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2025-05-09 19:05:21, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_153613 1908 bp mRNA linear PRI 12-MAY-2013
DEFINITION Homo sapiens lysophosphatidylcholine acyltransferase 4 (LPCAT4),
mRNA.
ACCESSION NM_153613
VERSION NM_153613.2 GI:87116680
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1908)
AUTHORS Cao,J., Shan,D., Revett,T., Li,D., Wu,L., Liu,W., Tobin,J.F. and
Gimeno,R.E.
TITLE Molecular identification of a novel mammalian brain isoform of
acyl-CoA:lysophospholipid acyltransferase with prominent
ethanolamine lysophospholipid acylating activity, LPEAT2
JOURNAL J. Biol. Chem. 283 (27), 19049-19057 (2008)
PUBMED 18458083
REMARK GeneRIF: LPEAT2 as an important enzyme in the biosynthesis of
ethanolamine-containing phospholipids, especially in brain.
REFERENCE 2 (bases 1 to 1908)
AUTHORS Ye,G.M., Chen,C., Huang,S., Han,D.D., Guo,J.H., Wan,B. and Yu,L.
TITLE Cloning and characterization a novel human
1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7
JOURNAL DNA Seq. 16 (5), 386-390 (2005)
PUBMED 16243729
REMARK GeneRIF: report the cloning and characterization of a novel human
1-acyl-sn-glycerol-3-phosphate acyltransferase member AGPAT7
(1-acyl-sn-glycerol-3-phosphate acyltransferase 7) gene, which was
mapped to human chromosome 15q14
REFERENCE 3 (bases 1 to 1908)
AUTHORS Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
White,O. et al.
TITLE Initial assessment of human gene diversity and expression patterns
based upon 83 million nucleotides of cDNA sequence
JOURNAL Nature 377 (6547 SUPPL), 3-174 (1995)
PUBMED 7566098
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC048430.1, BC092463.1 and T29943.1.
On Feb 10, 2006 this sequence version replaced gi:23957707.
Summary: Members of the 1-acylglycerol-3-phosphate
O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze
the conversion of lysophosphatidic acid (LPA) to phosphatidic acid
(PA), a precursor in the biosynthesis of all glycerolipids. Both
LPA and PA are involved in signal transduction (Ye et al., 2005
[PubMed 16243729]).[supplied by OMIM, May 2008].
##Evidence-Data-START##
Transcript exon combination :: BC048430.1, AL832237.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-3 BC048430.1 3-5
4-1887 BC092463.1 1-1884
1888-1908 T29943.1 290-310
FEATURES Location/Qualifiers
source 1..1908
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q14"
gene 1..1908
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/note="lysophosphatidylcholine acyltransferase 4"
/db_xref="GeneID:254531"
/db_xref="HGNC:30059"
/db_xref="MIM:612039"
exon 1..208
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
STS 26..1231
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/db_xref="UniSTS:486579"
STS 73..1285
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/db_xref="UniSTS:494902"
CDS 95..1669
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/EC_number="2.3.1.25"
/note="acyl-CoA:lysophosphatidylethanolamine
acyltransferase 2; acyltransferase like 3;
1-acylglycerol-3-phosphate O-acyltransferase 7
(lysophosphatidic acid acyltransferase, eta); plasmalogen
synthase; PLSC domain containing protein; 1-AGPAT 7;
acyltransferase-like 3; 1-AGP acyltransferase 7"
/codon_start=1
/product="lysophospholipid acyltransferase LPCAT4"
/protein_id="NP_705841.2"
/db_xref="GI:87116681"
/db_xref="CCDS:CCDS32191.1"
/db_xref="GeneID:254531"
/db_xref="HGNC:30059"
/db_xref="MIM:612039"
/translation="
MSQGSPGDWAPLDPTPGPPASPNPFVHELHLSRLQRVKFCLLGALLAPIRVLLAFIVLFLLWPFAWLQVAGLSEEQLQEPITGWRKTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLQAPVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEFLPVYHPSPEESRDPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGRLKVALEPQLWELGKVLRKAGLSAGYVDAGAEPGRSRMISQEEFARQLQLSDPQTVAGAFGYFQQDTKGLVDFRDVALALAALDGGRSLEELTRLAFELFAEEQAEGPNRLLYKDGFSTILHLLLGSPHPAATALHAELCQAGSSQGLSLCQFQNFSLHDPLYGKLFSTYLRPPHTSRGTSQTPNASSPGNPTALANGTVQAPKQKGD
"
misc_feature 212..280
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q643R3.1);
transmembrane region"
misc_feature 353..415
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q643R3.1);
transmembrane region"
misc_feature 434..1012
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/note="Lysophospholipid Acyltransferases (LPLATs) of
Glycerophospholipid Biosynthesis: LPCAT1-like; Region:
LPLAT_LPCAT1-like; cd07991"
/db_xref="CDD:153253"
misc_feature <452..>805
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/note="1-acyl-sn-glycerol-3-phosphate acyltransferase
[Lipid metabolism]; Region: PlsC; COG0204"
/db_xref="CDD:30553"
misc_feature order(479..481,488..490,494..496,536..547,704..712)
