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2025-05-09 18:36:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002290 7355 bp mRNA linear PRI 28-MAY-2013
DEFINITION Homo sapiens laminin, alpha 4 (LAMA4), transcript variant 2, mRNA.
ACCESSION NM_002290
VERSION NM_002290.4 GI:380503848
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7355)
AUTHORS Wang,Y., Fu,W., Xie,F., Wang,Y., Chu,X., Wang,H., Shen,M., Wang,Y.,
Wang,Y., Sun,W., Lei,R., Yang,L., Wu,H., Foo,J., Liu,J., Jin,L. and
Huang,W.
TITLE Common polymorphisms in ITGA2, PON1 and THBS2 are associated with
coronary atherosclerosis in a candidate gene association study of
the Chinese Han population
JOURNAL J. Hum. Genet. 55 (8), 490-494 (2010)
PUBMED 20485444
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 2 (bases 1 to 7355)
AUTHORS Senyurek,I., Klein,G., Kalbacher,H., Deeg,M. and Schittek,B.
TITLE Peptides derived from the human laminin alpha4 and alpha5 chains
exhibit antimicrobial activity
JOURNAL Peptides 31 (8), 1468-1472 (2010)
PUBMED 20433883
REMARK GeneRIF: Data from experiment with peptide fragments suggest
laminin alpha4 (and laminin alpha5) may be part of host defense
response and may protect tissues from invading pathogens.
REFERENCE 3 (bases 1 to 7355)
AUTHORS Lugassy,C., Torres-Munoz,J.E., Kleinman,H.K., Ghanem,G., Vernon,S.
and Barnhill,R.L.
TITLE Overexpression of malignancy-associated laminins and laminin
receptors by angiotropic human melanoma cells in a chick
chorioallantoic membrane model
JOURNAL J. Cutan. Pathol. 36 (12), 1237-1243 (2009)
PUBMED 19469865
REMARK GeneRIF: LAMC2, LAMA4, ITGB1, ITGB3, RSPA and MMP2) are
overexpressed in angiotropic melanoma cells vs. non-angiotropic
melanoma cells from the same tumor
REFERENCE 4 (bases 1 to 7355)
AUTHORS Sprenger,C.C., Drivdahl,R.H., Woodke,L.B., Eyman,D., Reed,M.J.,
Carter,W.G. and Plymate,S.R.
TITLE Senescence-induced alterations of laminin chain expression modulate
tumorigenicity of prostate cancer cells
JOURNAL Neoplasia 10 (12), 1350-1361 (2008)
PUBMED 19048114
REMARK GeneRIF: LM alpha4 and beta2 have roles in in vitro migration and
in vivo tumorigenicity of prostate cancer cells
REFERENCE 5 (bases 1 to 7355)
AUTHORS Xiao,S., Lux,M.L., Reeves,R., Hudson,T.J. and Fletcher,J.A.
TITLE HMGI(Y) activation by chromosome 6p21 rearrangements in
multilineage mesenchymal cells from pulmonary hamartoma
JOURNAL Am. J. Pathol. 150 (3), 901-910 (1997)
PUBMED 9060828
REFERENCE 6 (bases 1 to 7355)
AUTHORS Richards,A., Al-Imara,L. and Pope,F.M.
TITLE The complete cDNA sequence of laminin alpha 4 and its relationship
to the other human laminin alpha chains
JOURNAL Eur. J. Biochem. 238 (3), 813-821 (1996)
PUBMED 8706685
REFERENCE 7 (bases 1 to 7355)
AUTHORS Iivanainen,A., Sainio,K., Sariola,H. and Tryggvason,K.
TITLE Primary structure and expression of a novel human laminin alpha 4
chain
JOURNAL FEBS Lett. 365 (2-3), 183-188 (1995)
PUBMED 7781776
REFERENCE 8 (bases 1 to 7355)
AUTHORS Ryan,M.C., Tizard,R., VanDevanter,D.R. and Carter,W.G.
