2025-05-09 19:01:06, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001164803 2071 bp mRNA linear PRI 31-MAY-2013 DEFINITION Homo sapiens RNA binding motif protein, X-linked (RBMX), transcript variant 2, mRNA. ACCESSION NM_001164803 VERSION NM_001164803.1 GI:258645149 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2071) AUTHORS Matsunaga,S., Takata,H., Morimoto,A., Hayashihara,K., Higashi,T., Akatsuchi,K., Mizusawa,E., Yamakawa,M., Ashida,M., Matsunaga,T.M., Azuma,T., Uchiyama,S. and Fukui,K. TITLE RBMX: a regulator for maintenance and centromeric protection of sister chromatid cohesion JOURNAL Cell Rep 1 (4), 299-308 (2012) PUBMED 22832223 REMARK GeneRIF: RBMX is a cohesion regulator that maintains the proper cohesion of sister chromatids. REFERENCE 2 (bases 1 to 2071) AUTHORS Adamson,B., Smogorzewska,A., Sigoillot,F.D., King,R.W. and Elledge,S.J. TITLE A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response JOURNAL Nat. Cell Biol. 14 (3), 318-328 (2012) PUBMED 22344029 REMARK GeneRIF: Data show that RBMX accumulated at DNA lesions through multiple domains in a poly(ADP-ribose) polymerase 1-dependent manner and promoted HR by facilitating proper BRCA2 expression. Publication Status: Online-Only REFERENCE 3 (bases 1 to 2071) AUTHORS Shin,K.H., Kim,R.H., Yu,B., Kang,M.K., Elashoff,D., Christensen,R., Pucar,A. and Park,N.H. TITLE Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer JOURNAL Oral Oncol. 47 (11), 1011-1016 (2011) PUBMED 21840245 REMARK GeneRIF: studied the genetic and expression states of hnRNP G in normal, premalignant and malignant human oral tissues to further understand the relationship between the hnRNP G alterations and the development of human oral cancer REFERENCE 4 (bases 1 to 2071) AUTHORS Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N., Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H., Sperling,J., Sperling,R. and Stamm,S. TITLE Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA JOURNAL J. Biol. Chem. 284 (21), 14303-14315 (2009) PUBMED 19282290 REFERENCE 5 (bases 1 to 2071) AUTHORS Shin,K.H., Kim,R.H., Kim,R.H., Kang,M.K. and Park,N.H. TITLE hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip JOURNAL Biochem. Biophys. Res. Commun. 372 (4), 880-885 (2008) PUBMED 18541147 REMARK GeneRIF: These studies indicate that hnRNP G promotes the expression of Txnip and mediates its tumor-suppressive effect. REFERENCE 6 (bases 1 to 2071) AUTHORS Mazeyrat,S., Saut,N., Mattei,M.G. and Mitchell,M.J. TITLE RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene JOURNAL Nat. Genet. 22 (3), 224-226 (1999) PUBMED 10391207 REFERENCE 7 (bases 1 to 2071) AUTHORS Delbridge,M.L., Lingenfelter,P.A., Disteche,C.M. and Graves,J.A. TITLE The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome JOURNAL Nat. Genet. 22 (3), 223-224 (1999) PUBMED 10391206 REFERENCE 8 (bases 1 to 2071) AUTHORS Venables,J.P., Vernet,C., Chew,S.L., Elliott,D.J., Cowmeadow,R.B., Wu,J., Cooke,H.J., Artzt,K. and Eperon,I.C. TITLE T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis JOURNAL Hum. Mol. Genet. 8 (6), 959-969 (1999) PUBMED 10332027 REFERENCE 9 (bases 1 to 2071) AUTHORS Soulard,M., Della Valle,V., Siomi,M.C., Pinol-Roma,S., Codogno,P., Bauvy,C., Bellini,M., Lacroix,J.C., Monod,G., Dreyfuss,G. et al. TITLE hnRNP G: sequence and characterization of a glycosylated RNA-binding protein JOURNAL Nucleic Acids Res. 21 (18), 4210-4217 (1993) PUBMED 7692398 REFERENCE 10 (bases 1 to 2071) AUTHORS Le Coniat,M., Soulard,M., Della Valle,V., Larsen,C.J. and Berger,R. TITLE Localization of the human gene encoding heterogeneous nuclear RNA ribonucleoprotein G (hnRNP-G) to chromosome 6p12 JOURNAL Hum. Genet. 88 (5), 593-595 (1992) PUBMED 1551662 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM147410.1, DC337568.1, AK304868.1 and BX647131.1. This sequence is a reference standard in the RefSeqGene project. Summary: This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns. [provided by RefSeq, Sep 2009]. Transcript Variant: This variant (2) lacks several alternate exon and contains a different 3' end, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus when it is compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK304868.