2025-05-09 18:43:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015429 4488 bp mRNA linear PRI 14-MAY-2013 DEFINITION Homo sapiens ABI family, member 3 (NESH) binding protein (ABI3BP), mRNA. ACCESSION NM_015429 NM_024801 VERSION NM_015429.3 GI:194578880 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4488) AUTHORS Perlis,R.H., Huang,J., Purcell,S., Fava,M., Rush,A.J., Sullivan,P.F., Hamilton,S.P., McMahon,F.J., Schulze,T.G., Potash,J.B., Zandi,P.P., Willour,V.L., Penninx,B.W., Boomsma,D.I., Vogelzangs,N., Middeldorp,C.M., Rietschel,M., Nothen,M., Cichon,S., Gurling,H., Bass,N., McQuillin,A., Hamshere,M., Craddock,N., Sklar,P. and Smoller,J.W. CONSRTM Wellcome Trust Case Control Consortium Bipolar Disorder Group TITLE Genome-wide association study of suicide attempts in mood disorder patients JOURNAL Am J Psychiatry 167 (12), 1499-1507 (2010) PUBMED 21041247 REMARK GeneRIF: Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) Erratum:[Am J Psychiatry. 2011 Jan;168(1):100. Schulze, Thomas [corrected to Schulze, Thomas G]] REFERENCE 2 (bases 1 to 4488) AUTHORS Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A., Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S., Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M., Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A. and Wijmenga,C. TITLE Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling JOURNAL Gut 58 (8), 1078-1083 (2009) PUBMED 19240061 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 3 (bases 1 to 4488) AUTHORS Wakoh,T., Uekawa,N., Terauchi,K., Sugimoto,M., Ishigami,A., Shimada,J. and Maruyama,M. TITLE Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression JOURNAL Biochem. Biophys. Res. Commun. 380 (4), 807-812 (2009) PUBMED 19338757 REMARK GeneRIF: These results suggest that TARSH plays an important role in proliferation of replicative senescence and may serve as a trigger of tumor development. REFERENCE 4 (bases 1 to 4488) AUTHORS Latini,F.R., Hemerly,J.P., Oler,G., Riggins,G.J. and Cerutti,J.M. TITLE Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion JOURNAL Endocr. Relat. Cancer 15 (3), 787-799 (2008) PUBMED 18559958 REMARK GeneRIF: The loss of ABI3BP expression could play a functional role in thyroid tumorigenesis. REFERENCE 5 (bases 1 to 4488) AUTHORS Terauchi,K., Shimada,J., Uekawa,N., Yaoi,T., Maruyama,M. and Fushiki,S. TITLE Cancer-associated loss of TARSH gene expression in human primary lung cancer JOURNAL J. Cancer Res. Clin. Oncol. 132 (1), 28-34 (2006) PUBMED 16205947 REMARK GeneRIF: expression of TARSH mRNA is remarkably downregulated in all lung cancer cell lines examined; also TARSH expression was significantly low in all of the tumor specimens when compared to the expression in corresponding non-neoplastic lung tissue specimens REFERENCE 6 (bases 1 to 4488) AUTHORS Uekawa,N., Terauchi,K., Nishikimi,A., Shimada,J. and Maruyama,M. TITLE Expression of TARSH gene in MEFs senescence and its potential implication in human lung cancer JOURNAL Biochem. Biophys. Res. Commun. 329 (3), 1031-1038 (2005) PUBMED 15752759 REMARK GeneRIF: Thus, TARSH presumably represents a trigger gene for evoking cellular senescence, which has also been suggested to be involved in the prevention of tumorigenesis. REFERENCE 7 (bases 1 to 4488) AUTHORS Matsuda,S., Iriyama,C., Yokozaki,S., Ichigotani,Y., Shirafuji,N., Yamaki,K., Hayakawa,T. and Hamaguchi,M. TITLE Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3 JOURNAL J. Hum. Genet. 46 (8), 483-486 (2001) PUBMED 11501947 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA342832.1, BC030221.1 and AL117664.1. On Jul 29, 2008 this sequence version replaced gi:33667043. ##Evidence-Data-START## Transcript exon combination :: BC030221.