacagagtcagattcagactctgagcccgagacccagcgcagagggaggggaagaagacccgttgccatgcagaagcgcccctttccttatgaaattgatgagattctgggtgtccgcgatctcaggaaggtccttgccttgcttcagaaatctgatgatcctttcatccaacaggtagctttgctcactctgagcaacaatgccaattattcatgcaatcaagagacaatccgcaaattgggaggcctcccaattattgcaaacatgatcaacaaaactgatccacacattaaggaaaaagccttaatggccatgaataacctgagtgagaattatgaaaatcagggccggcttcaggtgtacatgaataaagtgatggatgatatcatggcctctaacctgaactcagcagttcaagtagttggactaaaatttctaacaaacatgactattactaatgactaccagcacctgcttgtcaattccattgcaaactttttccgtttgctatctcagggaggtggaaaaatcaaggttgagattttgaaaatcctttcgaattttgctgaaaatccagatatgttgaagaaacttctcagtacccaagtgccagcatcatttagttccctctataattcttacgtggaatcagaaatccttattaatgcccttactctatttgagattatctatgacaatctcagagcagaagtgtttaactatagagaattcaataaaggttcccttttttacttatgcactacatctggagtgtgtgttaagaaaattagagccttagcaaatcaccatgacctcttagtgaaagtgaaagttataaaactagtgaacaaattctgattggttatgtaccgtcaaaagacttgaagaaatttcatgattttgcagtgtggaagcgttgaaaattgaaagttactgcttttccacttgctcatatagtaaagggatcctttcagctgccagtgttgaataatgtatcatccagagtgatgttatctgtgacagtcaccagctttaagctgaaccattttatgaataccaaataaatagacctcttgtactgaaaacatatttgtgactttaatcgtgctgcttggatagaaatatttttactggttcttctgaattgacagtaaacctgtccattatgaatggcctactgttctattatttgttttgacttgaatttatccaccaaagacttcatttgtgtatcatcaataaagttgtatgtttcaactgacaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9823 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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