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025088 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-209 BM147410.1 1-209 210-319 DC337568.1 155-264 320-828 AK304868.1 265-773 829-2071 BX647131.1 3662-4904 FEATURES Location/Qualifiers source 1..2071 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="X" /map="Xq26.3" gene 1..2071 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /note="RNA binding motif protein, X-linked" /db_xref="GeneID:27316" /db_xref="HGNC:9910" /db_xref="MIM:300199" exon 1..184 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /inference="alignment:Splign:1.39.8" misc_feature 163..165 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /note="upstream in-frame stop codon" exon 185..319 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /inference="alignment:Splign:1.39.8" variation 210 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="a" /replace="c" /db_xref="dbSNP:2011584" CDS 211..801 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /note="isoform 2 is encoded by transcript variant 2; RNA binding motif protein, X chromosome; heterogeneous nuclear ribonucleoprotein G; hnRNP G; glycoprotein p43; RNA-binding motif protein, X chromosome" /codon_start=1 /product="RNA-binding motif protein, X chromosome isoform 2" /protein_id="NP_001158275.1" /db_xref="GI:258645150" /db_xref="CCDS:CCDS55510.1" /db_xref="GeneID:27316" /db_xref="HGNC:9910" /db_xref="MIM:300199" /translation="
MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPADAKDAARDMNGKLLYHVEEIVMEVHLEGNRCPLVEMFICPQEMMGILLKTAIQAEITQVLVILEIMHHHHEIILTVIMVIPVHVMTIHQEDIAIEMDMVVIVTIQIIQVEVPTEIHMRVMVGDFAHYGRGVLIDSQ
" misc_feature <211..>435 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /note="RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724" /db_xref="CDD:31068" misc_feature 235..432 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /note="RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590" /db_xref="CDD:100104" misc_feature order(241..243,361..363,367..369) /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /note="RNA/DNA binding site [nucleotide binding]; other site" /db_xref="CDD:100104" exon 320..426 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /inference="alignment:Splign:1.39.8" exon 427..541 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /inference="alignment:Splign:1.39.8" variation 509 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:1056264" exon 542..667 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /inference="alignment:Splign:1.39.8" variation 637 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:11556431" exon 668..750 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /inference="alignment:Splign:1.39.8" variation 693 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:374604645" exon 751..828 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /inference="alignment:Splign:1.39.8" exon 829..2052 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /inference="alignment:Splign:1.39.8" variation 991 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="g" /db_xref="dbSNP:3209406" variation 1201 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="g" /db_xref="dbSNP:3209407" variation 1207 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="a" /replace="g" /db_xref="dbSNP:3209408" variation 1241 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="g" /replace="t" /db_xref="dbSNP:3209409" variation 1319 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="a" /replace="g" /db_xref="dbSNP:3209410" variation 1656 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="g" /replace="t" /db_xref="dbSNP:3209412" variation 1659 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="a" /replace="g" /db_xref="dbSNP:1053044" variation 1681 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="g" /db_xref="dbSNP:1053053" variation 1686 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:1053065" variation 1690 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:1053069" variation 1694 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:1053075" variation 1700 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:1053083" variation 1716 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="a" /replace="c" /db_xref="dbSNP:1063808" variation 1734 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:1053103" variation 1743 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="a" /replace="g" /db_xref="dbSNP:1053111" variation 1749 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:1053114" variation 1763 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="a" /replace="g" /db_xref="dbSNP:1053121" variation 1777 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:1053122" variation 1801 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="a" /replace="t" /db_xref="dbSNP:1053123" variation 1845 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:1053150" variation 1867 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="a" /replace="c" /db_xref="dbSNP:1053158" variation 1876 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:1053161" variation 1887 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="a" /replace="g" /db_xref="dbSNP:1053163" variation 1940 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="t" /db_xref="dbSNP:1053170" variation 1963 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" /replace="c" /replace="g" /db_xref="dbSNP:1053172" polyA_signal 2035..2040 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" polyA_site 2052 /gene="RBMX" /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT; RNMX" ORIGIN
