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2025-05-09 19:54:53, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_028041 3643 bp RNA linear PRI 16-JUL-2013
DEFINITION Homo sapiens glutamate receptor, metabotropic 8 (GRM8), transcript
variant 3, non-coding RNA.
ACCESSION NR_028041 NM_001127326
VERSION NR_028041.1 GI:253970408
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3643)
AUTHORS Yanagawa,M., Yamashita,T. and Shichida,Y.
TITLE Glutamate acts as a partial inverse agonist to metabotropic
glutamate receptor with a single amino acid mutation in the
transmembrane domain
JOURNAL J. Biol. Chem. 288 (14), 9593-9601 (2013)
PUBMED 23420844
REMARK GeneRIF: Glutamate acts as a partial inverse agonist to
metabotropic glutamate receptor with a single amino acid mutation
in the transmembrane domain
REFERENCE 2 (bases 1 to 3643)
AUTHORS Girotto,G., Pirastu,N., Sorice,R., Biino,G., Campbell,H.,
d'Adamo,A.P., Hastie,N.D., Nutile,T., Polasek,O., Portas,L.,
Rudan,I., Ulivi,S., Zemunik,T., Wright,A.F., Ciullo,M., Hayward,C.,
Pirastu,M. and Gasparini,P.
TITLE Hearing function and thresholds: a genome-wide association study in
European isolated populations identifies new loci and pathways
JOURNAL J. Med. Genet. 48 (6), 369-374 (2011)
PUBMED 21493956
REMARK GeneRIF: Eight suggestive significant loci were detected with a
series of genes expressed within the inner ear that underlie the
auditory function, such as: DCLK1, PTPRD, GRM8, CMIP.
REFERENCE 3 (bases 1 to 3643)
AUTHORS Terracciano,A., Tanaka,T., Sutin,A.R., Sanna,S., Deiana,B., Lai,S.,
Uda,M., Schlessinger,D., Abecasis,G.R., Ferrucci,L. and Costa,P.T.
Jr.
TITLE Genome-wide association scan of trait depression
JOURNAL Biol. Psychiatry 68 (9), 811-817 (2010)
PUBMED 20800221
REFERENCE 4 (bases 1 to 3643)
AUTHORS Saus,E., Brunet,A., Armengol,L., Alonso,P., Crespo,J.M.,
Fernandez-Aranda,F., Guitart,M., Martin-Santos,R., Menchon,J.M.,
Navines,R., Soria,V., Torrens,M., Urretavizcaya,M., Valles,V.,
Gratacos,M. and Estivill,X.
TITLE Comprehensive copy number variant (CNV) analysis of neuronal
pathways genes in psychiatric disorders identifies rare variants
within patients
JOURNAL J Psychiatr Res 44 (14), 971-978 (2010)
PUBMED 20398908
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 3643)
AUTHORS Fonseca,F., Gratacos,M., Escaramis,G., De Cid,R., Martin-Santos,R.,
Fernandez-Espejo,E., Estivill,X. and Torrens,M.
TITLE Response to methadone maintenance treatment is associated with the
MYOCD and GRM6 genes
JOURNAL Mol Diagn Ther 14 (3), 171-178 (2010)
PUBMED 20560679
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 6 (bases 1 to 3643)
AUTHORS Thomas,N.K., Wright,R.A., Howson,P.A., Kingston,A.E., Schoepp,D.D.
and Jane,D.E.
TITLE (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist,
activates metabotropic glutamate receptors on primary afferent
terminals in the neonatal rat spinal cord
JOURNAL Neuropharmacology 40 (3), 311-318 (2001)
PUBMED 11166323
REFERENCE 7 (bases 1 to 3643)
AUTHORS Malherbe,P., Kratzeisen,C., Lundstrom,K., Richards,J.G., Faull,R.L.
and Mutel,V.
