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2025-05-09 18:50:26, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004376 6450 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens cytochrome c oxidase assembly homolog 15 (yeast)
(COX15), transcript variant 2, mRNA.
ACCESSION NM_004376
VERSION NM_004376.5 GI:189011539
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6450)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 2 (bases 1 to 6450)
AUTHORS Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
Peter,I.
TITLE A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
novel susceptibility loci
JOURNAL PLoS Genet. 8 (3), E1002559 (2012)
PUBMED 22412388
REFERENCE 3 (bases 1 to 6450)
AUTHORS Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
TITLE Genetic variants in nuclear-encoded mitochondrial genes influence
AIDS progression
JOURNAL PLoS ONE 5 (9), E12862 (2010)
PUBMED 20877624
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 6450)
AUTHORS Vitali,M., Venturelli,E., Galimberti,D., Benerini Gatta,L.,
Scarpini,E. and Finazzi,D.
TITLE Analysis of the genes coding for subunit 10 and 15 of cytochrome c
oxidase in Alzheimer's disease
JOURNAL J Neural Transm 116 (12), 1635-1641 (2009)
PUBMED 19826901
REMARK GeneRIF: COX 15 mRNA was significantly more abundant in the
cerebral tissue of Alzheimer's disease (AD) patients and COX10 and
COX15 SNP were significantly less represented in the patient group,
suggesting a possible protective role toward the risk for AD
GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 6450)
AUTHORS Dassa,E.P., Dufour,E., Goncalves,S., Paupe,V., Hakkaart,G.A.,
Jacobs,H.T. and Rustin,P.
TITLE Expression of the alternative oxidase complements cytochrome c
oxidase deficiency in human cells
JOURNAL EMBO Mol Med 1 (1), 30-36 (2009)
PUBMED 20049701
REMARK GeneRIF: The expression of the AOX, well-tolerated by the cells,
compensates for both the growth defect and the pronounced
oxidant-sensitivity of COX-deficient human cells.
REFERENCE 6 (bases 1 to 6450)
AUTHORS Oquendo,C.E., Antonicka,H., Shoubridge,E.A., Reardon,W. and
Brown,G.K.
TITLE Functional and genetic studies demonstrate that mutation in the
COX15 gene can cause Leigh syndrome
JOURNAL J. Med. Genet. 41 (7), 540-544 (2004)
PUBMED 15235026
REMARK GeneRIF: A patient with typical clinical and neuroradiological
features of Leigh syndrome and cytochrome oxidase deficiency was
found to have a mutation in the COX15 gene.
REFERENCE 7 (bases 1 to 6450)
AUTHORS Antonicka,H., Mattman,A., Carlson,C.G., Glerum,D.M., Hoffbuhr,K.C.,
Leary,S.C., Kennaway,N.G. and Shoubridge,E.A.
TITLE Mutations in COX15 produce a defect in the mitochondrial heme
biosynthetic pathway, causing early-onset fatal hypertrophic
cardiomyopathy
JOURNAL Am. J. Hum. Genet. 72 (1), 101-114 (2003)
PUBMED 12474143
REMARK GeneRIF: Mutations in COX15 produce a defect in the mitochondrial
heme biosynthetic pathway, causing early-onset fatal hypertrophic
cardiomyopathy
REFERENCE 8 (bases 1 to 6450)
AUTHORS Barros,M.H., Carlson,C.G., Glerum,D.M. and Tzagoloff,A.
TITLE Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation
of heme O
JOURNAL FEBS Lett. 492 (1-2), 133-138 (2001)
PUBMED 11248251
REFERENCE 9 (bases 1 to 6450)
AUTHORS Petruzzella,V., Tiranti,V., Fernandez,P., Ianna,P., Carrozzo,R. and
Zeviani,M.
TITLE Identification and characterization of human cDNAs specific to
BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the
formation and function of the mitochondrial respiratory chain
JOURNAL Genomics 54 (3), 494-504 (1998)
PUBMED 9878253
REFERENCE 10 (bases 1 to 6450)
AUTHORS Kennaway,N.G., Carrero-Valenzuela,R.D., Ewart,G., Balan,V.K.,
Lightowlers,R., Zhang,Y.Z., Powell,B.R., Capaldi,R.A. and
Buist,N.R.
TITLE Isoforms of mammalian cytochrome c oxidase: correlation with human
cytochrome c oxidase deficiency
JOURNAL Pediatr. Res. 28 (5), 529-535 (1990)
PUBMED 2175025
REMARK Review article
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BX537557.1, DB094258.1,
AF044323.1, BC078161.1 and AL133353.6.
