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2025-05-09 18:55:50, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015057 15025 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens MYC binding protein 2, E3 ubiquitin protein ligase
(MYCBP2), mRNA.
ACCESSION NM_015057
VERSION NM_015057.4 GI:291190786
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 15025)
AUTHORS Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
and Wijmenga,C.
TITLE Coeliac disease-associated risk variants in TNFAIP3 and REL
implicate altered NF-kappaB signalling
JOURNAL Gut 58 (8), 1078-1083 (2009)
PUBMED 19240061
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 2 (bases 1 to 15025)
AUTHORS Maeurer,C., Holland,S., Pierre,S., Potstada,W. and Scholich,K.
TITLE Sphingosine-1-phosphate induced mTOR-activation is mediated by the
E3-ubiquitin ligase PAM
JOURNAL Cell. Signal. 21 (2), 293-300 (2009)
PUBMED 19000755
REMARK GeneRIF: PAM protein activated by facilitating the GDP/GTP-exchange
of RHEBL1 protein which is an activator of mTOR protein.
REFERENCE 3 (bases 1 to 15025)
AUTHORS Gao,X. and Patel,T.B.
TITLE Histidine residues 912 and 913 in protein associated with Myc are
necessary for the inhibition of adenylyl cyclase activity
JOURNAL Mol. Pharmacol. 67 (1), 42-49 (2005)
PUBMED 15470080
REMARK GeneRIF: Identifies the region in PAM that inhibits the domain of
type V adenylyl cyclase.
REFERENCE 4 (bases 1 to 15025)
AUTHORS Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
TITLE Large-scale characterization of HeLa cell nuclear phosphoproteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
PUBMED 15302935
REFERENCE 5 (bases 1 to 15025)
AUTHORS Pierre,S.C., Hausler,J., Birod,K., Geisslinger,G. and Scholich,K.
TITLE PAM mediates sustained inhibition of cAMP signaling by
sphingosine-1-phosphate
JOURNAL EMBO J. 23 (15), 3031-3040 (2004)
PUBMED 15257286
REMARK GeneRIF: PAM the longest lasting nontranscriptional regulator of
adenylyl cyclase activity known to date and presents a novel
mechanism for the temporal regulation of cAMP signaling
REFERENCE 6 (bases 1 to 15025)
AUTHORS Murthy,V., Han,S., Beauchamp,R.L., Smith,N., Haddad,L.A., Ito,N.
and Ramesh,V.
TITLE Pam and its ortholog highwire interact with and may negatively
regulate the TSC1.TSC2 complex
JOURNAL J. Biol. Chem. 279 (2), 1351-1358 (2004)
PUBMED 14559897
REMARK GeneRIF: Pam, through its interaction with tuberin, could regulate
the ubiquitination and proteasomal degradation of the
tuberin-hamartin complex particularly in the CNS
REFERENCE 7 (bases 1 to 15025)
AUTHORS Guo,Q., Xie,J., Dang,C.V., Liu,E.T. and Bishop,J.M.
TITLE Identification of a large Myc-binding protein that contains
RCC1-like repeats
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (16), 9172-9177 (1998)
PUBMED 9689053
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL159158.12, AF075587.1, AL159154.16, AL359257.9 and AC001226.1.
