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2025-05-09 18:57:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001198801 6515 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens eukaryotic translation initiation factor 4 gamma, 3
(EIF4G3), transcript variant 1, mRNA.
ACCESSION NM_001198801
VERSION NM_001198801.1 GI:311771713
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6515)
AUTHORS Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
TITLE A probability-based approach for high-throughput protein
phosphorylation analysis and site localization
JOURNAL Nat. Biotechnol. 24 (10), 1285-1292 (2006)
PUBMED 16964243
REFERENCE 2 (bases 1 to 6515)
AUTHORS Lejeune,F., Ranganathan,A.C. and Maquat,L.E.
TITLE eIF4G is required for the pioneer round of translation in mammalian
cells
JOURNAL Nat. Struct. Mol. Biol. 11 (10), 992-1000 (2004)
PUBMED 15361857
REFERENCE 3 (bases 1 to 6515)
AUTHORS Gradi,A., Foeger,N., Strong,R., Svitkin,Y.V., Sonenberg,N.,
Skern,T. and Belsham,G.J.
TITLE Cleavage of eukaryotic translation initiation factor 4GII within
foot-and-mouth disease virus-infected cells: identification of the
L-protease cleavage site in vitro
JOURNAL J. Virol. 78 (7), 3271-3278 (2004)
PUBMED 15016848
REFERENCE 4 (bases 1 to 6515)
AUTHORS Qin,H., Raught,B., Sonenberg,N., Goldstein,E.G. and Edelman,A.M.
TITLE Phosphorylation screening identifies translational initiation
factor 4GII as an intracellular target of
Ca(2+)/calmodulin-dependent protein kinase I
JOURNAL J. Biol. Chem. 278 (49), 48570-48579 (2003)
PUBMED 14507913
REFERENCE 5 (bases 1 to 6515)
AUTHORS Miura,T., Shiratori,Y. and Shimma,N.
TITLE Backbone resonance assignment of human eukaryotic translation
initiation factor 4E (eIF4E) in complex with 7-methylguanosine
diphosphate (m7GDP) and a 17-amino acid peptide derived from human
eIF4GII
JOURNAL J. Biomol. NMR 27 (3), 279-280 (2003)
PUBMED 12975586
REFERENCE 6 (bases 1 to 6515)
AUTHORS Waskiewicz,A.J., Johnson,J.C., Penn,B., Mahalingam,M., Kimball,S.R.
and Cooper,J.A.
TITLE Phosphorylation of the cap-binding protein eukaryotic translation
initiation factor 4E by protein kinase Mnk1 in vivo
JOURNAL Mol. Cell. Biol. 19 (3), 1871-1880 (1999)
PUBMED 10022874
REFERENCE 7 (bases 1 to 6515)
AUTHORS Pyronnet,S., Imataka,H., Gingras,A.C., Fukunaga,R., Hunter,T. and
Sonenberg,N.
TITLE Human eukaryotic translation initiation factor 4G (eIF4G) recruits
mnk1 to phosphorylate eIF4E
JOURNAL EMBO J. 18 (1), 270-279 (1999)
PUBMED 9878069
REFERENCE 8 (bases 1 to 6515)
AUTHORS Gingras,A.C., Raught,B. and Sonenberg,N.
TITLE eIF4 initiation factors: effectors of mRNA recruitment to ribosomes
and regulators of translation
JOURNAL Annu. Rev. Biochem. 68, 913-963 (1999)
PUBMED 10872469
REMARK Review article
REFERENCE 9 (bases 1 to 6515)
AUTHORS Imataka,H., Gradi,A. and Sonenberg,N.
TITLE A newly identified N-terminal amino acid sequence of human eIF4G
binds poly(A)-binding protein and functions in poly(A)-dependent
translation
JOURNAL EMBO J. 17 (24), 7480-7489 (1998)
PUBMED 9857202
REFERENCE 10 (bases 1 to 6515)
AUTHORS Gradi,A., Imataka,H., Svitkin,Y.V., Rom,E., Raught,B., Morino,S.
and Sonenberg,N.
