LOCUS       XM_003403700            3547 bp    mRNA    linear   PRI 30-OCT-2012
DEFINITION  PREDICTED: Homo sapiens glutamate receptor, ionotropic,
            N-methyl-D-aspartate 3B (GRIN3B), mRNA.
ACCESSION   XM_003403700
VERSION     XM_003403700.1  GI:341914127
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_001838476) annotated using gene prediction method: GNOMON,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: NCBI
            Annotation Status   :: Full annotation
            Annotation Version  :: Homo sapiens Annotation Release 104
            Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
            Annotation Method   :: Best-placed RefSeq; Gnomon
            Features Annotated  :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3547
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /sex="male"
                     /dev_stage="adult"
     gene            1..3547
                     /gene="GRIN3B"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GNOMON. Supporting evidence
                     includes similarity to: 3 ESTs, 3 Proteins"
                     /db_xref="GeneID:116444"
                     /db_xref="HGNC:16768"
                     /db_xref="MIM:606651"
     CDS             1..3417
                     /gene="GRIN3B"
                     /codon_start=1
                     /product="glutamate [NMDA] receptor subunit 3B"
                     /protein_id="XP_003403748.1"
                     /db_xref="GI:341914128"
                     /db_xref="GeneID:116444"
                     /db_xref="HGNC:16768"
                     /db_xref="MIM:606651"
                     /translation="

MCPCTLGPWTQAPSVPLHARSRTVITLSAQSSQTCSGTAAPPCVVIAGLGAMETVMTSSFRPPAPGGPTDSQRDGAGTGEAKALTSGDAGVHRARPTPPARLLGTRRPPGRSAEGASEPGRGPPPAPWSRWLXXXXXXXRAPLARARARAALARAALAPRLPHNLSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQLYFLAAATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQDPGGLVALWTSRAGRPPQLVLDLSRRDTGDAGLRARLAPMAAPVGGEAPVPAAVLLGCDIARARRVLEAVPPGPHWLLGTPLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDSEPGGASARPPPPQGAQVRPKLRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSMWLGVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGERIRLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAEAEPSGPEVEQQQQQQDQPTAPEGWKRARRAVDKERRVRFLLEPAVVVAPEADAEAEAAPREGPVWLCSNGRPPAARPTGAPQPGELQELERRIEVARERLRQALVRRGELLAQLGDSARHRPRRLLQARAAPAEAPPHSGRPGSQE

"
     misc_feature    487..1500
                     /gene="GRIN3B"
                     /note="N-terminal leucine/isoleucine/valine-binding
                     protein (LIVBP)-like domain of the NR3 subunit of NMDA
                     receptor family; Region: PBP1_iGluR_NMDA_NR3; cd06377"
                     /db_xref="CDD:107372"
     misc_feature    order(538..540,544..549,556..561,652..654,847..849,
                     856..858,892..894,898..900)
                     /gene="GRIN3B"
                     /note="putative dimerization interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:107372"
     misc_feature    1717..>1959
                     /gene="GRIN3B"
                     /note="Bacterial periplasmic transport systems use
                     membrane-bound complexes and substrate-bound,
                     membrane-associated, periplasmic binding proteins (PBPs)
                     to transport a wide variety of  substrates, such as, amino
                     acids, peptides, sugars, vitamins and inorganic...;
                     Region: PBPb; cd00134"
                     /db_xref="CDD:29040"
     misc_feature    2011..2781
                     /gene="GRIN3B"
                     /note="Ligand-gated ion channel; Region: Lig_chan;
                     pfam00060"
                     /db_xref="CDD:189368"
     misc_feature    2311..2715
                     /gene="GRIN3B"
                     /note="Eukaryotic homologues of bacterial periplasmic
                     substrate binding proteins; Region: PBPe; smart00079"
                     /db_xref="CDD:197504"
     variation       complement(3528)
                     /gene="GRIN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1058618"
ORIGIN      