On Mar 18, 2010 this sequence version replaced gi:126116564.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support ERS025081, ERS025082
[ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-569 AL159158.12 53337-53905 c
570-861 AF075587.1 335-626
862-1015 AL159158.12 5621-5774 c
1016-1698 AF075587.1 781-1463
1699-1837 AL159154.16 115378-115516 c
1838-2119 AF075587.1 1603-1884
2120-2284 AL159154.16 112155-112319 c
2285-2896 AF075587.1 2050-2661
2897-3004 AL159154.16 84883-84990 c
3005-4711 AF075587.1 2770-4476
4712-4986 AL159154.16 36830-37104 c
4987-6607 AF075587.1 4752-6372
6608-6726 AL159154.16 17000-17118 c
6727-8407 AF075587.1 6492-8172
8408-10051 AL359257.9 46474-48117 c
10052-10221 AL359257.9 45416-45585 c
10222-10466 AL359257.9 44462-44706 c
10467-11142 AF075587.1 10235-10910
11143-11303 AL359257.9 32136-32296 c
11304-14188 AF075587.1 11072-13956
14189-15025 AC001226.1 76066-76902 c
FEATURES Location/Qualifiers
source 1..15025
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q22"
gene 1..15025
/gene="MYCBP2"
/gene_synonym="PAM"
/note="MYC binding protein 2, E3 ubiquitin protein ligase"
/db_xref="GeneID:23077"
/db_xref="HGNC:23386"
/db_xref="MIM:610392"
exon 1..569
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
misc_feature 136..138
/gene="MYCBP2"
/gene_synonym="PAM"
/note="upstream in-frame stop codon"
CDS 268..14304
/gene="MYCBP2"
/gene_synonym="PAM"
/note="protein associated with Myc; myc-binding protein 2;
pam/highwire/rpm-1 protein"
/codon_start=1
/product="probable E3 ubiquitin-protein ligase MYCBP2"
/protein_id="NP_055872.4"
/db_xref="GI:291190787"
/db_xref="GeneID:23077"
/db_xref="HGNC:23386"
/db_xref="MIM:610392"
/translation="
MMMCAATASPAAASSGLGGDGFYPAATFSSSPAPGALFMPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRNKKILNKKKLKRKQKSKSKVKTRSKSENLENTVIIPDIKLHSNPSAFNIYCNVRHCVLEWQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRFSHPSLCLRSLQALLNVLQGQQPEGLQSEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALSCACLFSLVASWGETGRTLQAISAILTNNGSHACQTIQVPTILNSLQRSVQAVLVGKIQIQDWFSNGIKKAALMHKWPLKEISVDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGHIYNSTSRIRNRKEKKSWLGYAQGYLLYRDVNNHSMTAIRISPETLEQDGTVMLPDCHTEGQNILFTDGEYINQIAASRDDGFVVRIFATSTEPVLQQELQLKLARKCLHACGISLFDLEKDLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGESGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPGVNIEEHLQLRQEEKRQRVIRRHRLEEGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEALINSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFNDSEQEDLQGFGVCLDPVYDVIWRFRPNTRELWCYNAVVADARLPSAADMQSRCSILSPELALPTGSRALTTRSHAALHILGCLDTLAAMQDLKMGVASTEEETQAVMKVYSKEDYSVVNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQIPQLLYRLPTSDGSASKGKQQTSEPVHILKRSFARTVSVECFESLLSILHWSWTTLVLGVEELRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCEIYPVSATGKAVVEETSKLAECIGKTRTLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAVLQECHNTFTACFHSFYPTPALQWACLCDLLNCLDQDIQEANFKTSSSRLLAAVMSALCHTSVKLTSIFPIAYDGEVLLRSIVKQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMTSFREVLEKMLVIVVLPVRNSLRRENELFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSLHSVKASANRFTKTSQGRSWNTGNGSPDAICFSVDKPGIVVVGFSVYGGGGIHEYELEVLVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGSRTANGDGGMTTVQCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSKANEEDKNCSRALSVVSTVVRASKDLLHRALAVDADDIPELLSSSSLFSMLLPLIIAYIGPVAAAIPKVAVEVFGLVQQLLPSVAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTTSSHYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQNSGYGPKLTSVHENLNSWIELKKFSGSSGWPTMVLVLPGNEALFSLETASDYVKDDKASFYGFKCFAIGYEFSPGPDEGVIQLEKELANLGGVCAAALMKKDLALPIGNELEEDLEILEEAALQVCKTHSGILGKGLALSHSPTILEALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARWLQPDSYADPQKTSLILNKDDIRCGWPTTITVQTKDQYGDVVHVPNMKVEVKAVPVSQKKMSLQQDQAKKPQRIPGSPAVTAASSNTDMTYGGLASPKLDVSYEPMIVKEARYIAITMMKVYENYSFEELRFASPTPKRPSENMLIRVNNDGTYCANWTPGAIGLYTLHVTIDGIEIDAGLEVKVKDPPKGMIPPGTQLVKPKSEPQPNKVRKFVAKDSAGLRIRSHPSLQSEQIGIVKVNGTITFIDEIHNDDGVWLRLNDETIKKYVPNMNGYTEAWCLSFNQHLGKSLLVPVDESKTNTDDFFKDINSCCPQEATMQEQDMPFLRGGPGMYKVVKTGPSGHNIRSCPNLRGIPIGMLVLGNKVKAVGEVTNSEGTWVQLDQNSMVEFCESDEGEAWSLARDRGGNQYLRHEDEQALLDQNSQTPPPSPFSVQAFNKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKHSRSLKPDGRMSRTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLSSPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPDTLRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRAPSPHVVQENLHSEVVEVCTSSTLKTNSLTDSTCDDSSEFKSVDEGSNKVHFSIGKAPLKDEQEMRASPKISRKCANRHTRPKKEKSSFLFKGDGSKPLEPAKQAMSPSVAECARAVFASFLWHEGIVHDAMACSSFLKFHPELSKEHAPIRSSLNSQQPTEEKETKLKNRHSLEISSALNMFNIAPHGPDISKMGSINKNKVLSMLKEPPLHEKCEDGKTETTFEMSMHNTMKSKSPLPLTLQHLVAFWEDISLATIKAASQNMIFPSPGSCAVLKKKECEKENKKSKKEKKKKEKAEVRPRGNLFGEMAQLAVGGPEKDTICELCGESHPYPVTYHMRQAHPGCGRYAGGQGYNSIGHFCGGWAGNCGDGGIGGSTWYLVCDRCREKYLREKQAAAREKVKQSRRKPMQVKTPRALPTMEAHQVIKANALFLLSLSSAAEPSILCYHPAKPFQSQLPSVKEGISEDLPVKMPCLYLQTLARHHHENFVGYQDDNLFQDEMRYLRSTSVPAPYISVTPDASPNVFEEPESNMKSMPPSLETSPITDTDLAKRTVFQRSYSVVASEYDKQHSILPARVKAIPRRRVNSGDTEVGSSLLRHPSPELSRLISAHSSLSKGERNFQWPVLAFVIQHHDLEGLEIAMKQALRKSACRVFAMEAFNWLLCNVIQTTSLHDILWHFVASLTPAPVEPEEEEDEENKTSKENSEQEKDTRVCEHPLSDIVIAGEAAHPLPHTFHRLLQTISDLMMSLPSGSSLQQMALRCWSLKFKQSDHQFLHQSNVFHHINNILSKSDDGDSEESFSISIQSGFEAMSQELCIVMCLKDLTSIVDIKTSSRPAMIGSLTDGSTETFWESGDEDKNKTKNITINCVKGINARYVSVHVDNSRDLGNKVTSMTFLTGKAVEDLCRIKQVDLDSRHIGWVTSELPGGDNHIIKIELKGPENTLRVRQVKVLGWKDGESTKIAGQISASVAQQRNCEAETLRVFRLITSQVFGKLISGDAEPTPEQEEKALLSSPEGEEKVYNATSDADLKEHMVGIIFSRSKLTNLQKQVCAHIVQAIRMEATRVREEWEHAISSKENANSQPNDEDASSDAYCFELLSMVLALSGSNVGRQYLAQQLTLLQDLFSLLHTASPRVQRQVTSLLRRVLPEVTPSRLASIIGVKSLPPADISDIIHSTEKGDWNKLGILDMFLGCIAKALTVQLKAKGTTITGTAGTTVGKGVTTVTLPMIFNSSYLRRGESHWWMKGSTPTQISEIIIKLIKDMAAGHLSEAWSRVTKNAIAETIIALTKMEEEFRSPVRCIATTRLWLALASLCVLDQDHVDRLSSGRWMGKDGQQKQMPMCDNHDDGETAAIILCNVCGNLCTDCDRFLHLHRRTKTHQRQVFKEEEEAIKVDLHEGCGRTKLFWLMALADSKTMKAMVEFREHTGKPTTSSSEACRFCGSRSGTELSAVGSVCSDADCQEYAKIACSKTHPCGHPCGGVKNEEHCLPCLHGCDKSATSLKQDADDMCMICFTEALSAAPAIQLDCSHIFHLQCCRRVLENRWLGPRITFGFISCPICKNKINHIVLKDLLDPIKELYEDVRRKALMRLEYEGLHKSEAITTPGVRFYNDPAGYAMNRYAYYVCYKCRKAYFGGEARCDAEAGRGDDYDPRELICGACSDVSRAQMCPKHGTDFLEYKCRYCCSVAVFFCFGTTHFCNACHDDFQRMTSIPKEELPHCPAGPKGKQLEGTECPLHVVHPPTGEEFALGCGVCRNAHTF
"
misc_feature 2314..2403
/gene="MYCBP2"
/gene_synonym="PAM"
/note="Regulator of chromosome condensation (RCC1) repeat;
Region: RCC1_2; pfam13540"
/db_xref="CDD:205718"
misc_feature 3094..3180
/gene="MYCBP2"
/gene_synonym="PAM"
/note="Regulator of chromosome condensation (RCC1) repeat;
Region: RCC1_2; pfam13540"
/db_xref="CDD:205718"
misc_feature 3139..3285
/gene="MYCBP2"
/gene_synonym="PAM"
/note="Regulator of chromosome condensation (RCC1) repeat;
Region: RCC1; pfam00415"
/db_xref="CDD:201217"
misc_feature 3247..3333
/gene="MYCBP2"
/gene_synonym="PAM"
/note="Regulator of chromosome condensation (RCC1) repeat;
Region: RCC1_2; pfam13540"
/db_xref="CDD:205718"
misc_feature 3970..4425
/gene="MYCBP2"
/gene_synonym="PAM"
/note="PHR domain; Region: PHR; pfam08005"
/db_xref="CDD:191925"
misc_feature 5443..5919
/gene="MYCBP2"
/gene_synonym="PAM"
/note="PHR domain; Region: PHR; pfam08005"
/db_xref="CDD:191925"
misc_feature <7447..7602
/gene="MYCBP2"
/gene_synonym="PAM"
/note="Filamin-type immunoglobulin domains; Region:
IG_FLMN; smart00557"
/db_xref="CDD:197788"
misc_feature 11509..>11787
/gene="MYCBP2"
/gene_synonym="PAM"
