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2025-05-09 18:24:19, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014782 2807 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens armadillo repeat containing, X-linked 2 (ARMCX2),
mRNA.
ACCESSION NM_014782
VERSION NM_014782.5 GI:157427678
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2807)
AUTHORS Zeller,C., Dai,W., Steele,N.L., Siddiq,A., Walley,A.J.,
Wilhelm-Benartzi,C.S., Rizzo,S., van der Zee,A., Plumb,J.A. and
Brown,R.
TITLE Candidate DNA methylation drivers of acquired cisplatin resistance
in ovarian cancer identified by methylome and expression profiling
JOURNAL Oncogene 31 (42), 4567-4576 (2012)
PUBMED 22249249
REMARK GeneRIF: Data indicate that ARMCX2, COL1A1, MDK, MEST and MLH1
genes acquired methylation in drug-resistant ovarian
cancer-sustaining (side population) cells.
REFERENCE 2 (bases 1 to 2807)
AUTHORS Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
Willey,D.L., Williams,G., Williams,L., Williamson,A.,
Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
Bentley,D.R.
TITLE The DNA sequence of the human X chromosome
JOURNAL Nature 434 (7031), 325-337 (2005)
PUBMED 15772651
REFERENCE 3 (bases 1 to 2807)
AUTHORS Goehler,H., Lalowski,M., Stelzl,U., Waelter,S., Stroedicke,M.,
Worm,U., Droege,A., Lindenberg,K.S., Knoblich,M., Haenig,C.,
Herbst,M., Suopanki,J., Scherzinger,E., Abraham,C., Bauer,B.,
Hasenbank,R., Fritzsche,A., Ludewig,A.H., Bussow,K., Coleman,S.H.,
Gutekunst,C.A., Landwehrmeyer,B.G., Lehrach,H. and Wanker,E.E.
TITLE A protein interaction network links GIT1, an enhancer of huntingtin
aggregation, to Huntington's disease
JOURNAL Mol. Cell 15 (6), 853-865 (2004)
PUBMED 15383276
REMARK Erratum:[Mol Cell. 2005 Jul 22;19(2):287. Buessow, Konrad
[corrected to Bussow, Konrad]]
REFERENCE 4 (bases 1 to 2807)
AUTHORS Kurochkin,I.V., Yonemitsu,N., Funahashi,S.I. and Nomura,H.
TITLE ALEX1, a novel human armadillo repeat protein that is expressed
differentially in normal tissues and carcinomas
JOURNAL Biochem. Biophys. Res. Commun. 280 (1), 340-347 (2001)
PUBMED 11162520
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BG548388.1, BC012541.1,
Z83131.1, BX648494.1 and BM676866.1.
On Sep 24, 2007 this sequence version replaced gi:41327765.
Summary: This gene encodes a member of the ALEX family of proteins
and may play a role in tumor suppression. The encoded protein
contains a potential N-terminal transmembrane domain and a single
Armadillo (arm) repeat. Other proteins containing the arm repeat
are involved in development, maintenance of tissue integrity, and
tumorigenesis. This gene is closely localized with other family
members, including ALEX1 and ALEX3, on the X chromosome. Two
alternative transcripts that encode the same protein but differ in
the 5' UTR have been described. Additional alternative transcripts
may exist but their full length natures have not been determined. A
pseudogene for this locus is located on chromosome 7. [provided by
RefSeq, Jul 2008].
