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2025-05-09 19:10:35, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001144878 3597 bp mRNA linear PRI 14-JUL-2013
DEFINITION Homo sapiens inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1),
transcript variant 2, mRNA.
ACCESSION NM_001144878
VERSION NM_001144878.1 GI:221625486
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3597)
AUTHORS Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K,
Buckley M, Fridley BL, Tyrer JP, Shen H, Weber R, Karevan R, Larson
MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis
J, Dicks E, Aben KK, Anton-Culver H, Antonenkova N, Armasu SM,
Baglietto L, Bandera EV, Beckmann MW, Birrer MJ, Bloom G, Bogdanova
N, Brenton JD, Brinton LA, Brooks-Wilson A, Brown R, Butzow R,
Campbell I, Carney ME, Carvalho RS, Chang-Claude J, Chen YA, Chen
Z, Chow WH, Cicek MS, Coetzee G, Cook LS, Cramer DW, Cybulski C,
Dansonka-Mieszkowska A, Despierre E, Doherty JA, Dork T, du Bois A,
Durst M, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher
D, Flanagan J, Gao YT, Garcia-Closas M, Gentry-Maharaj A, Giles G,
Gjyshi A, Gore M, Gronwald J, Guo Q, Halle MK, Harter P, Hein A,
Heitz F, Hillemanns P, Hoatlin M, Hogdall E, Hogdall CK, Hosono S,
Jakubowska A, Jensen A, Kalli KR, Karlan BY, Kelemen LE, Kiemeney
LA, Kjaer SK, Konecny GE, Krakstad C, Kupryjanczyk J, Lambrechts D,
Lambrechts S, Le ND, Lee N, Lee J, Leminen A, Lim BK, Lissowska J,
Lubinski J, Lundvall L, Lurie G, Massuger LF, Matsuo K, McGuire V,
McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod
SA, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson
S, Orlow I, Paul J, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC,
Poole EM, Qu X, Risch HA, Rodriguez-Rodriguez L, Rossing MA,
Rudolph A, Runnebaum I, Rzepecka IK, Salvesen HB, Schwaab I, Severi
G, Shen H, Shridhar V, Shu XO, Sieh W, Southey MC, Spellman P,
Tajima K, Teo SH, Terry KL, Thompson PJ, Timorek A, Tworoger SS,
van Altena AM, van den Berg D, Vergote I, Vierkant RA, Vitonis AF,
Wang-Gohrke S, Wentzensen N, Whittemore AS, Wik E, Winterhoff B,
Woo YL, Wu AH, Yang HP, Zheng W, Ziogas A, Zulkifli F, Goodman MT,
Hall P, Easton DF, Pearce CL, Berchuck A, Chenevix-Trench G,
Iversen E, Monteiro AN, Gayther SA, Schildkraut JM and Sellers TA.
CONSRTM Australian Cancer Study; Australian Ovarian Cancer Study Group
TITLE GWAS meta-analysis and replication identifies three new
susceptibility loci for ovarian cancer
JOURNAL Nat. Genet. 45 (4), 362-370 (2013)
PUBMED 23535730
REFERENCE 2 (bases 1 to 3597)
AUTHORS Singh,N., Halliday,A.C., Knight,M., Lack,N.A., Lowe,E. and
Churchill,G.C.
TITLE Cloning, expression, purification, crystallization and X-ray
analysis of inositol monophosphatase from Mus musculus and Homo
sapiens
JOURNAL Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68 (PT 10),
1149-1152 (2012)
PUBMED 23027737
REMARK GeneRIF: Comparison of MmIMPase 1 and HsIMPase 1 revealed a core
r.m.s. deviation of 0.516 A
REFERENCE 3 (bases 1 to 3597)
AUTHORS Ohnishi,T., Watanabe,A., Ohba,H., Iwayama,Y., Maekawa,M. and
Yoshikawa,T.