TITLE Cloning of the LamA3 gene encoding the alpha 3 chain of the
adhesive ligand epiligrin. Expression in wound repair
JOURNAL J. Biol. Chem. 269 (36), 22779-22787 (1994)
PUBMED 8077230
REFERENCE 9 (bases 1 to 7355)
AUTHORS Richards,A.J., al-Imara,L., Carter,N.P., Lloyd,J.C., Leversha,M.A.
and Pope,F.M.
TITLE Localization of the gene (LAMA4) to chromosome 6q21 and isolation
of a partial cDNA encoding a variant laminin A chain
JOURNAL Genomics 22 (1), 237-239 (1994)
PUBMED 7959779
REFERENCE 10 (bases 1 to 7355)
AUTHORS Burgeson,R.E., Chiquet,M., Deutzmann,R., Ekblom,P., Engel,J.,
Kleinman,H., Martin,G.R., Meneguzzi,G., Paulsson,M., Sanes,J. et
al.
TITLE A new nomenclature for the laminins
JOURNAL Matrix Biol. 14 (3), 209-211 (1994)
PUBMED 7921537
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP234809.1, X91171.1,
AB210027.1 and Z99289.1.
On Mar 16, 2012 this sequence version replaced gi:157419121.
Summary: Laminins, a family of extracellular matrix glycoproteins,
are the major noncollagenous constituent of basement membranes.
They have been implicated in a wide variety of biological processes
including cell adhesion, differentiation, migration, signaling,
neurite outgrowth and metastasis. Laminins are composed of 3 non
identical chains: laminin alpha, beta and gamma (formerly A, B1,
and B2, respectively) and they form a cruciform structure
consisting of 3 short arms, each formed by a different chain, and a
long arm composed of all 3 chains. Each laminin chain is a
multidomain protein encoded by a distinct gene. Several isoforms of
each chain have been described. Different alpha, beta and gamma
chain isomers combine to give rise to different heterotrimeric
laminin isoforms which are designated by Arabic numerals in the
order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is
laminin 1. The biological functions of the different chains and
trimer molecules are largely unknown, but some of the chains have
been shown to differ with respect to their tissue distribution,
presumably reflecting diverse functions in vivo. This gene encodes
the alpha chain isoform laminin, alpha 4. The domain structure of
alpha 4 is similar to that of alpha 3, both of which resemble
truncated versions of alpha 1 and alpha 2, in that approximately
1,200 residues at the N-terminus (domains IV, V and VI) have been
lost. Laminin, alpha 4 contains the C-terminal G domain which
distinguishes all alpha chains from the beta and gamma chains. The
RNA analysis from adult and fetal tissues revealed developmental
regulation of expression, however, the exact function of laminin,
alpha 4 is not known. Tissue-specific utilization of alternative
polyA-signal has been described in literature. Alternative splicing
results in multiple transcript variants encoding distinct isoforms.
[provided by RefSeq, Aug 2011].
Transcript Variant: This variant (2) uses an alternate in-frame
splice site in the 5' coding region, compared to variant 1,
resulting in a shorter protein (isoform 2), compared to isoform 1.
Variants 2 and 3 encode the same isoform (2).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: S78569.1, X91171.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-115 BP234809.1 1-115
116-1868 X91171.1 1-1753
1869-6154 AB210027.1 1742-6027
6155-7355 Z99289.1 50993-52193 c
FEATURES Location/Qualifiers
source 1..7355
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q21"
gene 1..7355
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="laminin, alpha 4"
/db_xref="GeneID:3910"
/db_xref="HGNC:6484"
/db_xref="MIM:600133"
exon 1..257
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 258..593
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
misc_feature 309..311
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="upstream in-frame stop codon"
CDS 399..5849
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="isoform 2 precursor is encoded by transcript
