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2025-05-09 18:59:23, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001162536 5128 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens RNA binding motif protein, X-linked-like 1 (RBMXL1),
transcript variant 1, mRNA.
ACCESSION NM_001162536
VERSION NM_001162536.2 GI:242247050
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5128)
AUTHORS Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Rewerts,C.,
Maccarrone,G., Dias-Neto,E. and Turck,C.W.
TITLE Prefrontal cortex shotgun proteome analysis reveals altered calcium
homeostasis and immune system imbalance in schizophrenia
JOURNAL Eur Arch Psychiatry Clin Neurosci 259 (3), 151-163 (2009)
PUBMED 19165527
REFERENCE 2 (bases 1 to 5128)
AUTHORS Marques,A.C., Dupanloup,I., Vinckenbosch,N., Reymond,A. and
Kaessmann,H.
TITLE Emergence of young human genes after a burst of retroposition in
primates
JOURNAL PLoS Biol. 3 (11), E357 (2005)
PUBMED 16201836
REFERENCE 3 (bases 1 to 5128)
AUTHORS Emerson,J.J., Kaessmann,H., Betran,E. and Long,M.
TITLE Extensive gene traffic on the mammalian X chromosome
JOURNAL Science 303 (5657), 537-540 (2004)
PUBMED 14739461
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC397531.1, DA216732.1,
BC012942.1, BF901720.1 and AL832785.1.
On Jun 27, 2009 this sequence version replaced gi:242117970.
Summary: This gene represents a retrogene of RNA binding motif
protein, X-linked (RBMX), which is located on chromosome X. While
all introns in the coding sequence have been processed out compared
to the RBMX locus, the ORF is intact and there is specific evidence
for transcription at this location. The preservation of the ORF by
purifying selection in all Old World monkeys carrying it suggests
that this locus is likely to be functional, possibly during male
meiosis when X chromosomal genes are silenced or during haploid
stages of spermatogenesis. This gene shares 5' exon structure with
the cysteine conjugate-beta lyase 2 locus on chromosome 1, but the
coding sequences are non-overlapping. Alternative splicing results
in two transcript variants. [provided by RefSeq, Jun 2009].
Transcript Variant: This variant (1) represents the longer
transcript. Both variants 1 and 2 encode the same protein.
CCDS Note: This CCDS represents a retrogene of RBMX (RNA binding
motif protein, X-linked), which is located on chromosome X. While
all introns in the coding sequence have been processed out compared
to the RBMX locus, the ORF is intact and there is specific evidence
for transcription at this location. Studies in PMID:16201836
indicate that this locus is likely to be functional because the ORF
has been preserved by purifying selection in all six Old World
primates carrying this retrogene. Given that X chromosomal genes in
mammals can generate a statistically significant excess of
autosomal retrogenes relative to genes on other chromosomes
(PMID:14739461), it is possible that this retrogene may be
functional during male meiosis when X chromosomal genes are
silenced or during haploid stages of spermatogenesis
(PMID:16201836). In addition, it should be noted that this
retrogene shares its first non-coding exon with the cysteine
conjugate-beta lyase 2 (CCBL2) locus on chromosome 1, but the
coding sequences are non-overlapping.