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-575 DA342832.1 1-575 576-4151 BC030221.1 556-4131 4152-4488 AL117664.1 1962-2298 FEATURES Location/Qualifiers source 1..4488 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3q12" gene 1..4488 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /note="ABI family, member 3 (NESH) binding protein" /db_xref="GeneID:25890" /db_xref="HGNC:17265" /db_xref="HPRD:09380" /db_xref="MIM:606279" exon 1..185 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" CDS 86..3313 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /note="target of Nesh-SH3; ABI gene family, member 3 (NESH) binding protein; nesh-binding protein; ABI gene family member 3-binding protein" /codon_start=1 /product="target of Nesh-SH3 precursor" /protein_id="NP_056244.2" /db_xref="GI:33667044" /db_xref="CCDS:CCDS46880.1" /db_xref="GeneID:25890" /db_xref="HGNC:17265" /db_xref="HPRD:09380" /db_xref="MIM:606279" /translation="
MRGGKCNMLSSLGCLLLCGSITLALGNAQKLPKGKRPNLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIVDAEPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHDWTLPSHCPNDRFYTIRYREKDKEKKWIFQICPATETIVENLKPNTVYEFGVKDNVEGGIWSKIFNHKTVVGSKKVNGKIQSTYDQDHTVPAYVPRKLIPITIIKQVIQNVTHKDSAKSPEKAPLGGVILVHLIIPGLNETTVKLPASLMFEISDALKTQLAKNETLALPAESKTPEVEKISARPTTVTPETVPRSTKPTTSSALDVSETTLASSEKPWIVPTAKISEDSKVLQPQTATYDVFSSPTTSDEPEISDSYTATSDRILDSIPPKTSRTLEQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERTTSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHTKPAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLPHKPYPEVSQSEPAPLETRGIPFIPMISPSPSQEELQTTLEETDQSTQEPFTTKIPRTTELAKTTQAPHRFYTTVRPRTSDKPHIRPGVKQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGIISSGPITTPPLRSTPRPTGTPLERIETDIKQPTVPASGEELENITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNSPCSITDSVKRFPKEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVSAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW
" sig_peptide 86..169 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="COORDINATES: ab initio prediction:SignalP:4.0" mat_peptide 170..3310 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /product="Target of Nesh-SH3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q7Z7G0.1)" misc_feature 452..718 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /note="Fibronectin type III domain; Region: fn3; pfam00041" /db_xref="CDD:200951" misc_feature 2600..2875 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:28945" misc_feature order(2792..2794,2837..2839) /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /note="Interdomain contacts; other site" /db_xref="CDD:28945" misc_feature order(2840..2845,2849..2854) /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /note="Cytokine receptor motif; other site" /db_xref="CDD:28945" variation 86 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /replace="a" /replace="g" /db_xref="dbSNP:3732895" exon 186..365 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 366..434 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 435..567 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" variation 505 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /replace="a" /replace="c" /db_xref="dbSNP:34999788" exon 568..749 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 750..802 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 803..851 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 852..923 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 924..1016 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1017..1094 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1095..1169 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1170..1244 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1245..1310 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1311..1385 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1386..1460 