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2025-05-09 18:47:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_205845 3521 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens aldo-keto reductase family 1, member C2 (AKR1C2),
transcript variant 2, mRNA.
ACCESSION NM_205845 XM_001128335 XM_001128348 XM_001128387 XM_001128420
VERSION NM_205845.2 GI:359751396
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3521)
AUTHORS Kuang,P., Zhou,C., Li,X., Ren,S., Li,B., Wang,Y., Li,J., Tang,L.,
Zhang,J. and Zhao,Y.
TITLE Proteomics-based identification of secreted protein dihydrodiol
dehydrogenase 2 as a potential biomarker for predicting cisplatin
efficacy in advanced NSCLC patients
JOURNAL Lung Cancer 77 (2), 427-432 (2012)
PUBMED 22534668
REMARK GeneRIF: DDH2 expression might be a potential predictor and monitor
of cisplatin efficacy in advanced NSCLC patients.
REFERENCE 2 (bases 1 to 3521)
AUTHORS Veilleux,A., Cote,J.A., Blouin,K., Nadeau,M., Pelletier,M.,
Marceau,P., Laberge,P.Y., Luu-The,V. and Tchernof,A.
TITLE Glucocorticoid-induced androgen inactivation by aldo-keto reductase
1C2 promotes adipogenesis in human preadipocytes
JOURNAL Am. J. Physiol. Endocrinol. Metab. 302 (8), E941-E949 (2012)
PUBMED 22275760
REMARK GeneRIF: Data suggest that modulation of AKR1C2 by glucocorticoids
(dexamethasone in this study) locally modifies exposure of adipose
cells to endogenous androgens; thus, AKR1C2 activation/inactivation
may be involved in regional fat deposition.
REFERENCE 3 (bases 1 to 3521)
AUTHORS Roberson,A.E., Hyatt,K., Kenkel,C., Hanson,K. and Myers,D.A.
TITLE Interleukin 1beta regulates progesterone metabolism in human
cervical fibroblasts
JOURNAL Reprod Sci 19 (3), 271-281 (2012)
PUBMED 22064385
REMARK GeneRIF: Data suggest that interleukin-1beta facilitates
progesterone metabolism in cervical fibroblasts by regulating
expression of AKR1C1 and AKR1C2.
Erratum:[Reprod Sci. 2012 Jun;19(6):666]
REFERENCE 4 (bases 1 to 3521)
AUTHORS Jin,Y., Mesaros,A.C., Blair,I.A. and Penning,T.M.
TITLE Stereospecific reduction of 5beta-reduced steroids by human
ketosteroid reductases of the AKR (aldo-keto reductase)
superfamily: role of AKR1C1-AKR1C4 in the metabolism of
testosterone and progesterone via the 5beta-reductase pathway
JOURNAL Biochem. J. 437 (1), 53-61 (2011)
PUBMED 21521174
REMARK GeneRIF: role of AKR1C2 in the metabolism of testosterone and
progesterone via the 5beta-reductase pathway.
REFERENCE 5 (bases 1 to 3521)
AUTHORS Basehore,H.K. and Ropson,I.J.
TITLE Residual interactions in unfolded bile acid-binding protein by 19F
NMR
JOURNAL Protein Sci. 20 (2), 327-335 (2011)
PUBMED 21280124
REMARK GeneRIF: The folding initiation mechanism of human bile
acid-binding protein (BABP) has been examined by (19) F NMR.
REFERENCE 6 (bases 1 to 3521)
AUTHORS Khanna,M., Qin,K.N., Klisak,I., Belkin,S., Sparkes,R.S. and
Cheng,K.C.
TITLE Localization of multiple human dihydrodiol dehydrogenase (DDH1 and
DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by
the polymerase chain reaction and fluorescence in situ
hybridization
JOURNAL Genomics 25 (2), 588-590 (1995)
PUBMED 7789999
REFERENCE 7 (bases 1 to 3521)
AUTHORS Qin,K.N., Khanna,M. and Cheng,K.C.
TITLE Structure of a gene coding for human dihydrodiol dehydrogenase/bile
acid-binding protein
JOURNAL Gene 149 (2), 357-361 (1994)
PUBMED 7959017
REFERENCE 8 (bases 1 to 3521)
AUTHORS Ciaccio,P.J. and Tew,K.D.
TITLE cDNA and deduced amino acid sequences of a human colon dihydrodiol
dehydrogenase
JOURNAL Biochim. Biophys. Acta 1186 (1-2), 129-132 (1994)
PUBMED 8011662
REFERENCE 9 (bases 1 to 3521)
AUTHORS Qin,K.N., New,M.I. and Cheng,K.C.