variant 2; laminin subunit alpha-4; laminin alpha 4 chain"
/codon_start=1
/product="laminin subunit alpha-4 isoform 2 precursor"
/protein_id="NP_002281.3"
/db_xref="GI:380503849"
/db_xref="CCDS:CCDS34514.1"
/db_xref="GeneID:3910"
/db_xref="HGNC:6484"
/db_xref="MIM:600133"
/translation="
MALSSAWRSVLPLWLLWSAACSRAASGDDNAFPFDIEGSSAVGRQDPPETSEPRVALGRLPPAAEKCNAGFFHTLSGECVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNCAVCNCGGGPCDSVTGECLEEGFEPPTGCDKCVWDLTDDLRLAALSIEEGKSGVLSVSSGAAAHRHVNEINATIYLLKTKLSERENQYALRKIQINNAENTMKSLLSDVEELVEKENQASRKGQLVQKESMDTINHASQLVEQAHDMRDKIQEINNKMLYYGEEHELSPKEISEKLVLAQKMLEEIRSRQPFFTQRELVDEEADEAYELLSQAESWQRLHNETRTLFPVVLEQLDDYNAKLSDLQEALDQALNYVRDAEDMNRATAARQRDHEKQQERVREQMEVVNMSLSTSADSLTTPRLTLSELDDIIKNASGIYAEIDGAKSELQVKLSNLSNLSHDLVQEAIDHAQDLQQEANELSRKLHSSDMNGLVQKALDASNVYENIVNYVSEANETAEFALNTTDRIYDAVSGIDTQIIYHKDESENLLNQARELQAKAESSSDEAVADTSRRVGGALARKSALKTRLSDAVKQLQAAERGDAQQRLGQSRLITEEANRTTMEVQQATAPMANNLTNWSQNLQHFDSSAYNTAVNSARDAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSVASKIQVSMMFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLELATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFFRLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRALRAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNGLLFYYASGSDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCHLSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVTPCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDGHPVSFSKAALVSGAVSINSCPAA
"
sig_peptide 399..479
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 480..5846
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/product="laminin subunit alpha-4 isoform 2"
misc_feature 639..770
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin-type epidermal growth factor-like domain;
laminins are the major noncollagenous components of
basement membranes that mediate cell adhesion, growth
migration, and differentiation; the laminin-type epidermal
growth factor-like module occurs in...; Region: EGF_Lam;
cd00055"
/db_xref="CDD:28937"
misc_feature 642..761
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin EGF-like (Domains III and V); Region:
Laminin_EGF; pfam00053"
/db_xref="CDD:200961"
misc_feature order(642..644,648..650,669..671,690..692,699..701,
726..728)
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="EGF-like motif; other site"
/db_xref="CDD:28937"
misc_feature 810..950
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin EGF-like (Domains III and V); Region:
Laminin_EGF; pfam00053"
/db_xref="CDD:200961"
misc_feature 816..953
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin-type epidermal growth factor-like domain;
laminins are the major noncollagenous components of
basement membranes that mediate cell adhesion, growth
migration, and differentiation; the laminin-type epidermal
growth factor-like module occurs in...; Region: EGF_Lam;
cd00055"
/db_xref="CDD:28937"
misc_feature order(834..836,861..863,867..869,894..896)
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="EGF-like motif; other site"
/db_xref="CDD:28937"
misc_feature 957..1112
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin-type epidermal growth factor-like domain;
laminins are the major noncollagenous components of
basement membranes that mediate cell adhesion, growth
migration, and differentiation; the laminin-type epidermal
growth factor-like module occurs in...; Region: EGF_Lam;
cd00055"
/db_xref="CDD:28937"
misc_feature 957..1097
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin EGF-like (Domains III and V); Region:
Laminin_EGF; pfam00053"
/db_xref="CDD:200961"
misc_feature order(957..959,963..965,1002..1004,1023..1025,1032..1034,
1059..1061)
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="EGF-like motif; other site"
/db_xref="CDD:28937"
misc_feature 1299..2042
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin Domain I; Region: Laminin_I; pfam06008"