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1461..1535 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1536..1607 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1608..1682 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1683..1757 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1758..1832 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1833..1892 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1893..1973 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 1974..2051 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 2052..2114 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 2115..2192 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 2193..2285 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 2286..2414 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 2415..2483 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 2484..2693 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 2694..2802 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 2803..2882 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 2883..2912 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 2913..3074 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 3075..3197 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" exon 3198..4473 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /inference="alignment:Splign:1.39.8" STS 3755..3883 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /standard_name="SHGC-77161" /db_xref="UniSTS:63187" STS 4149..4343 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /standard_name="SHGC-57683" /db_xref="UniSTS:57992" variation 4152 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /replace="a" /replace="g" /db_xref="dbSNP:1048364" variation 4222 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /replace="a" /replace="t" /db_xref="dbSNP:1027704" variation 4244..4245 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /replace="" /replace="aact" /db_xref="dbSNP:16334" variation 4246 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /replace="a" /replace="t" /db_xref="dbSNP:1048406" variation 4319 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" /replace="c" /replace="t" /db_xref="dbSNP:1027705" polyA_signal 4448..4453 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" polyA_site 4471 /gene="ABI3BP" /gene_synonym="NESHBP; TARSH" ORIGIN
gtgcagccgcccgcctctgtcactgggagacagtccacttaaatgcagctccagggttgcgaggcacccaccagcatcattccccatgcgaggtggcaaatgcaacatgctctccagtttggggtgtctacttctctgtggaagtattacactagccctgggaaatgcacagaaattgccaaaaggtaaaaggccaaacctcaaagtccacatcaataccacaagtgactccatcctcttgaagttcttgcgtccaagtccaaatgtaaagcttgaaggtcttctcctgggatatggcagcaatgtatcaccaaaccagtacttccctcttcccgctgaagggaaattcacagaagctatagttgatgcagagccgaaatatctgatagttgtgcgacctgctccacctccaagtcaaaagaagtcatgttcaggtaaaactcgttctcgcaaacctctgcagctggtggttggcactctgacaccgagctcggtcttcctgtcctggggtttcctcatcaacccacaccatgactggacattgccaagtcactgtcccaatgacagattttatacaattcgctatcgagaaaaggataaagaaaagaagtggatttttcaaatctgtccagccactgaaacaattgtggaaaacctaaagcccaacacagtttatgaatttggagtgaaagacaatgtggaaggtggaatttggagtaagattttcaatcacaagactgttgttggaagtaaaaaagtaaatgggaaaatccaaagtacctatgaccaagaccacacagtgccagcatatgtcccaaggaaactaatcccaataacaatcatcaagcaagtgattcagaatgttactcacaaggattcagctaaatccccagaaaaagctccactgggaggagtgatactagtccaccttattattccaggtcttaatgaaactactgtaaaacttcctgcatccctaatgtttgagatttcagatgcactcaagacacaattagctaagaatgaaaccttggcattacctgccgaatctaaaacaccagaggttgaaaaaatctcagcacgacccacaacagtgactcctgaaacagttccaagaagcactaaacccactacgtctagtgcattagatgtttcagaaacaacactggcttcaagtgaaaagccatggattgtgcctacagctaaaatatctgaagattccaaagttctgcagcctcaaactgcaacttatgatgttttctcaagccctacaacatcagatgagcctgagatatcagattcctacacagcaacaagtgatcgtattctggattctatcccacctaaaacttctagaactcttgaacagccaagggcaacactggctccaagtgaaacaccatttgttcctcaaaaactggaaatctttaccagtccagaaatgcagcctacgacacctgctccccagcaaactacatctatcccttctacacctaaacgacgcccccggcccaaaccgccaagaaccaaacctgaaagaaccacaagtgccggaacaattacacctaaaatttctaaaagccctgaacctacatggacaacaccggctcccggtaaaacacaatttatttctctgaaacctaaaatccctctcagcccagaagtgacacacaccaaacctgctcccaagcagacaccacgtgctcctcctaagccaaaaacatcaccacgcccaagaatcccacaaacacaaccagttcctaaggtgccccagcgtgttactgcaaaaccaaaaacgtcaccaagtccagaagtgtcatacaccacacctgctccaaaagatgtgctccttcctcataaaccataccctgaggtctctcagagcgaacctgctcctctagagacacgaggcatcccttttatacccatgatttccccaagtcctagtcaagaggaactacagaccactctggaagaaacagaccaatccacccaagaacctttcacaactaagattccacgaacaactgaactagcaaagacaactcaggcgccacacagattttatactactgtgaggcccagaacatctgacaagccacacatcagacctggggtcaagcaagcacccaggccatcaggtgctgatagaaatgtatcagtggactctacccaccccactaaaaagccagggactcgccgcccacccttgccacccagacctacacacccacgaagaaaacctttaccaccaaataatgtcactggaaagccaggaagtgcaggaatcatttcatcaggcccaataactacaccacccctgaggtcaacacccaggcctactggaactcccttggagagaatagagacagatataaagcaaccaacagttcctgcctctggagaagaactggaaaatataactgactttagctcaagcccaacaagagaaactgatcctcttgggaagccaagattcaaaggacctcatgtgcgatacatccaaaagcctgacaacagtccctgctccattactgactctgtcaaacggttccccaaagaggaggccacagaggggaatgccaccagcccaccacagaacccacccaccaacctcactgtggtcaccgtggaagggtgcccctcatttgtcatcttggactgggaaaagccactaaatgacactgtcactgaatatgaagttatatccagagaaaatgggtcattcagtgggaagaacaagtccattcaaatgacaaatcagacattttccacagtagaaaatctgaaaccaaacacgagttatgaattccaggtgaaacccaaaaacccgcttggtgaaggcccggtcagcaacacagtggcattcagtactgaatcagcggacccaagagtgagtgagccagtttctgcaggaagagatgccatctggactgaaagaccctttaattcagactcttactcagagtgtaagggcaaacaatatgtcaaaaggacatggtataaaaaatttgtaggagtgcagctgtgcaactctctcagatacaagatttacttgagcgactccctcacaggaaaattttataacataggtgatcagaggggccatggagaagatcactgccagtttgtggattcatttttagatggacgcactgggcagcaactcacttctgaccagttaccaatcaaagaaggttatttcagagcagttcgccaggaacctgtccaatttggagaaataggtggtcacacccaaatcaattatgttcagtggtatgaatgtgggactacaattcctggaaaatggtagatgctgcacaaagttaccttctgtttcatcattgcaaacaaaaatcattgaaaatactatgccgcattcatttaaagctattttgtttactatgtataaaagtctacaatctaattaatagcaatactagatgtttattattagaaaagattgctgagagtatttatcaggttttacaaagtcattttaagaaagcaagatactgatgttaacagaataacatttttggggaagctggctccctattcatggtattttaagagatcatttgtatattatttatcacactgttgtaatgatgttttgagatacttttataacaaaattaacatcaaaaaggtatatactttttaaaaaaaatttacttttattgatgtgtactcttcctattgatgagttaattccataaatctctacttagtttaacttattggatcaaattatcttcagcatgtatatctggggaaaaaaggtccgaattttcacatttatatttaaacttcaattttttatatttaaacttcaattttttagcaacagctgaatagctttgcggaggagtttaatagttacacattcatgctaatatacatttcctttaaacatccacaaattcttaaaaagattgaatcagtaaatttcatttcagctaaaaatggagtctaatatattgtttcaaaagatacatttttacccaccataaatgttacaatatctgaatatgctttgtcaaactatccctttatgcaatcgtcttcatattgtttttatgattctaatcaagctgtatgtagagactgaatgtgaagtcaagtctgagcacaaaaagataatgcacgatgagattgcctaccattttataggatatttactatgtatttatacgttaagacctctatgaatgaatgtatcagagaatgtctttgtaactgtttaattcaatctgtaataaaaatctaactaactaactcatttatttctattaaaaaggtattgtcctttaggcggggaatgggaatccttgctgcactgttgcagtcattctgaaaggacctttccctgtacttacctttcaacatgcttcaatcttatcaacgctacattttgtatttttcaaacaagtataaattctgcaataaagagatgtagtttttttttaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:25890 -> Molecular function: GO:0005518 [collagen binding] evidence: IEA GeneID:25890 -> Molecular function: GO:0008201 [heparin binding] evidence: IEA GeneID:25890 -> Biological process: GO:0010811 [positive regulation of cell-substrate adhesion] evidence: IEA GeneID:25890 -> Biological process: GO:0030198 [extracellular matrix organization] evidence: IEA GeneID:25890 -> Cellular component: GO:0005614 [interstitial matrix] evidence: IEA GeneID:25890 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA GeneID:25890 -> Cellular component: GO:0031012 [extracellular matrix] evidence: IDA
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