TITLE A novel functional human eukaryotic translation initiation factor
4G
JOURNAL Mol. Cell. Biol. 18 (1), 334-342 (1998)
PUBMED 9418880
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CN402454.1, BC072413.1, BC094683.1, AB209119.1 and BF084093.1.
Transcript Variant: This variant (1) encodes the longest isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC072413.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-41 CN402454.1 2-42
42-4567 BC072413.1 1-4526
4568-5687 BC094683.1 3101-4220
5688-6324 AB209119.1 5557-6193
6325-6515 BF084093.1 90-280
FEATURES Location/Qualifiers
source 1..6515
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36.12"
gene 1..6515
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/note="eukaryotic translation initiation factor 4 gamma,
3"
/db_xref="GeneID:8672"
/db_xref="HGNC:3298"
/db_xref="MIM:603929"
misc_feature 50..52
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/note="upstream in-frame stop codon"
CDS 623..5488
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/note="isoform 1 is encoded by transcript variant 1;
eIF-4-gamma 3; eIF-4-gamma II"
/codon_start=1
/product="eukaryotic translation initiation factor 4 gamma
3 isoform 1"
/protein_id="NP_001185730.1"
/db_xref="GI:311771714"
/db_xref="GeneID:8672"
/db_xref="HGNC:3298"
/db_xref="MIM:603929"
/translation="
MNSQPQTRSPFFQRPQIQPPRATIPNSSPSIRPGAQTPTAVYQANQHIMMVNHLPMPYPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFPNAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPPQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIAELPLPPSPTTVSSVARSTIAAPTSSALSSQPIFTTAIDDRCELSSPREDTIPIPSLTSCTETSDPLPTNENDDDICKKPCSVAPNDIPLVSSTNLINEINGVSEKLSATESIVEIVKQEVLPLTLELEILENPPEEMKLECIPAPITPSTVPSFPPTPPTPPASPPHTPVIVPAAATTVSSPSAAITVQRVLEEDESIRTCLSEDAKEIQNKIEVEADGQTEEILDSQNLNSRRSPVPAQIAITVPKTWKKPKDRTRTTEEMLEAELELKAEEELSIDKVLESEQDKMSQGFHPERDPSDLKKVKAVEENGEEAEPVRNGAESVSEGEGIDANSGSTDSSGDGVTFPFKPESWKPTDTEGKKQYDREFLLDFQFMPACIQKPEGLPPISDVVLDKINQPKLPMRTLDPRILPRGPDFTPAFADFGRQTPGGRGVPICKVQSRHGLPILEQSKAPTCPPLVMSHPPMKSLPLGLLNVGSRRSQPGQRREPRKIITVSVKEDVHLKKAENAWKPSQKRDSQADDPENIKTQELFRKVRSILNKLTPQMFNQLMKQVSGLTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDKADDDVFEKKQKELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKPTIDEKIQLVPKAQLGSWGKGSSGGAKASETDALRSSASSLNRFSALQPPAPSGSTPSTPVEFDSRRTLTSRGSMGREKNDKPLPSATARPNTFMRGGSSKDLLDNQSQEEQRREMLETVKQLTGGVDVERNSTEAERNKTRESAKPEISAMSAHDKAALSEEELERKSKSIIDEFLHINDFKEAMQCVEELNAQGLLHVFVRVGVESTLERSQITRDHMGQLLYQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWLYLAELVTPMLKEGGISMRELTIEFSKPLLPVGRAGVLLSEILHLLCKQMSHKKVGALWREADLSWKDFLPEGEDVHNFLLEQKLDFIESDSPCSSEALSKKELSAEELYKRLEKLIIEDKANDEQIFDWVEANLDEIQMSSPTFLRALMTAVCKAAIIADSSTFRVDTAVIKQRVPILLKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQNGKGVALKSVTAFFTWLREAEEESEDN
"
misc_feature 2993..3670
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/note="MIF4G domain; Region: MIF4G; pfam02854"
/db_xref="CDD:202432"
misc_feature 4415..4732
