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2025-05-09 18:26:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_002839 10127 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens protein tyrosine phosphatase, receptor type, D
(PTPRD), transcript variant 1, mRNA.
ACCESSION NM_002839
VERSION NM_002839.3 GI:283484017
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 10127)
AUTHORS Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
Ferrucci,L., Fornage,M. and Mozaffarian,D.
TITLE Genome-wide association study identifies novel loci associated with
concentrations of four plasma phospholipid fatty acids in the de
novo lipogenesis pathway: results from the Cohorts for Heart and
Aging Research in Genomic Epidemiology (CHARGE) consortium
JOURNAL Circ Cardiovasc Genet 6 (2), 171-183 (2013)
PUBMED 23362303
REFERENCE 2 (bases 1 to 10127)
AUTHORS Du,Y., Su,T., Tan,X., Li,X., Xie,J., Wang,G., Shen,J., Hou,J. and
Cao,G.
TITLE Polymorphism in protein tyrosine phosphatase receptor delta is
associated with the risk of clear cell renal cell carcinoma
JOURNAL Gene 512 (1), 64-69 (2013)
PUBMED 23069849
REMARK GeneRIF: Polymorphism in protein tyrosine phosphatase receptor
delta is associated with the risk of clear cell renal cell
carcinoma.
REFERENCE 3 (bases 1 to 10127)
AUTHORS Meng,W., Butterworth,J., Bradley,D.T., Hughes,A.E., Soler,V.,
Calvas,P. and Malecaze,F.
TITLE A genome-wide association study provides evidence for association
of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in
the French Population
JOURNAL Invest. Ophthalmol. Vis. Sci. 53 (13), 7983-7988 (2012)
PUBMED 23049088
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 10127)
AUTHORS Wilk,J.B., Shrine,N.R., Loehr,L.R., Zhao,J.H., Manichaikul,A.,
Lopez,L.M., Smith,A.V., Heckbert,S.R., Smolonska,J., Tang,W.,
Loth,D.W., Curjuric,I., Hui,J., Cho,M.H., Latourelle,J.C.,
Henry,A.P., Aldrich,M., Bakke,P., Beaty,T.H., Bentley,A.R.,
Borecki,I.B., Brusselle,G.G., Burkart,K.M., Chen,T.H., Couper,D.,
Crapo,J.D., Davies,G., Dupuis,J., Franceschini,N., Gulsvik,A.,
Hancock,D.B., Harris,T.B., Hofman,A., Imboden,M., James,A.L.,
Khaw,K.T., Lahousse,L., Launer,L.J., Litonjua,A., Liu,Y.,
Lohman,K.K., Lomas,D.A., Lumley,T., Marciante,K.D., McArdle,W.L.,
Meibohm,B., Morrison,A.C., Musk,A.W., Myers,R.H., North,K.E.,
Postma,D.S., Psaty,B.M., Rich,S.S., Rivadeneira,F., Rochat,T.,
Rotter,J.I., Artigas,M.S., Starr,J.M., Uitterlinden,A.G.,
Wareham,N.J., Wijmenga,C., Zanen,P., Province,M.A., Silverman,E.K.,
Deary,I.J., Palmer,L.J., Cassano,P.A., Gudnason,V., Barr,R.G.,
Loos,R.J., Strachan,D.P., London,S.J., Boezen,H.M.,
Probst-Hensch,N., Gharib,S.A., Hall,I.P., O'Connor,G.T., Tobin,M.D.
and Stricker,B.H.
TITLE Genome-wide association studies identify CHRNA5/3 and HTR4 in the
development of airflow obstruction
JOURNAL Am. J. Respir. Crit. Care Med. 186 (7), 622-632 (2012)
PUBMED 22837378
REFERENCE 5 (bases 1 to 10127)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 6 (bases 1 to 10127)
AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
TITLE Intra- and intermolecular interactions between intracellular
domains of receptor protein-tyrosine phosphatases
JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002)
PUBMED 12376545
REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
a common but specific mechanism that is likely to be regulated-
domain2s and the wedge structures are crucial determinants of
binding specificity, thus regulating cross-talk between RPTPs
REFERENCE 7 (bases 1 to 10127)
AUTHORS Wallace,M.J., Fladd,C., Batt,J. and Rotin,D.