/note="APC10-like DOC1 domains in E3 ubiquitin ligases
that mediate substrate ubiquitination; Region: APC10-like;
cl02148"
/db_xref="CDD:176595"
misc_feature order(11569..11571,11659..11661,11680..11682,11686..11688)
/gene="MYCBP2"
/gene_synonym="PAM"
/note="putative ligand binding site [chemical binding];
other site"
/db_xref="CDD:176482"
misc_feature 13540..13704
/gene="MYCBP2"
/gene_synonym="PAM"
/note="Zinc finger, C3HC4 type (RING finger); Region:
zf-C3HC4_2; pfam13923"
/db_xref="CDD:206094"
misc_feature 13546..13713
/gene="MYCBP2"
/gene_synonym="PAM"
/note="RING-finger (Really Interesting New Gene) domain, a
specialized type of Zn-finger of 40 to 60 residues that
binds two atoms of zinc; defined by the 'cross-brace'
motif C-X2-C-X(9-39)-C-X(1-3)-
H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
in...; Region: RING; cd00162"
/db_xref="CDD:29102"
misc_feature order(13549..13551,13558..13560,13603..13605,13609..13611,
13618..13620,13627..13629,13690..13692,13699..13701)
/gene="MYCBP2"
/gene_synonym="PAM"
/note="cross-brace motif; other site"
/db_xref="CDD:29102"
exon 570..645
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 646..861
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 862..1015
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 1016..1212
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 1213..1455
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 1456..1527
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 1528..1624
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 1625..1698
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 1699..1837
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 1838..1914
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 1915..2119
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 2120..2284
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 2285..2443
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 2444..2648
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 2649..2794
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 2795..2896
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 2897..3004
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 3005..3124
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 3125..3206
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 3207..3324
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 3325..3529
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 3530..3683
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 3684..3856
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 3857..3982
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 3983..4110
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 4111..4202
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 4203..4337
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 4338..4421
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 4422..4518
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 4519..4711
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 4712..4986
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 4987..5208
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 5209..5400
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 5401..5607
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 5608..5739
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 5740..5918
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 5919..6061
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 6062..6162
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 6163..6381
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 6382..6607