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/note="MA3 domain; Region: MA3; pfam02847"
/db_xref="CDD:111714"
misc_feature 5012..5398
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/note="C-terminal W2 domain of eukaryotic translation
initiation factor 4 gamma 1 and similar proteins; Region:
W2_eIF4G1_like; cd11559"
/db_xref="CDD:211397"
misc_feature <5333..5473
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/note="C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon;
Region: W2; cl17013"
/db_xref="CDD:212634"
variation 1388
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/replace="a"
/replace="g"
/db_xref="dbSNP:1062981"
STS 2820..2943
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/standard_name="SHGC-74327"
/db_xref="UniSTS:69800"
variation 4285
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/replace="a"
/replace="t"
/db_xref="dbSNP:2230572"
variation 4568
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230573"
STS 5560..5700
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/standard_name="SHGC-74345"
/db_xref="UniSTS:77072"
STS 5566..5689
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/standard_name="EST28C5"
/db_xref="UniSTS:263320"
STS 5649..6409
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/standard_name="EIF4G3_1535"
/db_xref="UniSTS:277201"
STS 6092..6171
/gene="EIF4G3"
/gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
/standard_name="SHGC-74329"
/db_xref="UniSTS:83013"
ORIGIN
gccggactgctggaggcggccacagcgccatgttggatgctctgctcgttgagtgaagaaaatccaccggcatcgcctgagccccgctaccgagaagggcgccgcttcctccggggagggggataaagatcccccgccgccggcccatgaggatattgccgtgaaaggcacagcgactgcagcaggaaccggacccggcaccggagcggcggcggcggcggcagcagcggtaccgcctcctcacccggcggcggcagcagcggcggcggcggcggcggcggcggcggcggcggcagcggtcccccctcctcacccgaacatcagggccctccagactcaggcgccccaacaaattcctagaggacctgtgcaacaacctcttgaggatcgaatcttcactcccgctgtctcagcagtctacagcacggtaacacaagtggcaagacagccgggaacccctaccccatccccttattcagcacatgaaataaacaaggggcatccaaatcttgcggcaacgcccccgggacatgcatcgtcccctggactctctcaaaccccttatccctctggacagaatgcaggtccaaccacgctggtataccctcaaacccctcagacaatgaattcacaacctcaaacccgttctccgtttttccagaggcctcaaatacagcctcctagagctaccatcccgaacagcagtccttccattcgtcctggtgcacagacacccactgcagtgtaccaggctaatcagcacatcatgatggttaaccatctgcccatgccgtacccagtgccccaggggcctcagtactgtataccacagtaccgtcatagtggccctccttatgttgggcccccccaacaatatccagttcaaccaccggggccaggtcctttttatcctggaccaggacctggggacttccccaatgcttatggaacgcctttttacccaagtcagccggtgtatcagtcagcacctatcatagtgcctacgcagcaacagccgcctccagccaagagagagaaaaaaactataagaattcgggatccaaaccagggaggtaaagacataacagaggagattatgtctggaggtggcagcagaaatcctactccacccataggaagacccacgtccacacctactcctcctcagctgcccagccaggtccccgagcacagccctgtggtttatgggactgtggagagcgctcatcttgctgccagcacccctgtcactgcagctagcgaccagaagcaagaggagaagccaaaaccagatccagtgttaaagtctccttccccagtccttaggctagtcctcagtggagagaagaaagaacaagaaggccagacatctgaaactactgcaatagtatccatagcagagcttcctctgcctccatcacctaccactgtttcttctgttgctcgaagtacaattgcagcccccacctcttctgctcttagtagccaaccaatattcaccactgctatagatgacagatgtgaactctcatccccaagagaagacacaattcctatacccagcctcacatcttgcacagaaacatcagaccctttaccaacaaatgaaaatgatgatgatatatgcaagaaaccctgtagtgtagcacctaatgatattccactggtttctagtactaacctaattaatgaaataaatggagttagcgaaaaattatcagccacggagagcattgtggaaatagtaaaacaggaagtattgccattgactcttgaattggagattctcgaaaatcccccagaagaaatgaaactggagtgtatcccagctcccatcaccccttccacagttccttcctttcctccaactcctccaactcctccagcttctcctcctcacactccagtcattgttcctgctgctgccactactgttagttctccgagtgctgccatcacagtccagagagtcctagaggaggacgagagcataagaacttgccttagtgaagatgcaaaagagattcagaacaaaatagaggtagaagcagatgggcaaacagaagagattttggattctcaaaacttaaattcaagaaggagccctgtcccagctcaaatagctataactgtaccaaagacatggaagaaaccaaaagatcggacccgaaccactgaagagatgttagaggcagaattggagcttaaagctgaagaggagctttccattgacaaagtacttgaatctgaacaagataaaatgagccaggggtttcatcctgaaagagacccctctgacctaaaaaaagtgaaagctgtggaagaaaatggagaagaagctgagccagtacgtaatggtgctgagagtgtttctgagggtgaaggaatagatgctaattcaggctccacagatagttctggtgatggggttacatttccatttaaaccagaatcctggaagcctactgatactgaaggtaagaagcagtatgacagggagtttctgctggacttccagttcatgcctgcctgtatacaaaaaccagagggcctgcctcctatcagtgatgtggttcttgacaagatcaaccaacccaaattgccaatgcgaactctggatcctcgaattttgcctcgaggaccagactttacaccagcctttgctgattttggaaggcagacacctggtggaagaggcgtacctatttgcaaagtgcagagcaggcatggattgccaattctggaacagagcaaagccccaacttgccctccactggtgatgtcacacccacccatgaagagcctgcctctagggttgttgaatgttgggtcacgaagatctcaacctggccaaagaagagaacccagaaagatcatcacagtttctgtaaaagaagatgtacacctgaaaaaggcagaaaatgcctggaagccaagccaaaaacgagacagccaagccgatgatcccgaaaacattaaaacccaggagctttttagaaaagttcgaagtatcttaaataaattgacaccacagatgttcaatcaactgatgaagcaagtgtcaggacttactgttgacacagaggagcggctgaaaggagttattgacctggtctttgagaaggctattgatgaacccagtttctctgtggcttacgcaaacatgtgtcgatgtctagtaacgctgaaagtacccatggcagacaagcctggtaacacagtgaatttccggaagctgctactgaaccgttgccagaaggagtttgaaaaagataaagcagatgatgatgtctttgagaagaagcagaaagaacttgaggctgccagtgctccagaggagaggacaaggcttcatgatgaactggaagaagccaaggacaaagcccggcggagatccattggcaacatcaagtttattggagaactctttaaactcaaaatgctgactgaagccatcatgcatgactgtgtggtgaagctgctaaagaaccatgatgaagaatccctggagtgcctgtgtcgcctgctcaccaccattggcaaagacttggactttgaaaaagcaaagccacgtatggaccagtactttaatcagatggagaaaattgtgaaagaaagaaaaacctcatctaggattcggttcatgcttcaagatgttatagacctaaggctgtgcaattgggtatctcgaagagcagatcaagggcctaaaactatcgaacagattcacaaagaggctaaaatagaagaacaagaagagcaaaggaaggtccagcaactcatgaccaaagagaagagaagaccaggtgtccagagagtggacgaaggtgggtggaacactgtacaaggggccaagaacagtcgggtactggacccctcaaaattcctaaaaatcactaagcctacaattgatgaaaaaattcagctggtacctaaagcacagctaggcagctggggaaaaggcagcagtggtggagcaaaggcaagtgagactgatgccttacggtcaagtgcttccagtttaaacagattctctgccctgcaacctccagcaccctcagggtccacgccatccacgcctgtagagtttgattcccgaaggaccttaactagtcgtggaagtatgggcagggagaagaatgacaagccccttccatctgcaacagctcggccaaatactttcatgaggggtggcagcagtaaagacctgctagacaatcagtctcaagaagagcagcggagagagatgctggagaccgtgaagcagctcacaggaggtgtggatgtggagaggaacagcactgaggctgagcgaaataaaacaagggagtcagcaaaaccagaaatttcagcaatgtcagctcatgacaaggctgcattatcagaagaggaactggagaggaagtcgaaatctatcattgatgaatttctacacattaatgattttaaggaagccatgcagtgtgtggaagagctgaatgcccagggcctactacatgtttttgtgagagtgggagtggagtccaccctggaaaggagccagatcaccagggatcacatgggccaattactctatcagctggtacagtcagaaaaactcagcaaacaggactttttcaaaggtttttcagaaactttggaattggcagatgacatggccattgatattccccatatttggttgtaccttgctgaactggtgacccccatgttaaaagaaggtggaatctccatgagagaacttaccatagaatttagcaaacctttacttcctgttggaagagctggggtcttgctatctgaaatattgcacctactatgcaaacaaatgagccataagaaagtgggagccttatggagggaggctgacctcagctggaaggactttttaccagaaggagaagatgtacataattttcttttggagcagaagttggacttcatagagtctgacagtccctgttcctctgaagcactttcaaagaaagaactgtctgccgaagagctgtataagcgactcgagaaactcattattgaggacaaagcgaatgatgaacagatctttgactgggtagaggctaatctagacgaaatccagatgagttcacctacattccttagagctttaatgactgctgtttgtaaagcagctattatagccgactcttctaccttcagagtggacactgctgttatcaagcagagagtgccgatcttactcaagtacctagactcagatacagagaaggaactgcaagcactttatgcactacaagcatcgatagtaaaacttgatcaacctgccaatttgctgcggatgttttttgattgtctatatgacgaggaggtgatctccgaggatgccttctacaaatgggagagcagcaaggaccctgcagagcagaatgggaagggcgtggctctgaaatctgtcacggcattcttcacgtggctgcgggaagcagaagaggagtctgaggataactaaaacttcaaatacacaaaatgaaacaaaagaaacaatttaagtatttttttaaaaagtttcacgtcttcgccaatcacagtgcagcaaggccaattctcgcagaaacccccacgtgtgcacgagtgggagaggggaaagagaaaaaaaggtgatcatggaggaaaaaggtactggataaaagtaaacttcaaaccttagggcgggagcactaaaaccaaaatacatgtattatttatagaaaatattttctgttttaatcttttctttttaaacaaggactcatacttaaaaaaatgtttagcaaaaaaaaaaaaagttgagaacttttaatttattttaaggactgcaaatgccagtgtaattttttaatttgcagtttctgtaaacaacttgtataatagaaaagcagagaaataaatttccctccccttcaagatgcacctcatgtttgttttaaggtatagcatttagtccagatttgagaaagtttggggtgaacaaggtaagaaagatttttttttttttggcatcaaatctttctgcctgcctctcagcttgcttcagaaaatttaaaaaatcacaatagtaatcaaaacatacataacattgaaacagaaggaaatgctgtggaccacagaactccaagaattgtttaaaaaaaaaaaagtgctaccctgagaaaagtactcttaatactcttgaaatctttagagcaactttaaggcttgtaaatacatagaacaaatatttaaaaaaacaaaaagaaattgactcagtactatttcttttcactttgaaaatataaagaacaaaataaagacaaacattgcaagtttaaaagaaagtaaagtgacttctcctttggacagctgctgcatgtgtgcccattcctgggggtgctgtctggctatttattgtctaattcaaatcactcctgaggggagagagataaaacgagagagagtgagagagtgtgtgtatgtgcgtgtatgcgcacgtatgtgcatgcacatgtatgtatgtatat
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8672 -> Molecular function: GO:0000339 [RNA cap binding] evidence: TAS
GeneID:8672 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:8672 -> Molecular function: GO:0003743 [translation initiation factor activity] evidence: IEA
GeneID:8672 -> Molecular function: GO:0008135 [translation factor activity, nucleic acid binding] evidence: TAS
GeneID:8672 -> Biological process: GO:0006446 [regulation of translational initiation] evidence: TAS
GeneID:8672 -> Biological process: GO:0016070 [RNA metabolic process] evidence: IEA
GeneID:8672 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:8672 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS
GeneID:8672 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:8672 -> Cellular component: GO:0016281 [eukaryotic translation initiation factor 4F complex] evidence: TAS
by
@meso_cacase at
DBCLS
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