TITLE The second catalytic domain of protein tyrosine phosphatase delta
(PTP delta) binds to and inhibits the first catalytic domain of PTP
sigma
JOURNAL Mol. Cell. Biol. 18 (5), 2608-2616 (1998)
PUBMED 9566880
REFERENCE 8 (bases 1 to 10127)
AUTHORS Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M.
TITLE The LAR/PTP delta/PTP sigma subfamily of transmembrane
protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and
PTP sigma isoforms are expressed in a tissue-specific manner and
associate with the LAR-interacting protein LIP.1
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995)
PUBMED 8524829
REFERENCE 9 (bases 1 to 10127)
AUTHORS Pulido,R., Krueger,N.X., Serra-Pages,C., Saito,H. and Streuli,M.
TITLE Molecular characterization of the human transmembrane
protein-tyrosine phosphatase delta. Evidence for tissue-specific
expression of alternative human transmembrane protein-tyrosine
phosphatase delta isoforms
JOURNAL J. Biol. Chem. 270 (12), 6722-6728 (1995)
PUBMED 7896816
REFERENCE 10 (bases 1 to 10127)
AUTHORS Krueger,N.X., Streuli,M. and Saito,H.
TITLE Structural diversity and evolution of human receptor-like protein
tyrosine phosphatases
JOURNAL EMBO J. 9 (10), 3241-3252 (1990)
PUBMED 2170109
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC028038.1, AL390723.21,
AB211400.1, AL356584.21, AL445926.5 and BM680342.1.
On Jan 8, 2010 this sequence version replaced gi:104487003.
Summary: The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP contains an extracellular
region, a single transmembrane segment and two tandem
intracytoplasmic catalytic domains, and thus represents a
receptor-type PTP. The extracellular region of this protein is
composed of three Ig-like and eight fibronectin type III-like
domains. Studies of the similar genes in chicken and fly suggest
the role of this PTP is in promoting neurite growth, and regulating
neurons axon guidance. Multiple alternatively spliced transcript
variants of this gene have been reported. A related pseudogene has
been identified on chromosome 5. [provided by RefSeq, Jan 2010].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: AB211400.1, L38929.1 [ECO:0000331]
RNAseq introns :: mixed/partial sample support ERS025081,
ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-215 BC028038.1 1-215
216-216 AL390723.21 23944-23944 c
217-1703 AB211400.1 185-1671
1704-1704 AL356584.21 20392-20392 c
1705-6657 AB211400.1 1673-6625
6658-9471 AL445926.5 119217-122030 c
9472-10127 BM680342.1 1-656 c
FEATURES Location/Qualifiers
source 1..10127
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p23-p24.3"
gene 1..10127
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="protein tyrosine phosphatase, receptor type, D"
/db_xref="GeneID:5789"
/db_xref="HGNC:9668"
/db_xref="HPRD:03358"
/db_xref="MIM:601598"
exon 1..36
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 37..144
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 145..199
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 200..272
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 273..376
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 377..418
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 419..457
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 458..507
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 508..541
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 542..601
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 602..640
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 641..807
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
misc_feature 660..662
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="upstream in-frame stop codon"
CDS 744..6482
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/EC_number="3.1.3.48"
/note="isoform 1 precursor is encoded by transcript
variant 1; protein tyrosine phosphatase, receptor type,
delta polypeptide; receptor-type tyrosine-protein
phosphatase delta; R-PTP-delta; protein-tyrosine
phosphatase delta"
/codon_start=1
/product="receptor-type tyrosine-protein phosphatase delta
isoform 1 precursor"