TITLE Behavioral analyses of transgenic mice harboring bipolar disorder
candidate genes, IMPA1 and IMPA2
JOURNAL Neurosci. Res. 67 (1), 86-94 (2010)
PUBMED 20153384
REMARK GeneRIF: The current study did not support a substantial role of
the upregulation of IMPase in bipolar disorder, although the
lithium-insensitivity trait seen in IMPA2 transgenic mice might
represent some aspect relevant to the inositol depletion
hypothesis.
REFERENCE 4 (bases 1 to 3597)
AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
Dunham,I., Hill,D.E. and Vidal,M.
TITLE hORFeome v3.1: a resource of human open reading frames representing
over 10,000 human genes
JOURNAL Genomics 89 (3), 307-315 (2007)
PUBMED 17207965
REFERENCE 5 (bases 1 to 3597)
AUTHORS Ohnishi,T., Ohba,H., Seo,K.C., Im,J., Sato,Y., Iwayama,Y.,
Furuichi,T., Chung,S.K. and Yoshikawa,T.
TITLE Spatial expression patterns and biochemical properties distinguish
a second myo-inositol monophosphatase IMPA2 from IMPA1
JOURNAL J. Biol. Chem. 282 (1), 637-646 (2007)
PUBMED 17068342
REMARK GeneRIF: IMPA2 has a separate function in vivo from that of IMPA1
REFERENCE 6 (bases 1 to 3597)
AUTHORS Bone,R., Frank,L., Springer,J.P. and Atack,J.R.
TITLE Structural studies of metal binding by inositol monophosphatase:
evidence for two-metal ion catalysis
JOURNAL Biochemistry 33 (32), 9468-9476 (1994)
PUBMED 8068621
REFERENCE 7 (bases 1 to 3597)
AUTHORS Bone,R., Frank,L., Springer,J.P., Pollack,S.J., Osborne,S.A.,
Atack,J.R., Knowles,M.R., McAllister,G., Ragan,C.I., Broughton,H.B.
et al.
TITLE Structural analysis of inositol monophosphatase complexes with
substrates
JOURNAL Biochemistry 33 (32), 9460-9467 (1994)
PUBMED 8068620
REFERENCE 8 (bases 1 to 3597)
AUTHORS Bone,R., Springer,J.P. and Atack,J.R.
TITLE Structure of inositol monophosphatase, the putative target of
lithium therapy
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (21), 10031-10035 (1992)
PUBMED 1332026
REFERENCE 9 (bases 1 to 3597)
AUTHORS McAllister,G., Whiting,P., Hammond,E.A., Knowles,M.R., Atack,J.R.,
Bailey,F.J., Maigetter,R. and Ragan,C.I.
TITLE cDNA cloning of human and rat brain myo-inositol monophosphatase.
Expression and characterization of the human recombinant enzyme
JOURNAL Biochem. J. 284 (PT 3), 749-754 (1992)
PUBMED 1377913
REFERENCE 10 (bases 1 to 3597)
AUTHORS Hallcher,L.M. and Sherman,W.R.
TITLE The effects of lithium ion and other agents on the activity of
myo-inositol-1-phosphatase from bovine brain
JOURNAL J. Biol. Chem. 255 (22), 10896-10901 (1980)
PUBMED 6253491
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC375686.1, BP270804.1,
AK300750.1, AF042729.2, BC008381.1, AI921211.1, AC090255.4 and
DB299262.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: This gene encodes an enyzme that dephosphorylates
myo-inositol monophosphate to generate free myo-inositol, a
precursor of phosphatidylinositol, and is therefore an important
modulator of intracellular signal transduction via the production
of the second messengers myoinositol 1,4,5-trisphosphate and
diacylglycerol. This enzyme can also use
myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate,
scyllo-inositol-phosphate, glucose-1-phosphate,
glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate,
and 2'-AMP as substrates. This enzyme shows magnesium-dependent
phosphatase activity and is inhibited by therapeutic concentrations
of lithium. Inhibition of inositol monophosphate hydroylosis and
subsequent depletion of inositol for phosphatidylinositol synthesis
may explain the anti-manic and anti-depressive effects of lithium
administered to treat bipolar disorder. Alternative splicing
results in multiple transcript variants encoding distinct isoforms.