TITLE Molecular cloning of multiple cDNAs encoding human enzymes
structurally related to 3 alpha-hydroxysteroid dehydrogenase
JOURNAL J. Steroid Biochem. Mol. Biol. 46 (6), 673-679 (1993)
PUBMED 8274401
REFERENCE 10 (bases 1 to 3521)
AUTHORS Winters,C.J., Molowa,D.T. and Guzelian,P.S.
TITLE Isolation and characterization of cloned cDNAs encoding human liver
chlordecone reductase
JOURNAL Biochemistry 29 (4), 1080-1087 (1990)
PUBMED 2187532
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA451165.1, BC063574.1,
BC007024.1, AL713867.6 and CA450425.1.
On Dec 9, 2011 this sequence version replaced gi:45446744.
Summary: This gene encodes a member of the aldo/keto reductase
superfamily, which consists of more than 40 known enzymes and
proteins. These enzymes catalyze the conversion of aldehydes and
ketones to their corresponding alcohols using NADH and/or NADPH as
cofactors. The enzymes display overlapping but distinct substrate
specificity. This enzyme binds bile acid with high affinity, and
shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This
gene shares high sequence identity with three other gene members
and is clustered with those three genes at chromosome 10p15-p14.
Three transcript variants encoding two different isoforms have been
found for this gene. [provided by RefSeq, Dec 2011].
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Variants 1 and 2 encode the same isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC063574.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-33 DA451165.1 1-33
34-291 BC063574.1 1-258
292-1508 BC007024.1 1-1217
1509-3325 AL713867.6 19622-21438 c
3326-3521 CA450425.1 1-196 c
FEATURES Location/Qualifiers
source 1..3521
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10p15-p14"
gene 1..3521
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/note="aldo-keto reductase family 1, member C2"
/db_xref="GeneID:1646"
/db_xref="HGNC:385"
/db_xref="HPRD:11857"
/db_xref="MIM:600450"
exon 1..134
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/inference="alignment:Splign:1.39.8"
exon 135..397
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/inference="alignment:Splign:1.39.8"
misc_feature 272..274
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/note="upstream in-frame stop codon"
CDS 314..1285
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/EC_number="1.1.1.213"
/EC_number="1.3.1.20"
/note="isoform 1 is encoded by transcript variant 2; type
II dihydrodiol dehydrogenase;
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;
pseudo-chlordecone reductase; dihydrodiol dehydrogenase 2;
bile acid binding protein; 3-alpha hydroxysteroid
dehydrogenase, type III; DD-2; DD/BABP; 3-alpha-HSD3;
chlordecone reductase homolog HAKRD"
/codon_start=1
/product="aldo-keto reductase family 1 member C2 isoform
1"
/protein_id="NP_995317.1"
/db_xref="GI:45446745"
/db_xref="CCDS:CCDS7062.1"
/db_xref="GeneID:1646"
/db_xref="HGNC:385"
/db_xref="HPRD:11857"
/db_xref="MIM:600450"
/translation="
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY
"
misc_feature 344..1210
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/note="Aldo-keto reductases (AKRs) are a superfamily of
soluble NAD(P)(H) oxidoreductases whose chief purpose is
to reduce aldehydes and ketones to primary and secondary
alcohols. AKRs are present in all phyla and are of
importance to both health and industrial...; Region:
Aldo_ket_red; cd06660"
/db_xref="CDD:119408"
misc_feature 368..1216
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/note="Aldo/keto reductase family; Region: Aldo_ket_red;
pfam00248"
/db_xref="CDD:201112"
misc_feature order(377..385,461..463,476..478,563..565,662..667,
809..814,881..883,959..976,1070..1072,1115..1126,
1139..1141,1148..1153)
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/note="active site"
/db_xref="CDD:119408"
misc_feature order(461..463,476..478,563..565,662..664)
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/note="catalytic tetrad [active]"
/db_xref="CDD:119408"
misc_feature 563..565
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/inference="non-experimental evidence, no additional
details recorded"
/note="Lowers pKa of active site Tyr (By similarity);
propagated from UniProtKB/Swiss-Prot (P52895.3); other
site"
exon 398..565
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/inference="alignment:Splign:1.39.8"
variation 416
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="c"
/replace="t"
/db_xref="dbSNP:8625"
variation 425
