2025-05-09 18:48:34, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001354 3621 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens aldo-keto reductase family 1, member C2 (AKR1C2), transcript variant 1, mRNA. ACCESSION NM_001354 XM_937757 XM_943409 XM_943412 XM_943415 XM_943419 XM_943424 XM_943425 XM_943427 VERSION NM_001354.5 GI:359751395 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3621) AUTHORS Kuang,P., Zhou,C., Li,X., Ren,S., Li,B., Wang,Y., Li,J., Tang,L., Zhang,J. and Zhao,Y. TITLE Proteomics-based identification of secreted protein dihydrodiol dehydrogenase 2 as a potential biomarker for predicting cisplatin efficacy in advanced NSCLC patients JOURNAL Lung Cancer 77 (2), 427-432 (2012) PUBMED 22534668 REMARK GeneRIF: DDH2 expression might be a potential predictor and monitor of cisplatin efficacy in advanced NSCLC patients. REFERENCE 2 (bases 1 to 3621) AUTHORS Veilleux,A., Cote,J.A., Blouin,K., Nadeau,M., Pelletier,M., Marceau,P., Laberge,P.Y., Luu-The,V. and Tchernof,A. TITLE Glucocorticoid-induced androgen inactivation by aldo-keto reductase 1C2 promotes adipogenesis in human preadipocytes JOURNAL Am. J. Physiol. Endocrinol. Metab. 302 (8), E941-E949 (2012) PUBMED 22275760 REMARK GeneRIF: Data suggest that modulation of AKR1C2 by glucocorticoids (dexamethasone in this study) locally modifies exposure of adipose cells to endogenous androgens; thus, AKR1C2 activation/inactivation may be involved in regional fat deposition. REFERENCE 3 (bases 1 to 3621) AUTHORS Roberson,A.E., Hyatt,K., Kenkel,C., Hanson,K. and Myers,D.A. TITLE Interleukin 1beta regulates progesterone metabolism in human cervical fibroblasts JOURNAL Reprod Sci 19 (3), 271-281 (2012) PUBMED 22064385 REMARK GeneRIF: Data suggest that interleukin-1beta facilitates progesterone metabolism in cervical fibroblasts by regulating expression of AKR1C1 and AKR1C2. Erratum:[Reprod Sci. 2012 Jun;19(6):666] REFERENCE 4 (bases 1 to 3621) AUTHORS Jin,Y., Mesaros,A.C., Blair,I.A. and Penning,T.M. TITLE Stereospecific reduction of 5beta-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5beta-reductase pathway JOURNAL Biochem. J. 437 (1), 53-61 (2011) PUBMED 21521174 REMARK GeneRIF: role of AKR1C2 in the metabolism of testosterone and progesterone via the 5beta-reductase pathway. REFERENCE 5 (bases 1 to 3621) AUTHORS Basehore,H.K. and Ropson,I.J. TITLE Residual interactions in unfolded bile acid-binding protein by 19F NMR JOURNAL Protein Sci. 20 (2), 327-335 (2011) PUBMED 21280124 REMARK GeneRIF: The folding initiation mechanism of human bile acid-binding protein (BABP) has been examined by (19) F NMR. REFERENCE 6 (bases 1 to 3621) AUTHORS Khanna,M., Qin,K.N., Klisak,I., Belkin,S., Sparkes,R.S. and Cheng,K.C. TITLE Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization JOURNAL Genomics 25 (2), 588-590 (1995) PUBMED 7789999 REFERENCE 7 (bases 1 to 3621) AUTHORS Qin,K.N., Khanna,M. and Cheng,K.C. TITLE Structure of a gene coding for human dihydrodiol dehydrogenase/bile acid-binding protein JOURNAL Gene 149 (2), 357-361 (1994) PUBMED 7959017 REFERENCE 8 (bases 1 to 3621) AUTHORS Ciaccio,P.J. and Tew,K.D. TITLE cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase JOURNAL Biochim. Biophys. Acta 1186 (1-2), 129-132 (1994) PUBMED 8011662 REFERENCE 9 (bases 1 to 3621) AUTHORS Qin,K.N., New,M.I. and Cheng,K.C. TITLE Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase JOURNAL J. Steroid Biochem. Mol. Biol. 46 (6), 673-679 (1993) PUBMED 8274401 REFERENCE 10 (bases 1 to 3621) AUTHORS Winters,C.J., Molowa,D.T. and Guzelian,P.S. TITLE Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase JOURNAL Biochemistry 29 (4), 1080-1087 (1990) PUBMED 2187532 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA451165.1, DA458030.1, AL391427.9, BC007024.1, AL713867.6 and CA450425.1. This sequence is a reference standard in the RefSeqGene project. On Dec 9, 2011 this sequence version replaced gi:45446741. Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC063574.1, AK290304.