A pseudogene of this gene is also present on chromosome 8q21.13.
[provided by RefSeq, Nov 2009].
Transcript Variant: This variant (2) contains an additional
in-frame coding exon compared to transcript variant 1, resulting in
an isoform (2) with a longer and a novel N-terminus compared to
isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no quality transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK300750.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-103 DC375686.1 1-103
104-586 BP270804.1 83-565
587-1251 AK300750.1 516-1180
1252-2357 AF042729.2 1022-2127
2358-2557 BC008381.1 2123-2322
2558-2900 AI921211.1 2-344 c
2901-3170 AC090255.4 36028-36297
3171-3597 DB299262.1 1-427 c
FEATURES Location/Qualifiers
source 1..3597
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q21.13-q21.3"
gene 1..3597
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/note="inositol(myo)-1(or 4)-monophosphatase 1"
/db_xref="GeneID:3612"
/db_xref="HGNC:6050"
/db_xref="MIM:602064"
exon 1..103
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/inference="alignment:Splign:1.39.8"
exon 104..304
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/inference="alignment:Splign:1.39.8"
misc_feature 146..148
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/note="upstream in-frame stop codon"
CDS 152..1162
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/EC_number="3.1.3.25"
/note="isoform 2 is encoded by transcript variant 2;
inositol monophosphatase 1; lithium-sensitive myo-inositol
monophosphatase A1; IMP 1; IMPase 1; inositol-1(or
4)-monophosphatase 1"
/codon_start=1
/product="inositol monophosphatase 1 isoform 2"
/protein_id="NP_001138350.1"
/db_xref="GI:221625487"
/db_xref="CCDS:CCDS47883.1"
/db_xref="GeneID:3612"
/db_xref="HGNC:6050"
/db_xref="MIM:602064"
/translation="
MGQRPGPVLPAVAVLGQVAKRKVAWLLRWKAVTRTETAGNSSGVYGFGKMKIFVKYFQKMADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED
"
misc_feature 350..1090
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/note="IMPase, inositol monophosphatase and related
domains. A family of Mg++ dependent phosphatases,
inhibited by lithium, many of which may act on inositol
monophosphate substrate. They dephosphorylate inositol
phosphate to generate inositol, which may be...; Region:
IMPase; cd01639"
/db_xref="CDD:30137"
misc_feature order(434..436,449..451,467..469,536..541,596..613,
983..988)
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/note="active site"
/db_xref="CDD:30137"
misc_feature order(446..448,452..454,614..619,623..640,794..802,
806..808,812..817,842..847,854..856,863..868,875..877,
890..910,932..934,944..955)
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:30137"
exon 305..391
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/inference="alignment:Splign:1.39.8"
variation 325
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:465178"
variation 328
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:459801"
exon 392..525
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/inference="alignment:Splign:1.39.8"
exon 526..630
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/inference="alignment:Splign:1.39.8"
variation 568
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:204777"
variation 582
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="a"
/replace="c"
/db_xref="dbSNP:11549154"
exon 631..676
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/inference="alignment:Splign:1.39.8"
variation 653
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:204781"
exon 677..785
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/inference="alignment:Splign:1.39.8"
variation 742
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:2230385"
exon 786..894