##Evidence-Data-START##
Transcript exon combination :: BC012541.1, BF107384.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025086 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-34 BG548388.1 15-48
35-1996 BC012541.1 4-1965
1997-1998 Z83131.1 8751-8752 c
1999-2661 BC012541.1 1968-2630
2662-2746 BX648494.1 2673-2757
2747-2807 BM676866.1 1-61 c
FEATURES Location/Qualifiers
source 1..2807
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq21.33-q22.2"
gene 1..2807
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="armadillo repeat containing, X-linked 2"
/db_xref="GeneID:9823"
/db_xref="HGNC:16869"
/db_xref="HPRD:02293"
/db_xref="MIM:300363"
exon 1..121
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="alignment:Splign:1.39.8"
exon 122..182
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="alignment:Splign:1.39.8"
exon 183..291
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="alignment:Splign:1.39.8"
misc_feature 252..254
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="upstream in-frame stop codon"
exon 292..361
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="alignment:Splign:1.39.8"
exon 362..2796
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="alignment:Splign:1.39.8"
CDS 489..2387
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="armadillo repeat protein ALEX2; arm protein lost in
epithelial cancers, X chromosome, 2; ARM protein lost in
epithelial cancers on chromosome X 2"
/codon_start=1
/product="armadillo repeat-containing X-linked protein 2"
/protein_id="NP_055597.1"
/db_xref="GI:7662162"
/db_xref="CCDS:CCDS14490.1"
/db_xref="GeneID:9823"
/db_xref="HGNC:16869"
/db_xref="HPRD:02293"
/db_xref="MIM:300363"
/translation="
MSRVRDAGCVAAGIVIGAGAWYCVYKYTRGRDQTKKRMAKPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVAPAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAGAPKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSATGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAEVPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRPFPYEIDEILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDPHIKEKALMAMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNSYVESEILINALTLFEIIYDNLRAEVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLLVKVKVIKLVNKF
"
misc_feature 507..563
/gene="ARMCX2"
/gene_synonym="ALEX2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
transmembrane region"
misc_feature 1611..2342
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="Armadillo-like; Region: Arm_2; pfam04826"
/db_xref="CDD:191105"
misc_feature 1614..1736
/gene="ARMCX2"
/gene_synonym="ALEX2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
Region: ARM 1"
misc_feature 1626..1979
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="Armadillo/beta-catenin-like repeats. An
approximately 40 amino acid long tandemly repeated
sequence motif first identified in the Drosophila segment
polarity gene armadillo; these repeats were also found in
the mammalian armadillo homolog beta-catenin; Region: ARM;
cd00020"
/db_xref="CDD:28904"
misc_feature order(1701..1703,1713..1715,1725..1727,1815..1817,
1827..1829,1836..1838,1848..1850,1947..1949,1959..1961,
1968..1973)
/gene="ARMCX2"
/gene_synonym="ALEX2"
/note="protein binding surface [polypeptide binding];
other site"
/db_xref="CDD:28904"
misc_feature 1740..1859
/gene="ARMCX2"
/gene_synonym="ALEX2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
Region: ARM 2"
misc_feature 1980..2099
/gene="ARMCX2"
/gene_synonym="ALEX2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
Region: ARM 3"
STS 1882..2606
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="ARMCX2_8998"
/db_xref="UniSTS:468291"
STS 2552..2704