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="g"
/db_xref="dbSNP:3207898"
variation 426
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="c"
/replace="t"
/db_xref="dbSNP:3207901"
variation 439
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="t"
/db_xref="dbSNP:8493"
variation 445
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="c"
/replace="t"
/db_xref="dbSNP:3207903"
variation 448
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="c"
/replace="g"
/db_xref="dbSNP:3207904"
variation 450
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="t"
/db_xref="dbSNP:2854482"
variation 453
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="g"
/db_xref="dbSNP:3207905"
variation 469
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="t"
/db_xref="dbSNP:8314"
exon 566..682
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/inference="alignment:Splign:1.39.8"
variation 640
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="c"
/replace="t"
/db_xref="dbSNP:13945"
variation 645
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="c"
/replace="t"
/db_xref="dbSNP:2854486"
exon 683..760
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/inference="alignment:Splign:1.39.8"
exon 761..883
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/inference="alignment:Splign:1.39.8"
variation 848
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="g"
/db_xref="dbSNP:2518042"
variation 866
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="g"
/db_xref="dbSNP:2518043"
exon 884..993
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/inference="alignment:Splign:1.39.8"
exon 994..1159
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/inference="alignment:Splign:1.39.8"
exon 1160..1242
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/inference="alignment:Splign:1.39.8"
exon 1243..3506
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/inference="alignment:Splign:1.39.8"
STS 1375..1492
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/standard_name="RH11162"
/db_xref="UniSTS:89050"
variation 1402
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="c"
/replace="t"
/db_xref="dbSNP:1138738"
variation 1405
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="c"
/replace="t"
/db_xref="dbSNP:1138741"
variation 1411
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="c"
/replace="t"
/db_xref="dbSNP:1138743"
variation 1422
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="t"
/db_xref="dbSNP:1138745"
variation 1436
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="g"
/db_xref="dbSNP:1138758"
variation 1441
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="g"
/db_xref="dbSNP:1138759"
polyA_signal 1476..1481
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
polyA_site 1495
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
variation 2113
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="c"
/db_xref="dbSNP:4523595"
variation 2188
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="g"
/replace="t"
/db_xref="dbSNP:4336933"
variation 2940
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="a"
/replace="g"
/db_xref="dbSNP:4584482"
variation 2947
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
/replace="c"
/replace="t"
/db_xref="dbSNP:4526684"
polyA_site 3506
/gene="AKR1C2"
/gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD;
HBAB; MCDR2; SRXY8"
ORIGIN
tcataatagaattctcatgagatctggttgtttgaaagtgtgtagcacctccaccttctctctctctctccctctccctctcctgccagccaagtgaagacatgcttacttccccttcaccttccttcatgatggtaagaaacggttgaactggatgcaatttttatcacagcttgtgtaagactgcctctgtccctcctctcacatgccattggttaaccagcagacagtgtgctcaggggcgttgccagctcattgctcttatagcctgtgagggaggaagaaacatttgctaaccaggccagtgacagaaatggattcgaaataccagtgtgtgaagctgaatgatggtcacttcatgcctgtcctgggatttggcacctatgcgcctgcagaggttcctaaaagtaaagctctagaggccgtcaaattggcaatagaagccgggttccaccatattgattctgcacatgtttacaataatgaggagcaggttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattctacacttcaaagctttggagcaattcccatcgaccagagttggtccgaccagccttggaaaggtcactgaaaaatcttcaattggactatgttgacctctatcttattcattttccagtgtctgtaaagccaggtgaggaagtgatcccaaaagatgaaaatggaaaaatactatttgacacagtggatctctgtgccacatgggaggccatggagaagtgtaaagatgcaggattggccaagtccatcggggtgtccaacttcaaccacaggctgctggagatgatcctcaacaagccagggctcaagtacaagcctgtctgcaaccaggtggaatgtcatccttacttcaaccagagaaaactgctggatttctgcaagtcaaaagacattgttctggttgcctatagtgctctgggatcccatcgagaagaaccatgggtggacccgaactccccggtgctcttggaggacccagtcctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccagctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagacagaacgtgcaggtgtttgaattccagttgacttcagaggagatgaaagccatagatggcctaaacagaaatgtgcgatatttgacccttgatatttttgctggcccccctaattatccattttctgatgaatattaacatggagggcattgcatgaggtctgccagaaggccctgcgtgtggatggtgacacagaggatggctctatgctggtgactggacacatcgcctctggttaaatctctcctgcttggcgacttcagtaagctacagctaagcccatcggccggaaaagaaagacaataattttgtttttcattttgaaaaaattaaatgctctctcctaaagattcttcacctactttggtctccataacttctatgttttctctccttctgacacactagtgcccccaaattgtgatttgcctatacgtttagggccggggttggaagatgttaacaaccatttaagattcatttctgcagtgggagtgggtggagtttcaccctctgggaaaggggcaggtgacaggtatttatcagtcagtgcctctctagctcttgtaggaagaagcacacgcaggatggagtctagaggatgagcgatattgactagcaattcatgggctccctccagcagtgcgagggtcagagtttctggagccttgggaggaggcatccctgtgagggggggttagggagatgggagggcaccaggaaaagtgattagaagtcaggtatgggaaggctaaataggacagagtcgagtacatctctgcttggaaaaacatatcaacacccttttttttgatcattatatcttgttcataaaagaaaactttccacattgttttaacaaaccccacagctgagagtcaggcctgaatctttgatgtgtgcccattcacaacgttgaccctattggtttgtggtggggcaggacatcgaagatatcattgactcatcacattcccctgaatagctcatatttagaaaatattcttagattgtaaaaatgtactgttcatttgttatatgcaatcttttaaatgttttatactttaaacaaggcatagttacaagtataaaacataaatatcccaaagccattatgcatggcactcaagattaaaatgggaaataatacatctaataaatcaaatgttccaagacttcaaatgtcttttggaaacaggctatgtaaaacagcacactggtttcaaactttggtaaattttaagaagaactcttacaaaggcatttaattcttatacataattttcaggggaactaatcaaatcagctaatcatgaagacatgattttcgttttagaaaacacttttgaaaacttgggataatctcatgtcttaatgatcaaagcattatgagaaggacagtggttttttacctgggcacactttctaacacatttactctccactattcgtactctggtagccatgttaaccccatcagagattccttctcaagccatgtctcagagctgataggcatcccagcaagttttgcagctcacaatttttctgtaaattacttattctataaaattggaagaggccataaactttggagggccctagaccaattttttggattatttctggtctactctcattccgttgatgatcttagatattctctgcattaaatatcacctctaggctgagaaatccaccaaaaaatatttctagctcagcgttttcctccaaatcttcaatggaagatcataatgtgaactctgcatctccatgttaaagtttaatggacattcacacttagcatgtctcaaagaaatctcatgtaaaccatggccatcctgttctaccttaactttctgagtctatggaatgataatttcacatctcataaacttgactgatgtaagtgtcaagaaaagattgacattttgttaaaacttcgtagccaagtgtgtaacgcttaagcagactttcatatttcaaatctctatagcacgtgtaactcttttttcaagatgtgaaataatcattaggtcagtcatttgtaaatagtacggctgctgtgggctttttccagttcttcaccatccatttttataaaactcttattgttaaaaaaaaaaagttactcagaatttcataaagccaaacacctgatttcaggaacacttgagatgtaagaaaattttatagggacctccaatcactaattttcctattttttctctcaaagaaatgctgaagggaggaattcaggttgaatgaaaggaaatagtaacttacagccatatagagttataaagacttcttgtaaatgtgaacatatggtaaaatataaaaacatgtatttttgaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1646 -> Molecular function: GO:0004032 [alditol:NADP+ 1-oxidoreductase activity] evidence: IDA
GeneID:1646 -> Molecular function: GO:0004958 [prostaglandin F receptor activity] evidence: IDA
GeneID:1646 -> Molecular function: GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor] evidence: IDA
GeneID:1646 -> Molecular function: GO:0018636 [phenanthrene 9,10-monooxygenase activity] evidence: IDA
GeneID:1646 -> Molecular function: GO:0031406 [carboxylic acid binding] evidence: IDA
GeneID:1646 -> Molecular function: GO:0032052 [bile acid binding] evidence: IDA
GeneID:1646 -> Molecular function: GO:0047026 [androsterone dehydrogenase (A-specific) activity] evidence: IEA
GeneID:1646 -> Molecular function: GO:0047086 [ketosteroid monooxygenase activity] evidence: IDA
GeneID:1646 -> Molecular function: GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity] evidence: IDA
GeneID:1646 -> Biological process: GO:0006693 [prostaglandin metabolic process] evidence: IDA
GeneID:1646 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: IDA
GeneID:1646 -> Biological process: GO:0007586 [digestion] evidence: IDA
GeneID:1646 -> Biological process: GO:0008202 [steroid metabolic process] evidence: IDA
GeneID:1646 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
GeneID:1646 -> Biological process: GO:0034694 [response to prostaglandin stimulus] evidence: IDA
GeneID:1646 -> Biological process: GO:0042448 [progesterone metabolic process] evidence: IDA
GeneID:1646 -> Biological process: GO:0044597 [daunorubicin metabolic process] evidence: IMP
GeneID:1646 -> Biological process: GO:0044598 [doxorubicin metabolic process] evidence: IMP
GeneID:1646 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IDA
GeneID:1646 -> Biological process: GO:0055114 [oxidation-reduction process] evidence: IDA
GeneID:1646 -> Biological process: GO:0071395 [cellular response to jasmonic acid stimulus] evidence: IDA
GeneID:1646 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_995317 -> EC 1.1.1.213
NP_995317 -> EC 1.3.1.20
by
@meso_cacase at
DBCLS
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