##Evidence-Data-START##
Transcript exon combination :: BX418820.2, BQ421290.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-160 DC397531.1 68-227
161-693 DA216732.1 3-535
694-2247 BC012942.1 253-1806
2248-2272 BF901720.1 413-437
2273-4118 BC012942.1 1832-3677
4119-5128 AL832785.1 2960-3969
FEATURES Location/Qualifiers
source 1..5128
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p22.2"
gene 1..5128
/gene="RBMXL1"
/gene_synonym="RBM1"
/note="RNA binding motif protein, X-linked-like 1"
/db_xref="GeneID:494115"
/db_xref="HGNC:25073"
exon 1..376
/gene="RBMXL1"
/gene_synonym="RBM1"
/inference="alignment:Splign:1.39.8"
exon 377..476
/gene="RBMXL1"
/gene_synonym="RBM1"
/inference="alignment:Splign:1.39.8"
exon 477..5087
/gene="RBMXL1"
/gene_synonym="RBM1"
/inference="alignment:Splign:1.39.8"
misc_feature 675..677
/gene="RBMXL1"
/gene_synonym="RBM1"
/note="upstream in-frame stop codon"
CDS 717..1889
/gene="RBMXL1"
/gene_synonym="RBM1"
/note="heterogeneous nuclear ribonucleoprotein G-like 1"
/codon_start=1
/product="RNA binding motif protein, X-linked-like-1"
/protein_id="NP_001156008.1"
/db_xref="GI:242117971"
/db_xref="CCDS:CCDS716.1"
/db_xref="GeneID:494115"
/db_xref="HGNC:25073"
/translation="
MVEADRPGKLFIGGLNTETNEKALETVFGKYGRIVEVLLIKDRETNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFERGRHGPPPPPRSRGPPRGFGAGRGGSGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGPSPKRSAPSGLVRSSSGMGGRAPLSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYGDRDGYGRDRDYSDHPSGGSYRDSYESYGNSRSAPLTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDLYSSCDRVGRQERGLPPSVERGYPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY
"
misc_feature 741..962
/gene="RBMXL1"
/gene_synonym="RBM1"
/note="RRM (RNA recognition motif), also known as RBD (RNA
binding domain) or RNP (ribonucleoprotein domain), is a
highly abundant domain in eukaryotes found in proteins
involved in post-transcriptional gene expression processes
including mRNA and rRNA...; Region: RRM; cd00590"
/db_xref="CDD:100104"
misc_feature order(747..749,867..869,873..875)
/gene="RBMXL1"
/gene_synonym="RBM1"
/note="RNA/DNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 957..962
/gene="RBMXL1"
/gene_synonym="RBM1"
/note="RRM dimerization site [polypeptide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 978..980
/gene="RBMXL1"
/gene_synonym="RBM1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96E39.1); phosphorylation site"
misc_feature 1197..1199
/gene="RBMXL1"
/gene_synonym="RBM1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96E39.1); phosphorylation site"
misc_feature 1233..1367
/gene="RBMXL1"
/gene_synonym="RBM1"
/note="RBM1CTR (NUC064) family; Region: RBM1CTR;
pfam08081"
/db_xref="CDD:149260"
variation 3372
/gene="RBMXL1"
/gene_synonym="RBM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3209411"
STS 3850..3934
/gene="RBMXL1"
/gene_synonym="RBM1"
/standard_name="RH93455"
/db_xref="UniSTS:92375"
STS 3891..4050
/gene="RBMXL1"
/gene_synonym="RBM1"
/standard_name="A004S46"