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/note="putative acyl-acceptor binding pocket; other site"
/db_xref="CDD:153253"
misc_feature 479..496
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q643R3.1);
Region: HXXXXD motif"
exon 209..351
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 352..572
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 573..685
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 686..746
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 747..805
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 806..840
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 841..895
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 896..978
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 979..1104
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 1105..1237
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 1238..1336
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 1337..1493
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
exon 1494..1908
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/inference="alignment:Splign:1.39.8"
STS 1535..1677
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/standard_name="RH102924"
/db_xref="UniSTS:97258"
variation 1779
/gene="LPCAT4"
/gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2"
/replace="g"
/replace="t"
/db_xref="dbSNP:202247617"
ORIGIN
agcgccgccgccgccgctgctgcagcagcagctgctctgcagagtggtggccggggccagggccggggtgccctccctcccaccttctcccgccatgagccagggaagtccgggggactgggcccccctagatcccacccccggacccccagcatcccccaaccccttcgtgcatgagttacatctctctcgcctccagagggttaagttctgcctcctgggggcattgctggcccccatccgagtgcttctggcctttatcgtcctctttctcctctggccctttgcctggcttcaagtggccggtcttagtgaggagcagcttcaggagccaattacaggatggaggaagactgtgtgccacaacggggtgctaggcctgagccgcctgctgtttttcctgctgggcttcctccggattcgcgttcgtggccagcgagcctctcgccttcaagcccctgtccttgttgctgccccacactccactttctttgaccccattgttctgctgccctgtgacctgcccaaagttgtgtcccgagctgagaacctttccgttcctgtcattggagcccttcttcgattcaaccaagccatcctggtatcccggcatgacccggcttctcgacgcagagtggtggaggaggtccgaaggcgggccacctcaggaggcaagtggccgcaggtgctattctttcctgagggcacctgttccaacaagaaggctttgcttaagttcaaaccaggagccttcatcgcaggggtgcctgtgcagcctgtcctcatccgctaccccaacagtctggacaccaccagctgggcatggaggggtcctggagtactcaaagtcctctggctcacagcctctcagccctgcagcattgtggatgtggagttccttcctgtgtatcaccccagccctgaggagagcagggaccccaccctctatgccaacaatgttcagagggtcatggcacaggctctgggcattccagccaccgaatgtgagtttgtagggagcttacctgtgattgtggtgggccggctgaaggtggcgttggaaccacagctctgggaactgggaaaagtgcttcggaaggctgggctgtccgctggctatgtggacgctggggcagagccaggccggagtcgaatgatcagccaggaagagtttgccaggcagctacagctctctgatcctcagacggtggctggtgcctttggctacttccagcaggataccaagggtttggtggacttccgagatgtggcccttgcactagcagctctggatgggggcaggagcctggaagagctaactcgtctggcctttgagctctttgctgaagagcaagcagagggtcccaaccgcctgctgtacaaagacggcttcagcaccatcctgcacctgctgctgggttcaccccaccctgctgccacagctttgcatgctgagctgtgccaggcaggatccagccaaggcctctccctctgtcagttccagaacttctccctccatgacccactctatgggaaactcttcagcacctacctgcgccccccacacacctctcgaggcacctcccagacaccaaatgcctcatccccaggcaaccccactgctctggccaatgggactgtgcaagcacccaagcagaagggagactgagtgcctcagcctctcaccccctcctcctcagggcagcgctaggggcctcccctatgcctcagccccatctctgctcctgtttgaattttgttattgttgtttggttgttgtttttttaagttgattttaattttttgtttggttgatttttttgtaaaaaactattttatatataaatataaatctatatctatatctattaaaaaaaatgaagtccagtcatattgatgttaccatta
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:254531 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:254531 -> Molecular function: GO:0050200 [plasmalogen synthase activity] evidence: IEA
GeneID:254531 -> Biological process: GO:0006644 [phospholipid metabolic process] evidence: TAS
GeneID:254531 -> Biological process: GO:0006654 [phosphatidic acid biosynthetic process] evidence: TAS
GeneID:254531 -> Biological process: GO:0019432 [triglyceride biosynthetic process] evidence: TAS
GeneID:254531 -> Biological process: GO:0036148 [phosphatidylglycerol acyl-chain remodeling] evidence: TAS
GeneID:254531 -> Biological process: GO:0036150 [phosphatidylserine acyl-chain remodeling] evidence: TAS
GeneID:254531 -> Biological process: GO:0036151 [phosphatidylcholine acyl-chain remodeling] evidence: TAS
GeneID:254531 -> Biological process: GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] evidence: TAS
GeneID:254531 -> Biological process: GO:0044255 [cellular lipid metabolic process] evidence: TAS
GeneID:254531 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:254531 -> Biological process: GO:0046474 [glycerophospholipid biosynthetic process] evidence: TAS
GeneID:254531 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
GeneID:254531 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_705841 -> EC 2.3.1.25
NP_705841 -> EC 2.3.1.51
by
@meso_cacase at
DBCLS
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