/protein_id="NP_002830.1"
/db_xref="GI:4506309"
/db_xref="CCDS:CCDS43786.1"
/db_xref="GeneID:5789"
/db_xref="HGNC:9668"
/db_xref="HPRD:03358"
/db_xref="MIM:601598"
/translation="
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
"
sig_peptide 744..803
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 804..6479
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/product="receptor-type tyrosine-protein phosphatase delta
isoform 1"
misc_feature 813..1088
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 831..1088
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Immunoglobulin; Region: IG; smart00409"
/db_xref="CDD:197707"
misc_feature 1170..1415
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Second immunoglobulin (Ig)-like domain of the
receptor protein tyrosine phosphatase (RPTP)-F, also known
as LAR; Region: Ig2_RPTP_IIa_LAR_like; cd05738"
/db_xref="CDD:143215"
misc_feature 1281..1310
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P23468.2);
Region: Interaction with IL1RAPL1 (By similarity)"
misc_feature 1455..1700
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 1491..1697
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Third immunoglobulin (Ig)-like domain of the
receptor protein tyrosine phosphatase (RPTP)-F, also known
as LAR; Region: Ig3_RPTP_IIa_LAR_like; cd05739"
/db_xref="CDD:143216"
misc_feature 1710..1979
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(1710..1712,1896..1898,1941..1943)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(1944..1949,1953..1958)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 1998..2276
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(2193..2195,2238..2240)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(2241..2246,2250..2255)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 2289..2555
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(2289..2291,2472..2474,2517..2519)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(2520..2525,2529..2534)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 2577..2861
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(2778..2780,2823..2825)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(2826..2831,2835..2840)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 2880..3200
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(3117..3119,3162..3164)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(3165..3170,3174..3179)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 3213..3458
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(3213..3215,3402..3404,3447..3449)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature 3450..3455
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 3507..3782
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(3699..3701,3744..3746)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(3747..3752,3756..3761)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 3807..>4001
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature 4284..4289
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="non-experimental evidence, no additional
details recorded"
/note="Cleavage (Probable); propagated from
UniProtKB/Swiss-Prot (P23468.2); cleavage site"
misc_feature 4539..4613
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P23468.2);
transmembrane region"
misc_feature 4809..5576
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Protein tyrosine phosphatase, catalytic domain;
Region: PTPc; smart00194"
/db_xref="CDD:197567"
misc_feature 4887..5576
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Protein tyrosine phosphatases (PTP) catalyze the
dephosphorylation of phosphotyrosine peptides; they
regulate phosphotyrosine levels in signal transduction
pathways. The depth of the active site cleft renders the
enzyme specific for phosphorylated Tyr; Region: PTPc;
cd00047"
/db_xref="CDD:28929"
misc_feature order(5304..5306,5397..5402,5409..5411,5418..5423)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="active site"
/db_xref="CDD:28929"
misc_feature 5400..5420
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P23468.2);
Region: Substrate binding (By similarity)"
misc_feature 5670..6449
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Protein tyrosine phosphatase, catalytic domain;
Region: PTPc; smart00194"
/db_xref="CDD:197567"
misc_feature 5757..6449
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Protein tyrosine phosphatases (PTP) catalyze the
dephosphorylation of phosphotyrosine peptides; they
regulate phosphotyrosine levels in signal transduction
pathways. The depth of the active site cleft renders the
enzyme specific for phosphorylated Tyr; Region: PTPc;
cd00047"
/db_xref="CDD:28929"
misc_feature order(6171..6173,6270..6275,6282..6284,6291..6296)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="active site"
/db_xref="CDD:28929"
exon 808..953
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 954..1095
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 1096..1284
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
STS 1252..1523
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="GDB:582179"
/db_xref="UniSTS:157878"
exon 1285..1293
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 1294..1311
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 1312..1422
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 1423..1434
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 1435..1704
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 1705..2286
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
variation 1739
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:3763653"
STS 2271..3869
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="GDB:582186"
/db_xref="UniSTS:157880"
exon 2287..2420
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 2421..2565
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 2566..2871
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 2872..3065
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
STS 2885..3202
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="GDB:582183"
/db_xref="UniSTS:157879"
exon 3066..3092
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 3093..3210
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 3211..3798
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
variation 3632
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:3824417"
exon 3799..3896
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 3897..4156
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 4157..4247
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 4248..4457
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 4458..4618
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 4619..4731
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 4732..4829
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 4830..4953
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 4954..5129
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 5130..5249
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 5250..5404
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 5405..5690
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 5691..5869
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
STS 5763..5981
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="PTPRD"
/db_xref="UniSTS:512659"
exon 5870..5996
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
STS 5957..6462
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="Ptprd"
/db_xref="UniSTS:545976"
exon 5997..6122
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 6123..6277
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 6278..6413
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 6414..10110
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
STS 6493..6933
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="SGC35386"
/db_xref="UniSTS:31522"
variation 7383
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:1051863"
STS 7447..7465
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/db_xref="UniSTS:98954"
variation 8078
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/replace="a"
/replace="g"
/db_xref="dbSNP:11542527"
polyA_signal 8098..8103