TITLE Cloning and functional expression of alternative spliced variants
of the human metabotropic glutamate receptor 8
JOURNAL Brain Res. Mol. Brain Res. 67 (2), 201-210 (1999)
PUBMED 10216218
REFERENCE 8 (bases 1 to 3643)
AUTHORS Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
TITLE Group III human metabotropic glutamate receptors 4, 7 and 8:
molecular cloning, functional expression, and comparison of
pharmacological properties in RGT cells
JOURNAL Brain Res. Mol. Brain Res. 53 (1-2), 88-97 (1998)
PUBMED 9473604
REFERENCE 9 (bases 1 to 3643)
AUTHORS Scherer,S.W., Soder,S., Duvoisin,R.M., Huizenga,J.J. and Tsui,L.C.
TITLE The human metabotropic glutamate receptor 8 (GRM8) gene: a
disproportionately large gene located at 7q31.3-q32.1
JOURNAL Genomics 44 (2), 232-236 (1997)
PUBMED 9299241
REFERENCE 10 (bases 1 to 3643)
AUTHORS Scherer,S.W., Duvoisin,R.M., Kuhn,R., Heng,H.H., Belloni,E. and
Tsui,L.C.
TITLE Localization of two metabotropic glutamate receptor genes, GRM3 and
GRM8, to human chromosome 7q
JOURNAL Genomics 31 (2), 230-233 (1996)
PUBMED 8824806
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK315203.1, AJ236922.1,
BC093725.1, BG202742.1 and BG211606.1.
On Jul 15, 2009 this sequence version replaced gi:187960083.
Summary: L-glutamate is the major excitatory neurotransmitter in
the central nervous system and activates both ionotropic and
metabotropic glutamate receptors. Glutamatergic neurotransmission
is involved in most aspects of normal brain function and can be
perturbed in many neuropathologic conditions. The metabotropic
glutamate receptors are a family of G protein-coupled receptors,
that have been divided into 3 groups on the basis of sequence
homology, putative signal transduction mechanisms, and
pharmacologic properties. Group I includes GRM1 and GRM5 and these
receptors have been shown to activate phospholipase C. Group II
includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
and GRM8. Group II and III receptors are linked to the inhibition
of the cyclic AMP cascade but differ in their agonist
selectivities. Alternatively spliced transcript variants encoding
different isoforms have been described for this gene. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (3) contains an additional exon in
the central coding region that results in a frameshift, compared to
transcript variant 1. This variant is represented as non-coding
because the use of the 5'-most supported translational start codon,
as used in variant 1, renders the transcript a candidate for
nonsense-mediated mRNA decay (NMD). This variant was designated as
HmGluR8c by Malherbe et al, 1999 (PMID:10216218).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1668 AK315203.1 247-1914
1669-2684 AJ236922.1 1373-2388
2685-3137 BC093725.1 2329-2781
3138-3626 BG202742.1 82-570
3627-3643 BG211606.1 558-574
FEATURES Location/Qualifiers
source 1..3643
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q31.3-q32.1"
gene 1..3643
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="glutamate receptor, metabotropic 8"
/db_xref="GeneID:2918"
/db_xref="HGNC:4600"
/db_xref="MIM:601116"
misc_RNA 1..3643
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/product="glutamate receptor, metabotropic 8, transcript
variant 3"
/db_xref="GeneID:2918"
/db_xref="HGNC:4600"
/db_xref="MIM:601116"
exon 1..821
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 137
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="g"
/replace="t"
/db_xref="dbSNP:76817979"
variation 219
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:75009171"
misc_feature 312..1817
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="COORDINATES:
alignment:Blast2seq::RefSeq|NM_000845.2"
/note="primary ORF has stop codon >50 nucleotides from the
terminal splice site; nonsense-mediated decay (NMD)
candidate"
variation 340
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="g"
/db_xref="dbSNP:769194"
variation 373
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="g"
/replace="t"
/db_xref="dbSNP:769202"
variation 668
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:769200"
exon 822..1038
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
exon 1039..1174
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1055
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:1131702"
variation 1075
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="g"
/db_xref="dbSNP:78266043"
variation 1105..1106
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:2234945"
variation 1105
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:17150343"
exon 1175..1329
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
exon 1330..1467
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1396
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="t"
/db_xref="dbSNP:78124913"
variation 1414
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="g"
/db_xref="dbSNP:78947184"
exon 1468..1668
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1486
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="g"
/db_xref="dbSNP:2234947"
variation 1599
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:75863532"
exon 1669..1739
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
exon 1740..1876
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1846
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:769198"
exon 1877..2812
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 2025
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="g"
/replace="t"
/db_xref="dbSNP:2234948"
variation 2404
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="c"
/db_xref="dbSNP:77222071"
variation 2539
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="g"
/db_xref="dbSNP:769201"
variation 2685
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="t"
/db_xref="dbSNP:1051433"
exon 2813..3059
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
exon 3060..3630
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 3138
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:712723"
polyA_signal 3408..3413
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_site 3428
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_signal 3551..3556
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_site 3577
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_signal 3606..3611
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_site 3630
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
ORIGIN
gaataattctgctacaaggctgatttcaaggacatgaattgttgacctcatcccaacatcagaacctcagatgttctaatttttgcaccattccaggcaagttgatcttataaggaaataaaattgaaccttaggggtctgatggaaattcactgtgacattcaaatcaagaaaacttgctaatgcccacagagccttttccccatgggccctgatggtagcctccagaaggtgcagcctcaggtggtgccctttcttctgtggcaagaataaactttgggtcttggattgcaataccacctgtggagaaaatggtatgcgagggaaagcgatcagcctcttgcccttgtttcttcctcttgaccgccaagttctactggatcctcacaatgatgcaaagaactcacagccaggagtatgcccattccatacgggtggatggggacattattttggggggtctcttccctgtccacgcaaagggagagagaggggtgccttgtggggagctgaagaaggaaaaggggattcacagactggaggccatgctttatgcaattgaccagattaacaaggaccctgatctcctttccaacatcactctgggtgtccgcatcctcgacacgtgctctagggacacctatgctttggagcagtctctaacattcgtgcaggcattaatagagaaagatgcttcggatgtgaagtgtgctaatggagatccacccattttcaccaagcccgacaagatttctggcgtcataggtgctgcagcaagctccgtgtccatcatggttgctaacattttaagactttttaagatacctcaaatcagctatgcatccacagccccagagctaagtgataacaccaggtatgactttttctctcgagtggttccgcctgactcctaccaagcccaagccatggtggacatcgtgacagcactgggatggaattatgtttcgacactggcttctgaggggaactatggtgagagcggtgtggaggccttcacccagatctcgagggagattggtggtgtttgcattgctcagtcacagaaaatcccacgtgaaccaagacctggagaatttgaaaaaattatcaaacgcctgctagaaacacctaatgctcgagcagtgattatgtttgccaatgaggatgacatcaggaggatattggaagcagcaaaaaaactaaaccaaagtgggcattttctctggattggctcagatagttggggatccaaaatagcacctgtctatcagcaagaggagattgcagaaggggctgtgacaattttgcccaaacgagcatcaattgatggatttgatcgatactttagaagccgaactcttgccaataatcgaagaaatgtgtggtttgcagaattctgggaggagaattttggctgcaagttaggatcacatgggaaaaggaacagtcatataaagaaatgcacagggctggagcgaattgctcgggattcatcttatgaacaggaaggaaaggtccaatttgtaattgatgctgtatattccatggcttacgccctgcacaatatgcacaaagatctctgccctggatacattggcctttgtccacgaatgagtaccattgatgggaaagagctacttggttatattcgggctgtaaattttaatggttgccgaagagggatccagatgtctctaccctggccaactctttttactccttcattttccagtagttgggcagtgctggcactcctgtcacttttaatgaaaacggagatgctcctggacgttatgatatcttccagtatcaaataaccaacaaaagcacagagtacaaagtcatcggccactggaccaatcagcttcatctaaaagtggaagacatgcagtgggctcatagagaacatactcacccggcgtctgtctgcagcctgccgtgtaagccaggggagaggaagaaaacggtgaaaggggtcccttgctgctggcactgtgaacgctgtgaaggttacaactaccaggtggatgagctgtcctgtgaactttgccctctggatcagagacccaacatgaaccgcacaggctgccagcttatccccatcatcaaattggagtggcattctccctgggctgtggtgcctgtgtttgttgcaatattgggaatcatcgccaccacctttgtgatcgtgacctttgtccgctataatgacacacctatcgtgagggcttcaggacgcgaacttagttacgtgctcctaacggggatttttctctgttattcaatcacgtttttaatgattgcagcaccagatacaatcatatgctccttccgacgggtcttcctaggacttggcatgtgtttcagctatgcagcccttctgaccaaaacaaaccgtatccaccgaatatttgagcaggggaagaaatctgtcacagcgcccaagttcattagtccagcatctcagctggtgatcaccttcagcctcatctccgtccagctccttggagtgtttgtctggtttgttgtggatcccccccacatcatcattgactatggagagcagcggacactagatccagagaaggccaggggagtgctcaagtgtgacatttctgatctctcactcatttgttcacttggatacagtatcctcttgatggtcacttgtactgtttatgccattaaaacgagaggtgtcccagagactttcaatgaagccaaacctattggatttaccatgtataccacctgcatcatttggttagctttcatccccatcttttttggtacagcccagtcagcagaaaagatgtacatccagacaacaacacttactgtctccatgagtttaagtgcttcagtatctctgggcatgctctatatgcccaaggtttatattataatttttcatccagaacagaatgttcaaaaacgcaagaggagcttcaaggctgtggtgacagctgccaccatgcaaagcaaactgatccaaaaaggaaatgacagaccaaatggcgaggtgaaaagtgaactctgtgagagtcttgaaaccaacacttcctctaccaagacaacatatatcagttacagcaatcattcaatctgaaacagggaaatggcacaatctgaagagatgtggtatatgatcttaaatgatgaacatgagaccgcaaaaattcactcctggagatctccgtagactacaatcaatcaaatcaatagtcagtcttgtaaggaacaaaaattagccatgagccaaaagtatcaataaacggggagtgaagaaacccgttttatacaataaaaccaatgagtgtcaagctaaagtattgcttattcatgagcagttaaaacaaatcacaaaaggaaaactaatgttagctcgtgaaaaaaaatgctgttgaaataaataatgtctgatgttattcttgtatttttctgtgattgtgagaactcccgttcctgtcccacattgtttaacttgtataagacaatgagtctgtttcttgtaatggctgaccagattgaagccctgggttgtgctaaaaataaatgcaatgattgatgcatgcaattttttatacaaataatttatttctaataataaaggaatgttttgcaaatgttaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2918 -> Molecular function: GO:0001642 [group III metabotropic glutamate receptor activity] evidence: IEA
GeneID:2918 -> Molecular function: GO:0004930 [G-protein coupled receptor activity] evidence: TAS
GeneID:2918 -> Molecular function: GO:0008066 [glutamate receptor activity] evidence: TAS
GeneID:2918 -> Biological process: GO:0007194 [negative regulation of adenylate cyclase activity] evidence: TAS
GeneID:2918 -> Biological process: GO:0007601 [visual perception] evidence: TAS
GeneID:2918 -> Biological process: GO:0007608 [sensory perception of smell] evidence: IEA
GeneID:2918 -> Biological process: GO:0030818 [negative regulation of cAMP biosynthetic process] evidence: IDA
GeneID:2918 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:2918 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
by
@meso_cacase at
DBCLS
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