This sequence is a reference standard in the RefSeqGene project.
On May 22, 2008 this sequence version replaced gi:156071495.
Summary: Cytochrome c oxidase (COX), the terminal component of the
mitochondrial respiratory chain, catalyzes the electron transfer
from reduced cytochrome c to oxygen. This component is a
heteromeric complex consisting of 3 catalytic subunits encoded by
mitochondrial genes and multiple structural subunits encoded by
nuclear genes. The mitochondrially-encoded subunits function in
electron transfer, and the nuclear-encoded subunits may function in
the regulation and assembly of the complex. This nuclear gene
encodes a protein which is not a structural subunit, but may be
essential for the biogenesis of COX formation and may function in
the hydroxylation of heme O, according to the yeast mutant studies.
This protein is predicted to contain 5 transmembrane domains
localized in the mitochondrial inner membrane. Alternative splicing
of this gene generates two transcript variants diverging in the 3'
region. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) lacks an internal segment in
the 3' region, as compared to variant 1. The encoded isoform 2 has
a shorter and distinct C-terminus, as compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF044323.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025094 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: reported by MitoCarta
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-71 BX537557.1 1-71
72-182 DB094258.1 73-183
183-893 BX537557.1 183-893
894-1736 AF044323.1 328-1170
1737-3354 BC078161.1 2388-4005
3355-6450 AL133353.6 57310-60405 c
FEATURES Location/Qualifiers
source 1..6450
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q24"
gene 1..6450
/gene="COX15"
/gene_synonym="CEMCOX2"
/note="cytochrome c oxidase assembly homolog 15 (yeast)"
/db_xref="GeneID:1355"
/db_xref="HGNC:2263"
/db_xref="HPRD:04707"
/db_xref="MIM:603646"
exon 1..707
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="alignment:Splign:1.39.8"
variation 175
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2231674"
variation 183
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2231675"
misc_feature 387..389
/gene="COX15"
/gene_synonym="CEMCOX2"
/note="upstream in-frame stop codon"
variation 525
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="c"
/replace="g"
/db_xref="dbSNP:2231676"
variation 592
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2231677"
variation 595
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="g"
/replace="t"
/db_xref="dbSNP:2231678"
CDS 618..1784
/gene="COX15"
/gene_synonym="CEMCOX2"
/note="isoform 2 is encoded by transcript variant 2;
cytochrome c oxidase subunit 15; cytochrome c oxidase
assembly protein COX15 homolog; COX15 homolog, cytochrome
c oxidase assembly protein"
/codon_start=1
/product="cytochrome c oxidase assembly protein COX15
homolog isoform 2"
/protein_id="NP_004367.2"
/db_xref="GI:17921987"
/db_xref="CCDS:CCDS7481.1"
/db_xref="GeneID:1355"
/db_xref="HGNC:2263"
/db_xref="HPRD:04707"
/db_xref="MIM:603646"
/translation="
MQRLLFPPLRALKGRQYLPLLAPRAAPRAQCDCIRRPLRPGQYSTISEVALQSGRGTVSLPSKAAERVVGRWLLVCSGTVAGAVILGGVTRLTESGLSMVDWHLIKEMKPPTSQEEWEAEFQRYQQFPEFKILNHDMTLTEFKFIWYMEYSHRMWGRLVGLVYILPAAYFWRKGWLSRGMKGRVLALCGLVCFQGLLGWYMVKSGLEEKSDSHDIPRVSQYRLAAHLGSALVLYCASLWTSLSLLLPPHKLPETHQLLQLRRFAHGTAGLVFLTALSGAFVAGLDAGLVYNSFPKMGESWIPEDLFTFSPILRNVFENPTMVQFDHRILGITSVTAITVLYFLSRRIPLPRRTKMAAVTLLALAYTQGPVLFNFTFKISDLDEGIRNI
"
misc_feature 813..1718
/gene="COX15"
/gene_synonym="CEMCOX2"
/note="Cytochrome oxidase assembly protein; Region:
COX15-CtaA; cl15852"
/db_xref="CDD:210252"
misc_feature 816..1718
/gene="COX15"
/gene_synonym="CEMCOX2"
/note="Uncharacterized protein required for cytochrome
oxidase assembly [Posttranslational modification, protein
turnover, chaperones]; Region: CtaA; COG1612"
/db_xref="CDD:31800"
misc_feature 819..881
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7KZN9.1);
transmembrane region"
misc_feature 1077..1130
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7KZN9.1);
transmembrane region"
misc_feature 1167..1229
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7KZN9.1);
transmembrane region"
misc_feature 1296..1358
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7KZN9.1);
transmembrane region"
misc_feature 1422..1484
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7KZN9.1);
transmembrane region"
misc_feature 1587..1649
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7KZN9.1);
transmembrane region"
exon 708..889
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="alignment:Splign:1.39.8"
STS 743..874
/gene="COX15"
/gene_synonym="CEMCOX2"
/standard_name="A008T04"
/db_xref="UniSTS:17407"
exon 890..1012
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="alignment:Splign:1.39.8"
exon 1013..1199
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="alignment:Splign:1.39.8"
variation 1165
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="a"
/replace="g"
/db_xref="dbSNP:35483721"
exon 1200..1367
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="alignment:Splign:1.39.8"
variation 1281
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2231682"
exon 1368..1449
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="alignment:Splign:1.39.8"
exon 1450..1604
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="alignment:Splign:1.39.8"
exon 1605..1718
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="alignment:Splign:1.39.8"
exon 1719..6450
/gene="COX15"
/gene_synonym="CEMCOX2"
/inference="alignment:Splign:1.39.8"
variation 1737
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2231687"
variation 2701
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1802213"
STS 3045..3220
/gene="COX15"
/gene_synonym="CEMCOX2"
/standard_name="RH44559"
/db_xref="UniSTS:58606"
variation 3079
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="g"
/replace="t"
/db_xref="dbSNP:12416"
variation 3260
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1128642"
polyA_signal 3330..3335
/gene="COX15"
/gene_synonym="CEMCOX2"
polyA_site 3354
/gene="COX15"
/gene_synonym="CEMCOX2"
variation 5052
/gene="COX15"
/gene_synonym="CEMCOX2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1056844"
STS 6274..6440
/gene="COX15"
/gene_synonym="CEMCOX2"
/standard_name="RH65628"
/db_xref="UniSTS:73963"
ORIGIN
cacaaggtcgcagggccgttatgaggggaccccgggactcgaaccttggctccacagctgagccattctcgctacctgcccctcgtcacgccctccgtttccacacctttaacgcctcaaagatagaaggtgccgcccaaggggctggaaggagctgaggaaacgactccagaagaaatcaccactgactacgactcccgccggcccgccccggggagccttcggccgaccgtcccctcccccgccaccttccgcaccggccttcccggacggtatccgcgctcgttttcgctcagaggaggccccctgccttttcatgctccacgcgttcctccctcgtgcgcctgcagtttccacttggaatttgggctccggcgcgcaccagctaagaagcgcgtcaacagctgcgcgcgcccgtgcgcgcgtccccgacacctacgccccagcagcccccgcgaaagcggagtcgcaacgcaggcgcacttctgttcgctccggtccccagagaaggcggggctcccgctgcccgacccggaagtgcttctcttttccttggcggaggagggagaccacagagccctgggttgtggaagaggtggctgttccctgtcatcagtatgcagcgattgctctttccgccgttgagggccttgaaggggaggcagtatctgccgctcctggctcctagggcagcgcctagagcacagtgtgattgcatcaggcgccctttgaggccagggcaatacagcaccatctctgaagtagctttgcaatctggaaggggtacagtgtcccttccctcaaaggctgctgagcgggtggtgggccgatggctcctggtctgcagtggaacagtggctggagcagttattcttggtggagtaactaggttgacagagtctggcctctcgatggtagattggcatttaataaaggagatgaagccacctacaagccaagaggaatgggaagcagaattccaaagataccagcaatttccagaatttaaaatcttgaatcatgatatgacactgacagaattcaagttcatctggtacatggagtactcacaccgaatgtggggtcgccttgtaggccttgtgtacatcctgcctgctgcctacttttggagaaagggctggctcagccgtggcatgaaaggacgtgttcttgccctctgtggcctcgtctgcttccagggtctgttgggatggtatatggtgaaaagtggactagaagaaaaatcagactcccatgacatccctcgggtcagtcagtaccgccttgctgcccacctgggatcagccctggttctttattgtgccagcttgtggacctcactgtcactgctactccctccgcacaagttgcctgaaacccaccaactcctacagttgagacgatttgctcatggaacagcaggtctggtgttccttacggccctctcaggggcttttgtggcagggctagatgctgggcttgtttataactcctttcccaaaatgggagaatcctggatcccggaggacctctttaccttctcccccatcctgaggaatgtttttgagaatcccaccatggtgcagtttgatcaccggattctgggaatcacttcagtcactgccattacagtgctctacttcctctctcggagaattccccttcctagaaggaccaagatggcagcagtgactctgctggctttggcgtatacacagggccctgtcttattcaactttacttttaaaatcagtgatttggatgaaggcatcagaaacatctgatttgaggatggagcaacccaatattgctaatataatagatgacagtggcaactgaaaacagtcccagaatgaccccatcgagatgaaattaaacagattagaaatgtaacatactcatttaaattaaataagttgtataagtttgggctgaagaaacctggccttatatcatttcatataaaaaagacgggattttagttgtcctcaggttcaatatgaaccaagtagtattcatgttgttattatatgataacagaaaaattagtggtacttcaggttttatcagtagaagtgtcacagccatagtcaaaatacccctaacatactgcatttcactctgggtaccaaatttaagcaagatattgatggccactaagtgtgtatccagaagaagagatcagaatgatgagtccagaacccctgtcacacagggaataggtgaaggaactagggatatttaactggagcagagaacatctggagagagagcaagattcctgtccttgagaagttgaagccgtctcatgcagaagagggaatgagcttccattatgctgcagagctggcagcaatggatgaaagttgcaggaagttagttttagttctgtagaaggcaagagtagggtagaccaaatcaaatgctcactggggtcaggctgatggagacagtaacactggcgagcaggtgccccagctcggactatactgctgagttctggtctgttgctgccactctacaggtccagggttgttagatcttctgggtttttgttttgctttttgaaataaggaaaataagcttatcttaagtttatttttccttggatatacctagattccatacagtgacaatacaaatacaaaggaagaacatctggatttcatccttgacctcatttacaaagcaaaaagagatgctggattcagatataaatgtttaattttgcagtgtttaagtcagcaaatcttctgttttttaaaaataagccacatatctagatttttctgtgaaagctctcaattaagtgttgggaactaatttcaagattttaaaaaatgttatgcaggcttaacgtgtctgagagccataaatgacctaacgtttcccgttagtctctgaactaggtgatctcagttctctttcaactccagtactctgtaagtttctgtgacctgtagtgtaccattctcaggtggtgatatggtttggatgttttgtcccctccaaatctcatgttcaaagtgtgacattcagtgttagaggtgggcctagtaggaggtatttgggtcatgggggcggatcccttatgtatgactttgtgccatccccatagtaatgagtgagttctcactctggttgtttatgcaagagctggttgtttaaaagagcctggaacttcctcctctctcgcttgctctctctcaccatgtgacacactggctccccttcaccttctgccatgattgtaagcttcgtgaggccctcaccagaagcagatgccagcgccatgcttcctatacagttctatgcagaacagtgagccaaataaacctcttttctttctaaaaattgtcagtatttccttatagcaatgcaagccgactaacacaggtgattcttagcaaaacagtttgtcaatttttcataaatgctggaccctggctgggcttatgctattgcctagaagagattcccaacttctctcttatttgaatcttagaaaaatcccaaagcccaagcctcatctaagaccaattaagtcacaatccctggaggaagtaaaaggcatatttttaaagttccccaggtgattccaatgtgcagacaagtctagggaccactggcttaggtcctaatagcctagttaccttagaaagttctgactagcttattcccattcccttctaatttccaccccaccttatcatttgatctgctatgttgctcctattagtatgttagtaggatatggtctcttctggatagaatccttcaaagaaagggaactgtagttcctgaggcaggttcccacaccatcctctcctgatcctcaaacccaggttgtccttagttagtaactgagtcagcagagggcagtatgacccaacccaaagaaccatatattaatgcttctacagttgcctccaaggaagtagcaactcatgagtaagttaaggtttcagatgttttacttcatttttcttttattacagatgatgagtacatttggaaaaacaactggttgcatttagctatataactgtattatatctatgagcttctggtgaatgattatcttagggttttttttgtatttatgttattcccagcactcccagacacatatcaaatattgaattagtgaatgcatgaatggaaaatggataattacagattgatgttccaaatacctttttccaaaaaaacaagtcatcacatacctataggattaaatagatttcccttaatattttcaaaggtctctctgcacttacgtccattgtttttaaaacatgaaggaaattaaaacacatggctttcttaatcagtcaacctagaattttttgtctgtaacttagactgacaaatactatctattgtagcaggggtaatgactagcaactccctaaagcaatgttggttgcagagatcaacactgataatcatgattttaggataaccagtttatctacagctacccttgtggtcctgggatgaatggtgggttatatatcagcatatgtaacacatatacccatgtccctgcataagggagaatgcatcacctctctaacatgcatcacacattttcctcaacactgacctaaaatgtttgtcagtgagaattttaagaattcaaaattcaacaaaattattgtttaatgtgaagcagtagaaaaaacagagtcttaacaactccccaaagcaatgtaatacaggcagcctttggttttttaaagtgtagatcataataaaaagatgtctttcactacactccgcagaggccattgatcaaggtagaaataaagggggagtacatggcatgtacttcaggacttcaactaaagggtaattgtggaatgagaatttcaaatacaacatagtaactgaaacactagaaaccaaagtatgtgtctgggatccctgcttgcagaaaaacatttatgaagctagtaaggggcgtcttcaccagcagcaggccaaatgccggcaagtgctctgtaggaggggccacttaggaaagtaccagggctgccttggagtggagaaggaggagtggccaccagagggtatacaagtggttgccctttaaaagaagaggctcaggagcagacatgtctttatgctagcctgaagtcatgcatgtgtggctatacatagcctgtgattcagaagacttttcaactttggttttcataaaaatggcaagcaatgatggattacattttaaaagtgaaagcccttgtagtatgagtaatgattcagttttactaataaaaggatctccgtattgctcagattttcagagaaacaaaatggtcaactggtgtgttattccttcctcgtccctctgataacggtactgacaaactggaaaataatgaaatattagagcaaaagagaaatgtgtaataacacaagagaagtctattaggatataaggaagataagtagacagagcaggcttaaaatgaagcttgaacaagccatctgcagaaacagaaaacagggtagatgggacacccaaacagggtgccacagctttccaacttagatccaggttatgagagaatgagccaagaacacaacctaaaagttttcaatttgaggtatattcactgttgctattctatagtattaatcaaaatattattgactaataatcctgttattattaatcacaacttttggttttgagtcttagttttttaacagcaatattttttgtaacaccaggaaaatcctcacaagttattgccccaggggctggaatctggagctagcgtccctaagagactaatatgggagaatttgaaacatctgctatttctaccataattcttattcccaatcaacattacaccacataccacagcaaaaaggacaattagatactagttttgaattaatttgaaaagtttaaagacaacaaaaagaaacagccctctgtttctgtaacagagtctggaaactgcccaagaattacaacgaagttctttaatgaggtagatgtaataggcatttataccttcatctaggctgtagtcatctaatgaattgcttggatgttgtagtaaaggaaattgtataaaattgttttaaaaagatgtataaaatttaaaagtacgaaaagaaatacaggaacaagaatagatgtagtgaaaacttggcactatttctgacaaagtatttttttcaaagtttattcctaaatgtgagcaaagcagtcataaatgaatgtcagaagcagttgtaaagatggggcatggttagttgtggccagctgttttataaaaaatagattctgtttatacttgcagaaagattctgttaatgagcatttcattgtagctgacaaagtagttgggctaggaggccagtcactatgactttgcacatattacaactgctctaggcctcagttttatcacccatataaatcaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1355 -> Molecular function: GO:0004129 [cytochrome-c oxidase activity] evidence: IGI
GeneID:1355 -> Molecular function: GO:0004129 [cytochrome-c oxidase activity] evidence: TAS
GeneID:1355 -> Molecular function: GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] evidence: IEA
GeneID:1355 -> Biological process: GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen] evidence: IC
GeneID:1355 -> Biological process: GO:0006778 [porphyrin-containing compound metabolic process] evidence: TAS
GeneID:1355 -> Biological process: GO:0006783 [heme biosynthetic process] evidence: TAS
GeneID:1355 -> Biological process: GO:0006784 [heme a biosynthetic process] evidence: IEA
GeneID:1355 -> Biological process: GO:0006784 [heme a biosynthetic process] evidence: IGI
GeneID:1355 -> Biological process: GO:0007585 [respiratory gaseous exchange] evidence: TAS
GeneID:1355 -> Biological process: GO:0008535 [respiratory chain complex IV assembly] evidence: IMP
GeneID:1355 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:1355 -> Biological process: GO:0045333 [cellular respiration] evidence: IC
GeneID:1355 -> Biological process: GO:0055114 [oxidation-reduction process] evidence: TAS
GeneID:1355 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:1355 -> Cellular component: GO:0005743 [mitochondrial inner membrane] evidence: TAS
GeneID:1355 -> Cellular component: GO:0005746 [mitochondrial respiratory chain] evidence: TAS
GeneID:1355 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
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