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
polyA_site 8122
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
STS 8420..8600
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="D9S1044E"
/db_xref="UniSTS:151264"
STS 8455..8627
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="RH47322"
/db_xref="UniSTS:12791"
variation 8696
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/replace="a"
/replace="g"
/db_xref="dbSNP:1065682"
STS 9056..9173
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="A003M12"
/db_xref="UniSTS:64813"
STS 9119..9260
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="G31002"
/db_xref="UniSTS:79310"
variation 9368
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/replace="a"
/replace="c"
/db_xref="dbSNP:3739579"
polyA_signal 10088..10093
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
polyA_site 10110
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
ORIGIN
cggcgccgccagccagcctcggcggggagagtgcagtttattctgggcctgtgtggaatagaaagacaattctttatttgactggtaggaaagaaaagagaagactcctcagggtttccaaggaggactggagcggctgctttagtgaagaagtgaagaatcaaggaagtaaaggacctgtctcaaagtcacacaactaggaaatcttgaggagtctgatacttttcatcctccagctataaaatcatcttgtagggggaagctgtacattggtggaaaataaaaggcaagcagttcctggcccgtgatattccagttagaggtgtctgactgacagcatgttggcaccgagggaagcgatgggcttcggctccaggtttctgtcctgagaccacagcagaatgtgccttggacaaaggcttggactccttgatcttctggtaacttcaaaaatctggtctcagggtggtgaactttttcttcgaattcctaacctgtgagcttacgatgatggtgcctgtccattaactgaacaactgtggttttgaacttcttgaggccagggactgtgtctgaaaacaccgacggtggctaactcaagggagacgtctggtgaacacccgtgggatctaaagaacaagctctgaaagtgttccagctgaaatttcagatcggacagactcgctgcggctccggaggcagtgattccaagctgctcgcgcacgctgctgccaagctgcaggatggtgcacgtagccaggctgctgctgctgctcctcactttcttcctccgcacggatgctgagacacctccaaggtttacacgaacacccgttgatcagacaggggtctctggcggagttgcctctttcatctgccaagctacgggagacccaagacctaaaattgtctggaacaaaaaaggaaagaaagtcagcaatcagagatttgaggtaatagagtttgacgatgggtctggatcagttctcagaatacaacccttacggactccgagggatgaggccatttatgaatgtgtggcctcaaataatgtgggagaaataagtgtatccaccagactcacagttttgcgggaagatcaaattcccaggggcttccctaccattgacatgggcccacagttgaaggtggttgagcgtactcgcacggccaccatgctttgtgcagccagtggtaatccggatccagaaatcacttggtttaaagatttcttacctgtggacacaagcaacaacaatggtcgtattaagcagttacgatcagaatctattggtggtacaccaataagaggagcccttcagattgagcagagtgaagagtctgaccaaggaaaatatgagtgtgttgccaccaacagcgcgggcactcgctattccgctcctgccaatttatatgtcagagagctgcgagaagttcgccgtgtcccaccaagattctctatcccacccactaatcatgaaatcatgccaggcggaagcgttaatatcacctgtgtggccgtggggtcaccaatgccttatgtaaagtggatgttgggggcagaagatctgacacctgaagatgatatgccaataggaagaaatgtgctagaactgaatgatgtaagacagtcagcaaattacacctgtgttgctatgtcaacactgggtgtcattgaagcaatagcacagatcactgtcaaagccttacccaaacctccaggaactcctgtagtgaccgagagcacagctacaagcatcacactgacgtgggactctgggaaccctgagcctgtttcttattacataattcagcataaacctaaaaactctgaggaactttacaaagaaattgatggggtggcgaccacacgctacagtgtcgctggactaagtccctactcggattatgaattcagggttgttgctgtcaataacattgggcgggggcctcccagcgaacctgtgctaacacaaacctcagagcaagcaccatccagtgccccgagggatgtccaggcacgaatgttgagttcgaccaccattttggtacagtggaaggaacctgaagagccaaatggacagatccaaggatatagagtttattatacaatggatcccactcaacatgtcaacaactggatgaaacacaatgtagctgacagccaaatcactactattggcaacttagtgccccagaaaacatattctgtcaaagtcctggcttttacctcaattggagatggtcccctttcaagtgacatacaagtcatcactcagacaggagtaccagggcagccactaaacttcaaagcagaacctgagtctgaaacaagtattttgctctcttggacacctccacgttcagataccattgccaactatgaactggtctacaaagatggggagcatggagaggagcaacgaattaccattgagccagggacatcatataggctgcaaggactgaaaccaaacagcttatactatttccgtctggctgcacgctcccctcaaggcctgggtgcttctactgcagaaatatcagctagaaccatgcagtcaaagccgtcagctcctcctcaagacattagttgcaccagcccaagttccactagtattttggtaagttggcaacctccaccagtggaaaaacagaatggcattatcactgaatactccatcaagtacactgcagtggatggggaagatgacaagcctcacgagattttgggaattccttcggacactaccaaataccttttggaacagctggaaaaatggactgaataccggatcactgtgacagcccatacagatgtcggccctggccctgagagcttgtccgtgttgattcgaaccaatgaagatgttcctagtggtcctcctcgcaaagtcgaggtagaggctgtcaactcaacatctgttaaagtctcatggcgctcacccgtgcccaataaacagcatggccagataagaggatatcaggtgcattatgtgaggatggaaaatggtgagcccaagggccagcccatgctgaaagatgtcatgctggctgatgcacagtgggaatttgatgatactactgaacatgacatgatcatttctgggctccagcctgaaacttcctactccctcaccgtcacagcctacacaaccaaaggagatggtgctcgcagcaagcccaaactggtgtccaccactggggcagttccagggaaacctcggcttgtgattaaccacactcagatgaatactgctcttattcagtggcaccctccggtggacacatttggacctcttcagggctaccgtctaaaatttggccgcaaggatatggagccacttactactcttgagttctctgaaaaagaagatcactttacagctacagacatccacaagggagcatcatacgtcttcaggctctcagccagaaacaaagtgggctttggggaggagatggtgaaggagatttccattccagaagaagtaccaactggattccctcaaaaccttcactcagaaggcaccacttcaacctccgtccagttatcttggcaaccacctgtcctggcagagagaaatggcattatcaccaagtatacccttctttatagggatatcaacatcccccttctcccgatggagcagcttattgttccagctgacaccactatgacactcactggcttaaaaccagataccacatacgatgtaaaagtacgtgctcatacgagcaaagggcccgggccatatagtcccagtgtccagttcaggacactgcctgtggatcaagtgtttgcaaaaaattttcatgtcaaagcagtaatgaagacttccgtgttgctgtcttgggagattccagagaattataactccgccatgcctttcaaaattctttatgatgatgggaaaatggtagaagaagtggatggccgagccacacagaagttaattgtcaacctgaagcctgagaaatcatattcatttgtgctgacaaatcgtggaaacagtgctggtgggctgcagcacagggtcacggcaaagactgcaccagatgtattacgtaccaagcctgccttcattgggaagaccaacttggatggcatgattactgtgcaactgcctgaagtacctgcaaatgagaatataaaaggttactacataataattgtgcctttgaagaaatctcgcgggaaatttatcaagccatgggagagtccagatgaaatggaattagatgagctgcttaaggagatatctaggaagcgcagaagcatccgttatgggagagaagttgaattaaagccatatattgccgctcactttgatgtccttcccactgagttcaccctgggggatgacaagcattatggtggatttacaaacaagcaactccaaagtggtcaagaatatgtcttctttgtgttagcagtaatggaacatgcagagtctaagatgtatgcaaccagcccttactccgaccccgtggtgtcaatggatctggatccgcagccaatcacggatgaagaagaaggcttgatctgggttgtaggtcctgtccttgcagtggtctttatcatctgcattgtcattgctattcttctttataaaaggaagagggcagagtccgactctagaaaaagcagcataccgaacaataaggagatcccttcacaccacccaacagaccctgtagaactgaggcgccttaactttcaaacaccgggtatggctagccatcctccaatacccatcttggaacttgcagaccacattgaaagattgaaagcaaatgacaacttgaagttttcccaggaatatgagtcaattgaccctggccagcagttcacttgggaacattcaaacttggaagtaaacaaaccaaagaatagatacgcgaatgtaatcgcatatgatcattcccgggttctcctatcagctatagaagggatcccaggaagtgactatgtgaatgccaactacatagatgggtataggaagcaaaatgcctatattgcaacacagggatctctccccgaaacatttggggacttttggagaatgatatgggaacaacggagtgccacagttgtcatgatgacaaaactagaagaaagatcaagggtgaagtgtgaccagtattggcctagcagaggcacagaaacccacggactcgttcaagtaacgctgcttgatactgtggagctggccacatattgtgttcgaacatttgcactttacaagaatggttcaagtgagaagagagaagtgagacaattccagttcaccgcctggcctgatcatggtgttccagaacaccctacaccttttctagctttcttacgtagagtcaaaacctgtaaccctcccgatgctggtccgatggttgtgcactgcagtgcgggagttggccggactggttgcttcatcgtcatagatgccatgttagaaagaataaagcatgaaaaaactgtagatatttatggccatgtaactttaatgagagcccagaggaactatatggttcaaacagaagaccaatacatctttatccatgatgcactgttagaagcagtgacttgtggaaataccgaagtgccagctagaaacttgtatgcctacattcagaagctgacacaaatagaaacgggagagaatgtcacaggaatggagctcgaatttaagcgtctagccagctcaaaagctcacacctcaaggtttatcagtgccaatcttccatgtaataaattcaaaaatcgccttgttaatattatgccatatgaatccacaagggtatgcctgcagcctatccgtggagtagaaggatctgattacatcaatgccagttttattgatggatacagacaacagaaagcctacatcgctacccaggggcccttggcagagaccactgaagacttctggcggatgctctgggaacacaattccaccatagttgtgatgctcaccaagctgcgtgaaatgggcagagagaaatgtcaccaatactggccagcagaacggtctgcaagataccagtactttgttgtagatcccatggctgagtacaacatgccacagtatatcctaagggaattcaaggtcacagatgccagggacggccagtcccgaacagtaaggcagttccagttcactgactggccagagcaaggagtgccaaagtccggagaaggatttattgacttcatcggccaagtccataaaacaaaagaacagtttggccaagatggacccatttcagtccattgcagcgcgggcgttggaagaactggagtcttcataacgctaagcattgttttggaaagaatgagatatgaaggagttgtagatatcttccagactgtcaaaatgttaagaacacaacgaccagctatggtacagacagaggatcaatatcagttttcctatcgtgccgcactagagtacctgggcagctttgaccactatgcaacgtagaaacccctgacccattctggatttttactacaggcccttcaatatccatggagtctcttctgagccatacagggcacttgagaagtccttcttaacttctagctaacaactacttagtgggactattacacacaaaacaaattaaaaacaaattattccaggtggaccaagaattcacagtttaataatctaacctgaaaaataatgaagagaatcctgactgatgaggcatctgaaggattttatttacagatacctcaaggattcaaaatcaagggaagaagaaatcacagcaaagaaccaccatcttattcaggattgcttgaaaggtgcaaggagaaattgccagaatgctgcagttcagcacaagatatgtgctggtgtggcttctcacaatgaaacggactctgctttgacatcgccccttcccaccatactgctcataataacattttagggggaaaggggagggaatgtttaaaaagaaagtccttgatttagttttttagtattgtaaagatactgctgacctgtgcttcatttctaactgtgtaaacttttttttaacaaaatgtatcattcgataaagtgaattttaaaaaagttacataactcttcatttttttatttccaaatcgtaggtttttttaagctgtagaactgttatctgtaatatcttgctgtagaaatatcaaatcatttgaaaatttgcacatttttgtgcaaaactcaatctacagtatcagtctcgtcagatatattaattttacacttcagttttgattggtgagaaagtacccattctcttcaaataatcaaagataattattattttgttttgtttttggaatcaacagggaggcgcaaagtataaagttgctgctaacatatatacatatatatccatattttataagggtgtctatgtatatatagacagtgtgtccacacaaaaaatagatacagttatcagtcagtcagttcttccatgatttagtttttttaaacgtagaaaagctattgtaaacatctctttccatttattcttaattttttgacatattggtatttctttaaagggaaatgaggaatgcacatcagtgattgattgtcaaacctcaccccctgatttcctacctaatctacccccacctaaccaatcaatcacatccacaaattgttttgtttgtttgttagtcaggcttccaacaaagttcaatatttctaacactctagtgcaataaaaattattattaaatagctaagaggtgtgcatgtgggaaaggtcagtgcatatccctttaggaggggagaatgttgtaatatatcagctatcgagttgtttaaaaaaagtgtattcaatcgtatattgtctatagtatgtgctatgaaatttgcatttatgatatgtaacaggggcaaagccaaattcatgttactctgttcagtcagaaacattttgtggcatacagcattcctgggaagtgctgtactttgtttcgttttggttttagttttgcatttagagtgccttataattgatgcctattttaatagcatttctttttagcttttggttcgtatttccattcactgttcgtatctgttactttctattaaagcattatctgtttaccacatgtacaaaaactctttgaataatatgcattcctagttttcagccaagtcggggatgttagtgattgtaccagcccaaagcacttggataatcagggcccttcttccttttataatcaatcatcaacatcagaaaaagctacttgttttatttatattcccttccaaatccgctctggaacatgcagtaactgcaccaaacttattttagtaacaaatatcattggcaactttggaatatatttgatattccattaggatttttctaaaaggggaaataaactatatatatatatgtatcttacccccaattcttccaacagaatttctataggaagccatggatgatggcataagtttgccacatattacatgattttaaataatcctcaaaatacccaaggaactcttaaagagttttggtatgagtatactactttggtttaattttagcttcatggatgttctgcatggaaggatttttgttttccacattttcccattgctagcagagtgaaatccaagagaccaaacatttgcaagcattgtatttgagcacttttgtaaaaaacaaagaaaaagaaaaaaaagaaaatatatataatactaaaaaaaagtatctagaaggctacctcagaatgagactctctaacctacatcagaaccagagaagaatgtgcactatgtgggtctgttatcattattttcttttagtttgtatctttttggagatttatccaagtgccagattactcagtgctataattttcttttagttaaacaaagggggtcagacagacattgcatcatccagacatgccttgttggacatgtagaatccgatggagcactgcacaccagaatgattggccaatgagcagcttctctccctgaaacaataactgcccatttggcaaagggaaagatgacaataatcagaagaagaaaatgaatgggatgcataccatagacgaacgaggcggagactattgcgggaatcttactgttcaggagctgttcctagaactaactcccttactgtcattgatgtgcattccactctgtgcttttctgtacaaccattcaagttttaatttcccaggtgaaccatctttatctgccattaccacaagctttcaagtttccagttattttcatcatcataaccagtacggtgctattatttacctatgtacgtgtagttatgtataattttgtaattagttacaatggtaaaaaaaatcaaaatatataaaaagtgatttgtacagaactttattttagctcttttttaaaaatgatttgcatggttagaaaacggcgaggacagccaggggagggaagggcctctagggaactttgcactttctatacctttgtactatgcactgccctattgattctacacccaataatgatattacttgaacccatctgtaagaaactgcttcggaaattcatttgtgtgtatgtaaataacacaacatagaaacaggaagggaaaaaagtctgcagtaatgcacgtattttttttctttcctgtttattttcggttttgctttaagtccttttatttttaattccctttttgtttttctttttgggttttggttccttttgggtttatgggtgccctgatactccagcagagatcagaaggctacagatccattctatccatccgttatgtggctttgccatcccagcttggagtgtctttacaaagataataacagttgtgttctttgctctcgttttggatgcatagactgaaaaattaaaacaaataacttgtaaaatggcttgttaaaaaatacaattacctctaattagtagtacgcgtaaatgttttacagaatgaaaggcgtgctttttattttcttacttcgttacattggtggcgaaagaagtctgtatgaaaatcagttctttgctgacacaagttccatttgttacaaatgaattctaataaaaatgtcagtgttatgcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5789 -> Molecular function: GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] evidence: TAS
GeneID:5789 -> Molecular function: GO:0005102 [receptor binding] evidence: ISS
GeneID:5789 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5789 -> Molecular function: GO:0050839 [cell adhesion molecule binding] evidence: ISS
GeneID:5789 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: TAS
GeneID:5789 -> Biological process: GO:0006796 [phosphate-containing compound metabolic process] evidence: NAS
GeneID:5789 -> Biological process: GO:0007157 [heterophilic cell-cell adhesion] evidence: ISS
GeneID:5789 -> Biological process: GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway] evidence: TAS
GeneID:5789 -> Biological process: GO:0030182 [neuron differentiation] evidence: ISS
GeneID:5789 -> Biological process: GO:0050775 [positive regulation of dendrite morphogenesis] evidence: ISS
GeneID:5789 -> Biological process: GO:0097105 [presynaptic membrane assembly] evidence: ISS
GeneID:5789 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_002830 -> EC 3.1.3.48
by
@meso_cacase at
DBCLS
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