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-105 DA451165.1 1-105 106-167 DA458030.1 1-62 168-168 AL391427.9 13740-13740 c 169-680 DA458030.1 64-575 681-1608 BC007024.1 290-1217 1609-3425 AL713867.6 19622-21438 c 3426-3621 CA450425.1 1-196 c FEATURES Location/Qualifiers source 1..3621 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10p15-p14" gene 1..3621 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /note="aldo-keto reductase family 1, member C2" /db_xref="GeneID:1646" /db_xref="HGNC:385" /db_xref="HPRD:11857" /db_xref="MIM:600450" exon 1..134 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="alignment:Splign:1.39.8" exon 135..234 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="alignment:Splign:1.39.8" variation 196 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="c" /db_xref="dbSNP:1937865" exon 235..497 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="alignment:Splign:1.39.8" misc_feature 372..374 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /note="upstream in-frame stop codon" CDS 414..1385 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /EC_number="1.1.1.213" /EC_number="1.3.1.20" /note="isoform 1 is encoded by transcript variant 1; type II dihydrodiol dehydrogenase; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; pseudo-chlordecone reductase; dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III; DD-2; DD/BABP; 3-alpha-HSD3; chlordecone reductase homolog HAKRD" /codon_start=1 /product="aldo-keto reductase family 1 member C2 isoform 1" /protein_id="NP_001345.1" /db_xref="GI:4503285" /db_xref="CCDS:CCDS7062.1" /db_xref="GeneID:1646" /db_xref="HGNC:385" /db_xref="HPRD:11857" /db_xref="MIM:600450" /translation="
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY
" misc_feature 444..1310 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /note="Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660" /db_xref="CDD:119408" misc_feature 468..1316 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /note="Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248" /db_xref="CDD:201112" misc_feature order(477..485,561..563,576..578,663..665,762..767, 909..914,981..983,1059..1076,1170..1172,1215..1226, 1239..1241,1248..1253) /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /note="active site" /db_xref="CDD:119408" misc_feature order(561..563,576..578,663..665,762..764) /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /note="catalytic tetrad [active]" /db_xref="CDD:119408" misc_feature 663..665 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="non-experimental evidence, no additional details recorded" /note="Lowers pKa of active site Tyr (By similarity); propagated from UniProtKB/Swiss-Prot (P52895.3); other site" exon 498..665 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="alignment:Splign:1.39.8" variation 516 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="c" /replace="t" /db_xref="dbSNP:8625" variation 525 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="g" /db_xref="dbSNP:3207898" variation 526 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="c" /replace="t" /db_xref="dbSNP:3207901" variation 539 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="t" /db_xref="dbSNP:8493" variation 545 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="c" /replace="t" /db_xref="dbSNP:3207903" variation 548 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="c" /replace="g" /db_xref="dbSNP:3207904" variation 550 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="t" /db_xref="dbSNP:2854482" variation 553 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="g" /db_xref="dbSNP:3207905" variation 569 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="t" /db_xref="dbSNP:8314" exon 666..782 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="alignment:Splign:1.39.8" variation 740 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="c" /replace="t" /db_xref="dbSNP:13945" variation 745 