/db_xref="CDD:191425"
misc_feature 1392..1982
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 1665..1682
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 1698..2549
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Uncharacterized archaeal coiled-coil protein
[Function unknown]; Region: COG1340"
/db_xref="CDD:31531"
misc_feature 2400..>2948
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="HlyD family secretion protein; Region: HlyD;
pfam00529"
/db_xref="CDD:109580"
misc_feature 2577..2960
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin Domain II; Region: Laminin_II; pfam06009"
/db_xref="CDD:203372"
misc_feature 2880..3413
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin G domain; Laminin G-like domains are
usually Ca++ mediated receptors that can have binding
sites for steroids, beta1 integrins, heparin, sulfatides,
fibulin-1, and alpha-dystroglycans. Proteins that contain
LamG domains serve a variety of...; Region: LamG; cd00110"
/db_xref="CDD:29010"
misc_feature 3522..3998
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin G domain; Laminin G-like domains are
usually Ca++ mediated receptors that can have binding
sites for steroids, beta1 integrins, heparin, sulfatides,
fibulin-1, and alpha-dystroglycans. Proteins that contain
LamG domains serve a variety of...; Region: LamG; cd00110"
/db_xref="CDD:29010"
misc_feature 4086..4505
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin G domain; Laminin G-like domains are
usually Ca++ mediated receptors that can have binding
sites for steroids, beta1 integrins, heparin, sulfatides,
fibulin-1, and alpha-dystroglycans. Proteins that contain
LamG domains serve a variety of...; Region: LamG; cd00110"
/db_xref="CDD:29010"
misc_feature 4842..5249
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin G domain; Laminin G-like domains are
usually Ca++ mediated receptors that can have binding
sites for steroids, beta1 integrins, heparin, sulfatides,
fibulin-1, and alpha-dystroglycans. Proteins that contain
LamG domains serve a variety of...; Region: LamG; cd00110"
/db_xref="CDD:29010"
misc_feature 5322..5774
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/note="Laminin G domain; Laminin G-like domains are
usually Ca++ mediated receptors that can have binding
sites for steroids, beta1 integrins, heparin, sulfatides,
fibulin-1, and alpha-dystroglycans. Proteins that contain
LamG domains serve a variety of...; Region: LamG; cd00110"
/db_xref="CDD:29010"
variation 505
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:70940809"
exon 594..695
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 678
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35349917"
exon 696..820
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 821..901
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 902..1116
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 1117..1191
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 1192..1343
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 1344..1454
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 1349
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="a"
/replace="c"
/db_xref="dbSNP:70940813"
exon 1455..1566
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 1567..1734
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 1735..1928
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 1869
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1050348"
exon 1929..2045
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 2046..2194
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 2195..2336
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 2337..2433
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 2434..2550
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 2522
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:70940810"
exon 2551..2730