atgtgcccctgcacgctgggtccttggacacaagccccctcggtgcctctccatgcccgctcccgcaccgtcatcaccctctcggcccagagctcccagacgtgctcaggcaccgcggctccaccctgcgtcgtaattgccggtctgggtgcgatggaaacagtgatgacgtcatcgttcagaccccccgcccccggaggccccacagattctcagagggacggcgccgggactggggaggccaaggcgttgacgagcggggacgccggtgtgcacagggcacgtcccactccccccgcgcggttgctgggaacccggaggccgcccgggcggagcgcggagggcgcgtcggaacctggccggggccctccacccgcgccgtggtcccggtggttgcnnnnnnnnnnnnnnnnnnnncgcgcgcctctcgcccgcgcccgcgcccgcgccgccctggcccgggccgccctggcgccgcggctgccgcacaacctgagcttggagctggtggtcgccgcgccccccgcccgcgaccccgcctcgctgacccgcggcctgtgccaggcgctggtgcctccgggcgtggcggccctgctcgcctttcccgaggctcggcccgagctgctgcagctgtacttcctggcggccgccaccgagacccccgtgctcagcctgctgcggcgggaggcgcgcgcgcccctcggagccccgaacccattccacctgcagctgcactgggctagccccctggagacgctgctggatgtgctggtggcggtgctgcaggcgcacgcctgggaagacgtcggcctggccctgtgccgcactcaggaccccggcggcctggtggccctctggacaagccgggctggccggcccccacagctggtcctggacctaagccggcgggacacgggagatgcaggactgcgggcacgcctggccccgatggcggcgccagtggggggtgaagcaccggtacccgcggcggtcctcctcggctgtgacatcgcccgtgcccgtcgggtgctggaggccgtacctcccggcccccactggctgttggggacaccactgccgcccaaggccctgcccaccgcggggctgccaccagggctgctggcgctgggcgaggtggcacgacccccgctggaggccgccatccatgacattgtgcaactggtggcccgggcgctgggcagtgcggcccaggtgcagccgaagcgagccctcctccccgccccggtcaactgcggggacctgcagccggccgggcccgagtccccggggcgcttcttggcacggttcctggccaacacgtccttccagggccgcacgggccccgtgtgggtgacaggcagctcccaggtacacatgtctcggcactttaaggtgtggagccttcgccgggacccacggggcgccccggcctgggccacggtgggcagctggcgggacggccagctggactcggaaccgggaggtgcctctgcacggcccccgcccccacagggtgcccaggtccggcccaagctgcgtgtggtaacgctgttggaacacccatttgtgtttgcccgtgatccagacgaagacgggcagtgcccagcggggcagctgtgcctggaccccggcaccaacgactcggccaccctggacgcactgttcgccgcgctggccaacggctcagcgccccgtgccctgcgcaagtgctgctacggctactgcattgacctgctggagcggctggcggaggacacgcccttcgacttcgagctgtacctcgtgggtgacggcaagtacggcgccctgcgggacggccgctggaccggcctggtcggggacctgctggccggccgggcccacatggcggtcaccagcttcagtatcaactccgcccgctcacaggtggtggacttcaccagccccttcttctccaccagcctgggcatcatggtgcgggcacgggacacggcctcacccatcggtgcctttatgtggcccctgcactggtccatgtggctgggcgtctttgcggccctgcacctcaccgcgctcttcctcaccgtgtacgagtggcgtagcccctacggcctcacgccacgtggccgcaaccgcagcaccgtcttctcctactcctcagccctcaacctgtgctacgccatcctcttcagacgcaccgtgtccagcaagacgcccaagtgccccacgggccgcctgctcatgaacctctgggccatcttctgcctgctggtgctgtccagctacacggccaacctggctgccgtcatggtcggggacaagaccttcgaggagctctcggggatccacgaccccaagctgcaccacccggcgcagggcttccgcttcggcaccgtgtgggagagcagcgccgaggcgtacatcaagaagagcttccccgacatgcacgcacacatgcggcgccacagcgcgcccaccacgccccgcggcgtcgccatgctcacgagcgacccccccaagctcaacgccttcatcatggacaagtcgctcctggactacgaggtctccatcgacgccgactgcaaactgctgaccgtgggaaagcccttcgccattgagggtgagaggatcagactgccccagaactcgccgctcacctccaacctgtccgagttcatcagccgctacaagtcctccggcttcatcgacctgctccacgacaagtggtacaagatggtgccttgcggcaagcgggtctttgcggttacagagaccctgcagatgagcatctaccacttcgcgggcctcttcgtgttgctgtgcctgggcctgggcagcgctctgctcagctcgctgggcgagcacgccttcttccgcctggcgctgccgcgcatccgcaaggggagcaggctgcagtactggctgcacaccagccagaaaatccaccgcgccctcaacacggagccaccagaggggtcgaaggaggagacggcagaggcggagcccagcggccccgaggtggagcagcagcagcagcagcaggaccagccaacggctccggagggctggaaacgggcgcgccgggccgtggacaaggagcgccgcgtgcgcttcctgctggagcccgccgtggttgtggcacccgaagcggacgcggaggcggaggctgcgccgcgagagggccccgtctggctgtgctccaacggccgcccgcccgccgcaaggcccacgggggccccccagcccggggagctgcaggagctggagcgccgcatcgaagtcgcgcgtgagcggctccgccaggccctggtgcggcgcggcgagctcctggcacagctcggggacagcgcacgtcaccggcctcggcgcttgcttcaggccagagcggcccccgcggaggccccaccacactctggccgaccggggagccaggaatgaggcggcagccgggccgtttgggctcaagacacacacacagcgcagtgagccgctgtcaacagacagtttattctatatacaaacacaattttgtacactgcaattaaatagaatggaatgagcgctcctc

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:116444 -> Molecular function: GO:0004970 [ionotropic glutamate receptor activity] evidence: IEA
            GeneID:116444 -> Molecular function: GO:0005234 [extracellular-glutamate-gated ion channel activity] evidence: IEA
            GeneID:116444 -> Molecular function: GO:0005261 [cation channel activity] evidence: ISS
            GeneID:116444 -> Molecular function: GO:0005262 [calcium channel activity] evidence: ISS
            GeneID:116444 -> Molecular function: GO:0016594 [glycine binding] evidence: ISS
            GeneID:116444 -> Molecular function: GO:0030594 [neurotransmitter receptor activity] evidence: ISS
            GeneID:116444 -> Molecular function: GO:0042165 [neurotransmitter binding] evidence: ISS
            GeneID:116444 -> Biological process: GO:0007268 [synaptic transmission] evidence: ISS
            GeneID:116444 -> Biological process: GO:0035235 [ionotropic glutamate receptor signaling pathway] evidence: ISS
            GeneID:116444 -> Biological process: GO:0051205 [protein insertion into membrane] evidence: ISS
            GeneID:116444 -> Biological process: GO:0051924 [regulation of calcium ion transport] evidence: ISS
            GeneID:116444 -> Cellular component: GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex] evidence: ISS
            GeneID:116444 -> Cellular component: GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex] evidence: NAS
            GeneID:116444 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
            GeneID:116444 -> Cellular component: GO:0043025 [neuronal cell body] evidence: ISS
            GeneID:116444 -> Cellular component: GO:0045211 [postsynaptic membrane] evidence: IEA