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 6608..6726
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 6727..6814
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 6815..6864
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 6865..7037
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 7038..7182
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 7183..7398
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 7399..7454
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 7455..7570
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 7571..7668
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 7669..7785
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 7786..7926
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 7927..8151
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 8152..8284
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 8285..8407
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 8408..10051
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
variation 9681
/gene="MYCBP2"
/gene_synonym="PAM"
/replace="c"
/replace="t"
/db_xref="dbSNP:11400"
exon 10052..10221
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 10222..10466
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 10467..10634
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 10635..10792
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 10793..10992
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 10993..11142
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 11143..11303
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 11304..11460
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 11461..11685
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 11686..11751
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 11752..11991
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 11992..12090
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 12091..12171
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 12172..12438
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
variation 12412
/gene="MYCBP2"
/gene_synonym="PAM"
/replace="a"
/replace="c"
/db_xref="dbSNP:78239717"
exon 12439..12722
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 12723..12819
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 12820..12939
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 12940..13041
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 13042..13170
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 13171..13303
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 13304..13407
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 13408..13596
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 13597..13704
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 13705..13914
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 13915..14022
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
exon 14023..14188
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
variation 14096
/gene="MYCBP2"
/gene_synonym="PAM"
/replace="g"
/replace="t"
/db_xref="dbSNP:201978264"
exon 14189..15025
/gene="MYCBP2"
/gene_synonym="PAM"
/inference="alignment:Splign:1.39.8"
variation 14764
/gene="MYCBP2"
/gene_synonym="PAM"
/replace="a"
/replace="t"
/db_xref="dbSNP:199599409"
STS 14783..14995
/gene="MYCBP2"
/gene_synonym="PAM"
/standard_name="WI-21663"
/db_xref="UniSTS:74414"
ORIGIN