ggtccttcagcctcgttcccgggcagtataaagtttgctgtctcctttgttcgccctcgttgcgcagtagtgctagcggcttcgcggttcggtcctcgcacccggcagccgccactggtgctgagctgctaggaagcccctatcgccgagctcgttggagcttgaacccattgtcacccctccgactcaccggcccaaaaaaaaaaaaacatggttgaagcagatcgcccaggaaagctcttcattggtgggcttaatacggaaacaaatgagaaagctcttgaagcagtatttggcaaatatggacgaatagtggaagtactcttgatgaaagaccgtgaaaccaacaaatcaagaggatttgcttttgtcacctttgaaagcccagcagacgctaaggatgcagccagagacatgaatggaaagctcctgtatcacgtggaagagatagttatggaggtccacctcgaagggaaccgctgccctctcgtagagatgtttatttgtccccaagagatgatgggtattctactaaagacagctattcaagcagagattacccaagttctcgtgatactagagattatgcaccaccaccacgagattatacttaccgtgattatggtcattccagttcacgtgatgactatccatcaagaggatatagcgatagagatggatatggtcgtgatcgtgactattcagatcatccaagtggaggttcctacagagattcatatgagagttatggttggtgattttgctcattatggtcgtggagtgctgattgattcacagtagataaagctggcagtaagaaatgctaagagttgttgaagcagaaggcggctgattgtcaataagtcactacagttgcataagcagtgctgtcagaattggtttggtgcaggcaatagattttgccttcaggggttcctgtggatctgaggaaggcatcagtgttgattaacactcataactagggagtgactggtagttacttaaagcaagtaattgaccaaatggaaaaggggaagtaattaaggaaattggtaagtggaggtagtcaggaagttcttgtggttcttcacatagattttacagctttggctttcattttgtttagctaaagtcatggggacaactcttcaatttagaacttaagttgaattataaaaatgatggatataagtggtagctgtatctagtgaagtgtctgtcagtaagtgaaacattttttggtggtggcttatccacaaacagtttagttgtagaataaaacttatgagtgacatctggaaagtaaccatgctaagatggcaagcacactggaaacaattaggccacttggctttcttttgctgtattgttttataagcctactttacctcccagtcttggaaacaagttttagttttttattggtttggagactagagccaatagtataatgttctcaaaggaaacagacttgagttgttggattagaggaactaacccaacttatatgattttttttttgtttttgtcgtgtagttatggcactgtcttatttggaacatttgcaactagggataatacaacatttttaactctcatttgacaacctactactaatcacagaccacaagggtaatgaccaaatttatgtggtttttgcactccatagttgtcttagcccaatctttctatactcttacgattacttgggttaacgcttctgtgaggaccttctggctcttgagataccctaaatatttaagatatttagatatcttgaagatagtataggatatagagattgtaccaaataggaatataaggagtatgttaaaatgaccagatacctgtttgatagtttactgacctagcagatgtgtggaaaaggaatcagatcttgattcttctgggtttatactggttgtaaaacagaatgatacagaaaatgttttccttgtttaactggtagttgaacatagaacttgggtattatagatcacttttcactttttggaatgttttgtattgaaacttaataaaactttaacatggaaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:27316 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA GeneID:27316 -> Molecular function: GO:0001047 [core promoter binding] evidence: IDA GeneID:27316 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA GeneID:27316 -> Molecular function: GO:0003723 [RNA binding] evidence: IDA GeneID:27316 -> Molecular function: GO:0003723 [RNA binding] evidence: NAS GeneID:27316 -> Molecular function: GO:0003729 [mRNA binding] evidence: IDA GeneID:27316 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:27316 -> Biological process: GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] evidence: IDA GeneID:27316 -> Biological process: GO:0000398 [mRNA splicing, via spliceosome] evidence: IC GeneID:27316 -> Biological process: GO:0000398 [mRNA splicing, via spliceosome] evidence: TAS GeneID:27316 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: IDA GeneID:27316 -> Biological process: GO:0006509 [membrane protein ectodomain proteolysis] evidence: IDA GeneID:27316 -> Biological process: GO:0008380 [RNA splicing] evidence: TAS GeneID:27316 -> Biological process: GO:0010467 [gene expression] evidence: TAS GeneID:27316 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA GeneID:27316 -> Biological process: GO:0048025 [negative regulation of mRNA splicing, via spliceosome] evidence: ISS GeneID:27316 -> Biological process: GO:0048026 [positive regulation of mRNA splicing, via spliceosome] evidence: ISS GeneID:27316 -> Biological process: GO:0051260 [protein homooligomerization] evidence: ISS GeneID:27316 -> Biological process: GO:0071347 [cellular response to interleukin-1] evidence: IDA GeneID:27316 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:27316 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:27316 -> Cellular component: GO:0005719 [nuclear euchromatin] evidence: IDA GeneID:27316 -> Cellular component: GO:0044530 [supraspliceosomal complex] evidence: IDA GeneID:27316 -> Cellular component: GO:0070062 [extracellular vesicular exosome] evidence: IDA GeneID:27316 -> Cellular component: GO:0071013 [catalytic step 2 spliceosome] evidence: IDA
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