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="RH46199"
/db_xref="UniSTS:52966"
STS 2605..2724
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="A001V26"
/db_xref="UniSTS:784"
STS 2605..2724
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="G19687"
/db_xref="UniSTS:783"
STS 2610..2763
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="DXS7453"
/db_xref="UniSTS:99408"
STS 2657..2762
/gene="ARMCX2"
/gene_synonym="ALEX2"
/standard_name="SGC30561"
/db_xref="UniSTS:17375"
polyA_signal 2767..2772
/gene="ARMCX2"
/gene_synonym="ALEX2"
variation 2791
/gene="ARMCX2"
/gene_synonym="ALEX2"
/replace="a"
/replace="c"
/db_xref="dbSNP:3177613"
polyA_site 2796
/gene="ARMCX2"
/gene_synonym="ALEX2"
ORIGIN
cttaaagccctgaccgtcgttctccgtcctcctctgggtaccaactctattgcgcagctcgctgccgtgcgtttaacccaggcgaggaggaggaggagaaaattcccccagattcgggcagacacctccggcccacacagccgttcaccccccgtcttttcagtcctggaaaaggaattcgggctttcattgtctaacgtcgacagtctatatttctgctcttcagtctgtccttaggatgaagctctaactgaactgaagtaaggagaaacagccttgaatctttggagggtctgtcttccttttgggctctgtgcaactgcagctacagtggaaaaaagcaaactgctcttgatcccaggccctgcctaagcctcagcagaacttgtaagcctaaactgaagagcctcacccggacgagcaggcatcccttaaccttaagcaatccagttccacgccctggatcagtgaataaccccagctgcaccatgagccgcgttcgggatgctggctgtgtagcggcggggatagtgataggggctggtgcctggtactgtgtctacaaatacaccagggggagagaccagaccaagaagagaatggccaagcccaaaaaccgggctgtggctgggactggagccagggctagagctgggctaagagccggattcacaatcgaccttgggtcaggattcagtcccccaaccccagtccgtgctgaagcagaggacagggcccaggatgaagcctctgctctggacacagttggagctgaggcagtggccccagctgcatccagcgctgaggctcagagtggggcaggcagtcaggcccaagaggcagatggagccggggttgggcctaaggccgaatcagtagttggggctgcaatggcttctgcaatagcaccacctcccggggtgacagaggcccttggggctgcagaagcccctgcaatggcaggggctcccaaagtggcagaagctcccagagaagcggagacttccagggcagcggtgcctcctgggacagtggtgcctaccgaagcggcagcacccactgaggtgaccgagggtcctggggtagcagcacctaccaaggtagctgaagctcccggggtggcatcgcctaccgaggcagctgaggctcctgtgcccgcaacgcctactggggctgcagcacctactggggctgcagagtctcctggaacttctggttcccctagaacagcggtggttcctggaacatcagctgccaagaaagcaacccctggggctcacactggggctataccgaaagccacatcagcgactggagcggtacccaaaggtggaggcaagggtgtaaccaggtcccggaatgggggcaagggcaagggcaagaaaagcaaagttgaagtagacgaactggggatgggcttccgtcctggagatggggctgcagcagctgctgcagcctctgctaatggcggacaggctttcctggcagaggtccctgattctgaggaaggggagtccgggtggactgacacagagtcagattcagactctgagcccgagacccagcgcagagggaggggaagaagacccgttgccatgcagaagcgcccctttccttatgaaattgatgagattctgggtgtccgcgatctcaggaaggtccttgccttgcttcagaaatctgatgatcctttcatccaacaggtagctttgctcactctgagcaacaatgccaattattcatgcaatcaagagacaatccgcaaattgggaggcctcccaattattgcaaacatgatcaacaaaactgatccacacattaaggaaaaagccttaatggccatgaataacctgagtgagaattatgaaaatcagggccggcttcaggtgtacatgaataaagtgatggatgatatcatggcctctaacctgaactcagcagttcaagtagttggactaaaatttctaacaaacatgactattactaatgactaccagcacctgcttgtcaattccattgcaaactttttccgtttgctatctcagggaggtggaaaaatcaaggttgagattttgaaaatcctttcgaattttgctgaaaatccagatatgttgaagaaacttctcagtacccaagtgccagcatcatttagttccctctataattcttacgtggaatcagaaatccttattaatgcccttactctatttgagattatctatgacaatctcagagcagaagtgtttaactatagagaattcaataaaggttcccttttttacttatgcactacatctggagtgtgtgttaagaaaattagagccttagcaaatcaccatgacctcttagtgaaagtgaaagttataaaactagtgaacaaattctgattggttatgtaccgtcaaaagacttgaagaaatttcatgattttgcagtgtggaagcgttgaaaattgaaagttactgcttttccacttgctcatatagtaaagggatcctttcagctgccagtgttgaataatgtatcatccagagtgatgttatctgtgacagtcaccagctttaagctgaaccattttatgaataccaaataaatagacctcttgtactgaaaacatatttgtgactttaatcgtgctgcttggatagaaatatttttactggttcttctgaattgacagtaaacctgtccattatgaatggcctactgttctattatttgttttgacttgaatttatccaccaaagacttcatttgtgtatcatcaataaagttgtatgtttcaactgacaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9823 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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