cggcggcagtggcggcaccgcctcctcctcacattcccggggtggcggggttagatgagcggccccagtagcggcgagggcggcgcgggggggaggaggagaagaaggaggaggagaaggaggtcgctgtctttgtagtctccctgctgcgggagccagaggccgccgccggagccgtcgtcgttggaaaagggctgtgtgtgcgcgcgcgtgtctgcccgcccggcccgcggggacgaggcggcggcggcggcggcggcggcgaggatgatgatgtgcgcagcgactgcctcccccgccgccgcctcctcggggctcggcggggacggattctacccagccgccaccttctcttcctccccggcgccgggggcgctgttcatgccggttcccgacggctccgtggctgctgcggggctggggctggggctacccgccgcggactcccggggtcactaccagctgctgctgtcaggccgggccctggccgaccgctaccggaggatttataccgctgcgctcaatgacagggaccaggggggcggcagcgctggacacccagcctccaggaataagaaaattttaaataagaagaaattgaaaagaaaacagaagagcaaatcaaaagtgaagacaagaagcaagtctgaaaacttagagaatacagtaatcataccagatatcaaactacatagcaatccttctgctttcaatatttactgtaatgtacgccattgcgttctggaatggcagaaaaaggaaatatcattggcagccgcatctaagaactctgtgcagagtggagaatcagatagtgatgaagaagaggaatccaaagagccccctatcaagcttccaaagattattgaggttggcctttgtgaagtttttgaattgatcaaagagacacgattttctcatccatccctgtgtctcaggagtctccaagccctgctcaacgtgctgcagggccagcagccagaaggcctccagtctgagccacctgaggtcctagagtctctcttccagcttcttttggaaatcaccgttcgaagtactgggatgaatgacagcacaggacagtccttaacagcactttcctgtgcttgcctctttagtctggtggcttcttggggagaaacaggaaggacacttcaggccatctctgctatcctcaccaacaatggaagccatgcttgccaaactattcaggtgccaacaattctaaattcgctacagagaagtgtacaagcagttttggtgggaaaaattcaaattcaggactggtttagtaatggcattaagaaagcagctttaatgcacaagtggccattaaaagaaatatctgttgatgaagatgaccaatgtctacttcagaatgatggattttttctttatctattatgcaaggatggattatataaaataggctctggatacagtggaacagttaggggccatatatacaattctacatcccgtattagaaacagaaaagaaaaaaagtcttggttagggtatgctcagggttatttattatatagagatgtgaataaccacagcatgacagccataaggataagccctgaaacactggagcaagatggtactgtgatgttaccagattgccacactgaaggtcaaaatattttattcactgatggagaatatattaatcagatagctgcttcaagagatgatggctttgttgtcagaatatttgccacaagcactgaacctgttctacagcaagaattgcaacttaaactggctagaaaatgcttacatgcctgtggtatctcactattcgatctggaaaaggacttgcatattataagtacaggatttgatgaggagtcagcaattcttggtgcaggacgagagtttgcgctaatgaaaacagcaaatggaaagatatattacactggcaaataccagagtcttggaatcaaacaaggtggtccttcagcaggaaaatgggttgagctaccaattacaaaatctccaaagatagtacacttctcagttggacacgatggctctcacgcccttttagttgcagaagatgggagcatattctttacaggatctgctagtaaaggagaagatggagaatcaactaagagcagacggcaatccaaaccttataaacctaaaaagataattaagatggaaggaaagattgtggtatatacagcctgcaataatggaagtagttctgttatttctaaagatggagaactctacatgtttggaaaagatgccatttactctgatagttcaagtttggtaactgatttgaagggccattttgtaactcaggtagctatgggcaaagctcacacttgtgttttaatgaagaatggagaggtgtggacatttggtgtaaataataaaggacagtgtggacgagatactggtgccatgaaccaaggtgggaaagggtttggagttgaaaatatggcaacagcaatggatgaagacctggaagaagaactagatgaaaaagatgagaagtctatgatgtgccctccaggcatgcacaaatggaagctggagcagtgcatggtttgcactgtctgtggagactgtacaggttatggagccagctgtgtcagtagtggacggccagacagagtccccggagggatctgtggttgtggttccggagaatctggttgtgctgtgtgtggatgttgcaaggcctgtgcaagagagttagatggtcaagaggcaagacaaagaggaattcttgatgcagtgaaagaaatgatacctttagatcttcttttagctgtcccagtgcccggggttaacattgaagaacaccttcagttacgacaagaagaaaaacggcaacgtgtaatcagaaggcacagattagaggaaggaagaggcccccttgtatttgctggtcctatttttatgaaccatcgagaacaggctctagccagactcagatcccatccagcacagctaaagcataaacgggacaagcacaaagatggaagtggagaaagaggcgaaaaggatgcaagcaaaatcacaacataccctccaggctctgtgcgatttgactgtgagctccgggcagtccaagtcagctgtggatttcaccattcagtggttttaatggaaaatggagatgtctatacatttggttatgggcagcatgggcagctaggacatggagatgtcaactccaggggatgtcccactcttgttcaagcattgccaggccctagcacacaagtcactgcaggcagcaaccatacggcagtacttttaatggatggacaggtcttcacatttggaagtttttctaaaggacaactgggcagaccaattttggatgtgccatattggaatgcaaagccagctcccatgcctaacattggatcaaaatatggaagaaaagctacttggataggtgcaagtggggaccaaacttttttacgaattgatgaagcacttattaattctcatgtacttgctacatcagaaatttttgccagtaaacacataataggcttggtacctgcttctatatcagaacctcctccatttaaatgccttctgataaataaagtggatgggagttgtaaaacttttaatgactcagaacaagaggatctgcaaggatttggtgtgtgtcttgatcctgtatatgatgtaatttggaggtttcgaccaaatactagagagctgtggtgttacaatgcggtggttgctgatgccaggcttccctctgcagcagacatgcagtccagatgtagtatcctaagtcctgaacttgccttaccaacaggatcaagggccctcactacccgatctcatgcagctttgcacattttaggttgtcttgataccttggcagctatgcaggacttaaaaatgggtgttgcaagtacagaggaagagactcaagcagtaatgaaggtttattctaaagaagattatagtgtggtaaacaggtttgaaagtcatggaggaggctggggttattctgcccattcagtagaagctatacgtttcagtgccgacactgatattttacttggtggtcttggtctgtttggaggtagaggagaatatactgctaaaattaagctgtttgaattgggtcctgatggaggagatcatgaaactgatggtgaccttcttgcagagactgatgtattggcttatgactgtgctgctagagaaaaatatgcaatgatgtttgatgagcctgttctcctgcaagctgggtggtggtatgtggcatgggcccgagtgtcaggacccagcagtgactgtggatctcatggacaggcatctattaccacagatgatggggttgttttccagttcaagagttcaaagaaatcaaataatggtacagatgttaatgcgggtcagatacctcagttattatacagacttccaaccagtgatggcagtgcttcaaaaggcaaacagcaaaccagtgaacctgtacacattttaaagaggtcttttgcaagaactgtctcagtggaatgttttgagtcattgttgagtattcttcactggagctggaccaccttagtcttaggagttgaagaacttagaggattaaaaggattccagttcacagctacactcctagatttagagagactgcgctttgtgggtacctgttgtctgaggttattgcgtgtctatacctgtgaaatttacccagtgtcagctacaggaaaagcagttgtagaagaaactagcaaattagcagagtgtattggaaaaaccagaactttgttaagaaaaattttatcagaaggagttgatcactgcatggtgaaattggataatgatcctcaaggatatctcagtcaacccttgagtcttctagaagctgtccttcaggaatgtcataatactttcactgcctgctttcattctttctacccaactcctgccttacagtgggcttgcctttgtgatctgctgaattgtttggatcaggatatccaagaagcaaacttcaagacatcaagtagccgactccttgcagctgttatgtcagctctgtgtcacacgtctgttaagctgacttccatcttcccgattgcgtatgatggagaagtattactacgatcaattgttaaacaagttagtacagagaacgactcaacactagttcatcgttttccccttttggtggcacatatggaaaaactcagccagagtgaagagaatatctcagggatgacaagcttccgtgaagttctggagaaaatgctggtcattgttgtgctaccagtcaggaacagcctgaggagagaaaatgaactcttctcctcccacctcgtctctaacacctgtggattactggccagcattgtcagtgaactgacagcgtcagccctgggatctgaggttgatggacttaattctcttcactctgtaaaagctagtgctaaccgatttacaaaaacaagtcagggcagaagttggaacactgggaacgggtcccctgatgcaatctgtttttcagtagacaaacctggaatagttgtggttggtttctctgtctatggaggaggtggaattcatgaatatgaattagaggtgttggttgatgatagtgaacatgcaggagattcaactcattcccacagatggacatctctggaattagtgaaaggaacgtacacaacggatgactcacccagtgatatagctgagatcagacttgacaaagtggttcctttaaaggaaaatgttaaatatgctgtgcgcttgaggaactatggaagccgtacagccaatggagatggaggaatgaccacagttcagtgccctgatggtgtgacattcacattcagcacgtgcagcttgagcagtaacggcacaaaccaaaccagaggacagatcccacagatactctactataggagtgaatttgatggagatttacaatcccaacttctgagtaaagccaatgaagaagataaaaactgtagcagagcattgtctgttgtaagcactgtcgttcgagcctctaaggacctcctgcacagagctcttgctgtggatgctgatgacattccagaactgctgagttcttccagtctgttttccatgctgctcccccttattatagcctacataggaccagtagctgctgctattcccaaggtggctgtagaagtctttggccttgtccaacaattgcttccgtcagttgccattttgaatcagaagtatgcaccgcctgccttcaaccctaatcagtcgacagatagcaccacaggaaaccagcctgaacagggcctctctgcttgtacaacctccagtcactatgctgtcatagagagtgagcacccgtataaacctgcctgtgtgatgcattacaaggtgacattcccagaatgtgtgaggtggatgacaatcgaatttgaccctcagtgtggtactgcacagtcagaagatgtccttcgtttgttgattcctgtcagaactgttcagaattcaggatatggaccaaaattgacatctgttcatgaaaatcttaattcatggatagaattaaagaaattttcaggatcctctgggtggcctactatggttttggtgttgccaggaaatgaggcccttttttcattggagactgcatcagattatgtgaaagatgacaaagcttctttctatggttttaagtgttttgcaattggatatgaatttagccctggacctgatgagggagtcatccaattggaaaaagaattagccaatcttggtggggtttgtgcagcagctctgatgaagaaggacctagcacttcctattggtaatgaattagaagaagaccttgaaattcttgaggaggctgcattgcaggtgtgcaaaacccattctggaattcttggaaagggtctagctctttctcattcaccaactatattagaagcacttgagggaaatttaccactccaaatccaaagcaatgaacagtcttttctggatgattttattgcctgtgtcccaggatcaagtggtggaaggcttgcaaggtggcttcagccagattcatatgcggatcctcagaaaacatctttgatcctgaataaggatgatattcgttgtggttggcctaccaccataactgttcaaacaaaagaccagtatggggatgtggtacatgttcccaatatgaaggtggaagtgaaagctgtccctgtttctcagaaaaaaatgtctttacaacaagatcaagcaaagaaacctcaaaggattcctggcagtcctgcagtaacagctgcatcttctaatactgacatgacttatggagggctggcatcaccaaagctagatgtttcatatgaaccaatgatagtgaaggaagctcgatatattgccataacaatgatgaaggtttatgaaaattattcatttgaagaactacgttttgcatcaccaactcctaagagacccagtgagaatatgctgatccgtgtcaataatgatgggacttattgtgcaaattggactccaggggctattggactctacactcttcatgttaccattgatggcattgaaatcgatgctggtctggaagtaaaagtaaaagacccaccaaaagggatgataccaccaggaactcagttggtcaaaccaaagtctgaacctcagcctaataaggttcgaaaatttgtggccaaggacagtgcggggcttcgcatccgtagccacccttcccttcagagtgagcagataggcatagtgaaagtcaatggaactatcacttttattgatgagatccataatgatgatggtgtgtggctgaggctgaatgatgagacaataaagaagtatgtccctaacatgaatggttacactgaagcctggtgcctctcttttaatcaacatcttggcaagagtcttctggtccctgttgacgaatctaaaactaatactgatgactttttcaaagacataaactcctgctgcccacaggaagcaacaatgcaagaacaagatatgccattcttgcgaggagggccaggcatgtacaaggtagtgaagacgggaccttcaggtcacaacatcagaagctgccctaaccttagaggtatcccaattggaatgttagttctgggaaacaaagtcaaagcagtgggagaggtaaccaattctgaagggacatgggtgcaactggatcagaacagcatggtagagttctgtgagagtgatgaaggagaggcatggtccttagctagagacagaggcggaaaccagtacctccgacatgaagatgaacaagctcttctggatcagaattctcaaactcctcctccaagccctttctcagtgcaagcttttaataaaggggcaagttgcagtgcccaaggatttgattatggactcggaaatagcaaaggtgatcgaggaaacatctcaacatcttctaaaccagcctctacatcaggaaaatcagagctgtcctctaaacacagcagatcgcttaaacctgatggacgtatgagccggactactgctgatcagaagaagccaaggggcacagaaagtttatctgctagtgaatccctcatcttaaaatctgatgctgcaaagttgaggtcagattcccacagtaggtcattatcccccaaccataacaccttgcagacattgaaatctgatgggaggatgccttctagctccagagctgaatccccaggaccaggttctcggttgtcatctcctaagccaaagactctcccagccaataggtctagcccatcgggtgctagttctccacgctcctcctcaccacatgataaaaatctacctcaaaaaagtactgctcctgttaagacaaagcttgatcctcctcgggaacgttctaaatcagactcttacacacttgatccagataccctccgcaagaagaaaatgcccctcacagaacctttgagaggacggtcaacgtcaccaaaaccaaaatcagtaccaaaggattctacagattcccctggatctgaaaatagagctccctctccccatgtggtacaggaaaacctccacagtgaggtggtcgaagtctgcacctcaagtactttaaaaacaaatagtctaacagacagcacctgcgatgacagcagtgaatttaagagtgtggatgaaggttcaaataaagttcattttagcattggaaaagcaccactgaaagatgaacaggaaatgagagcatctcccaaaataagtcgaaaatgtgctaatagacacaccaggcccaaaaaagaaaaatcgagttttcttttcaaaggagatggatccaagcctttagagccagccaagcaagccatgtctccttctgtggccgaatgtgccagagctgtgtttgcttccttcctctggcatgaaggcatagtacatgatgcaatggcttgttcttctttcctaaagtttcatcctgaactttccaaagaacatgctcctataaggagtagtttaaatagccaacaacctacagaggaaaaagaaaccaagttaaaaaatagacattcattagaaatatcatctgcactgaatatgtttaatattgcaccccatggaccagatatatctaagatgggtagcatcaacaaaaacaaggtattgtctatgcttaaggaaccacctctgcatgaaaaatgtgaggatgggaaaaccgagaccacttttgaaatgtccatgcataacacaatgaagtctaagtctcctcttcccttaactttacaacatttagtggctttttgggaagacatctctttggctactatcaaagctgcttcccagaatatgatttttccaagtcctggttcctgtgcagttcttaaaaagaaagagtgtgagaaagagaataagaagtccaaaaaggaaaaaaagaaaaaagaaaaggcagaagttaggcccaggggtaatttgtttggagagatggcccagctggcagtaggaggaccagagaaagataccatctgtgaactgtgtg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catttttatacagtgataaagtcta
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23077 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IEA
GeneID:23077 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:23077 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IEA
GeneID:23077 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:23077 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:23077 -> Biological process: GO:0021785 [branchiomotor neuron axon guidance] evidence: IEA
GeneID:23077 -> Biological process: GO:0021952 [central nervous system projection neuron axonogenesis] evidence: IEA
GeneID:23077 -> Biological process: GO:0032880 [regulation of protein localization] evidence: IEA
GeneID:23077 -> Biological process: GO:0051493 [regulation of cytoskeleton organization] evidence: IEA
GeneID:23077 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:23077 -> Cellular component: GO:0015630 [microtubule cytoskeleton] evidence: IEA
GeneID:23077 -> Cellular component: GO:0030424 [axon] evidence: IEA
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