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 2731..2870
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 2871..3044
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 3032
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35772073"
exon 3045..3190
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 3187
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35605307"
exon 3191..3353
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 3354..3487
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 3488..3659
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 3660..3791
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 3733
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="c"
/replace="g"
/db_xref="dbSNP:1050349"
exon 3792..3934
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 3935..4073
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 4074..4211
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 4212..4345
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 4320
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:70940811"
exon 4346..4510
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 4442
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34753919"
exon 4511..4664
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 4550
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35042032"
exon 4665..4852
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 4853..5042
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 4935
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34256052"
exon 5043..5198
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 5093
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35679345"
exon 5199..5358
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 5359..5489
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 5490..5583
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
variation 5537
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="a"
/replace="t"
/db_xref="dbSNP:1050353"
exon 5584..5703
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
exon 5704..7355
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/inference="alignment:Splign:1.39.8"
STS 5819..5929
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/standard_name="D6S1133E"
/db_xref="UniSTS:35049"
variation 5820
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3734292"
variation 5896
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11495"
STS 5971..6097
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/standard_name="RH18133"
/db_xref="UniSTS:76207"
variation 6066
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/replace="a"
/replace="t"
/db_xref="dbSNP:1050447"
polyA_signal 6131..6136
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
polyA_site 6157
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
STS 7188..7287
/gene="LAMA4"
/gene_synonym="CMD1JJ; LAMA3; LAMA4*-1"
/standard_name="A006N46"
/db_xref="UniSTS:28608"
ORIGIN
gaatattcttctggagcccttggaggggctccaaactgagaggggagggaagaccgcagggaaaggcggacctcagtgtctgaaaagccagcttagagtgggagggcctgggagtagaaggtaaaaagggagtggtgagaatgaatgtgagaaggaagccaggacagcgcagtccccagtcccgaacggccagggagaggaggtggcctagcgctggcggggctcaccccaatccgtctgccttttgatgccgtactctgctggttgcgcagccacctcgggatactgcacacggagaggagggaaaataagcgaggcaccgccgcaccacgcgggagacctacggagacccacagcgcccgagccctggaagagcactactggatgtcagcggagaaatggctttgagctcagcctggcgctcggttctgcctctgtggctcctctggagcgctgcctgctcccgcgccgcgtccggggacgacaacgcttttccttttgacattgaagggagctcagcggttggcaggcaagacccgcctgagacgagcgaaccccgcgtggctctgggacgcctgccgcctgcggccgagaaatgcaatgctggattctttcacaccctgtcgggagaatgtgtgccctgcgactgtaatggcaattccaacgagtgtttggacggctcaggatactgtgtgcactgccagcggaacacaacaggagagcactgtgaaaagtgtctggatggttatatcggagattccatcaggggagcaccccaattctgccagccgtgcccctgtcccctgccccacttggccaattttgcagaatcctgctataggaaaaatggagctgttcggtgcatttgtaacgaaaattatgctggacctaactgtgaaagatgtgctcccggttactatggaaaccccttactcattggaagcacctgtaagaaatgtgactgcagtggaaattcagatcccaacctgatctttgaagattgtgatgaagtcactggccagtgtaggaattgcttacgcaacaccaccggattcaagtgtgaacgttgcgctcctggctactatggggacgccaggatagccaagaactgtgcagtgtgcaactgcgggggaggcccatgtgacagtgtaaccggagaatgcttggaagaaggttttgaaccccctacaggctgtgataagtgcgtctgggacctgactgatgacctgcggttagcagcgctctccatcgaggaaggcaaatccggggtgctgagcgtatcctctggggccgccgctcataggcacgtgaatgaaatcaacgccaccatctacctcctcaaaacaaaattgtcagaaagagaaaaccaatacgccctaagaaagatacaaatcaacaatgctgagaacacgatgaaaagccttctgtctgacgtagaggaattagttgaaaaggaaaatcaagcctccagaaaaggacaacttgttcagaaggaaagcatggacaccattaaccacgcaagtcagctggtagagcaagcccatgatatgagggataaaatccaagagatcaacaacaagatgctctattatggggaagagcatgaacttagccccaaggaaatctctgagaagctggtgttggcccagaagatgcttgaagagattagaagccgtcaaccatttttcacccaacgggagctcgtggatgaggaggcagatgaggcttacgaactactgagccaggctgagagctggcagcggctgcacaatgagacccgcactctgtttcctgtcgtcctggagcagctggatgactacaatgctaagttgtcagatctccaggaagcacttgaccaggcccttaactatgtcagggatgccgaagacatgaacagggccacagcagccaggcagcgggaccatgagaaacaacaggaaagagtgagggaacaaatggaagtggtgaacatgtctctgagcacatctgcggactctctgacaacacctcgtctaactctttcagaacttgatgatataataaagaatgcgtcagggatttatgcagaaatagatggagccaaaagtgaactacaagtaaaactatctaacctaagtaacctcagccatgatttagtccaagaagctattgaccatgcacaggaccttcaacaagaagctaatgaattgagcaggaagttgcacagttcagatatgaacgggctggtacagaaggctttggatgcatcaaatgtctatgaaaatattgttaattatgttagtgaagccaatgaaacagcagaatttgctttgaacaccactgaccgaatttatgatgcggtgagtgggattgatactcaaatcatttaccataaagatgaaagtgagaacctcctcaatcaagccagagaactgcaagcaaaggcagagtctagcagtgatgaagcagtggctgacactagcaggcgtgtgggtggagccctagcaaggaaaagtgcccttaaaaccagactcagtgatgccgttaagcaactacaagcagcagagagaggggatgcccagcagcgcctggggcagtctagactgatcaccgaggaagccaacaggacgacgatggaggtgcagcaggccactgcccccatggccaacaatctaaccaactggtcacagaatcttcaacattttgactcttctgcttacaacactgcagtgaactctgctagggatgcagtaagaaatctgaccgaggttgtccctcagctcctggatcagcttcgtacggttgagcagaagcgacctgcaagcaacgtttctgccagcatccagaggatccgagagctcattgctcagaccagaagtgttgccagcaagatccaagtctccatgatgtttgatggccagtcagctgtggaagtgcactcgagaaccagtatggatgacttaaaggccttcacgtctctgagcctgtacatgaaaccccctgtgaagcggccggaactgaccgagactgcagatcagtttatcctgtacctcggaagcaaaaacgccaaaaaagagtatatgggtcttgcaatcaaaaatgataatctggtatacgtctataatttgggaactaaagatgtggagattcccctggactccaagcccgtcagttcctggcctgcttacttcagcattgtcaagattgaaagggtgggaaaacatggaaaggtgtttttaacagtcccgagtctaagtagcacagcagaggaaaagttcattaaaaagggggaattttcgggagatgactctctgctggacctggaccctgaggacacagtgttttatgttggtggagtgccttccaacttcaagctccctaccagcttaaacctgcctggctttgttggctgcctggaactggccactttgaataatgatgtgatcagcttgtacaactttaagcacatctataatatggacccctccacatcagtgccatgtgcccgagataagctggccttcactcagagtcgggctgccagttacttcttcgatggctccggttatgccgtggtgagagacatcacaaggagagggaaatttggtcaggtgactcgctttgacatagaagttcgaacaccagctgacaacggccttattctcctgatggtcaatggaagtatgtttttcagactggaaatgcgcaatggttacctacatgtgttctatgattttggattcagcggtggccctgtgcatcttgaagatacgttaaagaaagctcaaattaatgatgcaaaataccatgagatctcaatcatttaccacaatgataagaaaatgatcttggtagttgacagaaggcatgtcaagagcatggataatgaaaagatgaaaataccttttacagatatatacattggaggagctcctccagaaatcttacaatccagggccctcagagcacaccttcccctagatatcaacttcagaggatgcatgaagggcttccagttccaaaagaaggacttcaatttactggagcagacagaaaccctgggagttggttatggatgcccagaagactcacttatatctcgcagagcatatttcaatggacagagcttcattgcttcaattcagaaaatatctttctttgatggctttgaaggaggttttaatttccgaacattacaaccaaatgggttactattctattatgcttcagggtcagacgtgttctccatctcactggataatggtactgtcatcatggatgtaaagggaatcaaagttcagtcagtagataagcagtacaatgatgggctgtcccacttcgtcattagctctgtctcacccacaagatatgaactgatagtagataaaagcagagttgggagtaagaatcctaccaaagggaaaatagaacagacacaagcaagtgaaaagaagttttacttcggtggctcaccaatcagtgctcagtatgctaatttcactggctgcataagtaatgcctactttaccagggtggatagagatgtggaggttgaagatttccaacggtatactgaaaaggtccacacttctctttatgagtgtcccattgagtcttcaccattgtttctcctccataaaaaaggaaaaaatttatccaagcctaaagcaagtcagaataaaaagggagggaaaagtaaagatgcaccttcatgggatcctgttgctctgaaactcccagagcggaatactccaagaaactctcattgccacctttccaacagccctagagcaatagagcacgcctatcaatatggaggaacagccaacagccgccaagagtttgaacacttaaaaggagattttggtgccaaatctcagttttccattcgtctgagaactcgttcctcccatggcatgatcttctatgtctcagatcaagaagagaatgacttcatgactctatttttggcccatggccgcttggtttacatgtttaatgttggtcacaaaaaactgaagattagaagccaggagaaatacaatgatggcctgtggcatgatgtgatatttattcgagaaaggagcagtggccgactggtaattgatggtctccgagtcctagaagaaagtcttcctcctactgaagctacctggaaaatcaagggtcccatttatttgggaggtgtggctcctggaaaggctgtgaaaaatgttcagattaactccatctacagttttagtggctgtctcagcaatctccagctcaatggggcctccatcacctctgcttctcagacattcagtgtgaccccttgctttgaaggccccatggaaacaggaacttacttttcaacagaaggaggatacgtggttctagatgaatctttcaatattggattgaagtttgaaattgcatttgaagtccgtcccagaagcagttccggaaccctggtccacggccacagtgtcaatggggagtacctaaatgttcacatgaaaaatggacaggtcatagtgaaagtcaataatggcatcagagatttttccacctcagttacacccaagcagagtctctgtgatggcagatggcacagaattacagttattagagattctaatgtggttcagttggatgtggactctgaagtgaaccatgtggttggacccctgaatccaaaaccaattgatcacagggagcctgtgtttgttggaggtgttccagaatctctactgacaccacgcttggcccccagcaaacccttcacaggctgcatacgccactttgtgattgatggacacccagtgagcttcagtaaagcagccctggtcagcggcgccgtaagcatcaactcctgtccagcagcctgacatgacagagcacagctgcccaaatacaaagttctttagagcactgaaagaaacacaaagccagccaggaggaacagtaactcttccttcgggtggaagctttcatcgagttgaacaggacttaaacgaatcatcagggaccggatatttcttatttctcatttggattcttaaccttgaatccaaagtgtctgcaatggacaacaattgaaggagtggcaaacttacttgtattgagagcacacgcaattcctactggtgaaattactgtttctgtttctaataaaatagaagggattccaaataaacacttgcacacatttttgaagtgcggctagattctcagattcacctttcttccagggaagataactttcaatctatataaaaatctctgtcctaaaactacctttctttattttgaagagacttactaacttacatataatctaaattagatgatagatttgtttttagcccttttgtttggtctatcagtataagaagaatattttaggtttatagctgaagttatcaaggtttaataaagtaaatttctaacagaatactagaaaaatgcagtataatttaattttttctaaataagaaacacaggaaatcaactactttttccccttccttatctccttaaaagaaaaataaaattgtacatgagaggaggcttctgtaggttattattaccattattgtgtgttctatgggaatcattgaggatatcacagcaaaaacagtaggacaaaatcataaaattcaatttaagagtacacaagtccttttattaaaagtttgctcctagcctgggcaacataatgagatcccatctctgcaaaaaaatttgtacatgggcatacacctgtagtcccagctacttgggaggctgagacgggaggatcgcttaagctcaggagttcaaggctgcagtgagctatgactgctgactgtacctgcactccagcctgggcaacagagtgagatcctgtctcaaaaacaaagtgtgctctccacatacctgcaacacaactagtcttatttctaaaatgttataatcttttttccaagtagctacattaatatagtctagaaaaaaatggacttgaatagctggtagaatattaaaatatagaaatgaaataaaagaattatatctaaaaacctcaactcagaagacagaaaaagagaaaataggccctgatatcaacagaattaacaatacataaaaggagtaacttttgaggggagaggatataaaatattttgaggaattaccaaggggaataaaacaatgttaccttgaaatgattatatatatattacatattggtatatatgtccatacctacctatatcccctgctacccttctgtctgaaatatacaaataatgataatgttgaagatatcgataaacatagctaatgtctgttcatagaggacttactaagtgccagccaccatgataagctaaagttaattattttatttgttc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3910 -> Molecular function: GO:0005102 [receptor binding] evidence: IEA
GeneID:3910 -> Molecular function: GO:0005201 [extracellular matrix structural constituent] evidence: TAS
GeneID:3910 -> Biological process: GO:0001568 [blood vessel development] evidence: IEA
GeneID:3910 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
GeneID:3910 -> Biological process: GO:0030155 [regulation of cell adhesion] evidence: IEA
GeneID:3910 -> Biological process: GO:0030198 [extracellular matrix organization] evidence: TAS
GeneID:3910 -> Biological process: GO:0030334 [regulation of cell migration] evidence: IEA
GeneID:3910 -> Biological process: GO:0045995 [regulation of embryonic development] evidence: IEA
GeneID:3910 -> Biological process: GO:0050873 [brown fat cell differentiation] evidence: IEA
GeneID:3910 -> Cellular component: GO:0005604 [basement membrane] evidence: IDA
GeneID:3910 -> Cellular component: GO:0005605 [basal lamina] evidence: TAS
GeneID:3910 -> Cellular component: GO:0005606 [laminin-1 complex] evidence: IEA
GeneID:3910 -> Cellular component: GO:0031012 [extracellular matrix] evidence: ISS
GeneID:3910 -> Cellular component: GO:0070062 [extracellular vesicular exosome] evidence: IDA
by
@meso_cacase at
DBCLS
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