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="c" /replace="t" /db_xref="dbSNP:2854486" exon 783..860 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="alignment:Splign:1.39.8" exon 861..983 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="alignment:Splign:1.39.8" variation 948 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="g" /db_xref="dbSNP:2518042" variation 966 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="g" /db_xref="dbSNP:2518043" exon 984..1093 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="alignment:Splign:1.39.8" exon 1094..1259 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="alignment:Splign:1.39.8" exon 1260..1342 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="alignment:Splign:1.39.8" exon 1343..3606 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /inference="alignment:Splign:1.39.8" STS 1475..1592 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /standard_name="RH11162" /db_xref="UniSTS:89050" variation 1502 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="c" /replace="t" /db_xref="dbSNP:1138738" variation 1505 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="c" /replace="t" /db_xref="dbSNP:1138741" variation 1511 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="c" /replace="t" /db_xref="dbSNP:1138743" variation 1522 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="t" /db_xref="dbSNP:1138745" variation 1536 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="g" /db_xref="dbSNP:1138758" variation 1541 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="g" /db_xref="dbSNP:1138759" polyA_signal 1576..1581 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" polyA_site 1595 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" variation 2213 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="c" /db_xref="dbSNP:4523595" variation 2288 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="g" /replace="t" /db_xref="dbSNP:4336933" variation 3040 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="a" /replace="g" /db_xref="dbSNP:4584482" variation 3047 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" /replace="c" /replace="t" /db_xref="dbSNP:4526684" polyA_site 3606 /gene="AKR1C2" /gene_synonym="AKR1C-pseudo; BABP; DD; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8" ORIGIN
tcataatagaattctcatgagatctggttgtttgaaagtgtgtagcacctccaccttctctctctctctccctctccctctcctgccagccaagtgaagacatgcttacttccccttcaccttccttcatgatgttaccattggaatgacatactgcatcctatagttataccatccactctgaaatcaatgtgaatttaacttcagttccatacagaaacttcttttccacaggtaagaaacggttgaactggatgcaatttttatcacagcttgtgtaagactgcctctgtccctcctctcacatgccattggttaaccagcagacagtgtgctcaggggcgttgccagctcattgctcttatagcctgtgagggaggaagaaacatttgctaaccaggccagtgacagaaatggattcgaaataccagtgtgtgaagctgaatgatggtcacttcatgcctgtcctgggatttggcacctatgcgcctgcagaggttcctaaaagtaaagctctagaggccgtcaaattggcaatagaagccgggttccaccatattgattctgcacatgtttacaataatgaggagcaggttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattctacacttcaaagctttggagcaattcccatcgaccagagttggtccgaccagccttggaaaggtcactgaaaaatcttcaattggactatgttgacctctatcttattcattttccagtgtctgtaaagccaggtgaggaagtgatcccaaaagatgaaaatggaaaaatactatttgacacagtggatctctgtgccacatgggaggccatggagaagtgtaaagatgcaggattggccaagtccatcggggtgtccaacttcaaccacaggctgctggagatgatcctcaacaagccagggctcaagtacaagcctgtctgcaaccaggtggaatgtcatccttacttcaaccagagaaaactgctggatttctgcaagtcaaaagacattgttctggttgcctatagtgctctgggatcccatcgagaagaaccatgggtggacccgaactccccggtgctcttggaggacccagtcctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccagctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagacagaacgtgcaggtgtttgaattccagttgacttcagaggagatgaaagccatagatggcctaaacagaaatgtgcgatatttgacccttgatatttttgctggcccccctaattatccattttctgatgaatattaacatggagggcattgcatgaggtctgccagaaggccctgcgtgtggatggtgacacagaggatggctctatgctggtgactggacacatcgcctctggttaaatctctcctgcttggcgacttcagtaagctacagctaagcccatcggccggaaaagaaagacaataattttgtttttcattttgaaaaaattaaatgctctctcctaaagattcttcacctactttggtctccataacttctatgttttctctccttctgacacactagtgcccccaaattgtgatttgcctatacgtttagggccggggttggaagatgttaacaaccatttaagattcatttctgcagtgggagtgggtggagtttcaccctctgggaaaggggcaggtgacaggtatttatcagtcagtgcctctctagctcttgtaggaagaagcacacgcaggatggagtctagaggatgagcgatattgactagcaattcatgggctccctccagcagtgcgagggtcagagtttctggagccttgggaggaggcatccctgtgagggggggttagggagatgggagggcaccaggaaaagtgattagaagtcaggtatgggaaggctaaataggacagagtcgagtacatctctgcttggaaaaacatatcaacacccttttttttgatcattatatcttgttcataaaagaaaactttccacattgttttaacaaaccccacagctgagagtcaggcctgaatctttgatgtgtgcccattcacaacgttgaccctattggtttgtggtggggcaggacatcgaagatatcattgactcatcacattcccctgaatagctcatatttagaaaatattcttagattgtaaaaatgtactgttcatttgttatatgcaatcttttaaatgttttatactttaaacaaggcatagttacaagtataaaacataaatatcccaaagccattatgcatggcactcaagattaaaatgggaaataatacatctaataaatcaaatgttccaagacttcaaatgtcttttggaaacaggctatgtaaaacagcacactggtttcaaactttggtaaattttaagaagaactcttacaaaggcatttaattcttatacataattttcaggggaactaatcaaatcagctaatcatgaagacatgattttcgttttagaaaacacttttgaaaacttgggataatctcatgtcttaatgatcaaagcattatgagaaggacagtggttttttacctgggcacactttctaacacatttactctccactattcgtactctggtagccatgttaaccccatcagagattccttctcaagccatgtctcagagctgataggcatcccagcaagttttgcagctcacaatttttctgtaaattacttattctataaaattggaagaggccataaactttggagggccctagaccaattttttggattatttctggtctactctcattccgttgatgatcttagatattctctgcattaaatatcacctctaggctgagaaatccaccaaaaaatatttctagctcagcgttttcctccaaatcttcaatggaagatcataatgtgaactctgcatctccatgttaaagtttaatggacattcacacttagcatgtctcaaagaaatctcatgtaaaccatggccatcctgttctaccttaactttctgagtctatggaatgataatttcacatctcataaacttgactgatgtaagtgtcaagaaaagattgacattttgttaaaacttcgtagccaagtgtgtaacgcttaagcagactttcatatttcaaatctctatagcacgtgtaactcttttttcaagatgtgaaataatcattaggtcagtcatttgtaaatagtacggctgctgtgggctttttccagttcttcaccatccatttttataaaactcttattgttaaaaaaaaaaagttactcagaatttcataaagccaaacacctgatttcaggaacacttgagatgtaagaaaattttatagggacctccaatcactaattttcctattttttctctcaaagaaatgctgaagggaggaattcaggttgaatgaaaggaaatagtaacttacagccatatagagttataaagacttcttgtaaatgtgaacatatggtaaaatataaaaacatgtatttttgaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:1646 -> Molecular function: GO:0004032 [alditol:NADP+ 1-oxidoreductase activity] evidence: IDA GeneID:1646 -> Molecular function: GO:0004958 [prostaglandin F receptor activity] evidence: IDA GeneID:1646 -> Molecular function: GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor] evidence: IDA GeneID:1646 -> Molecular function: GO:0018636 [phenanthrene 9,10-monooxygenase activity] evidence: IDA GeneID:1646 -> Molecular function: GO:0031406 [carboxylic acid binding] evidence: IDA GeneID:1646 -> Molecular function: GO:0032052 [bile acid binding] evidence: IDA GeneID:1646 -> Molecular function: GO:0047026 [androsterone dehydrogenase (A-specific) activity] evidence: IEA GeneID:1646 -> Molecular function: GO:0047086 [ketosteroid monooxygenase activity] evidence: IDA GeneID:1646 -> Molecular function: GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity] evidence: IDA GeneID:1646 -> Biological process: GO:0006693 [prostaglandin metabolic process] evidence: IDA GeneID:1646 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: IDA GeneID:1646 -> Biological process: GO:0007586 [digestion] evidence: IDA GeneID:1646 -> Biological process: GO:0008202 [steroid metabolic process] evidence: IDA GeneID:1646 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA GeneID:1646 -> Biological process: GO:0034694 [response to prostaglandin stimulus] evidence: IDA GeneID:1646 -> Biological process: GO:0042448 [progesterone metabolic process] evidence: IDA GeneID:1646 -> Biological process: GO:0044597 [daunorubicin metabolic process] evidence: IMP GeneID:1646 -> Biological process: GO:0044598 [doxorubicin metabolic process] evidence: IMP GeneID:1646 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IDA GeneID:1646 -> Biological process: GO:0055114 [oxidation-reduction process] evidence: IDA GeneID:1646 -> Biological process: GO:0071395 [cellular response to jasmonic acid stimulus] evidence: IDA GeneID:1646 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001345 -> EC 1.1.1.213 NP_001345 -> EC 1.3.1.20
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