/db_xref="UniSTS:70793"
variation 4090
/gene="RBMXL1"
/gene_synonym="RBM1"
/replace="a"
/replace="c"
/db_xref="dbSNP:1053196"
STS 4822..4998
/gene="RBMXL1"
/gene_synonym="RBM1"
/standard_name="SHGC-75112"
/db_xref="UniSTS:69922"
polyA_signal 5067..5072
/gene="RBMXL1"
/gene_synonym="RBM1"
polyA_site 5087
/gene="RBMXL1"
/gene_synonym="RBM1"
ORIGIN
gtggcccccaccccttccctcctccatttccatccattccgcgatcgcggcggaccccaccgtcatcgcgcgccgtgagtcacactccacagccaatccctggccacatccgggctcgcccccgccccgcccccttgttcccgcaagcccggaactgcccaaatcccgcccctcccctcccaaaaaaacacccctcatccagtctcttccagcctagagatcctggcctacccctccgccaaagcgcgcactgagtgcaaaccccagagtcaatccctgtcccggctccgccccccgcgtccgaatcccgcccagccgggccctcaagcccagtcgggactcgagcctagggaggcgaggttcccgcaccggatagcatgtttttggcccagaggagcctctgctctcttagcggtagagcaaaattcctgaagacaatttcttcttccaaaatcctcggattctctacttctgctgaacattctgttgttttcctctgccatctagtggcaaaagaaagtaattttcctggttttttgaatggatagccataccttaaaaagcatccagattgcgcagtagtgctagcggcttcgcggttcagtcctcctaactgacagccgccactggtgctgagctgctaggaagcccctgtcggcgagcttgttggagcttgaacccactgtcacccctccgactcaccggcaaaaaaaaaaatggttgaagcagatcgcccaggaaagctcttcattggtgggcttaatacggaaacaaatgagaaagctcttgaaacagtatttggcaaatatggacgaatagtggaagtactcttgataaaagaccgtgaaaccaacaaatcaagaggatttgcttttgtcacctttgaaagcccagcagacgctaaggatgcagccagagacatgaatggaaagtcattagatggaaaagccatcaaggtggaacaagccaccaaaccatcatttgaaagaggtagacatggaccgcccccacctccaagaagtagaggtcctccaagaggttttggagctggaagaggaggaagtggaggaaccaggggacctccttcacgaggaggacacatggatgatggtggatattccatgaattttaacatgagttcttccaggggaccactcccagtaaaaagaggaccaccaccaagaagtgggggtccttctcctaagagatctgcaccttcaggactagttcgcagcagcagtggaatgggaggaagagctcctctatcacgtggaagagatagttatggaggtccacctcgaagggaaccgctcccctctcgtagagatgtttatttgtccccaagagatgatgggtattctactaaagacagctattcaagcagagattacccaagttctcgtgatacaagagattatgcaccaccaccacgagattatacttaccgtgattatggtcattccagttcacgtgatgactatccatcaagaggctatggcgatagagatggatatggtcgtgatcgtgactattcagatcatccaagtggaggttcctacagagattcatatgagagttatggtaactcacgtagtgctccacttacacgagggcccccgccatcttatggtggaagcagtcgctatgatgattatagcagctcacgtgatggatatggtggaagtcgagacagttactcaagcagccgaagtgatctctactcaagttgtgacagggttggcagacaagaaagagggcttcccccttctgtagaaagggggtacccttcttcacgtgattcctacagcagttcaagccgcggagcaccaagaggtgctggccctggaggaagccgatctgatagagggggaggcagaagcagatactagaaacaaacaaaactttggaccaaaatcccagttcaaagaaacaaaaaaaagagtggaaactattctatcataactacccaaggactactaaaaggaaaaattgtgttaccttttttaaattccctgttaagtcccttccgtaatttttatgttcttgtgaggaaaaaagtaaaacatgtttaattttatttgactttatgacattgcttttcaacaagcaaatgttaaatgtgttaagccttgtagtactagtgttgtaactttccaagtaaaggtgtccctaaagaccacttcctatctggtttttcccagtaaatgaggcaagcaattctaagatcttccacaaaacatctagccaactaaaatggagagatgaatcattctgcctatacaaacaagctagctattagagggtggttggagtatgctactcataagatttcagggtgttttctaactgaaatctcactgttctcagtatgcaaaacctgaaatcagatgcctatgtaaggaaagtgctattcacccagtaaacccaaaaaaagcaaatggataatgctggccattttgcctttctgacatttccttgggaatctgcaagaacctcccctttcccctcccacaataagaccatttaagtgtgtgctaaacaactacggaatactaaataaaaagtttggccaaaaccaaccatgaagctgcaaaggtgcttgctcttactctttcaaatttttgcaactctaatgtctcacttttaaaggaacagcttgattgcaaaggagaaaatagataagcaatgaatttatctccaacttcctaaaggcttatgacttctaaaaagtgaatctatcagcattccacatcagatttaaagcatcaaatgcctgtgaaacagcaaagatggttgaagattgtgctcattatgtttgtggagtgctgattgattcacagtagataacgctggcagtaagagaaatcaaatgctaagagttgttgaagcagaaggcggctgattgttggtaagtcagtgcagttgcataagcagtgctgtcagaattggtttggtgcaggcaatagattttgccttcaagggttcctgtggatctcaggaaggcatcagtgttgattaacactcataactagggagtgagtggtagttacttaagtaattgaccaaatggaaaaggggaagtaattaaggaaattggtaagtggaggtagtcaggaggttctcgtggtcctttacacagattttacagctttgggtttcattttgtttagctaaagtcatggggacaactcttcaatttagaacttaagatgaattataaaaatgatggatataagtggtagctctatctggtgaagtgtcttgtcagtaagtgaaacatttttttgtggtggcttatccacaaacagtttagttgtagaataaaacttatgagtgacatctggaaagtaacaaccatgctaagatggcaaacacactggaaacaattgggccacttggctttcttttgctgtattgttttataagcctgctttacctccccgtcttggaaacaagttttagtttattgctttggagactagagccaatagtgtaatgttctcaaaggaaacagacttgagttgttggattagaggaactaactcaacttctaattttttttgttgtaattatggcactgtcatgttttaacatttgcaactagggatagtaagtacaacatttttaactctcatttggcagactactactaatcacagaccacaagggtaatgaccaaatttatgtggttgttacacttccatagttgtcttagccgaatccttccatattcttatgattacttgggttaaagcttctgtgaggaccttttggctcttaagatatcctaaatatttaaaatatttagatatcctaaatataggatatagagtttgtaccaaatatgaatgaatattgttcaaagcaaggagtatgttaaaatgaccagacacctgtttgataaatagtttactgaactagcagacgtgtggaaaaagaatcagatcttgattcttctgggtttatactggttgtaaaacagaatgatattagaaaatgttttccttgtttaagtggtagttgaacatagaacttgggtattatagatcacttttcactttttggaatgttttgtattgaaacttaatacaactttaacatggcaaaaaaaaaaaaaatccaaaatctatgagataattttgttaaagttggcttgcttgggcgggtgcttggtccagagggagaaaagaaggcatgatttcagaatactctggcagctttttaaattcagctttatcaagttacagtaaactgtatctgtttagaattacaactcaatggttattttgacagatgtatatgccatgaagccactgtcaccatcaacatgcagaacacttccatcgcccccaaaagattcctcaagttcctttgcagtccatccctcacgctgctgatttgtctttgtcaccatatattagtttgctttgtggtggtgtttagtattttatataaatgggattgtgtagcatgtacttttttgtttatggtttctttcacacacaatgactttgaaattcaccaggttgcagtgtatcagtagcttattccttttattgctgagtagtgtcccattatgtgaatatgccattatttgtttttctactcacctgttgatggaccttgggattgtttccagtttggggctactgtgaataaaactgttaggaacatttgtgtacaagccactgtgtagacataggttttcctttctcttgggtaaatacctaccagtaaaatggttgggttgcatggcagatttatgtttaataaagtaactgccaaactgtttgttttccaaaggggctatacccttttatattcccaccagggttgtatagagttccaactgccaacactcagttttcagccattctgatgggaatctagtggtatctcattgtggttttattttcatttccccgggtgactaatgctggtaagcatcttttaaggtactttttggccagttgtatattttctgtgaagtggctgtcaaatcttttgcccacttttaattggattgtttgtcttattgagttgtaaaagttctttatatatactgtattaaagtcctttgtaagacaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:494115 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA
GeneID:494115 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
GeneID:494115 -> Biological process: GO:0006397 [mRNA processing] evidence: IEA
GeneID:494115 -> Biological process: GO:0008380 [RNA splicing] evidence: IEA
GeneID:494115 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:494115 -> Cellular component: GO:0030529 [ribonucleoprotein complex] evidence: IEA
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