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/inference="alignment:Splign:1.39.8"
exon 895..1046
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/inference="alignment:Splign:1.39.8"
exon 1047..3597
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/inference="alignment:Splign:1.39.8"
variation 1314
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:2955014"
variation 2117
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:1058401"
variation 2136
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:204798"
STS 2146..2395
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/standard_name="D8S1976"
/db_xref="UniSTS:23879"
STS 2146..2287
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/standard_name="RH91172"
/db_xref="UniSTS:86946"
variation 2169
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="a"
/replace="c"
/db_xref="dbSNP:8176"
polyA_signal 2343..2348
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
polyA_site 2374
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
STS 2415..2523
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/standard_name="SGC35843"
/db_xref="UniSTS:60374"
polyA_signal 2514..2519
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
polyA_signal 2543..2548
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
polyA_site 2574
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
variation 2679
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="a"
/replace="t"
/db_xref="dbSNP:1135991"
variation 2681
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="g"
/replace="t"
/db_xref="dbSNP:1135992"
variation 2685
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:1135993"
variation 2693
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="a"
/replace="g"
/db_xref="dbSNP:1135994"
variation 2695
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="a"
/replace="t"
/db_xref="dbSNP:1135995"
variation 2716
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
/replace="c"
/replace="t"
/db_xref="dbSNP:1135997"
polyA_signal 2877..2882
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
polyA_site 2899
/gene="IMPA1"
/gene_synonym="IMP; IMPA"
ORIGIN
ttttaagggcggaacttcctgttgcgagtagcccctctacctccggaagagacgagtgcggtaacaccgttcacagagctagccggacgtcctccgactcaagctcctagaaacttggtgcatccccaggcccaggtagtcactctaagtgatggggcagcgcccaggtcctgtgctgcccgcagtcgcggtgctgggacaggtggcaaaaaggaaggtggcctggctcctacgctggaaggctgtgaccaggacagaaacagcaggaaacagttcaggtgtttatggctttgggaaaatgaaaatatttgtcaaatattttcagaagatggctgatccttggcaggaatgcatggattatgcagtaactctagcaagacaagctggagaggtagtttgtgaagctataaaaaatgaaatgaatgttatgctgaaaagttctccagttgatttggtaactgctacggaccaaaaagttgaaaaaatgcttatctcttccataaaggaaaagtatccatctcacagtttcattggtgaagaatctgtggcagctggggaaaaaagtatcttaaccgacaaccccacatggatcattgaccctattgatggaacaactaactttgtacatagatttccttttgtagctgtttcaattggctttgctgtaaataaaaagatagaatttggagttgtgtacagttgtgtggaaggcaagatgtacactgccagaaaaggaaaaggtgccttttgtaatggtcaaaaactacaagtttcacaacaagaagatattaccaaatctctcttggtgactgagttgggctcttccagaacaccagagactgtgagaatggttctttctaatatggaaaagcttttttgcattcctgttcatgggatccggagtgttggaacagcagctgttaatatgtgccttgtggcaactggcggagcagatgcatattatgaaatgggaattcactgctgggatgttgcaggagctggcattattgttactgaagctggtggcgtgctaatggatgttacaggtggaccatttgatttgatgtcacgaagagtaattgctgcaaataatagaatattagcagaaaggatagctaaagaaattcaggttatacctttgcaacgagacgacgaagattaattaaggcagcctcatagtcaatcccagttgcttttccccagatttggtgactcatcaatggatatgtgttttggatgtatgatatgcttggtttaaattctctttgtccaggtcaaaaatttggaacttgtttcttattttactatgtctaggtttgcaagaattgacataatgtttgtttcactgatttaaaaaattttgcatgtaagaatgtactttaggaaacatacccaggaagtacagttgataaatataacatcaactgaaatagtcaattagcaattttgtgtttctaaatatctatggtcccctgaaattttgacttagtatataggtgcagagacacccacttagaaagttaactgtttggaaaaacatttctctttagtttcaaaaaccatatataattaaatttgtaaggatatactgagtaccctaggccaacttttttttctttgcagagaaccttttttgttttattcttcagtgttcatatagcacctggcccattacatatctaggcaactaaaaacaaacattgtaagaatgaatatttttaatgtagtaattcctagttacaatagatacataaagtaatgaactcagcattctgtacttttgcttcaggtttgaagtaaaaattatctagttaaattttttttatttcacgttaccatgccatttcacattaccataccatcagatagcatggcttattgtgggcatttctgcagtgaatacattttccaaaacagttaaattgtctgtttggatttgctttaaagtcttgtgtaagagagaagaaactatttctataataaaaagcactctcatcagatatctgacataattagatacaatataacattttactaagttcagtattcatgttttaaaggtgtttatactgatttgattgtgctggcaaatatactgtattgttaatattgaactgtttatttttctcttagtcttcttatttaattaacttcattgccgctggattctgttcagcctttaaaaatatttcttagtggtcattgctctgcagaactcaaaaagaaaattgtacttgttcatagacatttttaaagggttaatttattgttcagccttatcccttggcacgtaaacagactactagacttattgtaggttcgtttgagctttgtgttgtaaaattaaaaatgcttctgtaaagttttcaaggtagggagtgattttattattgtgtatatctaatatattaagtatgtgtgatactaaggtttgactgctataattatttgtactgttgatcacatgtacttaaaacatctgatactgtattctaagacaggttgtttttgcaattaaatttattttaataagacgatcatgaataaaactttaaattgatatttttattattattaccattatcattattattatttttagattcagggtctcgctctgttgcccagggtctgtctctgactgtgctgtggtgcagtcatagctcactgtatccttaaattcctgggctcaagtgatcctcctctttcagtctcctgagtagctgggactataagttcatgccaccatgccctactaatgttttaattttatttttgtaaagatgggatcttcctatgttttccaggccccttggcctcccaaagtgctgggattacagatgtgagccaccgagccaggccatgatatttacattattaaagttaatagttcaaactacttttagaggctttgttttgtttttgttttttgaagacagtgtcttgctcttctgctcaaacagtaatgcagtggcatgatcaccattcattgcagtctcaaccttctgggctcaagcagtcctcccacctcagcctccctagtaactggaaccacaggcacatgccaccatgcctggctaattttttagtttttgtagagacagaatcttcctatgttgcttaggctggtctcattgggctcaagtgatcctcctgcctcagccttctaaagtgctgggattacagatgtgagccattgcacccaacatacttttagaggtttttgtgttgagttacaaatatttgaaacttgcaaatgtaatttaatatatgttcttattttttgcctgtaatctttccaacttttctaaaaacctatatttttttctacaatagcttttccatctgtttattctaaatgcagttgcatattttgtgtctgaaatttctttagatgctgaaaaaggatgatcgacaagtgaattatctaataatatttgaaaatatttctttgagtaacaggacttcttagacttaacatgtatattttgtatcagggtatattatctttctgcatgtggatacatacacagatacatacataaatatacataaatatatgtacttgaacacataaaatatatgtacttgcctttt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3612 -> Molecular function: GO:0008934 [inositol monophosphate 1-phosphatase activity] evidence: IDA
GeneID:3612 -> Molecular function: GO:0008934 [inositol monophosphate 1-phosphatase activity] evidence: IMP
GeneID:3612 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
GeneID:3612 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:3612 -> Molecular function: GO:0052832 [inositol monophosphate 3-phosphatase activity] evidence: IEA
GeneID:3612 -> Molecular function: GO:0052833 [inositol monophosphate 4-phosphatase activity] evidence: IEA
GeneID:3612 -> Biological process: GO:0006021 [inositol biosynthetic process] evidence: IEA
GeneID:3612 -> Biological process: GO:0006661 [phosphatidylinositol biosynthetic process] evidence: IMP
GeneID:3612 -> Biological process: GO:0006796 [phosphate-containing compound metabolic process] evidence: IMP
GeneID:3612 -> Biological process: GO:0007165 [signal transduction] evidence: IMP
GeneID:3612 -> Biological process: GO:0043647 [inositol phosphate metabolic process] evidence: TAS
GeneID:3612 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:3612 -> Biological process: GO:0046854 [phosphatidylinositol phosphorylation] evidence: IEA
GeneID:3612 -> Biological process: GO:0046855 [inositol phosphate dephosphorylation] evidence: IDA
GeneID:3612 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:3612 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:3612 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:3612 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:3612 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001138350 -> EC 3.1.3.25
by
@meso_cacase at
DBCLS
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